#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue: A single centre experience


Autoři: Sophia D. Lin aff001;  Jane E. Butler aff001;  Claire L. Boswell-Ruys aff001;  Phu Hoang aff001;  Tom Jarvis aff003;  Simon C. Gandevia aff001;  Euan J. McCaughey aff001
Působiště autorů: Neuroscience Research Australia, Randwick, NSW, Australia aff001;  School of Medical Sciences, University of New South Wales, Kensington, NSW, Australia aff002;  Continence Clinic, MS Limited, Sydney, Australia aff003;  Australian Catholic University, Sydney, Australia aff004;  Prince of Wales Clinical School, University of New South Wales Medicine, University of New South Wales, Sydney, NSW, Australia aff005
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222731

Souhrn

Background

Bowel and bladder problems affect more than 50% of people with Multiple Sclerosis (MS). These problems have a large impact on quality of life and place a significant burden on health systems.

Objectives

This study aimed to ascertain the frequency of bladder and bowel problems in a select Australian MS cohort and to investigate the relationships between level of disability, bladder and bowel problems, and fatigue.

Methods

Questionnaires on the nature and severity of MS symptoms were distributed to clients attending an Australian MS centre. Log-binomial regression and multiple linear regression models were used to investigate relationships between disability, fatigue, and bladder and bowel problems.

Results and conclusions

Of 167 questionnaires distributed, 136 were completed. Bladder problems were reported by 87 (74.4%) respondents, whilst 66 (48.9%) experienced functional constipation and 43 (31.9%) faecal incontinence. This frequency in our select Australian MS population is similar to that reported globally. There was a significant correlation between level of disability and: bladder problems (p = 0.015), faecal incontinence (p = 0.001), fatigue (p<0.001) and constipation (p = 0.016, relative risk: 1.16). Further investigation into the causal relationships between various MS symptoms may be beneficial in the development of novel therapeutic strategies for people with MS.

Klíčová slova:

Biology and life sciences – Anatomy – Renal system – Bladder – Medicine and health sciences – Clinical medicine – Clinical immunology – Autoimmune diseases – Multiple sclerosis – Immunology – Neurology – Demyelinating disorders – Neurodegenerative diseases – Diagnostic medicine – Signs and symptoms – Fatigue – Constipation – Pathology and laboratory medicine – Urology – Incontinence – Gastroenterology and hepatology – People and places – Geographical locations – Oceania – Australia – Computer and information sciences – Graph theory – Directed graphs – Directed acyclic graphs – Physical sciences – Mathematics – Statistics – Linear regression analysis – Research and analysis methods – Mathematical and statistical techniques – Statistical methods – Regression analysis


Zdroje

1. Multiple Sclerosis International Federation. Atlas of MS 2013: mapping multiple sclerosis around the world. Mult Scler Int Fed. 2013:1–28.

2. Multiple Sclerosis Specialist Nurses in Australia 2017 [Internet]. Sydney: MS Australia; 2017 [cited 2018 Aug 12]. Available from: https://www.msaustralia.org.au/sites/default/files/MSA%20MS%20Specialist%20Nurses%20Report%202017.pdf.

3. Compston A, Coles A. Multiple sclerosis. The Lancet. 2008;372(9648):1502–17.

4. Olek MJ, Narayan RN, Frohman EM, Frohman TC. Clinical features of multiple sclerosis in adults. In: González-Scarano F, editor. UpToDate. UpToDate, Waltham, MA. (Accessed on April 2, 2018)2018.

5. Amarenco G, de Sèze M, Ruffion A, Sheikh Ismael S. Clinical and urodynamic evaluations of urinary disorders in multiple sclerosis. Annals of Physical and Rehabilitation Medicine. 2014;57(5):277–87. doi: 10.1016/j.rehab.2014.05.006 24980885

6. Betts CD, Mellow MT, Fowler CJ. Urinary symptoms and the neurological features of bladder dysfunction in multiple sclerosis. Journal of Neurology, Neurosurgery &amp; Psychiatry. 1993;56(3):245.

