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EN

How to design a dose-finding study on combined agents: Choice of design and development of R functions

English version

Autoři: Monia Ezzalfani ^aff001
Působiště autorů: Institut Curie, PSL Research University, Biometry Unit, Paris, France ^aff001
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0224940

Souhrn

Background

In oncology, the aim of dose-finding phase I studies is to find the maximum tolerated dose for further studies. The use of combinations of two or more agents is increasing. Several dose-finding designs have been proposed for this situation. Numerous publications have however pointed out the complexity of evaluating therapies in combination due to difficulties in choosing between different designs for an actual trial, as well as complications related to their implementation and application in practice.

Methods

In this work, we propose R functions for Wang and Ivanova’s approach. These functions compute the dose for the next patients enrolled and provide a simulation study in order to calibrate the design before it is applied and to assess the performance of the design in different scenarios of dose-toxicity relationships. This choice of the method was supported by a simulation study which the aim was to compare two designs in the context of an actual phase I trial: i) in 2005, Wang and Ivanova developed an empirical three-parameter model-based method in Bayesian inference, ii) in 2008, Yuan and Yin proposed a simple, adaptive two-dimensional dose-finding design. In particular, they converted the two-dimensional dose-finding trial to a series of one-dimensional dose-finding sub-trials by setting the dose of one drug at a fixed level. The performance assessment of Wang’s design was then compared with those of designs presented in the paper by Hirakawa et al. (2015) in their simulation context.

Results and conclusion

It is recommended to assess the performances of the designs in the context of the clinical trial before beginning the trial. The two-dimensional dose-finding design proposed by Wang and Ivanova is a comprehensive approach that yields good performances. The two R functions that we propose can facilitate the use of this design in practice.

Klíčová slova:

Agent-based modeling – Algorithms – Probability density – Probability distribution – Simulation and modeling – Toxic agents – Toxicity – Phase I clinical investigation

Zdroje

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6. Mandrekar S. J. and Qin R. and Sargent D. J. Model-based phase I designs incorporating toxicity and efficacy for single and dual agent drug combinations: methods and challenges. Stat Med. 2010 May; 29(10):1077–1083. doi: 10.1002/sim.3706 20419760

7. Wages N. A. and Conaway M. R. and O’Quigley J. Continual reassessment method for partial ordering. Biometrics. 2011 Dec; 67(4):1555–1563. doi: 10.1111/j.1541-0420.2011.01560.x 21361888

8. Riviere M-K and Dubois F and Zohar S. Competing designs for drug combination in phase I dose-finding clinical trials. Statistics in medicine. 2015; 34(1):1–12. doi: 10.1002/sim.6094 24464821

9. Ivanova A. and Kim S. H. Dose finding for continuous and ordinal outcomes with a monotone objective function: a unified approach. Biometrics. 2009 Mar; 65(1):307–315. doi: 10.1111/j.1541-0420.2008.01045.x 18479486

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11. Iasonos A. and Wilton A. S. and Riedel E. R. and Seshan V. E. and Spriggs D. R. A comprehensive comparison of the continual reassessment method to the standard 3 + 3 dose escalation scheme in Phase I dose-finding studies. Clin Trials. 2008; 5(5):465–477. doi: 10.1177/1740774508096474 18827039

12. Hirakawa A. and Wages N. A. and Sato H. and Matsui S. A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies. Stat Med. 2015 Oct; 34(24):3194–3213. doi: 10.1002/sim.6533 25974405

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15. Wages N. A. and Conaway M. R. and O’Quigley J. Dose-finding design for multi-drug combinations”, Clin Trials. 2011 Aug; 8(4):380–389. doi: 10.1177/1740774511408748 21652689

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19. Hirakawa A. and Sato H. Authors’ Reply”. Stat Med. 2016 Feb; 35(3):479–480. doi: 10.1002/sim.6751 26757958

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Článek Protein synthesis rates of muscle, tendon, ligament, cartilage, and bone tissue in vivo in humans

Článek “What gets measured better gets done better”: The landscape of validation of global maternal and newborn health indicators through key informant interviews

Článek Contactless monitoring of heart and respiratory rate in anesthetized pigs using infrared thermography

Článek Molecular characterisation of genital human papillomavirus among women in Southwestern, Nigeria

Článek Impact of negative tuberculin skin test on growth among disadvantaged Bangladeshi children

Článek Streptococcal phosphotransferase system imports unsaturated hyaluronan disaccharide derived from host extracellular matrices

Článek The clot thickens: Autologous and allogeneic fibrin sealants are mechanically equivalent in an ex vivo model of cartilage repair

Článek Variation in hybridogenetic hybrid emergence between populations of water frogs from the Pelophylax esculentus complex

Článek Breast cancer in Tanzanian, black American, and white American women: An assessment of prognostic and predictive features, including tumor infiltrating lymphocytes

Článek A global overview of cassava genetic diversity

Článek Whole body periodic acceleration in normal and reduced mucociliary clearance of conscious sheep

Článek Minimal effects of oyster aquaculture on local water quality: Examples from southern Chesapeake Bay

Článek High salinity tolerance of invasive blue catfish suggests potential for further range expansion in the Chesapeake Bay region

Článek From waste to food: Optimising the breakdown of oil palm waste to provide substrate for insects farmed as animal feed

Článek Quantitative assessment of interstitial lung disease in Sjögren’s syndrome

Článek Reference ranges for ultrasonographic renal dimensions as functions of age and body indices: A retrospective observational study in Taiwan

Článek Finding phrases: On the role of co-verbal facial information in learning word order in infancy

Článek Effects of forest management and roe deer impact on a mountain forest development in the Italian Apennines: A modelling approach using LANDIS-II

Článek Effect of caffeine on neuromuscular function following eccentric-based exercise

Článek The household economic costs associated with depression symptoms: A cross-sectional household study conducted in the North West province of South Africa

Článek Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping

Článek Acute low- compared to high-load resistance training to failure results in greater energy expenditure during exercise in healthy young men

Článek Impact of body mass index and metabolically unhealthy status on mortality in the Japanese general population: The JMS cohort study

Článek Ecohydrology of urban trees under passive and active irrigation in a semiarid city

Článek Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats

Článek A popular Indian clove-based mosquito repellent is less effective against Culex quinquefasciatus and Aedes aegypti than DEET

Článek Yeasts affect tolerance of Drosophila melanogaster to food substrate with high NaCl concentration

Článek The effect of climate change on cholera disease: The road ahead using artificial neural network

Článek Micro-dislodgement during transcatheter aortic valve implantation with a contemporary self-expandable prosthesis

Článek Inflammatory cell infiltrates, hypoxia, vascularization, pentraxin 3 and osteoprotegerin in abdominal aortic aneurysms – A quantitative histological study

Článek Effects of virtual reality rehabilitation training on gait and balance in patients with Parkinson's disease: A systematic review

Článek Serum miR-33a is associated with steatosis and inflammation in patients with non-alcoholic fatty liver disease after liver transplantation

Článek Evaluation of upper limb superficial venous percussion as a sign of anatomical location and venous permeability. A comparative study of superficial venous percussion to ultrasound findings on non-renal patients and on chronic kidney disease patients

Článek An assessment of the Dutch experience with health insurers acting as healthcare advisors

Článek Perception of potential harm and benefits of HIV vaccine trial participation: A qualitative study from urban Tanzania

Článek Deep brain stimulation restores the glutamatergic and GABAergic synaptic transmission and plasticity to normal levels in kindled rats

Článek Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals

Článek Histochemical quantification of collagen content in articular cartilage

Článek Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon

Článek Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures

Článek Proton pump inhibitor use increases the risk of peritonitis in peritoneal dialysis patients

Článek Comparative distribution of extended-spectrum beta-lactamase–producing Escherichia coli from urine infections and environmental waters

Článek Sex differences in thigh muscle volumes, sprint performance and mechanical properties in national-level sprinters

Článek Maternal serum and cord blood leptin concentrations at delivery

Článek Winter nitrification in ice-covered lakes

Článek Monitoring exercise-induced muscle damage indicators and myoelectric activity during two weeks of knee extensor exercise training in young and old men

Článek Can adoption of pollution prevention techniques reduce pollution substitution?

Článek The association between self-efficacy and self-management behaviors among Chinese patients with type 2 diabetes

Článek Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat

Článek Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring

Článek Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal

Článek Clinical characteristics of neonatal fulminant necrotizing enterocolitis in a tertiary Children's hospital in the last 10 years

Článek Vasopressin SNP pain factors and stress in sickle cell disease

Článek Microbial metabolisms in an abyssal ferromanganese crust from the Takuyo-Daigo Seamount as revealed by metagenomics

Článek Incidence of chronic kidney disease hospitalisations and mortality in Espírito Santo between 1996 to 2017

Článek Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012

Článek Diversity, distribution and dynamics of large trees across an old-growth lowland tropical rain forest landscape

Článek Vaginal ring acceptability and related preferences among women in low- and middle-income countries: A systematic review and narrative synthesis

Článek UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal

Článek Positive selection and precipitation effects on the mitochondrial NADH dehydrogenase subunit 6 gene in brown hares (Lepus europaeus) under a phylogeographic perspective

Článek Evaluation of Minimum Inhibitory Concentrations for 154 Mycoplasma synoviae isolates from Italy collected during 2012-2017

Článek Enhancement of antibiotics antimicrobial activity due to the silver nanoparticles impact on the cell membrane

Článek Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored

Článek Correction: Effect of corruption on perceived difficulties in healthcare access in sub-Saharan Africa

Článek Pig farmers’ willingness to pay for management strategies to reduce aggression between pigs

Článek Metabolomic response of Euglena gracilis and its bleached mutant strain to light

Článek Grain filling of early-season rice cultivars grown under mechanical transplanting

Článek Correlative evidence for co-regulation of phosphorus and carbon exchanges with symbiotic fungus in the arbuscular mycorrhizal Medicago truncatula

Článek Trunk velocity-dependent Light Touch reduces postural sway during standing

Článek Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: An investigation in 78 cases using STARD guidelines

Článek Assessment of energy expenditure during high intensity cycling and running using a heart rate and activity monitor in young active adults

Článek Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)

Článek The calcium sensor OsCBL1 modulates nitrate signaling to regulate seedling growth in rice

Článek Contingent negative variation during a modified cueing task in simulated driving

Článek Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses’ Health Study

Článek Correction: Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study

Článek Retrospective comparative analysis of intraocular lens calculation formulas after hyperopic refractive surgery

Článek Development and validation of exhaled breath condensate microRNAs to identify and endotype asthma in children

Článek Arthroscopic release for frozen shoulder: Does the timing of intervention and diabetes affect outcome?

