Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning

English version

Autoři: Douglas D. Burman ^aff001
Působiště autorů: Department of Radiology, NorthShore University HealthSystem, Evanston, Illinois, United States of America ^aff001
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222064

Souhrn

Hippocampal interactions with the motor system are often assumed to reflect the role of memory in motor learning. Here, we examine hippocampal connectivity with sensorimotor cortex during two tasks requiring paced movements, one with a mnemonic component (sequence learning) and one without (repetitive tapping). Functional magnetic resonance imaging activity was recorded from thirteen right-handed subjects; connectivity was identified from sensorimotor cortex correlations with psychophysiological interactions in hippocampal activity between motor and passive visual tasks. Finger movements in both motor tasks anticipated the timing of the metronome, reflecting cognitive control, yet evidence of motor learning was limited to the sequence learning task; nonetheless, hippocampal connectivity was observed during both tasks. Connectivity from corresponding regions in the left and right hippocampus overlapped extensively, with improved sensitivity resulting from their conjunctive (global) analysis. Positive and negative connectivity were both evident, with positive connectivity in sensorimotor cortex ipsilateral to the moving hand during unilateral movements, whereas negative connectivity was prominent in whichever hemisphere was most active during movements. Results implicate the hippocampus in volitional finger movements even in the absence of motor learning or recall.

Klíčová slova:

Biology and life sciences – Neuroscience – Cognitive science – Cognitive psychology – Learning – Cognition – Memory – Learning and memory – Psychology – Anatomy – Brain – Hippocampus – Cerebral hemispheres – Left hemisphere – Right hemisphere – Musculoskeletal system – Body limbs – Fingers – Social sciences – Medicine and health sciences – Arms – Research and analysis methods – Database and informatics methods – Bioinformatics – Sequence analysis

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Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning

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