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Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis


Autoři: Xinlan Xu aff001;  Weide Li aff001;  Lan Qin aff001;  Wenjiao Yang aff002;  Guowei Yu aff003;  Qishan Wei aff004
Působiště autorů: School of Mathematics and Statistics, Lanzhou University, Lanzhou, Gansu, China aff001;  School of Public Health, Lanzhou University, Lanzhou, Gansu, China aff002;  Medical College of Northwest University for Nationalities, Lanzhou, Gansu, China aff003;  Maternal and Child Health Hospital, Lanzhou, Gansu, China aff004
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0221076

Souhrn

Background

Obesity is highly prevalent worldwide. More and more studies have been conducted on the relationship between H. pylori infection and obesity or overweight. But the relationship between them is controversial in the literatures and there is no comprehensive evidence for the correlation.

Aim

To evaluate the prevalence of H. pylori infection in Chinese adult subjects who received routine physical examinations and the relationship between H. pylori and obesity.

Methods

Literatures on H. pylori infection and obesity in Chinese population were searched in online databases. Relevant data were extracted independently by two researchers and meta-analysis was performed by using Review manager 5.3 software.

Results

22 articles were selected with a total sample size of 178033. The pooled prevalence of H. pylori was 42% (95%CI: 37% to 47%) and mean difference of BMI between subjects with and without H. pylori infection was 0.94 (95%CI: -0.04 to 1.91). 9 eligible studies with 27111 subjects were used to calculated pooled OR value because they contained obesity groups. The OR value showed that H. pylori-positive subjects tended to be obese at a risk of 1.20 (95% CI: 1.13 to 1.28).

Conclusion

In China, obesity has association with H. pylori infection. H. pylori infection may be one of the risk factors for obesity.

Klíčová slova:

Biology and life sciences – Microbiology – Medical microbiology – Microbial pathogens – Bacterial pathogens – Helicobacter pylori – Organisms – Bacteria – Helicobacter – Physiology – Physiological parameters – Obesity – Biochemistry – Lipids – Cholesterol – Medicine and health sciences – Pathology and laboratory medicine – Pathogens – Body weight – Body Mass Index – Infectious diseases – Bacterial diseases – Helicobacter pylori infection – Research and analysis methods – Mathematical and statistical techniques – Statistical methods – Metaanalysis – Database and informatics methods – Database searching – Research design – Cross-sectional studies – Physical sciences – Mathematics – Statistics


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