Článek Risk factors affecting dairy cattle protective grouping behavior, commonly known as bunching, against Stomoxys calcitrans (L.) on California dairies

Článek Characterisation and microbial community analysis of lipid utilising microorganisms for biogas formation

Článek Artificial insemination with fresh, liquid stored and frozen thawed semen in dromedary camels

Článek Numerical study on the start and unstart phenomena in a scramjet inlet-isolator model

Článek Urban growth simulation in different scenarios using the SLEUTH model: A case study of Hefei, East China

Článek Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases

Článek The impact of leisure activities on older adults’ cognitive function, physical function, and mental health

Článek Association of serum leptin and adiponectin concentrations with echocardiographic parameters and pathophysiological states in patients with cardiovascular disease receiving cardiovascular surgery

Článek Synthesis, purification and crystallization of a putative critical bulge of HAR1 RNA

Článek Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation

Článek A new early Eocene deperetellid tapiroid illuminates the origin of Deperetellidae and the pattern of premolar molarization in Perissodactyla

Článek Longevity and marginal bone loss of narrow-diameter implants supporting single crowns: A systematic review

Článek Impact of UVC-sustained recirculating air filtration on airborne bacteria and dust in a pig facility

Článek Determinants of preterm birth among mothers who gave birth at public hospitals in the Amhara region, Ethiopia: A case-control study

Článek Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births

Článek Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation

Článek The impacts of parity on lung function data (LFD) of healthy females aged 40 years and more issued from an upper middle income country (Algeria): A comparative study

Článek HIV prevalence and correlated factors among male clients of female sex workers in a border region of China

Článek Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis

Článek Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform

Článek Correction: KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway

Článek Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

Článek Correction: Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin

Článek Retraction: Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization

Článek Correction: Good and Bad in the Hands of Politicians: Spontaneous Gestures during Positive and Negative Speech

Článek Correction: Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era

Článek Correction: Using remote sensing to detect whale strandings in remote areas: The case of sei whales mass mortality in Chilean Patagonia

Článek Correction: Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods

Článek Correction: Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry

Článek Correction: Establishing an infrastructure for collaboration in primate cognition research

Článek Correction: The impact of public health insurance on health care utilisation, financial protection and health status in low- and middle-income countries: A systematic review

Článek Correction: A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization

Článek Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis

Článek Non-communicable diseases risk factors and their determinants: A cross-sectional state-wide STEPS survey, Haryana, North India

Článek Genotype-matched Newcastle disease virus vaccine confers improved protection against genotype XII challenge: The importance of cytoplasmic tails in viral replication and vaccine design

Článek Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep

Článek Long-term exposure to daily ethanol injections in DBA/2J and Swiss mice: Lessons for the interpretation of ethanol sensitization

Článek Taxonomic and functional anuran beta diversity of a subtropical metacommunity respond differentially to environmental and spatial predictors

Článek A simple way to improve a conventional A/O-MBR for high simultaneous carbon and nutrient removal from synthetic municipal wastewater

Článek Knowledge and awareness of cervical cancer in Southwestern Ethiopia is lacking: A descriptive analysis

Článek Flat electrode contacts for vagus nerve stimulation

Článek Circulating Th17.1 cells as candidate for the prediction of therapeutic response to abatacept in patients with rheumatoid arthritis: An exploratory research

Článek A randomized controlled trial comparing isosorbide dinitrate-oxytocin versus misoprostol-oxytocin at management of foetal intrauterine death

Článek Use of latent class analysis to identify multimorbidity patterns and associated factors in Korean adults aged 50 years and older

Článek Dissemination and stakeholder engagement practices among dissemination & implementation scientists: Results from an online survey

Článek Comparative analysis of the accelerated aged seed transcriptome profiles of two maize chromosome segment substitution lines

Článek Left parietal tACS at alpha frequency induces a shift of visuospatial attention

Článek Predictive factors for unfavourable treatment in MDR-TB and XDR-TB patients in Rio de Janeiro State, Brazil, 2000-2016

Článek Development of a multi-locus typing scheme for an Enterobacteriaceae linear plasmid that mediates inter-species transfer of flagella

Článek The roles of MRI-based prostate volume and associated zone-adjusted prostate-specific antigen concentrations in predicting prostate cancer and high-risk prostate cancer

Článek Re-modeling of foliar membrane lipids in a seagrass allows for growth in phosphorus-deplete conditions

Článek Effect of calcium intake and the dietary cation-anion difference during early lactation on the bone mobilization dynamics throughout lactation in dairy cows

Článek Facilitators and barriers to linkage to HIV care and treatment among female sex workers in a community-based HIV prevention intervention in Tanzania: A qualitative study

Článek Tuberculosis treatment outcome: The case of women in Ethiopia and China, ten-years retrospective cohort study

Článek Protein:Protein interactions in the cytoplasmic membrane apparently influencing sugar transport and phosphorylation activities of the e. coli phosphotransferase system

Článek A digital collection of rare and endangered lemurs and other primates from the Duke Lemur Center

Článek Computational fluid dynamics simulation of changes in the morphology and airflow dynamics of the upper airways in OSAHS patients after treatment with oral appliances

Článek Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm

Článek Lower limb chronic edema management program: Perspectives of disengaged patients on challenges, enablers and barriers to program attendance and adherence

Článek Modelling vegetation understory cover using LiDAR metrics

Článek CRISPR-Cas9 modified bacteriophage for treatment of Staphylococcus aureus induced osteomyelitis and soft tissue infection

Článek Forecasting type-specific seasonal influenza after 26 weeks in the United States using influenza activities in other countries

Článek Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression

Článek Characterization of the diverse plasmid pool harbored by the blaNDM-1-containing Acinetobacter bereziniae HPC229 clinical strain

Článek A cell-based evaluation of a non-essential amino acid formulation as a non-bioactive control for activation and stimulation of muscle protein synthesis using ex vivo human serum

Článek Conjugated linoleic acid as a novel insecticide targeting the agricultural pest Leptinotarsa decemlineata

Článek Depicting changes in land surface cover at Al-Hassa oasis of Saudi Arabia using remote sensing and GIS techniques

Článek Land snail dispersal, abundance and diversity on green roofs

Článek Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia

Článek Mesenchymal Stem/ Stromal Cells metabolomic and bioactive factors profiles: A comparative analysis on the umbilical cord and dental pulp derived Stem/ Stromal Cells secretome

Článek The association between caesarean section delivery and later life obesity in 21-24 year olds in an Urban South African birth cohort

Článek Toxicity and sublethal effects of two plant allelochemicals on the demographical traits of cotton aphid, Aphis gossypii Glover (Hemiptera: Aphididae)

Článek Protocol development for discovery of angiogenesis inhibitors via automated methods using zebrafish

Článek Friends with malefit. The effects of keeping dogs and cats, sustaining animal-related injuries and Toxoplasma infection on health and quality of life

Článek Trueness of digital intraoral impression in reproducing multiple implant position

Článek Norm values and psychometric properties of the short version of the Trier Inventory for Chronic Stress (TICS) in a representative German sample

Článek Maternal health and birth outcomes in a South African birth cohort study

Článek Structural characterization of scorpion peptides and their bactericidal activity against clinical isolates of multidrug-resistant bacteria

Článek Residential household yard care practices along urban-exurban gradients in six climatically-diverse U.S. metropolitan areas

Článek Evaluation of a global spring wheat panel for stripe rust: Resistance loci validation and novel resources identification

Článek The effect of bivalve filtration on eDNA-based detection of aquatic organisms

Článek Development and validation of rapid environmental DNA (eDNA) detection methods for bog turtle (Glyptemys muhlenbergii)

Článek Preference-based measure of health-related quality of life and its determinants in sickle cell disease in Nigeria

Článek Factors influencing participation dynamics in research for development interventions with multi-stakeholder platforms: A metric approach to studying stakeholder participation

Článek Contextual variation in young children’s acquisition of social-emotional skills

Článek A global assessment of street-network sprawl

Článek Mindfulness-Based Blood Pressure Reduction (MB-BP): Stage 1 single-arm clinical trial

Článek Behavioral response of naïve and non-naïve deer to wolf urine

Článek SNARE proteins rescue impaired autophagic flux in Down syndrome

Článek Change in left inferior frontal connectivity with less unexpected harmonic cadence by musical expertise

Článek How does open innovation lead competitive advantage? A dynamic capability view perspective

Článek Bull efficiency using dairy genetic traits

Článek Improved cortical boundary registration for locally distorted fMRI scans

Článek Extractive single document summarization using binary differential evolution: Optimization of different sentence quality measures

Článek Isolation and identification of an isoflavone reducing bacterium from feces from a pregnant horse

Článek Quantifying normal and parkinsonian gait features from home movies: Practical application of a deep learning–based 2D pose estimator

Článek Can visual interpretation of NucliSens graphs reduce the need for repeat viral load testing?

