Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma
Autoři:
Toshiyuki Tanaka aff001; Hideo Akiyoshi aff001; Hidetaka Nishida aff001; Keiichiro Mie aff001; Lee-Shuan Lin aff003; Yasumasa Iimori aff001; Mari Okamoto aff001
Působiště autorů:
Laboratory of Veterinary Surgery, Osaka Prefecture University, Department of Graduate School of Life and Environmental Sciences, Osaka, Japan
aff001; Kinki Animal Medical Training Institute and Veterinary Clinic, Osaka, Japan
aff002; Laboratory of Veterinary Diagnostic Imaging, College of Veterinary Medicine, Department of Veterinary Medicine, National Pingtung University of Science and Technology, Neipu, Taiwan
aff003
Vyšlo v časopise:
PLoS ONE 14(11)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0225211
Souhrn
In veterinary medicine, abdominal ultrasonography is used to rank the differential diagnosis of renal lesions. However, a conventional sonographic examination may show nonspecific findings. The purpose of this study was to assess the computed tomography (CT) findings of canine renal tumors, including renal cell carcinoma (RCC), lymphoma, and hemangiosarcoma (HSA). In this retrospective study, the following CT parameters were recorded for each dog: 1) extent of renal involvement of tumors, 2) enhancement pattern, 3) number of renal tumors, 4) renal tumor vessel enhancement in the corticomedullary phase, 5) presence of lymphadenopathy and lung metastasis, and 6) attenuation values of the renal tumors on the pre- and post-contrast corticomedullary, nephrographic, and excretory phase images. Fifteen dogs met the inclusion criteria, of which nine had RCCs, four had lymphomas, and two had HSAs. RCCs tended to show heterogeneous enhancement and unilateral renal involvement, and vessel enhancement was detected in the corticomedullary phase in dogs with RCC. Conversely, renal lymphomas showed homogeneous enhancement, bilateral renal involvement, and multiple masses; in these dogs, no vessel enhancement was detected in the corticomedullary phase, and the incidence of lymphadenopathy was low. However, in dogs with lymphadenopathy, the renal lymphoma was associated with regionally severe lymphadenopathy. Finally, renal HSAs tended to show heterogeneous enhancement with a non-enhanced area and unilateral renal involvement; in these dogs, vessel enhancement was detected in the nephrographic phase, with the enhancement expanding around the vessel. These findings had no significant differences. Further studies with a larger sample size are required to examine the association between CT and histopathological findings.
Klíčová slova:
Cancer detection and diagnosis – Computed axial tomography – Dogs – Lymphomas – Metastasis – Renal cancer – Renal cell carcinoma – Veterinary diagnostics
Zdroje
1. Deborah WK and Sarah KM. Tumors of the urinary system In: Vail DM, editor. Withrow and MacEwen’s small animal clinical oncology. 5th ed. St Louis: Saunders Elsevier, 2012; p.p. 579.
2. Baskin GB, De Paoli A. Primary renal neoplasms of the dog. Vet Pathol. 1977;14: 591–605. 201076
