#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Impact of pterygium on the ocular surface and meibomian glands


Autoři: Ana Claudia Viana Wanzeler aff001;  Italo Antunes França Barbosa aff001;  Bruna Duarte aff001;  Eduardo Buzolin Barbosa aff001;  Daniel Almeida Borges aff001;  Monica Alves aff001
Působiště autorů: Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas—UNICAMP, Campinas, SP, Brazil aff001;  Pontific Catholic University of Campinas–PUCCAMP, Campinas, SP, Brazil aff002
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0213956

Souhrn

Purpose

To analyze how ocular surface parameters correlate to presence of pterygium and investigate the possible impact of pterygia on tear film findings and meibomian glands findings.

Methods

We investigated objective parameters of the ocular surface such as conjunctival hyperemia, tear film stability and volume, meibomian gland dysfunction, dry eye disease, corneal topography comparing healthy individuals and correlating with the pterygium clinical presentation.

Results

A total of 83 patients were included. Corneal astigmatism induction was 2.65 ± 2.52 D (0.4–11.8). The impact of pterygium on the ocular surface parameters compared to matched controls was seen in: conjunctival hyperemia (control 1.55±0.39/pterygium 2.14±0.69; p = 0.0001), tear meniscus height (control 0.24±0.05 mm/pterygium 0.36±0.14mm; p 0.0002), meiboscore lower eyelid (control 0.29±0.64/pterygium 1.38±0.95; p 0.0001) and meiboscore upper eyelid (control 0.53±0.62/pterygium 0.98±0.75; p = 0.0083). We found a high number of pterygium patients (88%) presented meibomian gland alterations. Interestingly, meibomian gland loss was coincident to the localization of the pterygium in 54% of the upper and 77% lower lids.

Conclusion

Pterygium greatly impacts on ocular surface by inducing direct alterations in the pattern of meibomian glands besides corneal irregularities, conjunctival hyperemia and lacrimal film alterations, inducing significant symptoms and potential signs of dysfunction.

Klíčová slova:

Biology and life sciences – Anatomy – Cornea – Integumentary system – Skin – Eyelids – Head – Neuroscience – Sensory perception – Vision – Visual acuity – Psychology – Medicine and health sciences – Ocular system – Ocular anatomy – Eyes – Ophthalmology – Eye diseases – Inflammatory diseases – Social sciences


Zdroje

1. Saw SM, Tan D. Pterygium: prevalence, demography and risk factors. Ophthalmic epidemiology. 1999 Sep;6(3):219–28. 10487976

2. Chui J, Girolamo N Di, Wakefield D, Coroneo MT. The Pathogenesis of Pterygium: Current Concepts and Their Therapeutic Implications. The Ocular Surface [Internet]. 2008 Jan 1 [cited 2018 Mar 18];6(1):24–43. Available from: https://www.sciencedirect.com/science/article/pii/S1542012412701039 18264653

3. Chui J, Coroneo MT, Tat LT, Crouch R, Wakefield D, Di Girolamo N. Ophthalmic pterygium: A stem cell disorder with premalignant features. American Journal of Pathology [Internet]. 2011 Feb;178(2):817–27. Available from: doi: 10.1016/j.ajpath.2010.10.037 21281814

4. Liu L, Wu J, Geng J, Yuan Z, Huang D. Geographical prevalence and risk factors for pterygium: a systematic review and meta-analysis. BMJ Open [Internet]. 2013/11/19. 2013;3(11):e003787. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24253031 doi: 10.1136/bmjopen-2013-003787 24253031

5. Rezvan F, Khabazkhoob M, Hooshmand E, Yekta A, Saatchi M, Hashemi H. Prevalence and risk factors of pterygium: a systematic review and meta-analysis. Survey of ophthalmology. 2018 Sep;63(5):719–35. doi: 10.1016/j.survophthal.2018.03.001 29551597

6. Ozsutcu M, Arslan B, Erdur SK, Gulkilik G, Kocabora SM, Muftuoglu O. Tear osmolarity and tear film parameters in patients with unilateral pterygium. Cornea. 2014 Nov;33(11):1174–8. doi: 10.1097/ICO.0000000000000221 25255132

7. Ergin A, Bozdoğan Ö. Study on Tear Function Abnormality in Pterygium. Ophthalmologica [Internet]. 2001;215(3):204–8. Available from: https://www.karger.com/DOI/10.1159/000050859 11340392

8. Chan CML, Liu YP, Tan DTH. Ocular surface changes in pterygium. Cornea. 2002 Jan;21(1):38–42. 11805505

9. Wu H, Lin Z, Yang F, Fang X, Dong N, Luo S, et al. Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium. Scientific Reports [Internet]. 2017 Mar 24;7:45115. Available from: doi: 10.1038/srep45115 28338041

