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The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers


Autoři: Kristian Magnus Gundersen aff001;  Christoffer Nyborg aff001;  Øyvind Heiberg Sundby aff001;  Jonny Hisdal aff001
Působiště autorů: Section of Vascular Investigations, Department of Vascular Surgery, Division of Cardiovascular and Pulmonary Diseases, Oslo University Hospital, Oslo, Norway aff001;  Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway aff002
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0219814

Souhrn

Objective

To investigate the association between sympathetic activity, reactive hyperemia and brachial artery flow-mediated dilation (FMD).

Background

It is claimed that major surgery has an impact on endothelial function, as observed by post-operative reduced brachial artery FMD response. However, another explanation for the observed reduced FMD response post-operatively may be sympathetic stress-induced reduction in blood flow.

Methods

Seventeen healthy volunteers with a median age (25th-75th percentiles) of 23.5 (23–24.8) years were recruited. Participants’ brachial blood flow and FMD response were measured (i) during normal non-stress conditions (Normal1); (ii) during exposure to ice water; and (iii) afterwards, under normal non-stress conditions (Normal2). We continuously measured arterial blood pressure (Finometer), heart rate (ECG), skin blood flow of the index finger (laser Doppler), and brachial artery blood flow and diameter (Ultrasound Doppler). Measurements were taken at baseline; before a 5-min suprasystolic forearm occlusion; and following a 3-min post-occlusion, to measure reactive hyperemia and FMD.

Results

Median (25th-75th percentiles) FMD response after exposure to ice water was reduced compared to non-stress conditions [4.9 (2.9–8.4) % during ice water vs. 9.7 (7.6–12.2) % Normal1 and 9.7 (6.4–10.3) % Normal2, P < 0.001]. Blood flow 60 s after cuff-deflation during ice water exposure was significantly reduced to 328 (289–421) mL compared to non-stress conditions (both P < 0.05). No differences were observed between Normal1 [446 (359–506) mL] and Normal2 [455 (365–515) mL] (both P > 0.05). Heart rate significantly increased during ice water exposure [67 (59–69) beats/min)] compared to 55 (49–60) beats/min during Normal1 and 54 (47–60) beats/min during Normal2 (both P < 0.05). MAP did not change during Normal1 [72 (64–84)] or during Normal2 [71 (65–81) mm Hg] (both P > 0.05), but increased to 86 (75–98) mm Hg during ice water exposure (P < 0.05).

Conclusions

Increased sympathetic activity resulted in decreased blood flow and brachial artery FMD response in healthy volunteers, independent of endothelial dysfunction. Future studies should adjust for blood flow when interpreting the FMD response.

Klíčová slova:

Biology and life sciences – Anatomy – Body fluids – Blood – Blood flow – Physiology – Medicine and health sciences – Cardiovascular anatomy – Blood vessels – Arteries – Vascular medicine – Blood pressure – Public and occupational health – Physical activity – Surgical and invasive medical procedures – Cardiovascular procedures – Vascular surgery – Cardiology – Heart rate – Physical sciences – Physics – Classical mechanics – Mechanical stress – Shear stresses


Zdroje

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362(6423):801–9. Epub 1993/04/29. doi: 10.1038/362801a0 8479518.

2. Green DJ, Jones H, Thijssen D, Cable NT, Atkinson G. Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter? Hypertension (Dallas, Tex: 1979). 2011;57(3):363–9. Epub 2011/01/26. doi: 10.1161/hypertensionaha.110.167015 21263128.

3. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet (London, England). 1992;340(8828):1111–5. Epub 1992/11/07. doi: 10.1016/0140-6736(92)93147-f 1359209.

4. Thijssen DH, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, et al. Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. American journal of physiology Heart and circulatory physiology. 2011;300(1):H2–12. Epub 2010/10/19. doi: 10.1152/ajpheart.00471.2010 20952670; PubMed Central PMCID: PMC3023245.

5. Zanaboni P, Murray PA, Simon BA, Zehr K, Fleischer K, Tseng E, et al. Selective endothelial dysfunction in conscious dogs after cardiopulmonary bypass. J Appl Physiol (1985). 1997;82(6):1776–84. Epub 1997/06/01. doi: 10.1152/jappl.1997.82.6.1776 9173941.

