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proLékaře.cz / Odborné časopisy / PLOS One / 2020 - 1

Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2

English version

Autoři: Nhi Hin aff001;  Morgan Newman aff002;  Jan Kaslin aff003;  Alon M. Douek aff003;  Amanda Lumsden aff004;  Seyed Hani Moussavi Nik aff001;  Yang Dong aff001;  Xin-Fu Zhou aff005;  Noralyn B. Mañucat-Tan aff005;  Alastair Ludington aff001;  David L. Adelson aff006;  Stephen Pederson aff001;  Michael Lardelli aff002
Působiště autorů: Bioinformatics Hub, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia aff001;  Alzheimer’s Disease Genetics Laboratory, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia aff002;  Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia aff003;  College of Medicine and Public Health, and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia aff004;  School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia aff005;  Centre for Bioinformatics and Computational Genetics, School of Bioogical Sciences, Adelaide, South Australia, Australia aff006
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0227258

Souhrn

Background

The molecular changes involved in Alzheimer’s disease (AD) progression remain unclear since we cannot easily access antemortem human brains. Some non-mammalian vertebrates such as the zebrafish preserve AD-relevant transcript isoforms of the PRESENILIN genes lost from mice and rats. One example is PS2V, the alternative transcript isoform of the PSEN2 gene. PS2V is induced by hypoxia/oxidative stress and shows increased expression in late onset, sporadic AD brains. A unique, early onset familial AD mutation of PSEN2, K115fs, mimics the PS2V coding sequence suggesting that forced, early expression of PS2V-like isoforms may contribute to AD pathogenesis. Here we use zebrafish to model the K115fs mutation to investigate the effects of forced PS2V-like expression on the transcriptomes of young adult and aged adult brains.

Methods

We edited the zebrafish genome to model the K115fs mutation. To explore its effects at the molecular level, we analysed the brain transcriptome and proteome of young (6-month-old) and aged (24-month-old) wild type and heterozygous mutant female sibling zebrafish. Finally, we used gene co-expression network analysis (WGCNA) to compare molecular changes in the brains of these fish to human AD.

Results

Young heterozygous mutant fish show transcriptional changes suggesting accelerated brain aging and increased glucocorticoid signalling. These early changes precede a transcriptional ‘inversion’ that leads to glucocorticoid resistance and other likely pathological changes in aged heterozygous mutant fish. Notably, microglia-associated immune responses regulated by the ETS transcription factor family are altered in both our zebrafish mutant model and in human AD. The molecular changes we observe in aged heterozygous mutant fish occur without obvious histopathology and possibly in the absence of Aβ.

Conclusions

Our results suggest that forced expression of a PS2V-like isoform contributes to immune and stress responses favouring AD pathogenesis. This highlights the value of our zebrafish genetic model for exploring molecular mechanisms involved in AD pathogenesis.

Klíčová slova:

Alzheimer's disease – Gene expression – Genetic networks – Immune response – Mutation – Neural networks – Polymerase chain reaction – Zebrafish

Zdroje

1. Cadonic C, Sabbir MG, Albensi BC. Mechanisms of Mitochondrial Dysfunction in Alzheimer’s Disease. Mol Neurobiol. 2015. doi: 10.1007/s12035-015-9515-5 26537901.

2. Castellani R, Hirai K, Aliev G, Drew KL, Nunomura A, Takeda A, et al. Role of mitochondrial dysfunction in Alzheimer’s disease. J Neurosci Res. 2002;70(3):357–60. Epub 2002/10/23. doi: 10.1002/jnr.10389 12391597.

3. Fedrizzi L, Carafoli E. Ca2+ dysfunction in neurodegenerative disorders: Alzheimer’s disease. Biofactors. 2011;37(3):189–96. Epub 2011/06/24. doi: 10.1002/biof.157 21698698.

4. Mills E, Dong XP, Wang F, Xu H. Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders. Future Med Chem. 2010;2(1):51–64. doi: 10.4155/fmc.09.140 20161623.

5. Moir RD, Atwood CS, Huang X, Tanzi RE, Bush AI. Mounting evidence for the involvement of zinc and copper in Alzheimer’s disease. Eur J Clin Invest. 1999;29(7):569–70. Epub 1999/07/20. doi: 10.1046/j.1365-2362.1999.00472.x 10411660.

6. Arimon M, Takeda S, Post KL, Svirsky S, Hyman BT, Berezovska O. Oxidative stress and lipid peroxidation are upstream of amyloid pathology. Neurobiol Dis. 2015;84:109–19. doi: 10.1016/j.nbd.2015.06.013 26102023.

7. Oresic M, Hyotylainen T, Herukka SK, Sysi-Aho M, Mattila I, Seppanan-Laakso T, et al. Metabolome in progression to Alzheimer’s disease. Transl Psychiatry. 2011;1:e57. Epub 2011/01/01. doi: 10.1038/tp.2011.55 22832349.

8. Poirier J, Miron J, Picard C, Gormley P, Theroux L, Breitner J, et al. Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer’s disease. Neurobiol Aging. 2014;35 Suppl 2:S3–10. Epub 2014/06/29. doi: 10.1016/j.neurobiolaging.2014.03.037 24973118.

9. Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, et al. Neuroinflammation in Alzheimer’s disease. Lancet Neurol. 2015;14(4):388–405. Epub 2015/03/21. doi: 10.1016/S1474-4422(15)70016-5 25792098.