10. Bradley JC, Yang W, Bradley RH, Reid TW, Schwab IR. The science of pterygia. The British journal of ophthalmology. 2010 Jul;94(7):815–20. doi: 10.1136/bjo.2008.151852 19515643

11. Arita R, Suehiro J, Haraguchi T, Shirakawa R, Tokoro H, Amano S. Objective image analysis of the meibomian gland area. The British Journal of Ophthalmology [Internet]. 2014 Jun 27;98(6):746–55. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033206/ doi: 10.1136/bjophthalmol-2012-303014 23813417

12. Schellini SA, dos Reis Veloso CE, Lopes W, Padovani CR, Padovani CRP. Characteristics of patients with pterygium in the Botucatu region. Arquivos brasileiros de oftalmologia. 2005;68(3):291–4. 16059556

13. Murphy PJ, Lau JSC, Sim MML, Woods RL. How red is a white eye? Clinical grading of normal conjunctival hyperaemia. Eye (London, England). 2007 May;21(5):633–8.

14. Hilmi MR, Che Azemin MZ, Mohd Kamal K, Mohd Tamrin MI, Abdul Gaffur N, Tengku Sembok TM. Prediction of Changes in Visual Acuity and Contrast Sensitivity Function by Tissue Redness after Pterygium Surgery. Current eye research. 2017 Jun;42(6):852–6. doi: 10.1080/02713683.2016.1250277 28118054

15. Kampitak K, Leelawongtawun W. Precorneal tear film in pterygium eye. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2014 May;97(5):536–9. 25065094

16. Kampitak K, Tansiricharernkul W, Leelawongtawun W. A comparison of precorneal tear film pre and post pterygium surgery. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2015 Mar;98 Suppl 2:S53–5.

17. Han SB, Jeon HS, Kim M, Lee S-J, Yang HK, Hwang J- M, et al. Quantification of Astigmatism Induced by Pterygium Using Automated Image Analysis. Cornea. 2016 Mar;35(3):370–6. doi: 10.1097/ICO.0000000000000728 26684048

18. Avisar R, Loya N, Yassur Y, Weinberger D. Pterygium-induced corneal astigmatism. The Israel Medical Association journal: IMAJ. 2000 Jan;2(1):14–5. 10892364

19. Oner FH, Kaderli B, Durak I, Cingil G. Analysis of the Pterygium Size Inducing Marked Refractive Astigmatism. European Journal of Ophthalmology [Internet]. 2000 Jul 1;10(3):212–4. Available from: https://doi.org/10.1177/112067210001000304 11071028

20. Khan FA, Khan Niazi SP, Khan DA. The impact of pterygium excision on corneal astigmatism. Journal of the College of Physicians and Surgeons—Pakistan: JCPSP. 2014 Jun;24(6):404–7. doi: 06.2014/JCPSP.404407 24953913

21. Altan-Yaycioglu R, Kucukerdonmez C, Karalezli A, Corak F, Akova YA. Astigmatic changes following pterygium removal: comparison of 5 different methods. Indian journal of ophthalmology. 2013 Mar;61(3):104–8. doi: 10.4103/0301-4738.109379 23514644

22. Nelson JD, Shimazaki J, Benitez-del-Castillo JM, Craig JP, McCulley JP, Den S, et al. The international workshop on meibomian gland dysfunction: report of the definition and classification subcommittee. Investigative ophthalmology & visual science. 2011 Mar;52(4):1930–7.

23. Ye F, Zhou F, Xia Y, Zhu X, Wu Y, Huang Z. Evaluation of meibomian gland and tear film changes in patients with pterygium. Indian journal of ophthalmology. 2017 Mar;65(3):233–7. doi: 10.4103/ijo.IJO_743_16 28440253

24. Ibrahim OMA, Matsumoto Y, Dogru M, Adan ES, Wakamatsu TH, Shimazaki J, et al. In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. Ophthalmology. 2012 Oct;119(10):1961–8. doi: 10.1016/j.ophtha.2012.04.001 22717457

25. Arita R, Fukuoka S, Morishige N. Meibomian Gland Dysfunction and Contact Lens Discomfort. Eye & contact lens. 2017 Jan;43(1):17–22


Článek vyšel v časopise

PLOS One


2019 Číslo 9
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

plice
INSIGHTS from European Respiratory Congress
nový kurz

Současné pohledy na riziko v parodontologii
Autoři: MUDr. Ladislav Korábek, CSc., MBA

Svět praktické medicíny 3/2024 (znalostní test z časopisu)

Kardiologické projevy hypereozinofilií
Autoři: prof. MUDr. Petr Němec, Ph.D.

Střevní příprava před kolonoskopií
Autoři: MUDr. Klára Kmochová, Ph.D.

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#