Článek Association between metabolic body composition status and risk for impaired renal function: A cross-sectional study

Článek Infective endocarditis and diabetes mellitus: Results from a single-center study from 1994 to 2017

Článek Measuring the complexity of directed graphs: A polynomial-based approach

Článek Publication rates in animal research. Extent and characteristics of published and non-published animal studies followed up at two German university medical centres

Článek Exploring critical factors of the perceived usefulness of blended learning for higher education students

Článek Direct transport vs secondary transfer to level I trauma centers in a French exclusive trauma system: Impact on mortality and determinants of triage on road-traffic victims

Článek Postoperative delirium after lung resection for primary lung cancer: Risk factors, risk scoring system, and prognosis

Článek The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis

Článek Antibacterial efficacy of cold atmospheric plasma against Enterococcus faecalis planktonic cultures and biofilms in vitro

Článek Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages

Článek Application of ensemble methods to analyse the decline of organochlorine pesticides in relation to the interactions between age, gender and time

Článek Mitogenomic diversity in Sacred Ibis Mummies sheds light on early Egyptian practices

Článek Inducible UCP1 silencing: A lentiviral RNA-interference approach to quantify the contribution of beige fat to energy homeostasis

Článek iCrotoK-PseAAC: Identify lysine crotonylation sites by blending position relative statistical features according to the Chou’s 5-step rule

Článek Raising the bar: Recovery ambition for species at risk in Canada and the US

Článek Management of locally advanced non-small cell lung cancer in the modern era: A national Italian survey on diagnosis, treatment and multidisciplinary approach

Článek Incidence of colorectal cancer in Eritrea: Data from the National Health Laboratory, 2011-2017

Článek Integrated analysis of miRNA landscape and cellular networking pathways in stage-specific prostate cancer

Článek Statistical determination of synergy based on Bliss definition of drugs independence

Článek Dispersion of Legionella bacteria in atmosphere: A practical source location estimation method

Článek Why are undergraduate emerging adults anxious and avoidant in their romantic relationships? The role of family relationships

Článek Moving system with action sport cameras: 3D kinematics of the walking and running in a large volume

Článek Factors influencing subclinical atherosclerosis in patients with biopsy-proven nonalcoholic fatty liver disease

Článek A new resolution function to evaluate tree shape statistics

Článek Thermostat wars? The roles of gender and thermal comfort negotiations in household energy use behavior

Článek Lifetime prevalence of intimate partner violence against women in an urban Brazilian city: A cross-sectional survey

Článek Quantifying pediatric patient need for second- and third-line HIV treatment: A tool for decision-making in resource-limited settings

Článek Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors

Článek Iodine status of non-pregnant women and availability of food vehicles for fortification with iodine in a remote community in Gulf province, Papua New Guinea

Článek Psychology of personal data donation

Článek MARGO (Massively Automated Real-time GUI for Object-tracking), a platform for high-throughput ethology

Článek Visual detection of time-varying signals: Opposing biases and their timescales

Článek Results from a World Health Organization pilot of the Basic Emergency Care Course in Sub Saharan Africa

Článek Scientists’ opinions and attitudes towards citizens’ understanding of science and their role in public engagement activities

Článek Dacentrurine stegosaurs (Dinosauria): A new specimen of Miragaia longicollum from the Late Jurassic of Portugal resolves taxonomical validity and shows the occurrence of the clade in North America

Článek Morphology, phylogeny, and taxonomy of two species of colonial volvocine green algae from Lake Victoria, Tanzania

Článek Exploring local realities: Perceptions and experiences of healthcare workers on the management and control of drug-resistant tuberculosis in Addis Ababa, Ethiopia

Článek Barriers to integration of bioinformatics into undergraduate life sciences education: A national study of US life sciences faculty uncover significant barriers to integrating bioinformatics into undergraduate instruction

Článek Local unemployment changes the springboard effect of low pay: Evidence from England

Článek A comparison of body composition assessment methods in climbers: Which is better?

Článek Comparison of an in-house ‘home-brew’ and commercial ViroSeq integrase genotyping assays on HIV-1 subtype C samples

Článek Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A

Článek Complex interaction networks of cytokines after transarterial chemotherapy in patients with hepatocellular carcinoma

Článek Gender essentialism in transgender and cisgender children

Článek Being there: A scoping review of grief support training in medical education

Článek Does the psychological profile influence the position of promising young futsal players?

Článek Correlates of leisure-time sedentary behavior among 181,793 adolescents aged 12-15 years from 66 low- and middle-income countries

Článek Spatiotemporal analysis of historical records (2001–2012) on dengue fever in Vietnam and development of a statistical model for forecasting risk

Článek Effect of community based health education on knowledge and attitude towards iron and folic acid supplementation among pregnant women in Kiambu County, Kenya: A quasi experimental study

Článek Impacts of risk and competition on the profitability of banks: Empirical evidence from Pakistan

Článek Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing

Článek Joint image compression and encryption based on sparse Bayesian learning and bit-level 3D Arnold cat maps

Článek Urticating setae of tarantulas (Araneae: Theraphosidae): Morphology, revision of typology and terminology and implications for taxonomy

Článek Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells

Článek Amazon climatic factors driving terpene composition of Iryanthera polyneura Ducke in terra-firme forest: A statistical approach

Článek Differences in clinical features of cluster headache between drinkers and nondrinkers in Japan

Článek Distribution of macular ganglion cell layer thickness in foveal hypoplasia: A new diagnostic criterion for ocular albinism

Článek Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer

Článek Automated content analysis across six languages

Článek The prognostic significance of tumor-infiltrating lymphocytes assessment with hematoxylin and eosin sections in resected primary lung adenocarcinoma

Článek Effectiveness of novel fabrics to resist punctures and lacerations from white shark (Carcharodon carcharias): Implications to reduce injuries from shark bites

Článek Serial block-face scanning electron microscopy reveals neuronal-epithelial cell fusion in the mouse cornea

Článek Salt or fish (or salted fish)? The Bronze Age specialised sites along the Tyrrhenian coast of Central Italy: New insights from Caprolace settlement

Článek Latitudinal gradient of cyanobacterial diversity in tidal flats

Článek Gene expression based survival prediction for cancer patients—A topic modeling approach

Článek Comparative analysis on Facebook post interaction using DNN, ELM and LSTM

Článek Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy

Článek Left-handed metamaterial bandpass filter for GPS, Earth Exploration-Satellite and WiMAX frequency sensing applications

Článek In-situ time resolved spectrographic measurement using an additively manufactured metallic micro-fluidic analysis platform

Článek Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity

Článek Characterization of the placental transcriptome through mid to late gestation in the mare

Článek Indirect violence exposure and mental health symptoms among an urban public-school population: Prevalence and correlates

Článek Study of the epidemiological behavior of malaria in the Darien Region, Panama. 2015–2017

Článek Neighborhood crime, disorder and substance use in the Caribbean context: Jamaica National Drug Use Prevalence Survey 2016

Článek Modeling of inter-organizational coordination dynamics in resilience planning of infrastructure systems: A multilayer network simulation framework

Článek Manipulating the odds: The effects of Machiavellianism and construal level on cheating behavior

Článek Early recognition of anorexia through patient-generated assessment predicts survival in patients with oesophagogastric cancer

Článek ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico

Článek Cluster tendency assessment in neuronal spike data

Článek Psychometric properties of the Korean version of the Health Literacy on Social Determinants of Health Questionnaire (K-HL-SDHQ)

Článek Flood hazard mapping and assessment in data-scarce Nyaungdon area, Myanmar

Článek Methods for the identification of farm escapees in feral mink (Neovison vison) populations

Článek Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A

Článek Exploration of muscle loss and metabolic state during prolonged critical illness: Implications for intervention?

Článek Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model

Článek Early economic evaluation of MRI-guided laser interstitial thermal therapy (MRgLITT) and epilepsy surgery for mesial temporal lobe epilepsy

Článek Anterior tooth-use behaviors among early modern humans and Neandertals

Článek Association of thoracic spine deformity and cardiovascular disease in a mouse model for Marfan syndrome

Článek M3VR—A multi-stage, multi-resolution, and multi-volumes-of-interest volume registration method applied to 3D endovaginal ultrasound

Článek Fixation of genetic variation and optimization of gene expression: The speed of evolution in isolated lizard populations undergoing Reverse Island Syndrome

Článek Detection of Schistosoma japonicum and Oncomelania hupensis quadrasi environmental DNA and its potential utility to schistosomiasis japonica surveillance in the Philippines

Článek Does age influence the quality of life in children with atopic dermatitis?