10. Zotova E, Nicoll JA, Kalaria R, Holmes C, Boche D. Inflammation in Alzheimer’s disease: relevance to pathogenesis and therapy. Alzheimers Res Ther. 2010;2(1):1. Epub 2010/02/04. doi: 10.1186/alzrt24 20122289.

11. Abramsson A, Kettunen P, Banote RK, Lott E, Li M, Arner A, et al. The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation. Dev Biol. 2013;381(2):377–88. doi: 10.1016/j.ydbio.2013.06.026 23850871.

12. De Strooper B. Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiol Rev. 2010;90(2):465–94. doi: 10.1152/physrev.00023.2009 20393191.

13. Hipp MS, Park SH, Hartl FU. Proteostasis impairment in protein-misfolding and -aggregation diseases. Trends Cell Biol. 2014. Epub 2014/06/21. doi: 10.1016/j.tcb.2014.05.003 24946960.

14. Braak H, Braak E. Diagnostic criteria for neuropathologic assessment of Alzheimer’s disease. Neurobiol Aging. 1997;18(4 Suppl):S85–8. Epub 1997/07/01. doi: 10.1016/s0197-4580(97)00062-6 9330992.

15. Masters CL, Bateman RJ, Blennow K, Rowe CC, Sperling RA, Cummings JL. Alzheimer’s disease. Nature reviews Disease Primers. 2015;1:1–8. doi: 10.1038/nrdp.2015.56 27188934

16. Mehta D, Jackson R, Paul G, Shi J, Sabbagh M. Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010–2015. Expert Opin Investig Drugs. 2017;26(6):735–9. doi: 10.1080/13543784.2017.1323868 28460541.

17. Villemagne VL, Burnham S, Bourgeat P, Brown B, Ellis KA, Salvado O, et al. Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort study. Lancet Neurol. 2013;12(4):357–67. Epub 2013/03/13. doi: 10.1016/S1474-4422(13)70044-9 23477989.

18. Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, et al. Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N Engl J Med. 2012;367(9):795–804. doi: 10.1056/NEJMoa1202753 22784036.

19. Iturria-Medina Y, Sotero RC, Toussaint PJ, Mateos-Perez JM, Evans AC, Alzheimer’s Disease Neuroimaging I. Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis. Nat Commun. 2016;7:11934. doi: 10.1038/ncomms11934 27327500.

20. Quiroz YT, Schultz AP, Chen K, Protas HD, Brickhouse M, Fleisher AS, et al. Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study. JAMA Neurol. 2015;72(8):912–9. doi: 10.1001/jamaneurol.2015.1099 26121081.

21. Reiman EM, Quiroz YT, Fleisher AS, Chen K, Velez-Pardo C, Jimenez-Del-Rio M, et al. Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer’s disease in the presenilin 1 E280A kindred: a case-control study. Lancet Neurol. 2012;11(12):1048–56. doi: 10.1016/S1474-4422(12)70228-4 23137948.

22. Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, et al. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia. Proc Natl Acad Sci U S A. 2004;101(1):284–9. Epub 2003/12/23. doi: 10.1073/pnas.2635903100 14688411

23. Berchtold NC, Sabbagh MN, Beach TG, Kim RC, Cribbs DH, Cotman CW. Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer’s disease. Neurobiol Aging. 2014;35(9):1961–72. doi: 10.1016/j.neurobiolaging.2014.03.031 24786631.

24. Antonell A, Llado A, Altirriba J, Botta-Orfila T, Balasa M, Fernandez M, et al. A preliminary study of the whole-genome expression profile of sporadic and monogenic early-onset Alzheimer’s disease. Neurobiol Aging. 2013;34(7):1772–8. Epub 2013/02/02. doi: 10.1016/j.neurobiolaging.2012.12.026 23369545.

25. Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, et al. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med. 1999;5(1):101–6. doi: 10.1038/4789 9883847.

26. Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, et al. Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer’s disease in aged mice. Eur J Neurosci. 2004;19(10):2826–38. doi: 10.1111/j.0953-816X.2004.03397.x 15147316.

27. Siman R, Reaume AG, Savage MJ, Trusko S, Lin YG, Scott RW, et al. Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability. J Neurosci. 2000;20(23):8717–26. doi: 10.1523/JNEUROSCI.20-23-08717.2000 11102478.

28. Hargis KE, Blalock EM. Transcriptional signatures of brain aging and Alzheimer’s disease: What are our rodent models telling us? Behav Brain Res. 2017;322(Pt B):311–28. Epub 2016/05/04. doi: 10.1016/j.bbr.2016.05.007 27155503.

29. Sato N, Hori O, Yamaguchi A, Lambert JC, Chartier-Harlin MC, Robinson PA, et al. A novel presenilin-2 splice variant in human Alzheimer’s disease brain tissue. Journal of Neurochemistry. 1999;72(6):2498–505. doi: 10.1046/j.1471-4159.1999.0722498.x 10349860

30. Jayadev S, Leverenz JB, Steinbart E, Stahl J, Klunk W, Yu CE, et al. Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2. Brain. 2010;133:1143–54. doi: 10.1093/brain/awq033 20375137

31. Newman M, Wilson L, Verdile G, Lim A, Khan I, Moussavi Nik SH, et al. Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease. Hum Mol Genet. 2014;23(3):602–17. Epub 2013/10/09. doi: 10.1093/hmg/ddt448 24101600.

