#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members


Autoři: Ghadir Fakhri Aljayyousi aff001;  Manar E. Abdel-Rahman aff001;  Asmaa El- Heneidy aff002;  Rana Kurdi aff001;  Eman Faisal aff003
Působiště autorů: Department of Public Health, College of Health Sciences, Qatar University, Doha, Qatar aff001;  School of Medicine, Griffith University, Gold Coast, Australia aff002;  Graduate Assistant at the Department of Public Health, College of Health Sciences, Qatar University, Doha, Qatar aff003
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0225499

Souhrn

Background

Antimicrobial resistance (AMR) is a serious public health problem and a global concern. The inappropriate use of antibiotics has been identified by the World Health Organization as a major risk factor for AMR.

Methods

The purpose of this research study is to assess the prevalence of inappropriate antibiotic use among Qatar University students and their family members, detect sociodemographic factors associated with inappropriate use, evaluate the knowledge and attitude towards antibiotic use, and assess respondents’ opinions on healthcare providers’ antibiotic prescription practices. Participants (N = 596) completed a self-administered questionnaire. Descriptive analysis, the Pearson chi-squared test, and multivariate logistic regression analyses were performed.

Results

The major inappropriate antibiotic use practices followed by the respondents were using antibiotics without prescription (82%), not completing the antibiotic course (45%), and obtaining antibiotics from the pharmacy without prescription (23%). The chi-square test results showed that age (p = 0.031) and nationality (p = 0.041) were associated with using antibiotics without prescription. In addition, respondents less than 21 years of age (p<0.001), who had only a secondary education (p = 0.007), and who lived in one of the large and crowded cities in Qatar (p = 0.011) had higher odds of stopping the antibiotic before completing the course. Our study also revealed that almost 60% of the respondents had inadequate knowledge and a negative attitude towards antibiotic use. Nationality and municipality were the independent factors associated with having appropriate knowledge of antibiotic use. Univariate logistic regression analyses in our study demonstrated that older (>26 years), married and university-graduated participants were more likely to have a positive attitude towards antibiotic use than others. Respondents also reported that neither doctors nor pharmacists were providing adequate patient education about appropriate antibiotic use. The Socio-Ecological Model was applied to interpret the findings and frame implications.

Conclusion

The findings shed light on various factors shaping antibiotic use practices and provide evidence to design multilevel behavioral interventions to improve public practices of antibiotic use.

Klíčová slova:

Allied health care professionals – Antibiotic resistance – Antibiotics – Health care providers – Patients – Pharmacists – Physicians – Qatar


Zdroje

1. World Health Organization. Antibiotic resistance 2018 https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance.

2. Davies DS VE. Antimicrobial Resistance: In Search of a Collaborative Solution.Report of the Antimicrobial Resistance Working Group 2013.; 2013.

3. Centers for Disease Control and Prevention. About antimicrobial resistance 2018 https://www.cdc.gov/drugresistance/about.html?fbclid=IwAR1MiptNr4RaP1nsekpUJWiFQbtHUMCsl8KXZsuxEVcgT5-hftjbDXF4rsI.

4. Mackenbach JP, Looman CW. Secular trends of infectious disease mortality in The Netherlands, 1911–1978: quantitative estimates of changes coinciding with the introduction of antibiotics. Int J Epidemiol. 1988;17(3):618–24. doi: 10.1093/ije/17.3.618 3209342

5. Centers for Disease Control and Prevention. Antibiotic resistance threat in the United States. Atlanta, GA: US Department of Health and Human Services. 2013.

6. Cassini A, Hogberg LD, Plachouras D, Quattrocchi A, Hoxha A, Simonsen GS, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis. 2019;19(1):56–66. doi: 10.1016/S1473-3099(18)30605-4 30409683

7. Memish ZA, Ahmed QA, Arabi YM, Shibl AM, Niederman MS. Microbiology of community-acquired pneumonia in the Gulf Corporation Council states. J Chemother. 2007;19 Suppl 1:17–23.