Článek Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment

Článek Recent climate-driven ecological change across a continent as perceived through local ecological knowledge

Článek Effect of F1 and F2 generations on genetic variability and working steps of doubled haploid production in maize

Článek EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America

Článek 16S rDNA droplet digital PCR for monitoring bacterial DNAemia in bloodstream infections

Článek Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia

Článek Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches

Článek Development of a quantitative PCR assay for the detection and enumeration of a potentially ciguatoxin-producing dinoflagellate, Gambierdiscus lapillus (Gonyaulacales, Dinophyceae)

Článek Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)

Článek Seasonal oyster harvesting recorded in a Late Archaic period shell ring

Článek Trends and predictors of mother-to-child transmission of HIV in an era of protocol changes: Findings from two large health facilities in North East Nigeria

Článek Genome-wide identification and gene expression analysis of SOS family genes in tuber mustard (Brassica juncea var. tumida)

Článek Molecular epidemiological characteristics of dengue virus carried by 34 patients in Guangzhou in 2018

Článek Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study

Článek The plasma metabolome of women in early pregnancy differs from that of non-pregnant women

Článek Diminuendo al bottom—Clarifying the semantics of music notation by re-modeling

Článek Structural analysis of the manganese transport regulator MntR from Bacillus halodurans in apo and manganese bound forms

Článek Serum uromodulin is associated with the severity of clinicopathological findings in ANCA-associated glomerulonephritis

Článek Male support for cervical cancer screening and treatment in rural Ghana

Článek ADAPTS: Automated deconvolution augmentation of profiles for tissue specific cells

Článek Comparison of shape quantification methods for genomic prediction, and genome-wide association study of sorghum seed morphology

Článek Video abstracts and plain language summaries are more effective than graphical abstracts and published abstracts

Článek Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains

Článek Concurrent validity and discriminative ability of Dutch performance-based motor tests in 5 to 6 years old children

Článek Cumulative viral load as a predictor of CD4+ T-cell response to antiretroviral therapy using Bayesian statistical models

Článek Self-serving incentives impair collective decisions by increasing conformity

Článek Effects of Debaryomyces hansenii treatment on intestinal mucosa microecology in mice with antibiotic-associated diarrhea

Článek A novel wheat lodging resistance evaluation method and device based on the thrust force of the stalks

Článek Evolution of high tooth replacement rates in theropod dinosaurs

Článek Outpatient facility-based order variation in combined imaging

Článek Non-intubated anesthesia in patients undergoing video-assisted thoracoscopic surgery: A systematic review and meta-analysis

Článek Changes of serum pentraxin-3 and hypersensitive CRP levels during pregnancy and their relationship with gestational diabetes mellitus

Článek Investigating reindeer pastoralism and exploitation of high mountain zones in northern Mongolia through ice patch archaeology

Článek Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia

Článek The impact of “male clinics” on health-seeking behaviors of adult men in rural Kenya

Článek Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease

Článek Utility of the new cobas HCV test for viral load monitoring during direct-acting antiviral therapy

Článek Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy

Článek Effects of an incremental theory of personality intervention on the reciprocity between bullying and cyberbullying victimization and perpetration in adolescents

Článek Reproducibility, stability, and accuracy of microbial profiles by fecal sample collection method in three distinct populations

Článek Cooperation with autonomous machines through culture and emotion

Článek Intramolecular tautomerization of the quercetin molecule due to the proton transfer: QM computational study

Článek Identifying resurrection genes through the differentially expressed genes between Selaginella tamariscina (Beauv.) spring and Selaginella moellendorffii Hieron under drought stress

Článek Impact of hemodialysis on the concentrations of sodium and potassium during infusion of sodium thiosulfate using an In Vitro hemodialysis model

Článek Suboptimal infant and young child feeding practices in rural Boucle du Mouhoun, Burkina Faso: Findings from a cross-sectional population-based survey

Článek Comparative efficacy of tenofovir and entecavir in nucleos(t)ide analogue-naive chronic hepatitis B: A systematic review and meta-analysis

Článek Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization

Článek Evaluation of comprehensive improvement for mild and moderate soil salinization in arid zone

Článek Efficacy, acceptability and feasibility of daily text-messaging in promoting glycaemic control and other clinical outcomes in a low-resource setting of South Africa: A randomised controlled trial

Článek Magnitude and associated factors of postpartum depression among women in Nekemte town, East Wollega zone, west Ethiopia, 2019: A community-based study

Článek Comparison of continuous wave and cold lateral condensation filling techniques in 3D printed simulated C-shape canals instrumented with Reciproc Blue or Hyflex EDM

Článek AtUBL5 regulates growth and development through pre-mRNA splicing in Arabidopsis thaliana

Článek The gut microbiome of freshwater Unionidae mussels is determined by host species and is selectively retained from filtered seston

Článek Alcohol consumption and survival after breast cancer diagnosis in Japanese women: A prospective patient cohort study

Článek Selection of reference genes for normalization of cranberry (Vaccinium macrocarpon Ait.) gene expression under different experimental conditions

Článek Characterization of two thermophilic cellulases from Talaromyces leycettanus JCM12802 and their synergistic action on cellulose hydrolysis

Článek Cyclosporine A eyedrops with self-nanoemulsifying drug delivery systems have improved physicochemical properties and efficacy against dry eye disease in a murine dry eye model

Článek LFastqC: A lossless non-reference-based FASTQ compressor

Článek Highly accurate prediction of flammability limits of chemical compounds using novel integrated hybrid models

Článek Grit (effortful persistence) can be measured with a short scale, shows little variation across socio-demographic subgroups, and is associated with career success and career engagement

Článek Improving the antimicrobial efficacy against resistant Staphylococcus aureus by a combined use of conjugated oligoelectrolytes

Článek Kin discrimination and outer membrane exchange in Myxococcus xanthus: Experimental analysis of a natural population

Článek Association between housing tenure and self-rated health in Japan: Findings from a nationwide cross-sectional survey

Článek Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China

Článek One-year follow-up of changes in refraction and aberrations induced by corneal incision

Článek Veterans with Gulf War Illness exhibit distinct respiratory patterns during maximal cardiopulmonary exercise

Článek Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model

Článek Long-term retention on antiretroviral therapy among infants, children, adolescents and adults in Malawi: A cohort study

Článek Optogenetically transduced human ES cell-derived neural progenitors and their neuronal progenies: Phenotypic characterization and responses to optical stimulation

Článek Ion torrent high throughput mitochondrial genome sequencing (HTMGS)

Článek Outpatient antibiotic prescription rate and pattern in the private sector in India: Evidence from medical audit data

Článek Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination

Článek CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say

Článek Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches

Článek Intolerance of uncertainty fuels depressive symptoms through rumination: Cross-sectional and longitudinal studies

Článek Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study

Článek Evaluation of forearm vascular resistance during orthostatic stress: Velocity is proportional to flow and size doesn’t matter

Článek Proton pencil minibeam irradiation of an in-vivo mouse ear model spares healthy tissue dependent on beam size

Článek Aspartate aminotransferase-to-platelet ratio index (APRI): A potential marker for diagnosis in patients at risk of severe malaria caused by Plasmodium vivax

Článek Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology

Článek Effects of neuromuscular electrical stimulation training on muscle size in collegiate track and field athletes

Článek Adaptive fuzzy flow rate control considering multifractal traffic modeling and 5G communications

Článek Evaluation of four commercial tests for detecting ceftiofur in waste milk bulk tank samples

Článek A smart tele-cytology point-of-care platform for oral cancer screening

Článek Carbonate production of Micronesian reefs suppressed by thermal anomalies and Acanthaster as sea-level rises

Článek The impact of short-term machine perfusion on the risk of cancer recurrence after rat liver transplantation with donors after circulatory death

Článek Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS)

Článek The effects of prolonged single night session of videogaming on sleep and declarative memory

Článek Mapping developmental QTL for plant height in soybean [Glycine max (L.) Merr.] using a four-way recombinant inbred line population

Článek Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters

Článek Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects

Článek Integrated value-chain and risk assessment of Pig-Related Zoonoses in Ghana

Článek Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy

Článek Cassava yield traits predicted by genomic selection methods

Článek Verification of hub genes in the expression profile of aortic dissection

Článek Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis

Článek Newly educated care managers’ experiences of providing care for persons with stress-related mental disorders in the clinical primary care context

Článek Real-time telemetry monitoring of oxygen in the central complex of freely-walking Gromphadorhina portentosa

Článek Qualification programmes for immigrant health professionals: A systematic review

Článek An analytical model to minimize the latency in healthcare internet-of-things in fog computing environment

Článek Intercalation of small molecules into DNA in chromatin is primarily controlled by superhelical constraint

Článek Altered expression of Notch1 in Alzheimer's disease

Článek The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women

Článek Trade-offs in motivating volunteer effort: Experimental evidence on voluntary contributions to science

Článek Does caching strategy vary with microclimate in endangered Mt. Graham red squirrels?

Článek Implementation of a screening, brief intervention and referral to treatment programme for risky substance use in South African emergency centres: A mixed methods evaluation study

Článek Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study

Článek Acceptability of and treatment preferences for recurrent bacterial vaginosis—Topical lactic acid gel or oral metronidazole antibiotic: Qualitative findings from the VITA trial

Článek Mathematical determination of the HIV-1 matrix shell structure and its impact on the biology of HIV-1

Článek CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition

Článek Effect of feeding patterns on growth and nutritional status of children aged 0-24 months: A Chinese cohort study

Článek A fecal sequel: Testing the limits of a genetic assay for bat species identification

Článek Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study

Článek Short and long-term clinical effectiveness and cost-effectiveness of a late-phase community-based balance and gait exercise program following hip fracture. The EVA-Hip Randomised Controlled Trial

Článek Vaccine cold chain in general practices: A prospective study in 75 refrigerators (Keep Cool study)

Článek Brazilian norms for the Bank of Standardized Stimuli (BOSS)

Článek Distinct varieties of aesthetic chills in response to multimedia

Článek New formulation of the Gompertz equation to describe the kinetics of untreated tumors

Článek Development of visual perception of others’ actions: Children’s judgment of lifted weight

Článek Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution

Článek Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing

Článek Sexuality in male partners of women with fibromyalgia syndrome: A qualitative study

Článek Exploring optimization strategies for improving explicit water models: Rigid n-point model and polarizable model based on Drude oscillator

Článek Moving into an urban drug scene among people who use drugs in Vancouver, Canada: Latent class growth analysis

Článek Effects of dietary supplementation with apple peel powder on the growth, blood and liver parameters, and transcriptome of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)

Článek Factors associated with medication adherence among people with diabetes mellitus in poor urban areas of Cambodia: A cross-sectional study

Článek Mammary microbiome of lactating organic dairy cows varies by time, tissue site, and infection status

Článek Force field generalization and the internal representation of motor learning

Článek Polyphenism of visual and chemical secondary sexually-selected wing traits in the butterfly Bicyclus anynana: How different is the intermediate phenotype?