32. Moussavi Nik SH, Newman M, Wilson L, Ebrahimie E, Wells S, Musgrave I, et al. Alzheimer’s disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of gamma-secretase activity. Hum Mol Genet. 2015. Epub 2015/03/31. doi: 10.1093/hmg/ddv110 25814654.

33. Sharman MJ, Moussavi Nik SH, Chen MM, Ong D, Wijaya L, Laws SM, et al. The Guinea Pig as a Model for Sporadic Alzheimer’s Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes. PLoS One. 2013;8(6):e66235. doi: 10.1371/journal.pone.0066235 23805206.

34. Seshadri S, Wolf PA, Beiser A, Au R, McNulty K, White R, et al. Lifetime risk of dementia and Alzheimer’s disease. The impact of mortality on risk estimates in the Framingham Study. Neurology. 1997;49(6):1498–504. doi: 10.1212/wnl.49.6.1498 9409336.

35. Gamberger D, Ženko B, Mitelpunkt A, Shachar N, Lavrač N. Clusters of male and female Alzheimer’s disease patients in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Brain Inform. 2016;3(3):169–79. Epub 2016/03/30. doi: 10.1007/s40708-016-0035-5 27525218.

36. Oosterhof N, Holtman IR, Kuil LE, van der Linde HC, Boddeke EW, Eggen BJ, et al. Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish. Glia. 2017;65(1):138–49. Epub 2016/10/19. doi: 10.1002/glia.23083 27757989.

37. Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature. 2007;445(7124):168–76. Epub 2006/12/06. doi: 10.1038/nature05453 17151600.

38. Liberzon A, Birger C, Thorvaldsdottir H, Ghandi M, Mesirov JP, Tamayo P. The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst. 2015;1(6):417–25. doi: 10.1016/j.cels.2015.12.004 26771021.

39. de Sousa Abreu R, Penalva LO, Marcotte EM, Vogel C. Global signatures of protein and mRNA expression levels. Mol Biosyst. 2009;5(12):1512–26. Epub 2009/10/01. doi: 10.1039/b908315d 20023718.

40. Kumar D, Bansal G, Narang A, Basak T, Abbas T, Dash D. Integrating transcriptome and proteome profiling: Strategies and applications. Proteomics. 2016;16(19):2533–44. Epub 2016/08/25. doi: 10.1002/pmic.201600140 27343053.

41. Allen M, Carrasquillo MM, Funk C, Heavner BD, Zou F, Younkin CS, et al. Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases. Sci Data. 2016;3:160089. Epub 2016/10/11. doi: 10.1038/sdata.2016.89 27727239.

42. Ballouz S, Verleyen W, Gillis J. Guidance for RNA-seq co-expression network construction and analysis: safety in numbers. Bioinformatics. 2015;31(13):2123–30. doi: 10.1093/bioinformatics/btv118 25717192.

43. Zhang B, Horvath S. A General Framework for Weighted Gene Co-Expression Network Analysis. Statistical Applications in Genetics and Molecular Biology2005.

44. Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA, et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489(7416):391–9. doi: 10.1038/nature11405 22996553.

45. Winden KD, Oldham MC, Mirnics K, Ebert PJ, Swan CH, Levitt P, et al. The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol. 2009;5:291. doi: 10.1038/msb.2009.46 19638972.

46. Oldham MC, Horvath S, Geschwind DH. Conservation and evolution of gene coexpression networks in human and chimpanzee brains. Proceedings of the National Academy of Sciences. 2006;103(47):17973–8. doi: 10.1073/pnas.0605938103 17101986

47. Miller JA, Horvath S, Geschwind DH. Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proceedings of the National Academy of Sciences. 2010;107(28):12698–703.

48. Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Cell. 2013;153(3):707–20. doi: 10.1016/j.cell.2013.03.030 23622250.

49. Langfelder P, Luo R, Oldham MC, Horvath S. Is my network module preserved and reproducible? PLoS Comput Biol. 2011;7(1):e1001057. doi: 10.1371/journal.pcbi.1001057 21283776.

50. Solchenberger B, Russell C, Kremmer E, Haass C, Schmid B. Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology. PLoS One. 2015;10(3):e0118956. doi: 10.1371/journal.pone.0118956 25785851.

51. Moore DB, Gillentine MA, Botezatu NM, Wilson KA, Benson AE, Langeland JA. Asynchronous evolutionary origins of Abeta and BACE1. Mol Biol Evol. 2014;31(3):696–702. doi: 10.1093/molbev/mst262 24361992.

52. Hardy JA, Higgins GA. Alzheimer’s disease: the amyloid cascade hypothesis. Science. 1992;256(5054):184–5. doi: 10.1126/science.1566067 1566067.

53. Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW. Incipient Alzheimer’s disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci U S A. 2004;101(7):2173–8. doi: 10.1073/pnas.0308512100 14769913.

54. Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, et al. Functional alterations in memory networks in early Alzheimer’s disease. Neuromolecular Med. 2010;12(1):27–43. doi: 10.1007/s12017-009-8109-7 20069392.

55. Head E, Lott IT, Patterson D, Doran E, Haier RJ. Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention. J Alzheimers Dis. 2007;11(1):61–76. doi: 10.3233/jad-2007-11110 17361036.

56. Du X, Pang TY. Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases? Front Psychiatry. 2015;6:32. doi: 10.3389/fpsyt.2015.00032 25806005.

57. Silverman MN, Sternberg EM. Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann N Y Acad Sci. 2012;1261:55–63. doi: 10.1111/j.1749-6632.2012.06633.x 22823394.