7. Hinds JP, Eidelman BH, Wald A. Prevalence of bowel dysfunction in multiple sclerosis: a population survey. Gastroenterology. 1990;98(6):1538–42. doi: 10.1016/0016-5085(90)91087-m 2338192

8. Preziosi G, Emmanuel A. Neurogenic bowel dysfunction: pathophysiology, clinical manifestations and treatment. Expert review of gastroenterology & hepatology. 2009;3(4):417–23.

9. Simmons RD, Tribe KL, McDonald EA. Living with multiple sclerosis: longitudinal changes in employment and the importance of symptom management. Journal of Neurology. 2010;257(6):926–36. doi: 10.1007/s00415-009-5441-7 20084515

10. DasGupta R, Fowler CJ. Bladder, bowel and sexual dysfunction in multiple sclerosis. Drugs. 2003;63(2):153–66. doi: 10.2165/00003495-200363020-00003 12515563

11. Khan F, Pallant JF, Shea TL, Whishaw M. Multiple sclerosis: prevalence and factors impacting bladder and bowel function in an Australian community cohort. Disability and rehabilitation. 2009;31(19):1567–76. 19848557

12. Hennessey A, Robertson N, Swingler R, Compston D. Urinary, faecal and sexual dysfunction in patients with multiple sclerosis. Journal of neurology. 1999;246(11):1027–32. doi: 10.1007/s004150050508 10631634

13. Wollin J, Bennie M, Leech C, Windsor C, Spencer N. Multiple sclerosis and continence issues: an exploratory study. British Journal of Nursing. 2005;14(8):439–46. doi: 10.12968/bjon.2005.14.8.17926 15924024

14. Chia Y-W, Fowler CJ, Kamm MA, Henry MM, Lemieux M-C, Swash M. Prevalence of bowel dysfunction in patients with multiple sclerosis and bladder dysfunction. Journal of neurology. 1995;242(2):105–8. doi: 10.1007/bf00887825 7707085

15. Khan F, McPhail T, Brand C, Turner-Stokes L, Kilpatrick T. Multiple sclerosis: disability profile and quality of life in an Australian community cohort. 2006;29(2):87–96. doi: 10.1097/01.mrr.0000194393.56772.62 16609318

16. Higginson IJ, Hart S, Silber E, Burman R, Edmonds P. Symptom prevalence and severity in people severely affected by multiple sclerosis. Journal of palliative care. 2006;22(3):158. 17058754

17. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983;33(11):1444–. doi: 10.1212/wnl.33.11.1444 6685237

18. Bates D, Burks J, Globe D, Signori M, Hudgens S, Denys P, et al. Development of a short form and scoring algorithm from the validated actionable bladder symptom screening tool. BMC Neurology. 2013;13(1):78.

19. Burks J, Chancellor M, Bates D, Denys P, Macdiarmid S, Nitti V, et al. Development and validation of the actionable bladder symptom screening tool for multiple sclerosis patients. International journal of MS care. 2013;15(4):182–92. doi: 10.7224/1537-2073.2012-049 24453782

20. Jongen PJ, Blok BF, Heesakkers JP, Heerings M, Lemmens WA, Donders R. Simplified scoring of the Actionable 8-item screening questionnaire for neurogenic bladder overactivity in multiple sclerosis: a comparative analysis of test performance at different cut-off points. BMC Urology. 2015;15(1):106.

21. Rome Foundation. Rome III Diagnostic Criteria for Functional Gastrointestinal Disorders. 2006.

22. Sansoni J, Hawthorne G, Fleming G, Marosszeky N. The Revised Faecal Incontinence Scale: A Clinical Validation of a New, Short Measure for Assessment and Outcomes Evaluation. Diseases of the Colon & Rectum. 2013;56(5):652–9.

23. Sansoni JE, Hawthorne G, Marosszeky N, Moore KH, Fleming G, Owen EA. Validation and clinical translation of the revised continence and patient satisfaction tools. 2011.

24. Sansoni J, Hawthorne G, Fleming G, Owen E, Marosszeky N. Technical Manual and Instructions: Revised incontinence and Patient Satisfaction Tools. Centre for Health Service Development, Australian Health Services Research Institute, University of Wollongong; 2011.

