Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats
Autoři:
Kentaro Nakamura aff001; Hidekazu Tonouchi aff001; Akina Sasayama aff001; Taketo Yamaji aff001; Kinya Ashida aff001
Působiště autorů:
Nutrition Research Department, Food Microbiology & Function Research Laboratories, R&D Division, Meiji Co., Ltd., Hachiouji, Tokyo, Japan
aff001
Vyšlo v časopise:
PLoS ONE 14(11)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0225389
Souhrn
Cancer chemotherapy is frequently accompanied by adverse effects, such as diarrhoea and leukopenia, which lead to malnutrition and a decrease in the patients’ quality of life. We previously demonstrated that an immune-modulating formula (IMF)—an enteral formula enriched with immunonutrients, whey-hydrolysed peptides, and fermented milk—had anti-inflammatory effects and protective effects on intestinal disorders in some experimental models. Here, we investigated whether nutritional treatment with the IMF could prevent 5-fluorouracil (5-FU)-induced adverse effects in rats. Rats were randomised into CTR and IMF groups, which received a control formula or the IMD supplemented formula ad libitum. Two weeks after starting the formula, rats were intraperitoneally injected with 5-FU (300 mg/kg) on day 0. The treatment with 5-FU decreased their body weights, food intake, and leukocyte counts, and worsened the diarrhoea score. However, the body weights, food intake, and leukocyte counts were significantly higher in the IMF rats than in the CTR rats on day 1. The IMF also delayed the incidence of diarrhoea and significantly preserved the villus heights in the jejunum on day 2. In conclusion, nutritional treatment with the IMF alleviated the adverse effects induced by 5-FU injection in rats.
Klíčová slova:
Adverse reactions – Body weight – Cancer chemotherapy – Cancer treatment – Diarrhea – Gastrointestinal tract – Quality of life – White blood cells
Zdroje
1. Prado CM, Lieffers JR, McCargar LJ, Reiman T, Sawyer MB, Martin L, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol. 2008; 9(7): 629–635. Epub 2008/06/10. doi: 10.1016/S1470-2045(08)70153-0 18539529
2. Ravasco P, Monteiro-Grillo I, Vidal PM, Camilo ME. Cancer: disease and nutrition are key determinants of patients' quality of life. Support Care Cancer. 2004; 12(4): 246–252. Epub 2004/03/05. doi: 10.1007/s00520-003-0568-z 14997369
3. Stringer AM, Gibson RJ, Logan RM, Bowen JM, Yeoh AS, Hamilton J, et al. Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis. Exp Biol Med (Maywood). 2009; 234(4): 430–441. Epub 2009/01/30. doi: 10.3181/0810-rm-301 19176868
4. Chang CT, Ho TY, Lin H, Liang JA, Huang HC, Li CC, et al. 5-Fluorouracil induced intestinal mucositis via nuclear factor-kappaB activation by transcriptomic analysis and in vivo bioluminescence imaging. PLoS One. 2012; 7(3): e31808. Epub 2012/03/14. doi: 10.1371/journal.pone.0031808 22412841
5. Logan RM, Stringer AM, Bowen JM, Gibson RJ, Sonis ST, Keefe DM. Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs. Cancer Biol Ther. 2008; 7(7): 1139–1145. Epub 2008/06/07. doi: 10.4161/cbt.7.7.6207 18535404
6. Masuda Y, Inoue M, Miyata A, Mizuno S, Nanba H. Maitake beta-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice. Int Immunopharmacol. 2009; 9(5): 620–626. Epub 2009/03/03. doi: 10.1016/j.intimp.2009.02.005 19249389
7. Xue H, Sawyer MB, Wischmeyer PE, Baracos VE. Nutrition modulation of gastrointestinal toxicity related to cancer chemotherapy: from preclinical findings to clinical strategy. JPEN J Parenter Enteral Nutr. 2011; 35(1): 74–90. Epub 2011/01/13. doi: 10.1177/0148607110377338 21224434
8. Pontes-Arruda A, Demichele S, Seth A, Singer P. The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of outcome data. JPEN J Parenter Enteral Nutr. 2008; 32(6): 596–605. Epub 2008/11/01. doi: 10.1177/0148607108324203 18974237
9. Kume H, Okazaki K, Takahashi T, Yamaji T. Protective effect of an immune-modulating diet comprising whey peptides and fermented milk products on indomethacin-induced small-bowel disorders in rats. Clin Nutr. 2014; 33(6): 1140–1146. Epub 2014/01/28. doi: 10.1016/j.clnu.2013.12.014 24461940