58. Arlt S, Demiralay C, Tharun B, Geisel O, Storm N, Eichenlaub M, et al. Genetic risk factors for depression in Alzheimer`s disease patients. Curr Alzheimer Res. 2013;10(1):72–81. 23157339.

59. Lin JX, Leonard WJ. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene. 2000;19(21):2566–76. doi: 10.1038/sj.onc.1203523 10851055.

60. Moon RT, Bowerman B, Boutros M, Perrimon N. The promise and perils of Wnt signaling through beta-catenin. Science. 2002;296(5573):1644–6. doi: 10.1126/science.1071549 12040179

61. Rapoport SI, Hatanpaa K, Brady DR, Chandrasekaran K. Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease. Neurodegeneration. 1996;5(4):473–6. doi: 10.1006/neur.1996.0065 9117565.

62. Barron AM, Fuller SJ, Verdile G, Martins RN. Reproductive hormones modulate oxidative stress in Alzheimer’s disease. Antioxid Redox Signal. 2006;8(11–12):2047–59. doi: 10.1089/ars.2006.8.2047 17034349.

63. Schapira AH. Oxidative stress and mitochondrial dysfunction in neurodegeneration. Curr Opin Neurol. 1996;9(4):260–4. doi: 10.1097/00019052-199608000-00003 8858182.

64. Perry G, Nunomura A, Hirai K, Takeda A, Aliev G, Smith MA. Oxidative damage in Alzheimer’s disease: the metabolic dimension. Int J Dev Neurosci. 2000;18(4–5):417–21. Epub 2000/05/19. doi: 10.1016/s0736-5748(00)00006-x 10817925

65. Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, et al. Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol. 2001;60(8):759–67. Epub 2001/08/07. doi: 10.1093/jnen/60.8.759 11487050.

66. Perry G, Nunomura A, Hirai K, Zhu X, Perez M, Avila J, et al. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases? Free Radic Biol Med. 2002;33(11):1475–9. Epub 2002/11/26. doi: 10.1016/s0891-5849(02)01113-9 12446204

67. Scherz-Shouval R, Elazar Z. ROS, mitochondria and the regulation of autophagy. Trends Cell Biol. 2007;17(9):422–7. Epub 2007/09/07. doi: 10.1016/j.tcb.2007.07.009 17804237.

68. Daulatzai MA. Death by a thousand cuts in Alzheimer’s disease: hypoxia-the prodrome. Neurotox Res. 2013;24(2):216–43. doi: 10.1007/s12640-013-9379-2 23400634.

69. Daulatzai MA. Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer’s disease. J Neurosci Res. 2017;95(4):943–72. doi: 10.1002/jnr.23777 27350397.

70. Zhao WQ, Ravindranath L, Mohamed AS, Zohar O, Chen GH, Lyketsos CG, et al. MAP kinase signaling cascade dysfunction specific to Alzheimer’s disease in fibroblasts. Neurobiol Dis. 2002;11(1):166–83. doi: 10.1006/nbdi.2002.0520 12460556.

71. Drewes G, Lichtenberg-Kraag B, Döring F, Mandelkow EM, Biernat J, Goris J, et al. Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state. EMBO J. 1992;11(6):2131–8. 1376245.

72. Maroulakou IG, Bowe DB. Expression and function of Ets transcription factors in mammalian development: a regulatory network. Oncogene. 2000;19(55):6432–42. doi: 10.1038/sj.onc.1204039 11175359.

73. Kar A, Gutierrez-Hartmann A. Molecular mechanisms of ETS transcription factor-mediated tumorigenesis. Crit Rev Biochem Mol Biol. 2013;48(6):522–43. doi: 10.3109/10409238.2013.838202 24066765.

74. Gjoneska E, Pfenning AR, Mathys H, Quon G, Kundaje A, Tsai LH, et al. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease. Nature. 2015;518(7539):365–9. doi: 10.1038/nature14252 25693568.

75. Morgan SC, Taylor DL, Pocock JM. Microglia release activators of neuronal proliferation mediated by activation of mitogen-activated protein kinase, phosphatidylinositol-3-kinase/Akt and delta-Notch signalling cascades. J Neurochem. 2004;90(1):89–101. doi: 10.1111/j.1471-4159.2004.02461.x 15198670.

76. Herculano-Houzel S. Scaling of brain metabolism with a fixed energy budget per neuron: implications for neuronal activity, plasticity and evolution. PLoS One. 2011;6(3):e17514. doi: 10.1371/journal.pone.0017514 21390261.

77. Yamada T, Sasaki H, Furuya H, Miyata T, Goto I, Sakaki Y. Complementary DNA for the mouse homolog of the human amyloid beta protein precursor. Biochem Biophys Res Commun. 1987;149(2):665–71. doi: 10.1016/0006-291x(87)90419-0 3322280.

78. Musa A, Lehrach H, Russo VA. Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development. Dev Genes Evol. 2001;211(11):563–7. Epub 2002/02/28. doi: 10.1007/s00427-001-0189-9 11862463.

79. Monsell SE, Kukull WA, Roher AE, Maarouf CL, Serrano G, Beach TG, et al. Characterizing Apolipoprotein E epsilon4 Carriers and Noncarriers With the Clinical Diagnosis of Mild to Moderate Alzheimer Dementia and Minimal beta-Amyloid Peptide Plaques. JAMA Neurol. 2015;72(10):1124–31. doi: 10.1001/jamaneurol.2015.1721 26302353.

