Variants in ADIPOQ gene are linked to adiponectin levels and lung function in young males independent of obesity

English version

Autoři: Andria Christodoulou ^aff001; Despo Ierodiakonou ^aff002; Awoyemi A. Awofala ^aff003; Michael Petrou ^aff004; Stefanos N. Kales ^aff005; David C. Christiani ^aff005; Christos S. Mantzoros ^aff007; Costas A. Christophi ^aff001
Působiště autorů: Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus ^aff001; Department of Social Medicine Faculty of Medicine, University of Crete, Crete, Greece ^aff002; Department of Biological Sciences, Tai Solarin University of Education, Ijagun, Ogun State, Nigeria ^aff003; Cyprus Anti-doping Authority, Nicosia, Cyprus ^aff004; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America ^aff005; Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, United States of America ^aff006; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States of America ^aff007
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0225662

Souhrn

Background

Obesity is a major risk factor for many chronic diseases, including reduced lung function. The role of polymorphisms of the adiponectin gene, though linked with cardiometabolic consequences of obesity, has not been studied in relation to lung function.

Objectives

The aim of this study is to examine polymorphisms in the ADIPOQ, ADIPOR1, and ADIPOR2 genes in relation to adiponectin serum levels, BMI, and adiposity in 18-year old Cypriot males, as well as determine whether BMI, adipokines levels and polymorphisms in adipokine related genes are associated with lung function levels.

Results

From the participants, 8% were classified as obese, 22% as overweight, and the remaining 71% as normal. We found that rs266729 and rs1501299 in ADIPOQ and rs10920531 in ADIPOR1 were significantly associated with serum adiponectin levels, after adjusting for ever smoking. In addition, there was an overall significant increase in FEV₁% predicted with increasing BMI (β = 0.53, 95% CI: 0.27, 0.78) and in FVC % predicted (β = 1.02, 95% CI: 0.73, 1.30). There was also a decrease in FEV₁/FVC with increasing BMI (β = -0.53, 95% CI: -0.71, -0.35). Finally, rs1501299 was associated with lung function measures.

Discussion

Functional variants in the ADIPOQ gene were linked with lung function in young males. Further studies should concentrate on the role of adipokines on lung function which may direct novel therapeutic approaches.

Klíčová slova:

Adipokines – Adiponectin – Body Mass Index – Cyprus – Genome-wide association studies – Obesity – Pulmonary function – Variant genotypes

Zdroje

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Variants in ADIPOQ gene are linked to adiponectin levels and lung function in young males independent of obesity

Souhrn

Background

Objectives

Results

Discussion

Klíčová slova:

Zdroje

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