3. Sato T, Aoki K, Shibuya H, Machida T, Watari T. Leiomyosarcoma of the kidney in a dog. J Vet Med A Physiol Pathol Clin Med. 2003;50: 366–369. doi: 10.1046/j.1439-0442.2003.00561.x 14633231
4. Borjesson DL. Renal cytology. Vet Clin North Am Small Anim Pract. 2003;33: 119–134. doi: 10.1016/s0195-5616(02)00086-4 12512379
5. Haers H, Vignoli M, Paes G, Rossi F, Taeymans O, Daminet S, et al. Contrast harmonic ultrasonographic appearance of focal space-occupying renal lesions. Vet Radiol Ultrasound. 2010;51: 516–522. doi: 10.1111/j.1740-8261.2010.01690.x 20973385
6. Vaden SL. Renal biopsy of dogs and cats. Clin Tech Small Anim Pract. 2005;20: 11–22. doi: 10.1053/j.ctsap.2004.12.003 15822526
7. Sapierzyński R, Kliczkowska-Klarowicz K, Jankowska U, Jagielski D. Cytodiagnostics of canine lymphomas – Possibilities and limitations. Pol J Vet Sci. 2016;19: 433–439. doi: 10.1515/pjvs-2016-0055 27487521
8. Vaden SL, Levine JF, Lees GE, Groman RP, Grauer GF, Forrester SD. Renal biopsy: A retrospective study of methods and complications in 283 dogs and 65 cats. J Vet Intern Med. 2005;19: 794–801. doi: 10.1892/0891-6640(2005)19[794:rbarso]2.0.co;2 16355671
9. Taylor AJ, Lara-Garcia A, Benigni L. Ultrasonographic characteristics of canine renal lymphoma. Vet Radiol Ultrasound. 2014;55: 441–446. doi: 10.1111/vru.12152 24629062
10. Sheth S, Ali S, Fishman E. Imaging of renal lymphoma: Patterns of disease with pathologic correlation. Radiographics. 2006;26: 1151–1168. doi: 10.1148/rg.264055125 16844939
11. Diaz de Leon A, Pedrosa I. Imaging and screening of kidney cancer. Radiol Clin North Am. 2017;55: 1235–1250. doi: 10.1016/j.rcl.2017.06.007 28991563
12. Urban BA, Fishman EK. Renal lymphoma: CT patterns with emphasis on helical CT. Radiographics. 2000;20: 197–212. doi: 10.1148/radiographics.20.1.g00ja09197 10682781
13. Moe L, Lium B. Computed tomography of hereditary multifocal renal cystadenocarcinomas in German shepherd dogs. Vet Radiol Ultrasound. 1997;38: 335–343. doi: 10.1111/j.1740-8261.1997.tb02094.x 9335089
14. Tanaka T, Akiyoshi H, Mie K, Okamoto M, Yoshida Y, Kurokawa S. Contrast-enhanced computed tomography may be helpful for characterizing and staging canine gastric tumors. Vet Radiol Ultrasound. 2019;60: 7–18. doi: 10.1111/vru.12677 30123960
15. Zhu L, Wu G, Ghimire P, Xu L. CT features of peripheral T-cell lymphoma in the gastrointestinal tract in Chinese population and literature review. J Med Imaging Radiat Oncol. 2012;56: 143–150. doi: 10.1111/j.1754-9485.2011.02329.x 22498185
16. Beukers M, Grosso FV, Voorhout G. Computed tomographic characteristics of presumed normal canine abdominal lymph nodes. Vet Radiol Ultrasound. 2013;54: 610–617. doi: 10.1111/vru.12075 23815078
17. Cohen J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Lawrence Erlbaum.
18. Berben L, Sereika SM, Engberg S. Effect size estimation: methods and examples. Int J Nurs Stud. 2012;49:1039–1047. doi: 10.1016/j.ijnurstu.2012.01.015 22377339
19. Lipsey MW, Wilson MD. (2001). Practical Meta-Analysis (1st ed.). Sage Publications: Thousand Oaks.
20. Cho H, Lee DH, Cha AY, Kim DE, Chang DW, Choi J. Optimization of scan delay for multiphase computed tomography by using bolus tracking in normal canine kidney. J Vet Sci. 2018;19:290–295. doi: 10.4142/jvs.2018.19.2.290 29032657
