Early recognition of anorexia through patient-generated assessment predicts survival in patients with oesophagogastric cancer
Autoři:
Marc Abraham aff001; Zoe Kordatou aff002; Jorge Barriuso aff002; Angela Lamarca aff002; Jamie M. J. Weaver aff002; Claudia Cipriano aff002; George Papaxoinis aff002; Alison Backen aff002; Wasat Mansoor aff002
Působiště autorů:
Department of Nutrition & Dietetics, The Christie NHS Foundation Trust, Manchester, United Kingdom
aff001; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom
aff002; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom
aff003
Vyšlo v časopise:
PLoS ONE 14(11)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0224540
Souhrn
Cancer cachexia is common in patients with oesophagogastric cancer (OG) and is linked to overall survival (OS). One of the key components of cachexia is anorexia; it is not known whether anorexia impacts on OS and there is no method of routine screening in current practice. Diagnosis relies on patients describing the symptoms, clinicians diagnosing anorexia and acting upon it. Patients with oesophageal/gastroesophageal junction or gastric cancer were assessed using the Functional Assessment of Anorexia Cachexia Therapy Anorexia/Cachexia Subscale (FAACT A/CS). FAACT A/CS includes 12 questions validated previously to diagnose anorexia in patients with cancer. Of the 182 patients included, 69% scored ≤37/48 and were considered to be anorexic; FAACT A/CS was a better predictor of OS in metastatic patients than body mass index or weight loss in the six months prior to cancer diagnosis. The median OS of patients with FAACT A/CS scores of >37 was longer than patients with scores of ≤37 (19.3 months vs 6.7 months, Hazard Ratio [HR] 2.9, 95% Confidence Interval [CI] 1.4–6.0, p<0.0001). Patients with performance status (PS) 0–2 and FAACT A/CS >37 had substantially longer OS than those with PS 0–2 and FAACT A/CS ≤37 (18.7 months vs 7.9 months, HR 2.5 (95% CI 1.2–5.1, P<0.0001). The FAACT A/CS questionnaire allows clinicians to identify patients with anorexia who may benefit from early nutrition interventions. Importantly, this is the first study to show the association between anorexia and survival in patients with metastatic OG cancers. This will form the basis of future interventional studies to improve patient outcomes.
Klíčová slova:
Anorexia nervosa – Cancer detection and diagnosis – Cancer treatment – Gastric cancer – Metastasis – Paleoanthropology – Weight loss
Zdroje
1. Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5): 489–95. doi: 10.1016/S1470-2045(10)70218-7 21296615
2. Argilés JM, Anker SD, Evans WJ, Morley JE, Fearon KC, Strasser F et al. Consensus on cachexia definitions. J Am Med Dir Assoc. 2010;11(4): 229–30. doi: 10.1016/j.jamda.2010.02.004 20439040
3. Blum D, Stene GB, Solheim TS, Fayers P, Hjermstad MJ, Baracos VE et al. Validation of the Consensus-Definition for Cancer Cachexia and evaluation of a classification model—a study based on data from an international multicentre project (EPCRC-CSA). Ann Oncol. 2014;25(8): 1635–42. doi: 10.1093/annonc/mdu086 24562443
4. Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr. 2017;36(1): 11–48. doi: 10.1016/j.clnu.2016.07.015 27637832
5. Andreyev HJ, Norman AR, Oates J, Cunningham D. Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? Eur J Cancer. 1998;34(4): 503–9 doi: 10.1016/s0959-8049(97)10090-9 9713300
6. Ock CY, Oh DY, Lee J, Kim T-Y, Lee K-H, Han SW et al. Weight loss at the first month of palliative chemotherapy predicts survival outcomes in patients with advanced gastric cancer. Gastric Cancer. 2016;19(2): 597–606. doi: 10.1007/s10120-015-0481-4 25749718
7. Kamarajah SK, Bundred J, Tan BHL. Body composition assessment and sarcopenia in patients with gastric cancer: a systematic review and meta-analysis. Gastric Cancer. 2019;22 (1): 10–22. doi: 10.1007/s10120-018-0882-2 30276574
8. Boshier PR, Heneghan R, Markar SR, Baracos VE, Low DE et al. Assessment of body composition and sarcopenia in patients with esophageal cancer: a systematic review and meta-analysis. Dis Esophagus. 2018;31(8). doi: 10.1093/dote/doy047 29846548
