Circulating levels of free 25(OH)D increase at the onset of rheumatoid arthritis

English version

Autoři: Vidyanand Anaparti ^aff001; Xiaobo Meng ^aff001; Mahadevappa Hemshekhar ^aff001; Irene Smolik ^aff001; Neeloffer Mookherjee ^aff001; Hani El-Gabalawy ^aff001
Působiště autorů: Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada ^aff001; Manitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, Canada ^aff002
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0219109

Souhrn

Objective

Epidemiological studies suggest vitamin D deficiency as a potential risk factor for rheumatoid arthritis (RA) development, a chronic autoimmune disorder highly prevalent in indigenous North American (INA) population. We therefore profiled the circulating levels of 25-hydroxyvitaminD [25(OH)D], an active metabolite of vitamin D, in a cohort of at-risk first-degree relatives (FDR) of INA RA patients, a subset of whom subsequently developed RA (progressors).

Methods

2007 onward, serum samples from INA RA patients and FDR were collected at the time of a structured baseline visit and stored at -20°C. Anti-citrullinated protein antibodies (ACPA), 25(OH)D, hs-CRP, vitamin-D binding protein (VDBP) and parathyroid hormone (PTH) levels were determined using ELISA and rheumatoid factor (RF) seropositivity was determined by nephelometry.

Results

We demonstrate that 25 (OH) D concentrations were lower in winter than summer (P = 0.0538), and that serum 25(OH)D levels were higher in samples collected and stored after 2013 (P<0.0001). Analysis of samples obtained after 2013 demonstrated that 37.6% of study participants were 25(OH)D insufficient (<75nmol/L). Also, seropositive RA patients and FDR had lower 25(OH)D levels compared to ACPA-/FDR (P<0.05, P<0.01 respectively). Linear regression analysis showed 25(OH)D insufficiency was inversely associated with presence of RA autoantibodies. Longitudinal samples from 14 progressors demonstrated a consistent increase in 25(OH)D levels at the time they exhibited clinically detectable joint inflammation, without any significant change in VDBP or PTH levels. Spearman rank correlation analysis showed significant association between 25(OH)D and PTH levels, both in RA patients and progressors at RA onset time.

Conclusion

We demonstrate that 25(OH)D levels in serum increased at RA onset in progressors. The potential role that vitamin D metabolites and their downstream effects play in RA transition requires further investigation.

Klíčová slova:

Enzyme-linked immunoassays – Medical risk factors – Rheumatoid arthritis – Specimen storage – Summer – Winter – Parathyroid hormone

Zdroje

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Circulating levels of free 25(OH)D increase at the onset of rheumatoid arthritis

Souhrn

Objective

Methods

Results

Conclusion

Klíčová slova:

Zdroje

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