25. Fisk JD, Ritvo PG, Ross L, Haase DA, Marrie TJ, Schlech WF. Measuring the Functional Impact of Fatigue: Initial Validation of the Fatigue Impact Scale. Clinical Infectious Diseases. 1994;18(Supplement_1):S79–S83.

26. Mills RJ, Young CA, Pallant JF, Tennant A. Rasch analysis of the Modified Fatigue Impact Scale (MFIS) in multiple sclerosis. Journal of Neurology, Neurosurgery &amp; Psychiatry. 2010;81(9):1049.

27. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support. Journal of Biomedical Informatics. 2009;42(2):377–81. doi: 10.1016/j.jbi.2008.08.010 18929686

28. Hunter KF, Bharmal A, Moore KN. Long-term bladder drainage: Suprapubic catheter versus other methods: A scoping review. 2013;32(7):944–51. doi: 10.1002/nau.22356 23192860

29. Lekka E, Lee LK. Successful Treatment with Intradetrusor Botulinum-A Toxin for Urethral Urinary Leakage (Catheter Bypassing) in Patients with End-Staged Multiple Sclerosis and Indwelling Suprapubic Catheters. European Urology. 2006;50(4):806–10. doi: 10.1016/j.eururo.2005.12.015 16413661

30. Nortvedt MW, Riise T, Myhr KM, Landtblom AM, Bakke A, Nyland HI. Reduced quality of life among multiple sclerosis patients with sexual disturbance and bladder dysfunction. Multiple Sclerosis Journal. 2001;7(4):231–5. doi: 10.1177/135245850100700404 11548982

31. Nortvedt M, Riise T, Frugaård J, Mohn J, Bakke A, Skår A, et al. Prevalence of bladder, bowel and sexual problems among multiple sclerosis patients two to five years after diagnosis. Multiple Sclerosis Journal. 2007;13(1):106–12. doi: 10.1177/1352458506071210 17294618

32. Kos D, Kerckhofs E, Nagels G, D'Hooghe MB, Ilsbroukx S. Origin of Fatigue in Multiple Sclerosis: Review of the Literature. Neurorehabilitation and Neural Repair. 2007;22(1):91–100. doi: 10.1177/1545968306298934 17409388

33. Cincotta MC, Engelhard MM, Stankey M, Goldman MD. Fatigue and fluid hydration status in multiple sclerosis: A hypothesis. Multiple Sclerosis Journal. 2016;22(11):1438–43. doi: 10.1177/1352458516663854 27542703

34. Crayton H, Heyman RA, Rossman HS. A multimodal approach to managing the symptoms of multiple sclerosis. Neurology. 2004;63(11 suppl 5):S12.

35. Schwartz CE, Coulthard-Morris L, Zeng Q. Psychosocial correlates of fatigue in multiple sclerosis. Archives of Physical Medicine and Rehabilitation. 1996;77(2):165–70. doi: 10.1016/s0003-9993(96)90162-8 8607741

36. Amato MP, Ponziani G, Rossi F, Liedl CL, Stefanile C, Rossi L. Quality of life in multiple sclerosis: the impact of depression, fatigue and disability. Multiple Sclerosis Journal. 2001;7(5):340–4. doi: 10.1177/135245850100700511 11724451

37. Béthoux F. Fatigue and multiple sclerosis. Annales de Réadaptation et de Médecine Physique. 2006;49(6):355–60.


Článek vyšel v časopise

PLOS One


2019 Číslo 9
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

plice
INSIGHTS from European Respiratory Congress
nový kurz

Současné pohledy na riziko v parodontologii
Autoři: MUDr. Ladislav Korábek, CSc., MBA

Svět praktické medicíny 3/2024 (znalostní test z časopisu)

Kardiologické projevy hypereozinofilií
Autoři: prof. MUDr. Petr Němec, Ph.D.

Střevní příprava před kolonoskopií
Autoři: MUDr. Klára Kmochová, Ph.D.

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#