80. Jack CR Jr., Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):257–62. 21514247.

81. Whitehouse PJ, George DR. A tale of two reports: what recent publications from the Alzheimer’s Association and Institute of Medicine say about the state of the field. J Alzheimers Dis. 2016;49(1):21–5. doi: 10.3233/JAD-150663 26444797.

82. Morris GP, Clark IA, Vissel B. Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer’s disease. Acta Neuropathol. 2018;136(5):663–89. Epub 2018/10/22. doi: 10.1007/s00401-018-1918-8 30349969.

83. Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FR, et al. Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis. JAMA. 2015;313(19):1924–38. doi: 10.1001/jama.2015.4668 25988462.

84. Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, et al. Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Ann Clin Transl Neurol. 2019;6(4):762–77. Epub 2019/03/10. doi: 10.1002/acn3.755 31020001.

85. Nornes S, Newman M, Verdile G, Wells S, Stoick-Cooper CL, Tucker B, et al. Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Hum Mol Genet. 2008;17(3):402–12. Epub 2007/11/06. doi: 10.1093/hmg/ddm317 17981814.

86. Newman M, Hin N, Pederson S, Lardelli M. Brain transcriptome analysis of a familial Alzheimer’s disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Mol Brain. 2019;12(1):43. Epub 2019/05/03. doi: 10.1186/s13041-019-0467-y 31053140.

87. Huggett JF, Whale A. Digital PCR as a novel technology and its potential implications for molecular diagnostics. Clin Chem. 2013;59(12):1691–3. Epub 2013/10/07. doi: 10.1373/clinchem.2013.214742 24100808.

88. de St Groth Fazekas. The evaluation of limiting dilution assays. J Immunol Methods. 1982;49(2):R11–23. doi: 10.1016/0022-1759(82)90269-1 7040548.

89. Wisniewski JR, Zougman A, Nagaraj N, Mann M. Universal sample preparation method for proteome analysis. Nat Methods. 2009;6(5):359–62. doi: 10.1038/nmeth.1322 19377485.

90. Cox J, Hein MY, Luber CA, Paron I, Nagaraj N, Mann M. Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ. Mol Cell Proteomics. 2014;13(9):2513–26. doi: 10.1074/mcp.M113.031591 24942700.

91. Andrews S. FastQC. 0.11.5 ed2010.

92. Lindgreen S. AdapterRemoval: easy cleaning of next-generation sequencing reads. BMC Res Notes. 2012;5:337. doi: 10.1186/1756-0500-5-337 22748135.

93. Kim D, Langmead B, Salzberg SL. HISAT: a fast spliced aligner with low memory requirements. Nat Methods. 2015;12(4):357–60. doi: 10.1038/nmeth.3317 25751142.

94. Broad Institute. Picard. 2.14.0 ed2017. p. A set of command line tools (in Java) for manipulating high-throughput sequencing (HTS) data and formats such as SAM/BAM/CRAM and VCF.

95. Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014;30(7):923–30. doi: 10.1093/bioinformatics/btt656 24227677.

96. R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing; 2017.

97. Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26(1):139–40. doi: 10.1093/bioinformatics/btp616 19910308.

98. Liu R, Holik AZ, Su S, Jansz N, Chen K, Leong HS, et al. Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses. Nucleic Acids Res. 2015;43(15):e97. doi: 10.1093/nar/gkv412 25925576.

99. Phipson B, Lee S, Majewski IJ, Alexander WS, Smyth GK. Robust Hyperparameter Estimation Protects against Hypervariable Genes and Improves Power to Detect Differential Expression. Ann Appl Stat. 2016;10(2):946–63. doi: 10.1214/16-AOAS920 28367255.

100. Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47. doi: 10.1093/nar/gkv007 25605792.

101. Risso D, Ngai J, Speed TP, Dudoit S. Normalization of RNA-seq data using factor analysis of control genes or samples. Nat Biotechnol. 2014;32(9):896–902. doi: 10.1038/nbt.2931 25150836.

102. Kolde R. pheatmap: Pretty Heatmaps. 1.0.8 ed2015.

103. Durinck S, Moreau Y, Kasprzyk A, Davis S, De Moor B, Brazma A, et al. BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis. Bioinformatics. 2005;21(16):3439–40. doi: 10.1093/bioinformatics/bti525 16082012.

104. Durinck S, Spellman PT, Birney E, Huber W. Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt. Nat Protoc. 2009;4(8):1184–91. doi: 10.1038/nprot.2009.97 19617889.

105. Giner G, Smyth GK. FRY: a fast approximation to ROAST gene set test with mean aggregated set statistics [version 1; not peer reviewed]. F1000Research. 2016;5(2605). doi: 10.7490/f1000research.1113351.1

106. Wu D, Lim E, Vaillant F, Asselin-Labat ML, Visvader JE, Smyth GK. ROAST: rotation gene set tests for complex microarray experiments. Bioinformatics. 2010;26(17):2176–82. doi: 10.1093/bioinformatics/btq401 20610611.

107. Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010;38(4):576–89. doi: 10.1016/j.molcel.2010.05.004 20513432.

108. Benner C. HOMER (Hypergeometric Optimization of Motif EnRichment). v4.9 ed2017. p. Software for motif discovery and next generation sequencing analysis.

109. Choi M, Chang CY, Clough T, Broudy D, Killeen T, MacLean B, et al. MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments. Bioinformatics. 2014;30(17):2524–6. doi: 10.1093/bioinformatics/btu305 24794931.

