The role of C-reactive protein levels on the association of physical activity with lung function in adults
Autoři:
Elaine Fuertes aff001; Anne-Elie Carsin aff001; Vanessa Garcia-Larsen aff005; Stefano Guerra aff001; Isabelle Pin aff007; Bénédicte Leynaert aff010; Simone Accordini aff012; Jesús Martinez-Moratalla aff013; Josep M. Antó aff001; Isabel Urrutia aff015; Audrey Le Gouellec aff016; Joachim Heinrich aff017; Thorarinn Gislason aff019; Rain Jõgi aff020; Christer Janson aff021; Debbie Jarvis aff004; Judith Garcia-Aymerich aff001
Působiště autorů:
ISGlobal, Barcelona, Spain
aff001; Universitat Pompeu Fabra (UPF), Barcelona, Spain
aff002; CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain
aff003; National Heart and Lung Institute, Imperial College London, London, United Kingdom
aff004; Program in Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States of America
aff005; Asthma and Airway Disease Research Center, University of Arizona - Tucson, Arizona, United States of America
aff006; Department of Pediatrics, CHU Grenoble Alpes, Grenoble, France
aff007; INSERM, Institut for Advanced Biosciences, Grenoble, France
aff008; University Grenoble Alpes, Grenoble, France
aff009; UMR 1152, Pathophysiology and Epidemiology of Respiratory Diseases, INSERM, Paris, France
aff010; UMR 1152, University Paris Diderot Paris, Paris, France
aff011; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy
aff012; Servicio de Neumologia del Complejo, Servicio de Salud de Castilla – La Mancha (SESCAM), Hospitalario Universitario de Albacete, Albacete, Spain
aff013; Facultad de Medicina de Albacete, Universidad de Castilla - La Mancha, Albacete, Spain
aff014; Department of Respiratory, Galdakao Hospital, Galdakao, Spain
aff015; University Grenoble Alpes, CNRS, Grenoble INP, CHU Grenoble Alpes, TIMC-IMAG, Grenoble, France
aff016; Institute of Epidemiology, Helmholtz Zentrum Munchen - German Research Center for Environmental Health, Munich, Germany
aff017; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital Munich, Ludwig Maximilians University Munich, Munich, Germany
aff018; Department of Respiratory Medicine and Sleep, Landspitali University Hospital Reykjavik, Reykjavik, Iceland
aff019; Lung Clinic, Tartu University Hospital, Tartu, Estonia
aff020; Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
aff021; MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom
aff022
Vyšlo v časopise:
PLoS ONE 14(9)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0222578
Souhrn
Objective
Regular physical activity may be associated with improved lung function via reduced systemic inflammation, although studies exploring this mechanism are rare. We evaluated the role of C-reactive protein in blood, which is a common marker of systemic inflammation, on the association of physical activity with forced expiratory volume in one second and forced vital capacity.
Methods
Cross-sectional data on spirometry, C-reactive protein levels and self-reported physical activity (yes/no; ≥2 times and ≥1hr per week of vigorous physical activity) were available in the European Community Respiratory Health Survey (N = 2347 adults, 49.3% male, 28–56 years-old). A subsample was also assessed 10 years later using the International Physical Activity Questionnaire, and tertiles of Metabolic Equivalent of Task—minutes per week spent in vigorous, moderate and walking activities were calculated (N = 671, 49.6% male, 40–67 years-old). Adjusted cross-sectional mixed linear regression models and the “mediate” package in “R” were used to assess the presence of mediation.
Results
Despite positive significant associations between nearly all physical activity metrics with forced expiratory volume in one second and forced vital capacity, there was no evidence that C-reactive protein levels played a role. An influence of C-reactive protein levels was only apparent in the smaller subsample when comparing the medium to low tertiles of moderate activity (mean difference [95% CIs]: 21.1ml [5.2, 41.9] for forced expiratory volume in one second and 17.3ml [2.6, 38.0] for forced vital capacity).
Conclusions
In a population of adults, we found no consistent evidence that the association of physical activity with forced expiratory volume in one second or forced vital capacity is influenced by the level of C-reactive protein in blood.
Klíčová slova:
Inflammation – Physical activity – Professions – Pulmonary function – Questionnaires – Smoking habits – C-reactive proteins – Health surveys
Zdroje
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PLOS One
2019 Číslo 9
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