21. Kopka L, Fischer U, Zoeller G, Schmidt C, Ringert RH, Grabbe E. Dual-phase helical CT of the kidney: value of the corticomedullary and nephrographic phase for evaluation of renal lesions and preoperative staging of renal cell carcinoma. AJR Am J Roentgenol. 1997;169:1573–1578. doi: 10.2214/ajr.169.6.9393168 9393168
22. Waller KR, O'Brien RT, Zagzebski JA. Quantitative contrast ultrasound analysis of renal perfusion in normal dogs. Vet Radiol Ultrasound. 2007;48: 373–377. doi: 10.1111/j.1740-8261.2007.00259.x 17691639
23. Blomley MJ, Albrecht T, Cosgrove DO, Jayaram V, Eckersley RJ, Patel N, et al. Liver vascular transit time analyzed with dynamic hepatic venography with bolus injections of an US contrast agent: Early experience in seven patients with metastases. Radiology. 1998;209: 862–866. doi: 10.1148/radiology.209.3.9844688 9844688
24. Keegan KA, Schupp CW, Chamie K, Hellenthal NJ, Evans CP, Koppie TM. Histopathology of surgically treated renal cell carcinoma: Survival differences by subtype and stage. J Urol. 2012;188: 391–397. doi: 10.1016/j.juro.2012.04.006 22698625
25. Cangiano T, Liao J, Naitoh J, Dorey F, Figlin R, Belldegrun A. Sarcomatoid renal cell carcinoma: Biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. J Clin Oncol. 1999;17: 523–528. doi: 10.1200/JCO.1999.17.2.523 10080595
26. Lee S, Jung J, Chang J, Yoon J, Choi M. Evaluation of triphasic helical computed tomography of the kidneys in clinically normal dogs. Am J Vet Res. 2011;72: 345–349. doi: 10.2460/ajvr.72.3.345 21355737
27. Edmondson EF, Hess AM, Powers BE. Prognostic significance of histologic features in canine renal cell carcinomas: 70 nephrectomies. Vet Pathol. 2015;52: 260–268. doi: 10.1177/0300985814533803 24829287
28. McAloney CA, Sharkey LC, Feeney DA, Seelig DM, Avery AC, Jessen CR. Evaluation of the diagnostic utility of cytologic examination of renal fine-needle aspirates from dogs and the use of ultrasonographic features to inform cytologic diagnosis. J Am Vet Med Assoc. 2018;252: 1247–1256. doi: 10.2460/javma.252.10.1247 29701529
29. Pickhardt PJ, Lonergan GJ, Davis Jr CJ, Kashitani N, Wagner BJ. From the archives of the AFIP. Infiltrative renal lesions: Radiologic-pathologic correlation. Radiographics. 2000;20: 215–243. doi: 10.1148/radiographics.20.1.g00ja08215 10682782
30. Ballard DH, De Alba L, Migliaro M, Previgliano CH, Sangster GP. CT imaging spectrum of infiltrative renal diseases. Abdom Radiol. 2017;42: 2700–2709.
31. Yang PS, Lee KS, Lee SJ, Kim TS, Choo IW, Shim YM, et al. Esophageal leiomyoma: Radiologic findings in 12 patients. Korean J Radiol. 2001;2: 132–137. doi: 10.3348/kjr.2001.2.3.132 11752983
32. Hartman DS, Davidson AJ, Davis J. CJ, Goldman SM. Infiltrative renal lesions: CT-sonographic-pathologic correlation. Am J Roentgenol. 1988;150: 1061–1064.
33. Sheeran SR, Sussman SK. Renal lymphoma: Spectrum of CT findings and potential mimics. Am J Roentgenol. 1998;171: 1067–1072.
34. Semelka RC, Kelekis NL, Burdeny DA, Mitchell DG, Brown JJ, Siegelman ES. Renal lymphoma: Demonstration by MR imaging. Am J Roentgenol. 1996;166: 823–827.