9. Solheim TS, Laird BJA, Balstad TR, Bye A, Stene G, Baracos V et al. Cancer cachexia: rationale for the MENAC (Multimodal—Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial. BMJ Supportive & Palliative Care. 2018;8: 258–265. doi: 10.1136/bmjspcare-2017-001440 29440149
10. Lis CG, Gupta D, Grutsch JF. Can anorexia predict patient satisfaction with quality of life in advanced cancer? Support Care Cancer. 2009;17(2): 129–35. doi: 10.1007/s00520-008-0447-8 18386071
11. Aapro M, Arends J, Bozzetti F, Fearon K, Grunberg SM, Herrstedt J et al. Early recognition of malnutrition and cachexia in the cancer patient: a position paper of a European School of Oncology Task Force. Ann Oncol. 2014;25 (8): 1492–9. doi: 10.1093/annonc/mdu085 24569913
12. Ribaudo JM, Cella D, Hahn EA, Lloyd SR, Tchekmedyian NS, Von Roenn J et al. Re-validation and shortening of the Functional Assessment of Anorexia/Cachexia Therapy (FAACT) questionnaire. Qual Life Res. 2000;9(10): 1137–46 doi: 10.1023/a:1016670403148 11401046
13. Blauwhoff-Buskermolen S, Ruijgrok C, Ostelo RW, de Vet HCW, Verheul HMW, de van der Schueren MAE et al. The assessment of anorexia in patients with cancer: cut-off values for the FAACT-A/CS and the VAS for appetite. Support Care Cancer. 2016;24(2): 661–666. doi: 10.1007/s00520-015-2826-2 26160463
14. O'Rourke IC, Tiver K, Bull C, Gebski V, Langlands AO. Swallowing performance after radiation therapy for carcinoma of the esophagus. Cancer. 1988;61(10): 2022–6. doi: 10.1002/1097-0142(19880515)61:10<2022::aid-cncr2820611016>3.0.co;2-0 2452006
15. Martin L, Senesse P, Gioulbasanis I, Antoun S, Bozzetti F, Deans C et al. Diagnostic criteria for the classification of cancer-associated weight loss.J Clin Oncol. 2015;33(1): 90–9. doi: 10.1200/JCO.2014.56.1894 25422490
16. Fuchs CS, Doi T, Jang RW, Muro K, Satoh T, Machado M et al. Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer: Phase 2 Clinical KEYNOTE-059 Trial. JAMA Oncol. 2018;4(5): e180013. doi: 10.1001/jamaoncol.2018.0013 29543932
17. Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006;355: 11–20. doi: 10.1056/NEJMoa055531 16822992
18. Muscaritoli M, Lucia S, Farcomeni A, Lorusso V, Saracino V, Barone C et al. Prevalence of malnutrition in patients at first medical oncology visit: the PreMiO study. Oncotarget. 2017;8(45): 79884–79896. doi: 10.18632/oncotarget.20168 29108370
19. Lu Z, Yang L, Yu J, Lu M, Zhang X, Li J, et al. Change of body weight and macrophage inhibitory cytokine-1 during chemotherapyin advanced gastric cancer: what is their clinical significance? PLoS One. 2014;9: e88553. doi: 10.1371/journal.pone.0088553 24586342
20. Dewys WD, Begg C, Lavin PT, Band PR, Bennett JM, Bertino JR et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med. 69(4): 491–7 doi: 10.1016/s0149-2918(05)80001-3 7424938
21. Shen S, Araujo JL, Altorki NK, Sonett JR, Rodriguez A, Sungur-Stasik K et al. Variation by stage in the effects of prediagnosis weight loss on mortality in a prospective cohort of esophageal cancer patients. Dis Esophagus. 2017;30(9): 1–7. doi: 10.1093/dote/dox073 28859366
22. Blum D, Omlin A, Baracos VE, Solheim TS, Tan BH, Stone P et al. Cancer cachexia: a systematic literature review of items and domains associated with involuntary weight loss in cancer. Crit Rev Oncol Hematol. 2011;80: 114–144. doi: 10.1016/j.critrevonc.2010.10.004 21216616
23. Temel JS, Abernethy AP, Currow DC, Friend J, Duus EM, Yan Y et al. Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials. Lancet Oncol. 2016;17(4): 519–531. doi: 10.1016/S1470-2045(15)00558-6 26906526
Článek vyšel v časopise
PLOS One
2019 Číslo 11
- S diagnostikou Parkinsonovy nemoci může nově pomoci AI nástroj pro hodnocení mrkacího reflexu
- Proč při poslechu některé muziky prostě musíme tančit?
- Je libo čepici místo mozkového implantátu?
- Chůze do schodů pomáhá prodloužit život a vyhnout se srdečním chorobám
- Pomůže v budoucnu s triáží na pohotovostech umělá inteligence?
Nejčtenější v tomto čísle
- A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
- A 3’ UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction
- A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
- Molecular validation of clinical Pantoea isolates identified by MALDI-TOF
Zvyšte si kvalifikaci online z pohodlí domova
Všechny kurzy