8. Aly M, Balkhy HH. The prevalence of antimicrobial resistance in clinical isolates from Gulf Corporation Council countries. Antimicrob Resist Infect Control. 2012;1(1):26. doi: 10.1186/2047-2994-1-26 22958584

9. Zhang R, Eggleston K, Rotimi V, Zeckhauser RJ. Antibiotic resistance as a global threat: evidence from China, Kuwait and the United States. Global Health. 2006;2:6. doi: 10.1186/1744-8603-2-6 16603071

10. Alhomoud F, Aljamea Z, Basalelah L. "Antibiotics kill things very quickly"—consumers’ perspectives on non-prescribed antibiotic use in Saudi Arabia. BMC public health. 2018;18(1):1177. doi: 10.1186/s12889-018-6088-z 30326870

11. Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis. Bmj. 2010;340:c2096. doi: 10.1136/bmj.c2096 20483949

12. Bell BG, Schellevis F, Stobberingh E, Goossens H, Pringle M. A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance. BMC Infect Dis. 2014;14:13. doi: 10.1186/1471-2334-14-13 24405683

13. CDC. Improve Antibiotic Prescribing 2019 https://www.cdc.gov/drugresistance/protecting_patients.html.

14. Shapiro DJ, Hicks LA, Pavia AT, Hersh AL. Antibiotic prescribing for adults in ambulatory care in the USA, 2007–09. J Antimicrob Chemother. 2014;69(1):234–40. doi: 10.1093/jac/dkt301 23887867

15. Bianco A, Papadopoli R, Mascaro V, Pileggi C, Pavia M. Antibiotic prescriptions to adults with acute respiratory tract infections by Italian general practitioners. Infect Drug Resist. 2018;11:2199–205. doi: 10.2147/IDR.S170349 30519057

16. Lindberg BH, Gjelstad S, Foshaug M, Hoye S. Antibiotic prescribing for acute respiratory tract infections in Norwegian primary care out-of-hours service. Scand J Prim Health Care. 2017;35(2):178–85. doi: 10.1080/02813432.2017.1333301 28569649

17. Goggin K, Bradley-Ewing A, Myers AL, Lee BR, Hurley EA, Delay KB, et al. Protocol for a randomised trial of higher versus lower intensity patient-provider communication interventions to reduce antibiotic misuse in two paediatric ambulatory clinics in the USA. BMJ Open. 2018;8(5):e020981. 29743330

18. Currie J, Lin W, Zhang W. Patient knowledge and antibiotic abuse: Evidence from an audit study in China. J Health Econ. 2011;30(5):933–49. doi: 10.1016/j.jhealeco.2011.05.009 21733587

19. Zwisler G, Simpson E, Moodley M. Treatment of diarrhea in young children: results from surveys on the perception and use of oral rehydration solutions, antibiotics, and other therapies in India and Kenya. J Glob Health. 2013;3(1):010403-. doi: 10.7189/jogh.03.010403 23826507

20. Al-Niemat SI, Bloukh DT, Al-Harasis MD, Al-Fanek AF, Salah RK. Drug use evaluation of antibiotics prescribed in a Jordanian hospital outpatient and emergency clinics using WHO prescribing indicators. Saudi Med J. 2008;29(5):743–8. 18454225

21. Alhomoud F, Aljamea Z, Almahasnah R, Alkhalifah K, Basalelah L, Alhomoud FK. Self-medication and self-prescription with antibiotics in the Middle East-do they really happen? A systematic review of the prevalence, possible reasons, and outcomes. International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases. 2017;57:3–12.

22. Napolitano F, Izzo MT, Di Giuseppe G, Angelillo IF. Public knowledge, attitudes, and experience regarding the use of antibiotics in Italy. PLoS One. 2013;8(12):e84177. doi: 10.1371/journal.pone.0084177 24376793

23. Anderson A. Online health information and public knowledge, attitudes, and behaviours regarding antibiotics in the UK: Multiple regression analysis of Wellcome Monitor and Eurobarometer Data. PLoS One. 2018;13(10):e0204878. doi: 10.1371/journal.pone.0204878 30356302