110. Kammers K, Cole RN, Tiengwe C, Ruczinski I. Detecting Significant Changes in Protein Abundance. EuPA Open Proteom. 2015;7:11–9. doi: 10.1016/j.euprot.2015.02.002 25821719.

111. Magis AT, Funk CC, Price ND. SNAPR: a bioinformatics pipeline for efficient and accurate RNA-seq alignment and analysis. IEEE Life Sci Lett. 2015;1(2):22–5. Epub 2015/08/28. doi: 10.1109/LLS.2015.2465870 29270443.

112. Langfelder P, Zhang B, Horvath S. Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R. Bioinformatics. 2008;24(5):719–20. doi: 10.1093/bioinformatics/btm563 18024473.

113. Langfelder P, Horvath S. Fast R Functions for Robust Correlations and Hierarchical Clustering. J Stat Softw. 2012;46(11). 23050260.

114. Allaire JJ, Gandrud C, Russell K, Yetman CJ. networkD3: D3 JavaScript Network Graphs from R. 2017.

115. Martin S, Brown WM, Klavans R, Boyack KW, editors. OpenOrd: an open-source toolbox for large graph layout. IS&T/SPIE Electronic Imaging; 2011: SPIE.

116. Kroehne V, Freudenreich D, Hans S, Kaslin J, Brand M. Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors. Development. 2011:dev.072587. doi: 10.1242/dev.072587 22007133

117. Kaslin J, Kroehne V, Ganz J, Hans S, Brand M. Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration. Development. 2017;144(8):1462–71. Epub 2017/03/16. doi: 10.1242/dev.144907 28289134.