10. Kume H, Okazaki K, Yamaji T, Sasaki H. A newly designed enteral formula containing whey peptides and fermented milk product protects mice against concanavalin A-induced hepatitis by suppressing overproduction of inflammatory cytokines. Clin Nutr. 2012; 31(2): 283–289. Epub 2011/11/29. doi: 10.1016/j.clnu.2011.10.012 22119211
11. Nakamura K, Fukatsu K, Sasayama A, Yamaji T. An immune-modulating formula comprising whey peptides and fermented milk improves inflammation-related remote organ injuries in diet-induced acute pancreatitis in mice. Biosci Microbiota Food Health. 2018; 37(1): 1–8. Epub 2018/02/02. doi: 10.12938/bmfh.17-011 29387516
12. Nakamura K, Ogawa S, Dairiki K, Fukatsu K, Sasaki H, Kaneko T, et al. A new immune-modulating diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose attenuates gut ischemia-reperfusion injury in mice. Clin Nutr. 2011; 30(4): 513–516. Epub 2011/02/02. doi: 10.1016/j.clnu.2011.01.002 21281994
13. Nakamura K, Sasayama A, Takahashi T, Yamaji T. An immune-modulating diet in combination with chemotherapy prevents cancer cachexia by attenuating systemic inflammation in colon 26 tumor-bearing mice. Nutr Cancer. 2015; 67(6): 912–920. Epub 2015/07/03. doi: 10.1080/01635581.2015.1053495 26133950
14. Trifan OC, Durham WF, Salazar VS, Horton J, Levine BD, Zweifel BS, et al. Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11. Cancer Res. 2002; 62(20): 5778–5784. Epub 2002/10/18. 12384538
15. Xue H, Sawyer MB, Field CJ, Dieleman LA, Baracos VE. Nutritional modulation of antitumor efficacy and diarrhea toxicity related to irinotecan chemotherapy in rats bearing the ward colon tumor. Clin Cancer Res. 2007; 13(23): 7146–7154. Epub 2007/12/07. doi: 10.1158/1078-0432.CCR-07-0823 18056195
16. Arends J, Bodoky G, Bozzetti F, Fearon K, Muscaritoli M, Selga G, et al. ESPEN Guidelines on Enteral Nutrition: Non-surgical oncology. Clin Nutr. 2006; 25(2): 245–259. Epub 2006/05/16. doi: 10.1016/j.clnu.2006.01.020 16697500
17. Yang YH, Lee DS. The relationship of anorexia, nausea, vomiting, oral intake and nutritional status in patients receiving chemotherapy. J Korean Acad Nurs. 2000; 30(3): 720–730.
18. Lee H-O, Lee J-J. Nutritional intervention using nutrition care process in a malnourished patient with chemotherapy side effects. Clin Nutr Res. 2015; 4(1): 63–67. Epub 12/08. doi: 10.7762/cnr.2015.4.1.63 25713794
19. Cinausero M, Aprile G, Ermacora P, Basile D, Vitale MG, Fanotto V, et al. New frontiers in the pathobiology and treatment of cancer regimen-related mucosal injury. Front Pharmacol. 2017; 8(354). doi: 10.3389/fphar.2017.00354 28642709
20. Nurgali K, Jagoe RT, Abalo R. Editorial: adverse effects of cancer chemotherapy: Anything new to improve tolerance and reduce sequelae? Front Pharmacol. 2018; 9: 245–245. doi: 10.3389/fphar.2018.00245 29623040
21. Kume H, Nakamura K, Okazaki K, Matsuura M, Yamaji T, Ashida K. Influence of nutritional management using an enteral formula MHN-02 on intestinal tissue structure in rats. Milk Sci. 2018; 67(1): 30–33. doi: 10.11465/milk.67.30
22. Li H-L, Lu L, Wang X-S, Qin L-Y, Wang P, Qiu S-P, et al. Alteration of gut microbiota and inflammatory cytokine/chemokine profiles in 5-fluorouracil induced intestinal mucositis. Front Cell Infect Microbiol. 2017; 7(455). doi: 10.3389/fcimb.2017.00455 29124041
23. Osterlund P, Ruotsalainen T, Korpela R, Saxelin M, Ollus A, Valta P, et al. Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study. Br J Cancer. 2007; 97(8): 1028–1034. Epub 2007/09/27. doi: 10.1038/sj.bjc.6603990 17895895
24. Von Bultzingslowen I, Adlerberth I, Wold AE, Dahlen G, Jontell M. Oral and intestinal microflora in 5-fluorouracil treated rats, translocation to cervical and mesenteric lymph nodes and effects of probiotic bacteria. Oral Microbiol Immunol. 2003; 18(5): 278–284. Epub 2003/08/22. doi: 10.1034/j.1399-302x.2003.00075.x 12930518
25. Garcia-Albiach R, Pozuelo de Felipe MJ, Angulo S, Morosini MI, Bravo D, Baquero F, et al. Molecular analysis of yogurt containing Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus in human intestinal microbiota. Am J Clin Nutr. 2008; 87(1): 91–96. Epub 2008/01/08. doi: 10.1093/ajcn/87.1.91 18175741
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PLOS One
2019 Číslo 11
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