#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis


Autoři: Alessandra D’Abramo aff001;  Luciana Lepore aff001;  Marco Iannetta aff001;  Saba Gebremeskel Tekle aff001;  Angela Corpolongo aff001;  Laura Scorzolini aff001;  Nazario Bevilacqua aff001;  Andrea Mariano aff001;  Maria Letizia Giancola aff001;  Antonella Vulcano aff001;  Micaela Maritti aff001;  Alessandro Agresta aff001;  Mario Antonini aff001;  Umberto D’Alessandro aff002;  Emanuele Nicastri aff001
Působiště autorů: National Institute for Infectious Diseases, IRCCS, Lazzaro Spallanzani, Rome, Italy aff001;  MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Fajara, The Gambia aff002
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0225135

Souhrn

Objectives

This study aims to identify the risk factors for intensive care (IC) in severe malaria patients admitted to the “Lazzaro Spallanzani” National Institute for Infectious Diseases, Rome, Italy.

Methods

All patients with confirmed severe malaria and hospitalized between 2007 and 2015 were included in the analysis and stratified into two groups: those requiring IC and those who did not. Five prognostic malaria scores were estimated; clinical severity at IC unit admission was assessed using the Sequential Organ Failure Assessment and the quick-Sequential Organ Failure Assessment scores. Univariate and multivariate analysis were performed to assess factors independently associated to IC.

Results

A total of 98 severe malaria patients were included; 10 of them required IC. There were no deaths or sequelae. Patients requiring IC had higher severity scores. At the multivariate analysis, only the number of World Health Organization criteria and the aspartate aminotransferase value were independently associated with the need of IC.

Conclusions

An early and accurate assessment of the severity score is essential for the management of severe malaria patients.

Klíčová slova:

Aminotransferases – Coma – Intensive care units – Malaria – Malarial parasites – Parasitic diseases – Plasmodium


Zdroje

1. European Centre for Disease Prevention and Control. Annual epidemiological report 2014- emerging and vector-borne disease. Stockholm: ECDC; 2014

2. WHO. World malaria report 2015.World Health Organization, Geneva 2015.

3. Marks M, Gupta-Wright A, Doherty JF, Singer M and Walker D. Managing malaria in the intesive care unit. Br J Anaesth. 2014 Dec; 113(6): 910–921. doi: 10.1093/bja/aeu157 24946778

4. Arama C., Maiga B, Dolo A, Kouriba B., Traore B., Crompton PD., et al. Ethnic differeces in susceptibility to malaria: what have we learned from immuno-epidemiological studies in West Africa? Acta Trop 2015 Jun; 146:152–6. doi: 10.1016/j.actatropica.2015.03.023 25820030

5. Greenberg AE., Lobel HO. Mortality from Plasmodium falciparum malaria in travellers from the United States, 1959 to 1987. Ann Intern Med 1990; 113(4): 326–7. doi: 10.7326/0003-4819-113-4-326 2197915

6. Sabatinelli G., D’Ancona F., Majori G., Squarcione S. Fatal malaria in Italian travellers. Trans R Soc Trop Med Hyg 1994; 88:(3):314 doi: 10.1016/0035-9203(94)90097-3 7974674

7. WHO. World malaria report 2010.World Health Organization, Geneva 2010.

8. Mishra SK, Panigrahi P, Mishra R, Mohanty S. Prediction of outcome in adults with severe falciparum malaria: a new scoring system. Malar J 2007;6:24. doi: 10.1186/1475-2875-6-24 17326839

9. Hanson J, Lee SJ, Mohanty S, Faiz MA, Anstey NM, Charunwatthana P., et al. A simple score to predict the outcome of severe malaria in adults. Clin Infect Dis 2010;50:679–85. doi: 10.1086/649928 20105074

10. Mohapatra MK, Das SP. The malaria severity score: a method for severity assessment and risk prediction of hospital mortality for falciparum malaria in adults. J. Assoc Physicians India. 2009; 57:119–26. 19582979

11. Mohapatra BN., Janqid SK., Mohanty R. GCRBS score: a new scoring system for predicting outcome in severe falciparum malaria. J. Assoc Physicians India. 2014; 62(1)14–7. 25327086

12. Vincent JL, Moreno R, Takala J, Willotts S, De Mendronca A, Bruining H et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-related problems of the European Society of Intensive care medicine. Intensive Care Med 1996;22:707–10. doi: 10.1007/bf01709751 8844239

13. Seymour CM, Liu VX, Iwashyna TJ, Brukhorst FM, Rea TD, Scherag A. et al. Assessment of Clinical Criteria for Sepsis: for the third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 2016. 23; 315(8):762–74. doi: 10.1001/jama.2016.0288 26903335

14. Tatem AJ, Jia P, Ordanovich D, Falkner M., Huang Z., Howes R. et al. The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics. Lancet Infect Dis 2017; 17: 98–107. doi: 10.1016/S1473-3099(16)30326-7 27777030

15. Kain KC, Harrington MA, Tennyson S, Keystone JS. Imported malaria: prospective analysis of problems in diagnosis and management. Clin Infect Dis 1998; 27: 142–49. doi: 10.1086/514616 9675468

16. Bruneel F, Tubach F, Corne P, Megarbane B, Mira JP, Peytel E,et al. Severe Imported Malaria in Adults (SIMA) Study Group. Severe imported falciparum malaria: a cohort study in 400 critically ill adults. PLoS One. 2010 Oct 8;5(10):e13236. doi: 10.1371/journal.pone.0013236 20949045

17. Bruneel F., Raffetin A, Corne P, Llitjos JF, Mourvillier B, Argaud L,et al. Management of severe imported malaria in adults. Med Mal Infect. 2018 Sep 25. pii: S0399-077X(18)30587-0.

18. Dondorp AM, Fanello CI, Hendriksen IC, Gomes E., Seni A., Chhaganlal KD et al. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT). Lancet. 2010; 376:1647–1657. doi: 10.1016/S0140-6736(10)61924-1 21062666

19. Dondorp A, Nosten F, Stepniewska K, Day N, White N; South East Asian Quinine Artesunate Malaria Trial (SEAQUAMAT) group. Lancet 2005; 366: 717–25. doi: 10.1016/S0140-6736(05)67176-0 16125588


Článek vyšel v časopise

PLOS One


2019 Číslo 11
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

Svět praktické medicíny 3/2024 (znalostní test z časopisu)
nový kurz

Kardiologické projevy hypereozinofilií
Autoři: prof. MUDr. Petr Němec, Ph.D.

Střevní příprava před kolonoskopií
Autoři: MUDr. Klára Kmochová, Ph.D.

Aktuální možnosti diagnostiky a léčby litiáz
Autoři: MUDr. Tomáš Ürge, PhD.

Závislosti moderní doby – digitální závislosti a hypnotika
Autoři: MUDr. Vladimír Kmoch

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#