Článek Minimal genetic differentiation of the malaria vector Nyssorhynchus darlingi associated with forest cover level in Amazonian Brazil

Článek scafSLICR: A MATLAB-based slicing algorithm to enable 3D-printing of tissue engineering scaffolds with heterogeneous porous microarchitecture

Článek Operation of cognitive memory inhibition in adults with Down syndrome: Effects of maintenance load and material

Článek Influences on surgical antimicrobial prophylaxis decision making by surgical craft groups, anaesthetists, pharmacists and nurses in public and private hospitals

Článek Post-treatment Lyme disease symptoms score: Developing a new tool for research

Článek Expression of Concern: The Role of the RACK1 Ortholog Cpc2p in Modulating Pheromone-Induced Cell Cycle Arrest in Fission Yeast

Článek Equine bronchial fibroblasts enhance proliferation and differentiation of primary equine bronchial epithelial cells co-cultured under air-liquid interface

Článek Investigating cooperation with robotic peers

Článek Prosthetic push-off power in trans-tibial amputee level ground walking: A systematic review

Článek A case study of the use of verbal reports for talent identification purposes in soccer: A Messi affair!

Článek Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure

Článek Periodontal disease: Repercussions in pregnant woman and newborn health—A cohort study

Článek Origins of Chinese reindeer (Rangifer tarandus) based on mitochondrial DNA analyses

Článek Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis

Článek How effective are films in inducing positive and negative emotional states? A meta-analysis

Článek 3D nanostructural characterisation of grain boundaries in atom probe data utilising machine learning methods

Článek An outbreak of tuberculosis in a middle school in Henan, China: Epidemiology and risk factors

Článek Initial clinical radiological findings and staging to predict prognosis of primary hepatic angiosarcoma: A retrospective analysis

Článek Cold-related Florida manatee mortality in relation to air and water temperatures

Článek Conceptual fluency in inductive reasoning

Článek Clinical outcomes and treatment patterns among Medicare patients with nonvalvular atrial fibrillation (NVAF) and chronic kidney disease

Článek Improvements in the learnability of smartphone haptic interfaces for visually impaired users

Článek Role of the malic enzyme in metabolism of the halotolerant methanotroph Methylotuvimicrobium alcaliphilum 20Z

Článek Cyclic loading test study on a new cast-in-situ insulated sandwich concrete wall

Článek Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies

Článek Analysis of virulence potential of Escherichia coli O145 isolated from cattle feces and hide samples based on whole genome sequencing

Článek Pre-clinical medical student reflections on implicit bias: Implications for learning and teaching

Článek Prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients

Článek Real-world evidence of the effectiveness of ombitasvir-paritaprevir/r ± dasabuvir ± ribavirin in patients monoinfected with chronic hepatitis C or coinfected with human immunodeficiency virus-1 in Spain

Článek Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice

Článek Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth

Článek Achievement of weight loss in patients with overweight during dietetic treatment in primary health care

Článek Reorganization of spatial configurations in visual working memory: A matter of set size?

Článek Unravelling travellers’ route choice behaviour at full-scale urban network by focusing on representative OD pairs in computer experiments

Článek Evaluating the higher-order structure of the Profile of Emotional Competence (PEC): Confirmatory factor analysis and Bayesian structural equation modeling

Článek Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis

Článek Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population

Článek Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians

Článek Increasing knowledge of HIV status in a country with high HIV testing coverage: Results from the Botswana Combination Prevention Project

Článek Friends with benefits: The effects of vegetative shading on plant survival in a green roof environment

Článek Identifying candidate diagnostic markers for early stage of non-small cell lung cancer

Článek Unique developmental trajectories of risk behaviors in adolescence and associated outcomes in young adulthood

Článek Enhanced fibrinolysis detection in a natural occurring canine model with intracavitary effusions: Comparison and degree of agreement between thromboelastometry and FDPs, D-dimer and fibrinogen concentrations

Článek Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants

Článek Foxtail millet (Setaria italica (L.) P. Beauv) CIPKs are responsive to ABA and abiotic stresses

Článek Autonomous drone hunter operating by deep learning and all-onboard computations in GPS-denied environments

Článek Heterogeneity Diffusion Imaging of gliomas: Initial experience and validation

Článek Frequency cluster formation and slow oscillations in neural populations with plasticity

Článek DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy

Článek Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis

Článek Analytical solution to swing equations in power grids

Článek Pathways to conspiracy: The social and linguistic precursors of involvement in Reddit’s conspiracy theory forum

Článek Spatiotemporally random and diverse grid cell spike patterns contribute to the transformation of grid cell to place cell in a neural network model

Článek Empathic concern and personal distress depend on situational but not dispositional factors

Článek Who is more susceptible to job stressors and resources? Sensory-processing sensitivity as a personal resource and vulnerability factor

Článek Cost-effectiveness of integrating postpartum antiretroviral therapy and infant care into maternal & child health services in South Africa

Článek A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling

Článek One step at a time: Physical activity is linked to positive interpretations of ambiguity

Článek Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells

Článek Evaluation of various methods of selection of B. subtilis strains capable of secreting surface-active compounds

Článek Association between US Pharmacopeia (USP) monograph standards, generic entry and prescription drug costs

Článek Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects

Článek On sorption hysteresis in wood: Separating hysteresis in cell wall water and capillary water in the full moisture range

Článek Inbreeding, Allee effects and stochasticity might be sufficient to account for Neanderthal extinction

Článek Reliability and construct validity of the stepping-forward affordance perception test for fall risk assessment in community-dwelling older adults

Článek Socioeconomic determinants of nutritional status among ‘Baiga’ tribal children In Balaghat district of Madhya Pradesh: A qualitative study

Článek Study on characteristics of fire plume in building facade window under lateral blow

Článek ‘When you talk to someone in a bad way or always put her under pressure, it is actually worse than beating her’: Conceptions and experiences of emotional intimate partner violence in Rwanda and South Africa

Článek Effects of 6-mercaptopurine in pressure overload induced right heart failure

Článek The association between haemoglobin levels in the first 20 weeks of pregnancy and pregnancy outcomes

Článek Implementation and evaluation of an antimicrobial stewardship programme in companion animal clinics: A stepped-wedge design intervention study

Článek Factors associated with persistently high-cost health care utilization for musculoskeletal pain

Článek Nitrogen and chlorophyll status determination in durum wheat as influenced by fertilization and soil management: Preliminary results

Článek Effect of repeated in vivo microCT imaging on the properties of the mouse tibia

Článek Coupling environment and physiology to predict effects of climate change on the taxonomic and functional diversity of fish assemblages in the Murray-Darling Basin, Australia

Článek Hematology and plasma biochemistries in the Blanding’s turtle (Emydoidea blandingii) in Lake County, Illinois

Článek CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae

Článek Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors

Článek Antidepressant prescriptions, discontinuation, depression and perinatal outcomes, including breastfeeding: A population cohort analysis

Článek Why men with a low-risk prostate cancer select and stay on active surveillance: A qualitative study

Článek Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis

Článek Combined treatment (image-guided thrombectomy and endovascular therapy with open femoral access) for acute lower limb ischemia: Clinical efficacy and outcomes

Článek Low-latency single channel real-time neural spike sorting system based on template matching

Článek Quantifying the scale effect in geospatial big data using semi-variograms

Článek Paper-and-pencil versus computerized administration mode: Comparison of data quality and risk behavior prevalence estimates in the European school Survey Project on Alcohol and other Drugs (ESPAD)

Článek Regression adjusted colocalisation colour mapping (RACC): A novel biological visual analysis method for qualitative colocalisation analysis of 3D fluorescence micrographs

Článek Ostrich eggshell bead diameter in the Holocene: Regional variation with the spread of herding in eastern and southern Africa

Článek Spatial and temporal variations in female size at maturity of a Southern Rock Lobster (Jasus edwardsii) population: A likely response to climate change

Článek Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies

Článek Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity

Článek Magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, Southwest, Ethiopia, 2018: A cross -sectional study

Článek Effectiveness of telerehabilitation in the management of adults with stroke: A systematic review

Článek Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys

Článek Evaluation of neutral oral contrast agents for assessment of the small bowel at abdominal staging CT

Článek Blood type and breed-associated differences in cell marker expression on equine bone marrow-derived mesenchymal stem cells including major histocompatibility complex class II antigen expression

Článek Induced abortion and future use of IVF treatment; A nationwide register study

Článek Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan

Článek Measurement of finger joint angle using stretchable carbon nanotube strain sensor

Článek Determinants of mortality among patients with drug-resistant tuberculosis in northern Nigeria

Článek Drugs modulating stochastic gene expression affect the erythroid differentiation process

Článek Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study

Článek Prognostic value of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma treated with transarterial chemotherapy: A systematic review and meta-analysis

Článek Avermectin induces the oxidative stress, genotoxicity, and immunological responses in the Chinese Mitten Crab, Eriocheir sinensis

Článek Antibiotic use in mandarin production (Citrus reticulata Blanco) in major mandarin-producing areas in Thailand: A survey assessment

Článek Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits

Článek Adolescents with worse levels of oral health literacy have more cavitated carious lesions