24. Bert F, Gualano MR, Gili R, Scaioli G, Lovato E, Angelillo IF, et al. Knowledge and attitudes towards the use of antibiotics in the paediatric age group: a multicenter survey in Italy. Eur J Public Health. 2017;27(3):506–12. doi: 10.1093/eurpub/ckw209 27836969

25. Hawkings NJ, Butler CC, Wood F. Antibiotics in the community: a typology of user behaviours. Patient Educ Couns. 2008;73(1):146–52. doi: 10.1016/j.pec.2008.05.025 18640805

26. Morgan DJ, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S. Non-prescription antimicrobial use worldwide: a systematic review. Lancet Infect Dis. 2011;11(9):692–701. doi: 10.1016/S1473-3099(11)70054-8 21659004

27. Shaikhan F, Rawaf S, Majeed A, Hassounah S. Knowledge, attitude, perception and practice regarding antimicrobial use in upper respiratory tract infections in Qatar: a systematic review. JRSM open. 2018;9(9):2054270418774971.

28. Alkhuzaei AMJB, Salama RE, Eljak IEI, Chehab MA, Selim NA. Perceptions and practice of physicians and pharmacists regarding antibiotic misuse at primary health centres in Qatar: A cross-sectional study. Journal of Taibah University Medical Sciences. 2018;13(1):77–82. doi: 10.1016/j.jtumed.2017.09.001 31435306

29. Moienzadeh A, Massoud T, Black E. Evaluation of the general public’s knowledge, views and practices relating to appropriate antibiotic use in Qatar. Int J Pharm Pract. 2017;25(2):133–9. doi: 10.1111/ijpp.12233 26671211

30. Black E, Cartwright A, Bakharaiba S, Al-Mekaty E, Alsahan D. A qualitative study of pharmacists’ perceptions of, and recommendations for improvement of antibiotic use in Qatar. International journal of clinical pharmacy. 2014;36(4):787–94. doi: 10.1007/s11096-014-9960-7 24899213

31. Emeka PM, Al-Omar M, Khan TM. Public attitude and justification to purchase antibiotics in the Eastern region Al Ahsa of Saudi Arabia. Saudi Pharm J. 2014;22(6):550–4. doi: 10.1016/j.jsps.2014.02.014 25561868

32. Epi info software version 7. 2018 https://www.cdc.gov/epiinfo/pc.html.

33. World Health Organization. ANTIBIOTIC RESISTANCE: MULTI-COUNTRY PUBLIC AWARENESS SURVEY. 2015.

34. Awad AI, Aboud EA. Knowledge, attitude and practice towards antibiotic use among the public in Kuwait. PLoS One. 2015;10(2):e0117910–e. doi: 10.1371/journal.pone.0117910 25675405

35. Steinman MA, Landefeld CS, Gonzales R. Predictors of broad-spectrum antibiotic prescribing for acute respiratory tract infections in adult primary care. Jama. 2003;289(6):719–25. doi: 10.1001/jama.289.6.719 12585950

36. Little P, Dorward M, Warner G, Stephens K, Senior J, Moore M. Importance of patient pressure and perceived pressure and perceived medical need for investigations, referral, and prescribing in primary care: nested observational study. Bmj. 2004;328(7437):444. doi: 10.1136/bmj.38013.644086.7C 14966079

37. Butler CC, Rollnick S, Pill R, Maggs-Rapport F, Stott N. Understanding the culture of prescribing: qualitative study of general practitioners&#039; and patients&#039; perceptions of antibiotics for sore throats. BMJ. 1998;317(7159):637. doi: 10.1136/bmj.317.7159.637 9727992

38. Ong S, Nakase J, Moran GJ, Karras DJ, Kuehnert MJ, Talan DA. Antibiotic use for emergency department patients with upper respiratory infections: prescribing practices, patient expectations, and patient satisfaction. Ann Emerg Med. 2007;50(3):213–20. doi: 10.1016/j.annemergmed.2007.03.026 17467120

39. Institute of Medicine Forum on Emerging I. The National Academies Collection: Reports funded by National Institutes of Health. In: Knobler SL, Lemon SM, Najafi M, Burroughs T, editors. The Resistance Phenomenon in Microbes and Infectious Disease Vectors: Implications for Human Health and Strategies for Containment: Workshop Summary. Washington (DC): National Academies Press (US) National Academy of Sciences.; 2003.