6. Balciunas M, Bagdonaite L, Samalavicius R, Baublys A. Markers of endothelial dysfunction after cardiac surgery: soluble forms of vascular-1 and intercellular-1 adhesion molecules. Medicina (Kaunas). 2009;45(6):434–9. Epub 2009/07/17. 19605962.

7. Krispinsky L, Lamb F, Stark R, Parra D. Endothelial Dysfunction in Children after Cardiopulmonary Bypass. The FASEB Journal. 2016;30(1 Supplement):948.11.

8. Dora KA, Stanley CP, Al Jaaly E, Fiorentino F, Ascione R, Reeves BC, et al. Isolated Human Pulmonary Artery Structure and Function Pre‐ and Post‐Cardiopulmonary Bypass Surgery. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease. 2016;5(2):e002822. doi: 10.1161/JAHA.115.002822 PMC4802443. 26908407

9. Verrier ED, Morgan EN. Endothelial response to cardiopulmonary bypass surgery. The Annals of thoracic surgery. 1998;66(5 Suppl):S17–9; discussion S25-8. Epub 1998/12/30. doi: 10.1016/s0003-4975(98)00965-5 9869436.

10. Morelos M, Amyot R, Picano E, Rodriguez O, Mazzone AM, Glauber M, et al. Effect of coronary bypass and cardiac valve surgery on systemic endothelial function. The American journal of cardiology. 2001;87(3):364–6, a10. Epub 2001/02/13. doi: 10.1016/s0002-9149(00)01380-1 11165982.

11. Chello M, Goffredo C, Patti G, Candura D, Melfi R, Mastrobuoni S, et al. Effects of atorvastatin on arterial endothelial function in coronary bypass surgery. Eur J Cardiothorac Surg. 2005;28(6):805–10. Epub 2005/11/09. doi: 10.1016/j.ejcts.2005.09.013 16274999.

12. Dedichen HH, Hisdal J, Skogvoll E, Aadahl P, Kirkeby-Garstad I. Reduced reactive hyperemia may explain impaired flow-mediated dilation after on-pump cardiac surgery. Physiol Rep. 2017;5(10). Epub 2017/05/31. doi: 10.14814/phy2.13274 28554963; PubMed Central PMCID: PMC5449560.

13. Meyer AA, Joharchi MS, Kundt G, Schuff-Werner P, Steinhoff G, Kienast W. Predicting the risk of early atherosclerotic disease development in children after repair of aortic coarctation. Eur Heart J. 2005;26(6):617–22. Epub 2004/12/25. doi: 10.1093/eurheartj/ehi037 15618050.

14. Ohmichi M, Kanda Y, Hisamoto K, Morishige K, Takahashi K, Sawada K, et al. Rapid changes of flow-mediated dilatation after surgical menopause. Maturitas. 2003;44(2):125–31. Epub 2003/02/19. 12590008.

15. Dyson KS, Shoemaker JK, Hughson RL. Effect of acute sympathetic nervous system activation on flow-mediated dilation of brachial artery. American journal of physiology Heart and circulatory physiology. 2006;290(4):H1446–53. Epub 2005/11/15. doi: 10.1152/ajpheart.00771.2005 16284236

16. Lind L, Johansson K, Hall J. The effects of mental stress and the cold pressure test on flow-mediated vasodilation. Blood pressure. 2002;11(1):22–7. Epub 2002/04/03. 11926347.

17. Hijmering ML, Stroes ES, Olijhoek J, Hutten BA, Blankestijn PJ, Rabelink TJ. Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation. Journal of the American College of Cardiology. 2002;39(4):683–8. Epub 2002/02/19. doi: 10.1016/s0735-1097(01)01786-7 11849869.

18. Ghiadoni L, Donald AE, Cropley M, Mullen MJ, Oakley G, Taylor M, et al. Mental stress induces transient endothelial dysfunction in humans. Circulation. 2000;102(20):2473–8. Epub 2000/11/15. doi: 10.1161/01.cir.102.20.2473 11076819.

19. Brod J. Hæmodynamic basis of acute pressor reactions and hypertension. British Heart Journal. 1963;25(2):227–45. PMC1017985.

