Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
Autoři:
Arang Rhie aff001; Ho-Young Son aff001; Soo Jung Kwak aff001; Seungbok Lee aff001; Dong Young Kim aff005; Bark-Lynn Lew aff008; Woo-Young Sim aff008; Jeong-Sun Seo aff001; Ohsang Kwon aff005; Jong-Il Kim aff001; Seong Jin Jo aff005
Působiště autorů:
Genomic Medicine Institute (GMI), Medical Research Center, Seoul National University, Seoul, Korea
aff001; Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
aff002; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
aff003; Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea
aff004; Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea
aff005; Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea
aff006; Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea
aff007; Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
aff008
Vyšlo v časopise:
PLoS ONE 14(9)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0222533
Souhrn
Dutasteride, a dual inhibitor of both type I and II 5α-reductases, is used to treat male pattern hair loss (MPHL). However, patient response to dutasteride varies in each individual, the cause of which is yet to be identified. To identify genetic variants associated with response to dutasteride treatment for MPHL, a total of 42 men with moderate MPHL who had been treated with dutasteride for 6 months were genotyped and analysed by quantitative linear regression, case-control association tests, and Fisher’s exact test. The synonymous single nucleotide polymorphism (SNP) rs72623193 in DHRS9 was most significantly associated with response to dutasteride, followed by the non-synonymous SNP rs2241057 in CYP26B1. Additionally, variants in ESR1, SRD5A1, CYP19A1, and RXRG are suggested to be associated with response to dutasteride. Cumulative effect and interaction among these SNPs were presented in both additive and non-additive models.
Klíčová slova:
Biology and life sciences – Anatomy – Integumentary system – Hair – Skin – Hair follicles – Genetics – Heredity – Genetic mapping – Variant genotypes – Molecular genetics – Genetic loci – Alleles – Molecular biology – Biochemistry – Hormones – Androgens – Medicine and health sciences – Pharmacology – Pharmacokinetics – Drug metabolism – Research and analysis methods – Mathematical and statistical techniques – Statistical methods – Regression analysis – Physical sciences – Mathematics – Statistics – Linear regression analysis
Zdroje
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