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Článek Research on motion planning for an indoor spray arm based on an improved potential field method
Článek Camera-traps are a cost-effective method for surveying terrestrial squamates: A comparison with artificial refuges and pitfall traps
Článek Detailed analysis of the transverse arch of hallux valgus feet with and without pain using weightbearing ultrasound imaging and precise force sensors
Článek The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC
Článek Filling the human resource gap through public-private partnership: Can private, community-based skilled birth attendants improve maternal health service utilization and health outcomes in a remote region of Bangladesh?
Článek HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells
Článek Still standing: Recent patterns of post-fire conifer refugia in ponderosa pine-dominated forests of the Colorado Front Range
Článek Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling
Článek Biogeographic study of human gut-associated crAssphage suggests impacts from industrialization and recent expansion
Článek Apolipoprotein-AI mimetic peptides D-4F and L-5F decrease hepatic inflammation and increase insulin sensitivity in C57BL/6 mice
Článek Treating patients with driving phobia by virtual reality exposure therapy – a pilot study
Článek The impact of race relations on NFL attendance: An econometric analysis
Článek The potential impact of the Affordable Care Act and Medicaid expansion on reducing colorectal cancer screening disparities in African American males
Článek Efficient processing of raster and vector data
Článek Rewilding with large herbivores: Positive direct and delayed effects of carrion on plant and arthropod communities
Článek Early life experience and alterations of group composition shape the social grooming networks of former pet and entertainment chimpanzees (Pan troglodytes)
Článek Muscarinic modulation of M and h currents in gerbil spherical bushy cells
Článek Therapeutic hypothermia after out of hospital cardiac arrest improve 1-year survival rate for selective patients
Článek Carotid plaques and neurological impairment in patients with acute cerebral infarction
Článek Deep learning based image reconstruction algorithm for limited-angle translational computed tomography
Článek Subterranean Deuteraphorura Absolon, 1901, (Hexapoda, Collembola) of the Western Carpathians — Troglomorphy at the northern distributional limit in Europe
Článek Fragmentation and inefficiencies in US equity markets: Evidence from the Dow 30
Článek Association between coffee drinking and telomere length in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Článek Hyperbaric oxygen preconditioning and the role of NADPH oxidase inhibition in postischemic acute kidney injury induced in spontaneously hypertensive rats
Článek Rad51 paralogs and the risk of unselected breast cancer: A case-control study
Článek Aqueous ethanol extract of Libidibia ferrea (Mart. Ex Tul) L.P. Queiroz (juca) exhibits antioxidant and migration-inhibiting activity in human gastric adenocarcinoma (ACP02) cells
Článek Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy
Článek The role of narrative in collaborative reasoning and intelligence analysis: A case study
Článek Proportions of CD4 test results indicating advanced HIV disease remain consistently high at primary health care facilities across four high HIV burden countries
Článek Modelling of amino acid turnover in the horse during training and racing: A basis for developing a novel supplementation strategy
Článek Single-modal and multi-modal false arrhythmia alarm reduction using attention-based convolutional and recurrent neural networks
Článek Eye-gaze information input based on pupillary response to visual stimulus with luminance modulation
Článek Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation
Článek Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study
Článek Trends of litter decomposition and soil organic matter stocks across forested swamp environments of the southeastern US
Článek Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration
Článek Were ancient foxes far more carnivorous than recent ones?—Carnassial morphological evidence
Článek Disruption in daily eating-fasting and activity-rest cycles in Indian adolescents attending school
Článek Plasma proteome profiling of freshwater and seawater life stages of rainbow trout (Oncorhynchus mykiss)
Článek The earliest farming communities north of the Carpathians: The settlement at Gwoździec site 2
Článek Trends of the prevalence and incidence of hypertrophic cardiomyopathy in Korea: A nationwide population-based cohort study
Článek Percent amplitude of fluctuation: A simple measure for resting-state fMRI signal at single voxel level
Článek Antimicrobial activity of Asteraceae species against bacterial pathogens isolated from postmenopausal women
Článek Designing information provision to serve as a reminder of altruistic benefits: A case study of the risks of air pollution caused by industrialization
Článek Are changes in depressive symptoms, general health and residential area socio-economic status associated with trajectories of waist circumference and body mass index?
Článek Extracellular vesicles of U937 macrophage cell line infected with DENV-2 induce activation in endothelial cells EA.hy926
Článek FlexGraph: Flexible partitioning and storage for scalable graph mining
Článek Post-weaning infant-to-mother bonding in nutritionally independent female mice
Článek A little good is good enough: Ethical consumption, cheap excuses, and moral self-licensing
Článek Link-centric analysis of variation by demographics in mobile phone communication patterns
Článek Multimodal hand gesture recognition using single IMU and acoustic measurements at wrist
Článek Variance based weighting of multisensory head rotation signals for verticality perception
Článek Eligibility for hepatitis B antiviral therapy among adults in the general population in Zambia
Článek Tobacco smoking and health-related quality of life among university students: Mediating effect of depression
Článek Nutritional inadequacies in commercial vegan foods for dogs and cats
Článek LTA1 and dmLT enterotoxin-based proteins activate antigen-presenting cells independent of PKA and despite distinct cell entry mechanisms
Článek The Shapley value for a fair division of group discounts for coordinating cooling loads
Článek Comparison and evaluation of the morphology of crowns generated by biogeneric design technique with CEREC chairside system
Článek Assessing risk factors and impact of cyberbullying victimization among university students in Myanmar: A cross-sectional study
Článek Incidence of hospital-acquired pressure ulcers in patients with "minimal risk" according to the "Norton-MI" scale
Článek Intra-host symbiont diversity in eastern Pacific cold seep tubeworms identified by the 16S-V6 region, but undetected by the 16S-V4 region
Článek Lipoprotein(a) plasma levels are not associated with survival after acute coronary syndromes: An observational cohort study
Článek Use of Nanotrap particles for the capture and enrichment of Zika, chikungunya and dengue viruses in urine
Článek Pancreatic secretory trypsin inhibitor reduces multi-organ injury caused by gut ischemia/reperfusion in mice
Článek The effect of diet on the gastrointestinal microbiome of juvenile rehabilitating green turtles (Chelonia mydas)
Článek Biochemical characterization of Ty1 retrotransposon protease
Článek Lateral pressure equalisation as a principle for designing support surfaces to prevent deep tissue pressure ulcers
Článek Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1
Článek The validation of the Beijing version of the Montreal Cognitive Assessment in Chinese patients undergoing hemodialysis
Článek Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease
Článek Inflammasome expression is higher in ovarian tumors than in normal ovary
Článek HCV genotype profile in Brazil of mono-infected and HIV co-infected individuals: A survey representative of an entire country
Článek Engaging with change: Information and communication technology professionals’ perspectives on change at the mid-point in the UK/EU Brexit process
Článek Adherence to iron-folic acid supplement and associated factors among antenatal care attending pregnant mothers in governmental health institutions of Adwa town, Tigray, Ethiopia: Cross-sectional study
Článek Flower, seed, and fruit development in three Tunisian species of Polygonum: Implications for their taxonomy and evolution of distyly in Polygonaceae
Článek Development of a risk score for prediction of poor treatment outcomes among patients with multidrug-resistant tuberculosis
Článek Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus
Článek Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats
Článek Marine seafood production via intense exploitation and cultivation in China: Costs, benefits, and risks
Článek Signatures of medical student applicants and academic success
Článek Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia
