CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer’s disease

English version

Autoři: Zehui Liu ^aff001; Wanyan Wang ^aff001; Tingyu Huang ^aff002; Cunfang Wang ^aff002; Ying Huang ^aff003; Yong Tang ^aff004; Jin Huang ^aff001
Působiště autorů: State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China ^aff001; Guangdong Long Fu Pharmaceutical Co., Ltd, Guangdong, China ^aff002; Guangdong Institute for Drug Control, Guangdong, China ^aff003; Department of Urology, Wuming Hospital of Guangxi Medical University, Guangxi, China ^aff004
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222757

Souhrn

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and is the most common type of cognitive impairment and dementia. There is a pressing need to improve the clinical efficacy and quality of life for AD patients, as limited treatments options for AD patients have been developed until now. In this study, we aim to investigate the protective effect of CH(II), a cerebroprotein hydrolysate consisted of abundant biological peptides, on preclinical model of AD. We found that CH(II) treatment effectively protects oxygen glucose deprivation (OGD)-induced N2A cell viability impairment and cell apoptosis. In addition, CH(II) significantly reduces H₂O₂-induced ROS accumulation and exhibits the protective activities against H₂O₂-induced oxidative injury. Intriguingly, we found that CH(II) treatment can effectively promote neurite outgrowth of N2A cells. Moreover, CH(II) obviously improve the cognitive and memorial function in scopolamine-induced amnesia mice model. Taken together, this study provides evidences of the neuroprotective activities of CH(II) and offers a potential therapeutic strategy for AD patients.

Klíčová slova:

Alzheimer's disease – Apoptosis – Brain damage – Flow cytometry – Fluorescence imaging – Neurites – Neurogenesis – Neuronal death

Zdroje

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CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer’s disease

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