40. World health organization. WHO global strategy for containment of antimicrobial resistance. 2001.

41. Núñez M, Tresierra-Ayala M, Gil-Olivares F. Antibiotic self-medication in university students from Trujillo, Peru. Medicina Universitaria. 2016;18(73):205–9.

42. Almohammed RA, Bird EL. Public knowledge and behaviours relating to antibiotic use in Gulf Cooperation Council countries: A systematic review. J Infect Public Health. 2019;12(2):159–66. doi: 10.1016/j.jiph.2018.09.002 30245158

43. Scicluna EA, Borg MA, Gur D, Rasslan O, Taher I, Redjeb SB, et al. Self-medication with antibiotics in the ambulatory care setting within the Euro-Mediterranean region; results from the ARMed project. J Infect Public Health. 2009;2(4):189–97. doi: 10.1016/j.jiph.2009.09.004 20701882

44. Gualano MR, Gili R, Scaioli G, Bert F, Siliquini R. General population’s knowledge and attitudes about antibiotics: a systematic review and meta-analysis. Pharmacoepidemiology and drug safety. 2015;24(1):2–10. doi: 10.1002/pds.3716 25251203

45. Bin Nafisah S, Bin Nafesa S, Alamery AH, Alhumaid MA, AlMuhaidib HM, Al-Eidan FA. Over-the-counter antibiotics in Saudi Arabia, an urgent call for policy makers. J Infect Public Health. 2017;10(5):522–6. doi: 10.1016/j.jiph.2016.09.016 28162966

46. Bashwar Z, Malik MA, Fawaz M, Said H. Knowledge, Attitudes and Practices of Patients Attending West Bay Health Center Towards Upper Respiratory Tract Infections. Qatar Medical Journal. 2006;2006(1).

47. Huttner B, Goossens H, Verheij T, Harbarth S. Characteristics and outcomes of public campaigns aimed at improving the use of antibiotics in outpatients in high-income countries. Lancet Infect Dis. 2010;10(1):17–31. doi: 10.1016/S1473-3099(09)70305-6 20129146

48. Saam M, H B, Harbarth S. Evaluation of Antibiotic Awareness Campaigns. Geneva, Switzerland: WHO Collaborating Centre on Patient Safety, 2017.

49. McNulty CA, Boyle P, Nichols T, Clappison P, Davey P. Don’t wear me out—the public’s knowledge of and attitudes to antibiotic use. J Antimicrob Chemother. 2007;59(4):727–38. doi: 10.1093/jac/dkl558 17307770

50. Lum EPM, Page K, Nissen L, Doust J, Graves N. Australian consumer perspectives, attitudes and behaviours on antibiotic use and antibiotic resistance: a qualitative study with implications for public health policy and practice. BMC public health. 2017;17(1):799. doi: 10.1186/s12889-017-4813-7 29017473

51. Hawke KL, McGuire TM, Ranmuthugala G, van Driel ML. What do consumers want to know about antibiotics? Analysis of a medicines call centre database. Fam Pract. 2016;33(1):75–81. doi: 10.1093/fampra/cmv083 26502809

52. Zucco R, Lavano F, Anfosso R, Bianco A, Pileggi C, Pavia M. Internet and social media use for antibiotic-related information seeking: Findings from a survey among adult population in Italy. Int J Med Inform. 2018;111:131–9. doi: 10.1016/j.ijmedinf.2017.12.005 29425624


Článek vyšel v časopise

PLOS One


2019 Číslo 11
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

Současné pohledy na riziko v parodontologii
nový kurz
Autoři: MUDr. Ladislav Korábek, CSc., MBA

Svět praktické medicíny 3/2024 (znalostní test z časopisu)

Kardiologické projevy hypereozinofilií
Autoři: prof. MUDr. Petr Němec, Ph.D.

Střevní příprava před kolonoskopií
Autoři: MUDr. Klára Kmochová, Ph.D.

Aktuální možnosti diagnostiky a léčby litiáz
Autoři: MUDr. Tomáš Ürge, PhD.

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#