Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia

English version

Autoři: Heng Choon Cheong ^aff001; Polly Soo Xi Yap ^aff001; Chun Wie Chong ^aff002; Yi Ying Cheok ^aff001; Chalystha Yie Qin Lee ^aff001; Grace Min Yi Tan ^aff001; Sofiah Sulaiman ^aff003; Jamiyah Hassan ^aff003; Negar Shafiei Sabet ^aff004; Chung Yeng Looi ^aff005; Rishein Gupta ^aff006; Bernard Arulanandam ^aff006; Sazaly AbuBakar ^aff001; Cindy Shuan Ju Teh ^aff001; Li Yen Chang ^aff001; Won Fen Wong ^aff001
Působiště autorů: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia ^aff001; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor, Malaysia ^aff002; Department of Obstetrics and Gynecology, Faculty of medicine, University of Malaya, Kuala Lumpur, Malaysia ^aff003; Faculty of Medicine, SEGi University, Kota Damansara, Selangor, Malaysia ^aff004; School of Bioscience, Taylor’s University, Subang Jaya, Selangor, Malaysia ^aff005; Center of Excellence in Infection Genomics, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, Texas, United States of America ^aff006; Tropical Infectious Disease Research and Education Center, University of Malaya, Kuala Lumpur, Malaysia ^aff007
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0224658

Souhrn

The cervical microbiota constitutes an important protective barrier against the invasion of pathogenic microorganisms. A disruption of microbiota within the cervical milieu has been suggested to be a driving factor of sexually transmitted infections. These include Chlamydia trachomatis which frequently causes serious reproductive sequelae such as infertility in women. In this study, we profiled the cervical microbial composition of a population of 70 reproductive-age Malaysian women; among which 40 (57.1%) were diagnosed with genital C. trachomatis infection, and 30 (42.8%) without C. trachomatis infection. Our findings showed a distinct compositional difference between the cervical microbiota of C. trachomatis-infected subjects and subjects without C. trachomatis infection. Specifically, significant elevations of mostly strict and facultative anaerobes such as Streptococcus, Megasphaera, Prevotella, and Veillonella in the cervical microbiota of C. trachomatis-positive women were detected. The results from the current study highlights an interaction of C. trachomatis with the environmental microbiome in the endocervical region.

Klíčová slova:

Chlamydia infection – Lactobacillus – Microbiome – Pseudomonas infections – Ribosomal RNA – Streptococcal infections – Prevotella infection

Zdroje

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Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia

Souhrn

Klíčová slova:

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