Článek Effective methods for the inactivation of Francisella tularensis

Článek Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients

Článek Correlation between internal pudendal artery stenosis and erectile dysfunction in patients with suspected coronary artery disease

Článek Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation

Článek Population productivity of shovelnose rays: Inferring the potential for recovery

Článek Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis

Článek Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression

Článek Changes in weight and body composition across five years at university: A prospective observational study

Článek Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning

Článek Effects of insulin signaling on mouse taste cell proliferation

Článek Patient-level cost of home- and facility-based child pneumonia treatment in Suba Sub County, Kenya

Článek TAP: A static analysis model for PHP vulnerabilities based on token and deep learning technology

Článek Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil

Článek Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: Results of a cluster randomized controlled trial

Článek Changes over time in creatinine clearance and comparison of emergent adverse events for HIV-positive adults receiving standard doses (300 mg/day) of lamivudine-containing antiretroviral therapy with baseline creatinine clearance of 30–49 vs ≥50 mL/min

Článek Population dynamics of foxes during restricted-area culling in Britain: Advancing understanding through state-space modelling of culling records

Článek Impacts of experimental advisory exit speed sign on traffic speeds for freeway exit ramp

Článek In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium

Článek Monitoring quality indicators for the Xpert MTB/RIF molecular assay in Ethiopia

Článek Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids

Článek Comparison of the inoculum size effects of antibiotics on IMP-6 β-lactamase-producing Enterobacteriaceae co-harboring plasmid-mediated quinolone resistance genes

Článek Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma

Článek Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720

Článek Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster

Článek Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels

Článek Comparison of two experimental ARDS models in pigs using electrical impedance tomography

Článek Are primary school children attending full-day school still engaged in sports clubs?

Článek Stroke risks in women with dysmenorrhea by age and stroke subtype

Článek Changes in patterns of mortality rates and years of life lost due to firearms in the United States, 1999 to 2016: A joinpoint analysis

Článek In vitro modeling of Batrachochytrium dendrobatidis infection of the amphibian skin

Článek Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients

Článek Characterisation of early metazoan secretion through associated signal peptidase complex subunits, prohormone convertases and carboxypeptidases of the marine sponge (Amphimedon queenslandica)

Článek Time trends between 2002 and 2017 in correlates of self-reported sitting time in European adults

Článek Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis

Článek Changes in HbA1c during the first six years after the diagnosis of Type 2 diabetes mellitus predict long-term microvascular outcomes

Článek Correction: Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum

Článek Health provider and service-user experiences of sensory modulation rooms in an acute inpatient psychiatry setting

Článek Comparison of potential drug-drug interactions with metabolic syndrome medications detected by two databases

Článek The Polish version of the Cultural Intelligence Scale: Assessment of its reliability and validity among healthcare professionals and medical faculty students

Článek Selection of optimal reference genes for qRT-PCR analysis of shoot development and graviresponse in prostrate and erect chrysanthemums

Článek Metastasis risk prediction model in osteosarcoma using metabolic imaging phenotypes: A multivariable radiomics model

Článek Defining hospital community benefit activities using Delphi technique: A comparison between China and the United States

Článek Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1

Článek A robust multi-objective optimization framework to capture both cellular and intercellular properties in cardiac cellular model tuning: Analyzing different regions of membrane resistance profile in parameter fitting

Článek Sea star wasting disease demography and etiology in the brooding sea star Leptasterias spp.

Článek Diagnostic plasma miRNA-profiles for ovarian cancer in patients with pelvic mass

Článek Genetic diversity and drug resistance of HIV-1 among infected pregnant women newly diagnosed in Luanda, Angola

Článek I’ve been robbed! – Can changes in floral traits discourage bee pollination?

Článek Visualising statistical models using dynamic nomograms

Článek Assessing the capacity of Malawi’s district and central hospitals to manage traumatic diaphyseal femoral fractures in adults

Článek Diagnostic performance of basal cortisol level at 0900-1300h in adrenal insufficiency

Článek The Mastery Rubric for Bioinformatics: A tool to support design and evaluation of career-spanning education and training

Článek Microdissection and whole chromosome painting confirm karyotype transformation in cryptic species of the Lariophagus distinguendus (Förster, 1841) complex (Hymenoptera: Pteromalidae)

Článek Quality of Kangaroo Mother Care services in Ethiopia: Implications for policy and practice

Článek Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid cancer

Článek iTRAQ-based high-throughput proteomics analysis reveals alterations of plasma proteins in patients infected with human bocavirus

Článek The detection of a non-anemophilous plant species using airborne eDNA

Článek Perception and control of low cable operation forces in voluntary closing body-powered upper-limb prostheses

Článek Neoadjuvant chemotherapy plus surgery versus concurrent chemoradiotherapy in stage IB2-IIB cervical cancer: A systematic review and meta-analysis

Článek Randomized methods to characterize large-scale vortical flow networks

Článek Disentangling the coexistence strategies of mud-daubing wasp species through trophic analysis in oases of Baja California peninsula

Článek Front-of-pack nutritional labels: Understanding by low- and middle-income Mexican consumers

Článek Distress in patients with end-stage renal disease: Staff perceptions of barriers to the identification of mild-moderate distress and the provision of emotional support

Článek Pathways to antibiotics in Bangladesh: A qualitative study investigating how and when households access medicine including antibiotics for humans or animals when they are ill

Článek DOC export is exceeded by C fixation in May Creek: A late-successional watershed of the Copper River Basin, Alaska

Článek Behavioral observation of prosocial behavior and social initiative is related to preschoolers’ psychopathological symptoms

Článek Evaluating the impact of citations of articles based on knowledge flow patterns hidden in the citations

Článek Correction: Economic sanctions and academia: Overlooked impact and long-term consequences

Článek Price dispersion of generic medications

Článek Sex differences in body composition but not neuromuscular function following long-term, doxycycline-induced reduction in circulating levels of myostatin in mice

Článek The emotion regulation effect of cognitive control is related to depressive state through the mediation of rumination: An ERP study

Článek Comparison of SMS-EPI and 3D-EPI at 7T in an fMRI localizer study with matched spatiotemporal resolution and homogenized excitation profiles

Článek Left ventricular mass normalization for body size in children based on an allometrically adjusted ratio is as accurate as normalization based on the centile curves method

Článek Correction: Combining biophysical parameters, spectral indices and multivariate hyperspectral models for estimating yield and water productivity of spring wheat across different agronomic practices

Článek Correction: Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species

Článek 'Small small quarrels bring about happiness or love in the relationships’: Exploring community perceptions and gendered norms contributing to male perpetrated intimate partner violence in the Central Region of Ghana

Článek The performance of practitioners conducting facial comparisons on images of children across age

Článek Increased amounts and stability of telomeric repeat-containing RNA (TERRA) following DNA damage induced by etoposide

Článek Patients with limitation or withdrawal of life supporting care admitted in a medico-surgical intermediate care unit: Prevalence, description and outcome over a six-month period

Článek Correction: Diverse radiofrequency sensitivity and radiofrequency effects of mobile or cordless phone near fields exposure in Drosophila melanogaster

Článek Predicting the performance of TV series through textual and network analysis: The case of Big Bang Theory

Článek Risk of temperature, humidity and concentrations of air pollutants on the hospitalization of AECOPD

Článek Mixed methods grant applications in the health sciences: An analysis of reviewer comments

Článek Renal abnormalities among children with sickle cell conditions in highly resource-limited setting in Ghana

Článek Size matters: How reaching and vergence movements are influenced by the familiar size of stereoscopically presented objects

Článek Willingness to receive institutional and community-based eldercare among the rural elderly in China

Článek An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences

Článek Beyond executive functions, creativity skills benefit academic outcomes: Insights from Montessori education

Článek A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions

Článek Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease

Článek Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma

Článek The fight against polio through the NO-DO newsreels during the Francoism period in Spain

Článek Ocean sound levels in the northeast Pacific recorded from an autonomous underwater glider

Článek Cost-consequence analysis of influenza vaccination among the staff of a large teaching hospital in Rome, Italy: A pilot study

Článek The relationship among the progression of inflammation in umbilical cord, fetal inflammatory response, early-onset neonatal sepsis, and chorioamnionitis

Článek How medical professional students view older people with dementia: Implications for education and practice

Článek An enhanced nonparametric EWMA sign control chart using sequential mechanism

Článek Land use change, carbon stocks and tree species diversity in green spaces of a secondary city in Myanmar, Pyin Oo Lwin

Článek Is there a difference in women’s experiences of care with medication vs. manual vacuum aspiration abortions? Determinants of person-centered care for abortion services

Článek Maternal complications in pregnancy and childbirth for women with epilepsy: Time trends in a nationwide cohort

Článek Adsorption of oxytetracycline on kaolinite

Článek Interdisciplinary stratified care for low back pain: A qualitative study on the acceptability, potential facilitators and barriers to implementation

Článek The role of resource transfer in positive, non-additive litter decomposition

Článek The impact of language on the interpretation of resuscitation clinical care plans by doctors. A mixed methods study

Článek Quantum dots reveal heterogeneous membrane diffusivity and dynamic surface density polarization of dopamine transporter

Článek Genomic analysis of Shiga toxin-producing Escherichia coli from patients and asymptomatic food handlers in Japan

Článek The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress

Článek Anatomical, taxonomic, and phylogenetic reappraisal of a poorly known ghost knifefish, Tembeassu marauna (Ostariophysi: Gymnotiformes), using X-ray microcomputed tomography

Článek Matrix-assisted laser desorption/ionization time of flight mass spectrometry identification of Vibrio (Listonella) anguillarum isolated from sea bass and sea bream