20. Engelhart M, Kristensen JK. Evaluation of cutaneous blood flow responses by 133Xenon washout and a laser-Doppler flowmeter. The Journal of investigative dermatology. 1983;80(1):12–5. Epub 1983/01/01. 6571731.

21. Woodman RJ, Playford DA, Watts GF, Cheetham C, Reed C, Taylor RR, et al. Improved analysis of brachial artery ultrasound using a novel edge-detection software system. Journal of applied physiology (Bethesda, Md: 1985). 2001;91(2):929–37. Epub 2001/07/18. doi: 10.1152/jappl.2001.91.2.929 11457812.

22. Neunteufl T, Heher S, Katzenschlager R, Wolfl G, Kostner K, Maurer G, et al. Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain. The American journal of cardiology. 2000;86(2):207–10. Epub 2000/07/29. doi: 10.1016/s0002-9149(00)00857-2 10913483.

23. Matsuzawa Y, Kwon TG, Lennon RJ, Lerman LO, Lerman A. Prognostic Value of Flow‐Mediated Vasodilation in Brachial Artery and Fingertip Artery for Cardiovascular Events: A Systematic Review and Meta‐Analysis. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease. 2015;4(11):e002270. doi: 10.1161/JAHA.115.002270 PMC4845238. 26567372

24. Etsuda H, Takase B, Uehata A, Kusano H, Hamabe A, Kuhara R, et al. Morning attenuation of endothelium-dependent, flow-mediated dilation in healthy young men: possible connection to morning peak of cardiac events? Clinical cardiology. 1999;22(6):417–21. Epub 1999/06/22. doi: 10.1002/clc.4960220610 10376182.

25. Otto ME, Svatikova A, Barretto RB, Santos S, Hoffmann M, Khandheria B, et al. Early morning attenuation of endothelial function in healthy humans. Circulation. 2004;109(21):2507–10. Epub 2004/05/12. doi: 10.1161/01.CIR.0000128207.26863.C4 15136499.

26. Shaw JA, Chin-Dusting JP, Kingwell BA, Dart AM. Diurnal variation in endothelium-dependent vasodilatation is not apparent in coronary artery disease. Circulation. 2001;103(6):806–12. Epub 2001/02/15. doi: 10.1161/01.cir.103.6.806 11171787.

27. Elherik K, Khan F, McLaren M, Kennedy G, Belch JJ. Circadian variation in vascular tone and endothelial cell function in normal males. Clinical science (London, England: 1979). 2002;102(5):547–52. Epub 2002/05/01. 11980574.

28. Kollias GE, Stamatelopoulos KS, Papaioannou TG, Zakopoulos NA, Alevizaki M, Alexopoulos GP, et al. Diurnal variation of endothelial function and arterial stiffness in hypertension. Journal of human hypertension. 2009;23(9):597–604. Epub 2009/02/27. doi: 10.1038/jhh.2009.2 19242493.

29. Kawano H, Motoyama T, Yasue H, Hirai N, Waly HM, Kugiyama K, et al. Endothelial function fluctuates with diurnal variation in the frequency of ischemic episodes in patients with variant angina. Journal of the American College of Cardiology. 2002;40(2):266–70. Epub 2002/07/11. doi: 10.1016/s0735-1097(02)01956-3 12106930.

30. Grassi G, Bombelli M, Seravalle G, Dell'Oro R, Quarti-Trevano F. Diurnal blood pressure variation and sympathetic activity. Hypertension research: official journal of the Japanese Society of Hypertension. 2010;33(5):381–5. Epub 2010/03/06. doi: 10.1038/hr.2010.26 20203684.

31. Desborough JP. The stress response to trauma and surgery. British journal of anaesthesia. 2000;85(1):109–17. Epub 2000/08/06. doi: 10.1093/bja/85.1.109 10927999.

32. Dobson GP. Addressing the Global Burden of Trauma in Major Surgery. Frontiers in Surgery. 2015;2:43. doi: 10.3389/fsurg.2015.00043 PMC4558465. 26389122

33. Jansky L, Sramek P, Savlikova J, Ulicny B, Janakova H, Horky K. Change in sympathetic activity, cardiovascular functions and plasma hormone concentrations due to cold water immersion in men. European journal of applied physiology and occupational physiology. 1996;74(1–2):148–52. Epub 1996/01/01. 8891513.


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