Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation
Autoři:
Cristina Berastegui aff001; Susana Gómez-Ollés aff001; Alberto Mendoza-Valderrey aff001; Thais Pereira-Veiga aff001; Mario Culebras aff001; Victor Monforte aff001; Berta Saez aff001; Manuel López-Meseguer aff001; Helena Sintes-Permanyer aff001; Victoria Ruiz de Miguel aff001; Carlos Bravo aff001; Judit Sacanell aff003; María-Antonia Ramon aff001; Laura Romero aff004; María Deu aff004; Antonio Román aff001
Působiště autorů:
Servei de Pneumologia, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
aff001; Ciber Enfermedades Respiratorias (Ciberes)
aff002; Servei de Medicina Intensiva, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
aff003; Servei de Cirurgia Toràcica, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain
aff004
Vyšlo v časopise:
PLoS ONE 15(1)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0226488
Souhrn
KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8–1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients.
Klíčová slova:
Biomarkers – Bronchiolitis – Cystic fibrosis – Chronic obstructive pulmonary disease – Interstitial lung diseases – Lung transplantation – Opacity – Spirometry
Zdroje
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