Článek Recommendations of older adults on how to use the PROM ‘TOPICS-MDS’ in healthcare conversations: A Delphi study

Článek The winner takes it all—Competitiveness of single nodes in globalized supply networks

Článek Hamsters in the city: A study on the behaviour of a population of common hamsters (Cricetus cricetus) in urban environment

Článek Correction: Liquid biopsies for omics-based analysis in sentinel mussels

Článek Size matters! Association between journal size and longitudinal variability of the Journal Impact Factor

Článek Drug resistance and epidemiology characteristics of multidrug-resistant tuberculosis patients in 17 provinces of China

Článek A model-based framework for chronic hepatitis C prevalence estimation

Článek Adding rewards to regulation: The impacts of watershed conservation on land cover and household wellbeing in Moyobamba, Peru

Článek Clinical determinants of social media use in individuals with schizophrenia

Článek Arsenic and nutrient absorption characteristics and antioxidant response in different leaves of two ryegrass (Lolium perenne) species under arsenic stress

Článek An evolution of socioeconomic related inequality in teenage pregnancy and childbearing in Malawi

Článek A single plasmid based CRISPR interference in Synechocystis 6803 – A proof of concept

Článek Structural vulnerability to narcotics-driven firearm violence: An ethnographic and epidemiological study of Philadelphia’s Puerto Rican inner-city

Článek Temporal trends in intracerebral hemorrhage: Evidence from the Austrian Stroke Unit Registry

Článek Prevalence and risk factors for multi-drug resistant Escherichia coli among poultry workers in the Federal Capital Territory, Abuja, Nigeria

Článek Prediction of disease-related metabolites using bi-random walks

Článek Clinical use, efficacy, and durability of maraviroc for antiretroviral therapy in routine care: A European survey

Článek Biomarker discovery in inflammatory bowel diseases using network-based feature selection

Článek The Cinderella Complex: Word embeddings reveal gender stereotypes in movies and books

Článek Exoproteome profiling of Trypanosoma cruzi during amastigogenesis early stages

Článek Reproducible phenotype alteration due to prolonged cooling of the pupae of Polyommatus icarus butterflies

Článek Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats

Článek Pharmacy-based predictors of non-adherence, non-persistence and reinitiation of antihypertensive drugs among patients on oral diabetes drugs in the Netherlands

Článek Systematic review of the accuracy of plasma preparation tubes for HIV viral load testing

Článek Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex

Článek “Anybody can make kids; it takes a real man to look after your kids”: Aboriginal men’s discourse on parenting

Článek Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions

Článek Maternal interpregnancy weight change and premature birth: Findings from an English population-based cohort study

Článek Correction: Identifying performance benchmarks and determinants for reproductive performance and calf survival using a longitudinal field study of cow-calf herds in western Canada

Článek Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease

Článek Treatment of Urethral Pain Syndrome (UPS) in Sweden

Článek Migration and political polarization in the U.S.: An analysis of the county-level migration network

Článek Epidemiology and complications of late-onset sepsis: an Italian area-based study

Článek The relationship between women’s experience of intimate partner violence and other socio-demographic factors, and under-5 children’s health in South Africa

Článek Association between trunk and gluteus muscle size and long jump performance

Článek Multimorbidity and complex multimorbidity in Brazilian rural workers

Článek Correction: Interspecific Phylogenic Relationships within Genus Melilotus Based on Nuclear and Chloroplast DNA

Článek Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions

Článek Wolf diet and prey selection in the South-Eastern Carpathian Mountains, Romania

Článek In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms

Článek Sample size issues in multilevel logistic regression models

Článek Seed germination ecology of Ageratum houstonianum: A major invasive weed in Nepal

Článek Experiences of lifestyle change among women with gestational diabetes mellitus (GDM): A behavioural diagnosis using the COM-B model in a low-income setting

Článek Pharmacologic management of HCV treatment in patients with HCV monoinfection vs. HIV/HCV coinfection: Does coinfection really matter?

Článek The association between cigarette smoking and serum thyroid stimulating hormone, thyroid peroxidase antibodies and thyroglobulin antibodies levels in Chinese residents: A cross-sectional study in 10 cities

Článek Mouse movement measures enhance the stop-signal task in adult ADHD assessment

Článek Ecosystem functioning in urban grasslands: The role of biodiversity, plant invasions and urbanization

Článek Correction: KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services

Článek Does craniofacial morphology affect third molars impaction? Results from a population-based study in northeastern Germany

Článek Hyperconnectivity during screen-based stories listening is associated with lower narrative comprehension in preschool children exposed to screens vs dialogic reading: An EEG study

Článek Weight loss is associated with improved quality of life among rural women completers of a web-based lifestyle intervention

Článek Long-term high-grain diet altered the ruminal pH, fermentation, and composition and functions of the rumen bacterial community, leading to enhanced lactic acid production in Japanese Black beef cattle during fattening

Článek Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile

Článek Golgi reassembly and stacking protein 65 downregulation is required for the anti-cancer effect of dihydromyricetin on human ovarian cancer cells

Článek SSR marker development in Clerodendrum trichotomum using transcriptome sequencing

Článek Risk factors for the carriage of Streptococcus infantarius subspecies infantarius isolated from African fermented dairy products

Článek Development of an intervention tool for precision oral self-care: Personalized and evidence-based practice for patients with periodontal disease

Článek Personal values in adolescence and psychological distress in adults: A cross-sectional study based on a retrospective recall

Článek Overactive bladder and bladder pain syndrome/interstitial cystitis in primary Sjögren’s syndrome patients: A nationwide population-based study

Článek Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: A retrospective review from a single center

Článek Hip stress distribution - Predictor of dislocation in hip arthroplasties. A retrospective study of 149 arthroplasties

Článek Mortality, morbidity, and cardiac surgery in Injection Drug Use (IDU)-associated versus non-IDU infective endocarditis: The need to expand substance use disorder treatment and harm reduction services

Článek Pup mortality in New Zealand sea lions (Phocarctos hookeri) at Enderby Island, Auckland Islands, 2013-18

Článek In vitro endothelial cell migration from limbal edge-modified Quarter-DMEK grafts

Článek Liquid Chromatography/Mass Spectrometry based serum metabolomics study on recurrent abortion women with antiphospholipid syndrome

Článek Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors

Článek Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty

Článek Reliability of the Swedish version of the Evidence-Based Practice Attitude Scale assessing physiotherapist’s attitudes to implementation of evidence-based practice

Článek Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS

Článek Complete Chloroplast Genomes of Vachellia nilotica and Senegalia senegal: Comparative Genomics and Phylogenomic Placement in a New Generic System

Článek Retraction: Over-Expression of Superoxide Dismutase Ameliorates Cr(VI) Induced Adverse Effects via Modulating Cellular Immune System of Drosophila melanogaster

Článek Effect of pre-season training phase on anthropometric, hormonal and fitness parameters in young soccer players

Článek Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis

Článek Outcome of patients with heart failure after transcatheter aortic valve implantation

Článek Fatty acid profile of Romanian’s common bean (Phaseolus vulgaris L.) lipid fractions and their complexation ability by β-cyclodextrin

Článek Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding

Článek Treatment of corneal endothelial damage in a rabbit model with a bioengineered graft using human decellularized corneal lamina and cultured human corneal endothelium

Článek Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis

Článek Correction: Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals

Článek Correction: Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study

Článek Retraction: Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage

Článek Correction: Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5

Článek Correction: The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study

Článek Correction: Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors

Článek Discovering novel disease comorbidities using electronic medical records

Článek Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome

Článek Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics

Článek Social information use in adolescents: The impact of adults, peers and household composition

Článek Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members

Článek Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial

Článek Comparative studies of two generations of NanoString nCounter System

Článek General practitioners’ perceptions of delayed antibiotic prescription for respiratory tract infections: A phenomenographic study

Článek Can altered magnetic field affect the foraging behaviour of ants?

Článek Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011–2018

Článek A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma

Článek A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE

Článek Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma

Článek Seasonal alternation of the ontogenetic development of the moon jellyfish Aurelia coerulea in Maizuru Bay, Japan

Článek Reliability of measurement of active trunk movement in wheelchair basketball players

Článek Chinese SLE Treatment and Research group (CSTAR) registry: Clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus

Článek Does source credibility matter for point-of-decision prompts? A quasi-experimental field study to increase stair use

Článek Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study

Článek Quality and utilization patterns of maternity waiting homes at referral facilities in rural Zambia: A mixed-methods multiple case analysis of intervention and standard of care sites

Článek Determining an optimal pool size for testing beef herds for Johne’s disease in Australia

Článek Correction: Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling

Článek APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix

Článek Testing Species Assignments in Extant Terebratulide Brachiopods: A Three-dimensional Geometric Morphometric Analysis of Long-Looped Brachidia

Článek A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations

Článek Improved chemotherapy modeling with RAG-based immune deficient mice

Článek Effect of tracheal antimicrobial peptide on the development of Mannheimia haemolytica pneumonia in cattle

Článek The internal realities of individuals with type 2 diabetes – a functional framework of self-management practices via Grounded Theory approach

Článek Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia

Článek eIF4E and 4EBP1 are prognostic markers of head and neck squamous cell carcinoma recurrence after definitive surgery and adjuvant radiotherapy

Článek Smoking and other determinants of bone turnover

Článek Oxygen delivery, oxygen consumption and decreased kidney function after cardiopulmonary bypass

Článek School engagement of children in early grades: Psychometric, and gender comparisons

Článek Correction: A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)

Článek Perceived attractiveness of Czech faces across 10 cultures: Associations with sexual shape dimorphism, averageness, fluctuating asymmetry, and eye color