35. Hartman DS, David Jr CJ, Goldman SM, Friedman AC, Fritzsche P. Renal lymphoma: Radiologic-pathologic correlation of 21 cases. Radiology. 1982;144: 759–766. doi: 10.1148/radiology.144.4.7111721 7111721
36. Bae KT. Intravenous contrast medium administration and scan timing at CT: considerations and approaches. Radiology 2010;256:32–61. doi: 10.1148/radiol.10090908 20574084
37. Fukuda S, Kobayashi T, Robertson ID, Oshima F, Fukazawa E, Nakano Y, et al. Computed tomographic features of canine nonparenchymal hemangiosarcoma. Vet Radiol Ultrasound. 2014;55: 374–379. doi: 10.1111/vru.12136 24382330
38. Jones ID, Lamb CR, Drees R, Priestnall SL, Mantis P. Associations between dual-phase computed tomography features and histopathologic diagnoses in 52 dogs with hepatic or splenic masses. Vet Radiol Ultrasound. 2016;57: 144–153. doi: 10.1111/vru.12336 26763951
39. Kutara K, Seki M, Ishigaki K, Teshima K, Ishikawa C, Kagawa Y, et al. Triple-phase helical computed tomography in dogs with solid splenic masses. J Vet Med Sci. 2017;79: 1870–1877. doi: 10.1292/jvms.17-0253 28993600
40. Fosmire SP, Dickerson EB, Scott AM, Bianco SR, Pettengill MJ, Meylemans H, et al. Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium. Lab Invest. 2004;84: 562–572. doi: 10.1038/labinvest.3700080 15064773
41. Gustafson DL, Duval DL, Regan DP, Thamm DH. Canine sarcomas as a surrogate for the human disease. Pharmacol Ther. 2018;188: 80–96. doi: 10.1016/j.pharmthera.2018.01.012 29378221
42. Locke JE, Barber LG. Comparative aspects and clinical outcomes of canine renal hemangiosarcoma. J Vet Intern Med. 2006;20: 962–967. doi: 10.1892/0891-6640(2006)20[962:caacoo]2.0.co;2 16955823
43. Omiyale AO. Clinicopathological features of primary angiosarcoma of the kidney: A review of 62 cases. Transl Androl Urol. 2015;4: 464–473. doi: 10.3978/j.issn.2223-4683.2015.05.04 26816844
44. Bryan JN, Henry CJ, Turnquist SE, Tyler JW, Liptak JM, Rizzo SA, et al. Primary renal neoplasia of dogs. J Vet Intern Med. 2006;20: 1155–1160. doi: 10.1892/0891-6640(2006)20[1155:prnod]2.0.co;2 17063709
45. Russo P. Renal cell carcinoma: Presentation, staging, and surgical treatment. Semin Oncol. 2000;27: 160–176. 10768595
46. Capitanio U, Becker F, Blute ML, Mulders P, Patard JJ, Russo P, et al. Lymph node dissection in renal cell carcinoma. Eur Urol. 2011;60: 1212–1220. doi: 10.1016/j.eururo.2011.09.003 21940096
47. Lawindy SM, Kurian T, Kim T, Mangar D, Armstrong PA, Alsina AE, et al. Important surgical considerations in the management of renal cell carcinoma (RCC) with inferior vena cava (IVC) tumour thrombus. BJU Int. 2012;110: 926–939. doi: 10.1111/j.1464-410X.2012.11174.x 22540179
48. Thiel DD, Lohse CM, Arnold ML, Cheville JC, Leibovich BC, Parker AS. Does left side renal cell carcinoma (RCC) with renal vein/vena cava thrombus predict worse prognosis than equivalent right side RCC tumor thrombus? Int Urol Nephrol. 2012;44: 1005–1012. doi: 10.1007/s11255-012-0168-2 22528581
49. Limmer S, Wagner T, Leipprand E, Arnholdt H. Primary renal hemangiosarcoma. Case report and review of the literature. Pathologe. 2001;22: 343–348. doi: 10.1007/s002920100481 11572116
50. Yohn SE, Hawkins EC, Morrison WB, Reams RY, DeNicola DB, Blevins WE. Confirmation of a pulmonary component of multicentric lymphosarcoma with bronchoalveolar lavage in two dogs. J Am Vet Med Assoc. 1994;204:97–101. 8125829
51. Katayama K, Tomoda K, Ohya T, Asada H, Ohbayashi C, Kimura H. Ground-glass opacities and a solitary nodule on chest in intravascular large B-cell lymphoma. Respirol Case Rep. 2015;3: 108–111. doi: 10.1002/rcr2.116 26392859
Článek vyšel v časopise
PLOS One
2019 Číslo 11
- Jak a kdy u celiakie začíná reakce na lepek? Možnou odpověď poodkryla čerstvá kanadská studie
- Pomůže v budoucnu s triáží na pohotovostech umělá inteligence?
- Spermie, vajíčka a mozky – „jednohubky“ z výzkumu 2024/38
- Skotská studie upřesnila zdravotní benefity aktivního cestování za prací a studiem
- Metamizol jako analgetikum první volby: kdy, pro koho, jak a proč?
Nejčtenější v tomto čísle
- A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
- A 3’ UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction
- A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
- Molecular validation of clinical Pantoea isolates identified by MALDI-TOF
Zvyšte si kvalifikaci online z pohodlí domova
Všechny kurzy