Článek Discovery of stable and prognostic CT-based radiomic features independent of contrast administration and dimensionality in oesophageal cancer

Článek Correction: Population-based dementia prediction model using Korean public health examination data: A cohort study

Článek Location, location, location: Close ties among older continuing care retirement community residents

Článek Correction: ISED: Constructing a high-resolution elevation road dataset from massive, low-quality in-situ observations derived from geosocial fitness tracking data

Článek Correction: Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies

Článek Monitoring fine root growth to identify optimal fertilization timing in a forest plantation: A case study in Northeast Vietnam

Článek Metabolic costs of spontaneous swimming in Sprattus sprattus L., at different water temperatures

Článek Enterovirus 71 vaccine acceptance among parents of children < 5 years old and their knowledge of hand, foot and mouth disease, Chongqing, China, 2017

Článek Correction: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing

Článek Genetic diversity and antiretroviral resistance-associated mutation profile of treated and naive HIV-1 infected patients from the Northwest and Southwest regions of Cameroon

Článek Maximum parsimony interpretation of chromatin capture experiments

Článek Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species

Článek Incidence and characteristics of ventricular tachycardia in patients after percutaneous coronary revascularization of chronic total occlusions

Článek Estimating measures of latent variables from m-alternative forced choice responses

Článek Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates

Článek First evidence of hepatitis E virus infection in a small mammal (yellow-necked mouse) from Croatia

Článek The inhibitory effects of polypyrrole on the biofilm formation of Streptococcus mutans

Článek Self-reported adverse drug effects and associated factors among H. pylori infected patients on standard triple therapy: Prospective follow up study

Článek Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain

Článek Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target

Článek Remote heart rate monitoring - Assessment of the Facereader rPPg by Noldus

Článek Seroprevalence of rubella virus antibodies among pregnant women in the Center and South-West regions of Cameroon

Článek Effectiveness of steam sterilization of reusable medical devices in primary and secondary care public hospitals in Nepal and factors associated with ineffective sterilization: A nation-wide cross-sectional study

Článek Relevance of HTLV-1 proviral load in asymptomatic and symptomatic patients living in endemic and non-endemic areas of Argentina

Článek Ritualized aggressive behavior reveals distinct social structures in native and introduced range tawny crazy ants

Článek The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury

Článek Screening and characterization of long noncoding RNAs involved in the albinism of Ananas comosus var. bracteatus leaves

Článek Visual attention to emotional faces in adolescents with social anxiety disorder receiving cognitive behavioral therapy

Článek A Q fever outbreak associated to courier transport of pets

Článek Antibodies against measles and rubella virus among different age groups in Thailand: A population-based serological survey

Článek Molecular diet analysis of Anguilliformes leptocephalus larvae collected in the western North Pacific

Článek Correction: The relationship between context, structure, and processes with outcomes of 6 regional diabetes networks in Europe

Článek Correction: The C-reactive protein/albumin ratio as an independent predictor of mortality in patients with severe sepsis or septic shock treated with early goal-directed therapy

Článek Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection

Článek Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data

Článek The implementation of HTA in medicine pricing and reimbursement policies in Indonesia: Insights from multiple stakeholders

Článek International experiences during United States ophthalmology residency training: Current structure of international experiences and perspectives of faculty mentors at United States training institutions

Článek Questionable utility of digoxin in left-ventricular assist device recipients: A multicenter, retrospective analysis

Článek Genotyping and outcomes of presumptive second line ART failure cases switched to third line or maintained on second line ART in Mumbai, India

Článek A mathematical model of honey bee colony dynamics to predict the effect of pollen on colony failure

Článek Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner

Článek An odorant receptor from Anopheles gambiae that demonstrates enantioselectivity to the plant volatile, linalool

Článek Factors associated with full immunization of children 12–23 months of age in Ethiopia: A multilevel analysis using 2016 Ethiopia Demographic and Health Survey

Článek Additional evidence that the rat renal interstitium contracts in vivo

Článek Factors affecting acceptance of at-birth point of care HIV testing among providers and parents in Kenya: A qualitative study

Článek Removal efficiency of central vacuum system and protective masks to suspended particles from dental treatment

Článek Psychological well-being and distress in patients with generalized anxiety disorder: The roles of positive and negative functioning

Článek Conventional rotator cuff versus all-suture anchors—A biomechanical study focusing on the insertion angle in an unlimited cyclic model

Článek Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD

Článek An evaluation of genetic causes and environmental risks for bilateral optic atrophy

Článek Comparative vector competence of the Afrotropical soft tick Ornithodoros moubata and Palearctic species, O. erraticus and O. verrucosus, for African swine fever virus strains circulating in Eurasia

Článek Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs

Článek Carbogen gas-challenge BOLD fMRI in assessment of liver hypoxia after portal microcapsules implantation

Článek Socioeconomic determinants of cancer screening utilisation in Latin America: A systematic review

Článek Development of an easy-to-use questionnaire assessing critical care nursing competence in Japan: A cross-sectional study

Článek Towards successful business process improvement – An extension of change acceleration process model

Článek Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model

Článek Correction: Phylogenetic analysis of hepatitis C virus among HIV/ HCV co-infected patients in Nigeria

Článek Correction: Relationship between self-disclosure to first acquaintances and subjective well-being in people with schizophrenia spectrum disorders living in the community

Článek Impact of ATM rs1801516 on late skin reactions of radiotherapy for breast cancer: Evidences from a cohort study and a trial sequential meta-analysis

Článek Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport

Článek Soil organic matter rather than ectomycorrhizal diversity is related to urban tree health

Článek Clinical risk assessment in early pregnancy for preeclampsia in nulliparous women: A population based cohort study

Článek The relation between circulating levels of vitamin D and parathyroid hormone in children and adolescents with overweight or obesity: Quest for a threshold

Článek Behavioural evidence for segments as subordinate units in Chinese spoken word production: The form-preparation paradigm revisited

Článek Correction: Measuring the impact of an interdisciplinary learning project on nursing, architecture and landscape design students’ empathy

Článek Analysis of the characteristics of chemotherapy-resistant renal cell carcinomas based on global transcriptional analysis of their tissues and cell lines

Článek The characteristics and treatment patterns of patients with Parkinson’s disease in the United States and United Kingdom: A retrospective cohort study

Článek Sex differences in youth elite swimming

Článek Unconventional SCCmec types and low prevalence of the Panton-Valentine Leukocidin exotoxin in South African blood culture Staphylococcus aureus surveillance isolates, 2013-2016

Článek Prosocial perceptions of taxation predict support for taxes

Článek Correction: Clonality analysis of pulmonary tumors by genome-wide copy number profiling

Článek Improved oxygenation following methylprednisolone therapy and survival in paediatric acute respiratory distress syndrome

Článek Normative values for relative schoolbag weight in primary school children aged 6-14 from Czech Republic: A pilot study

Článek Correction: Intensive longitudinal modelling predicts diurnal activity of salivary alpha-amylase

Článek Correction: SNV discovery and functional candidate gene identification for milk composition based on whole genome resequencing of Holstein bulls with extremely high and low breeding values

Článek Monoclonal antibody anti-PBP2a protects mice against MRSA (methicillin-resistant Staphylococcus aureus) infections

Článek Diurnal variations of amplitude of accommodation in different age groups

Článek HHIP overexpression inhibits the proliferation, migration and invasion of non-small cell lung cancer

Článek Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood–brain-barrier permeability

Článek Correlation analysis of cold-related gene expression with physiological and biochemical indicators under cold stress in oil palm

Článek Student engagement and wellbeing over time at a higher education institution

Článek Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors

Článek Influence of season and social context on male giant panda (Ailuropoda melanoleuca) vocal behaviour

Článek Development of an intravaginal ring for the topical delivery of Aurora kinase A inhibitor, MLN8237

Článek Differential phosphorylation determines the repressor and activator potencies of GLI1 proteins and their efficiency in modulating the HPV life cycle

Článek Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women

Článek Depression increases the risk of rotator cuff tear and rotator cuff repair surgery: A nationwide population-based study

Článek Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes

Článek Correction: Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T

Článek Persistent post-discharge opioid prescribing after traumatic brain injury requiring intensive care unit admission: A cross-sectional study with longitudinal outcome

Článek Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP

Článek Aerobic exercise increases post-exercise exogenous protein oxidation in healthy young males

Článek Selection for tandem stop codons in ciliate species with reassigned stop codons

Článek Research ethics in inter- and multi-disciplinary teams: Differences in disciplinary interpretations

Článek Correction: Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study

Článek Correction: People making deontological judgments in the Trapdoor dilemma are perceived to be more prosocial in economic games than they actually are

Článek LFRET, a novel rapid assay for anti-tissue transglutaminase antibody detection

Článek Effects of isotemporal substitution of sedentary behavior with light-intensity or moderate-to-vigorous physical activity on cardiometabolic markers in male adolescents

Článek Topical estrogen application to wounds promotes delayed cutaneous wound healing in 80-week-old female mice

Článek Correction: An international randomised placebo-controlled trial of a four-component combination pill (“polypill”) in people with raised cardiovascular risk

Článek Correction: Evaluation of lung toxicity risk with computed tomography ventilation image for thoracic cancer patients

Článek Retraction: Pathological Roles of Interleukin-22 in the Development of Recurrent Hepatitis C after Liver Transplantation

Článek Correction: Elevational Distribution and Ecology of Small Mammals on Tanzania's Second Highest Mountain

Článek Correction: Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer

Článek Correction: Fecal microbiota dysbiosis in macaques and humans within a shared environment

Článek Correction: The center of pressure and ankle muscle co-contraction in response to anterior-posterior perturbations

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