Článek The effects of extended photoperiod and warmth on hair growth in ponies and horses at different times of year
Článek Modeling the effect of prolonged ethanol exposure on global gene expression and chromatin accessibility in normal 3D colon organoids
Článek Clinical, cytogenetic and molecular genetic characterization of a tandem fusion translocation in a male Holstein cattle with congenital hypospadias and a ventricular septal defect
Článek Severity of misophonia symptoms is associated with worse cognitive control when exposed to misophonia trigger sounds
Článek Detection of Torque Teno Virus (TTV) and TTV-Like Minivirus in patients with presumed infectious endophthalmitis in India
Článek CD4 rate of increase is preferred to CD4 threshold for predicting outcomes among virologically suppressed HIV-infected adults on antiretroviral therapy
Článek The evolution of secondary flow phenomena and their effect on primary shock conditions in shock tubes: Experimentation and numerical model
Článek Estimating the basic reproduction number of a pathogen in a single host when only a single founder successfully infects
Článek What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson’s disease? A preliminary pharmacoepidemiologic study
Článek Evaluating emotional distress and health-related quality of life in patients with heart failure and their family caregivers: Testing dyadic dynamics using the Actor-Partner Interdependence Model
Článek Community- and trophic-level responses of soil nematodes to removal of a non-native tree at different stages of invasion
Článek Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging
Článek Catchment-scale export of antibiotic resistance genes and bacteria from an agricultural watershed in central Iowa
Článek Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis
Článek Characterization of a universal screening approach for congenital CMV infection based on a highly-sensitive, quantitative, multiplex real-time PCR assay
Článek Proof-of-concept for a non-invasive, portable, and wireless device for cardiovascular monitoring in pediatric patients
Článek On PTV definition for glioblastoma based on fiber tracking of diffusion tensor imaging data
Článek Multiregional origins of the domesticated tetraploid wheats
Článek Racism against Totonaco women in Veracruz: Intercultural competences for health professionals are necessary
Článek Increased inflammation and endothelial markers in patients with late severe post-thrombotic syndrome
Článek Genes associated with body weight gain and feed intake identified by meta-analysis of the mesenteric fat from crossbred beef steers
Článek Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations
Článek Multiple paedomorphic lineages of soft-substrate burrowing invertebrates: parallels in the origin of Xenocratena and Xenoturbella
Článek Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells
Článek Simple non-mydriatic retinal photography is feasible and demonstrates retinal microvascular dilation in Chronic Obstructive Pulmonary Disease (COPD)
Článek Evaluating poverty alleviation strategies in a developing country
Článek Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter?
Článek Pan-cancer analysis of somatic mutations and epigenetic alterations in insulated neighbourhood boundaries
Článek Evaluation of a bioengineered ACL matrix’s osteointegration with BMP-2 supplementation
Článek Psychosocial profiles of physical activity fluctuation in office employees: A latent profile analysis
Článek Prevalence and characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) isolated from chicken meat in the province of Quebec, Canada
Článek HIV treatment response among female sex workers participating in a treatment as prevention demonstration project in Cotonou, Benin
Článek Soluble AXL as a marker of disease progression and survival in melanoma
Článek Using machine learning methods to determine a typology of patients with HIV-HCV infection to be treated with antivirals
Článek Quantifying tourism booms and the increasing footprint in the Arctic with social media data
Článek Gender differences influence over insomnia in Korean population: A cross-sectional study
Článek Impact of scion/rootstock reciprocal effects on metabolomics of fruit juice and phloem sap in grafted Citrus reticulata
Článek Adapting cognitive diagnosis computerized adaptive testing item selection rules to traditional item response theory
Článek Usability assessment of seven HIV self-test devices conducted with lay-users in Johannesburg, South Africa
Článek Autumn shifts in cold tolerance metabolites in overwintering adult mountain pine beetles
Článek Management of veterinary anaesthesia in small animals: A survey of current practice in Quebec
Článek Genetic structure of the European hedgehog (Erinaceus europaeus) in Denmark
Článek Molecular karyotyping of Siberian wild rye (Elymus sibiricus L.) with oligonucleotide fluorescence in situ hybridization (FISH) probes
Článek Umbilical cord separation time, predictors and healing complications in newborns with dry care
Článek The strain distribution in the lumbar anterior longitudinal ligament is affected by the loading condition and bony features: An in vitro full-field analysis
Článek Marine resource congestion in China: Identifying, measuring, and assessing its impact on sustainable development of the marine economy
Článek Analysis of attitudinal components towards statistics among students from different academic degrees
Článek Effects of fatigue induced by repeated-sprint on kicking accuracy and velocity in female soccer players
Článek A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB
Článek Leadership for success in transforming medical abortion policy in Canada
Článek Clinical correlates associated with the long-term response of bipolar disorder patients to lithium, valproate or lamotrigine: A retrospective study
Článek Determinants of change in long-acting or permanent contraceptives use in Ethiopia; A multivariate decomposition analysis of data from the Ethiopian demographic and health survey
Článek Forecasting stock prices with long-short term memory neural network based on attention mechanism
Článek On the genus Crossaster (Echinodermata: Asteroidea) and its distribution
Článek Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds
Článek Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme
Článek Optogenetically induced cellular habituation in non-neuronal cells
Článek An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect
Článek The effect of strontium and silicon substituted hydroxyapatite electrochemical coatings on bone ingrowth and osseointegration of selective laser sintered porous metal implants
Článek Modeling the Theory of Planned Behaviour to predict adherence to preventive dental visits in preschool children
Článek Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States
Článek Color discrimination and gas chromatography-mass spectrometry fingerprint based on chemometrics analysis for the quality evaluation of Schizonepetae Spica
Článek Comparisons of recurrence-free survival and overall survival between microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: A multiple centers retrospective cohort study with propensity score matching
Článek Transcriptome-wide identification of novel circular RNAs in soybean in response to low-phosphorus stress
Článek Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial
Článek The association between dietary patterns before and in early pregnancy and the risk of gestational diabetes mellitus (GDM): Data from the Malaysian SECOST cohort
Článek Gene expression noise in a complex artificial toxin expression system
Článek Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution
Článek Assertive, trainable and older dogs are perceived as more dominant in multi-dog households
Článek Prediction of Uropathogens by Flow Cytometry and Dip-stick Test Results of Urine Through Multivariable Logistic Regression Analysis
Článek Copper to Tuscany – Coals to Newcastle? The dynamics of metalwork exchange in early Italy
Článek Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance
Článek Detection of amitraz resistance and reduced treatment efficacy in the Varroa Mite, Varroa destructor, within commercial beekeeping operations
Článek Impact of viral disease hypophagia on pig jejunal function and integrity
Článek Enzyme response of activated sludge to a mixture of emerging contaminants in continuous exposure
Článek Molecular evidence for horizontal transmission of chelonid alphaherpesvirus 5 at green turtle (Chelonia mydas) foraging grounds in Queensland, Australia
Článek Technology anxiety and resistance to change behavioral study of a wearable cardiac warming system using an extended TAM for older adults
Článek Evaluation and validation of 2D biomechanical models of the knee for radiograph-based preoperative planning in total knee arthroplasty
Článek Soil-Transmitted Helminth infections reduction in Bhutan: A report of 29 years of deworming
Článek Age-related differences in the temporal dynamics of spectral power during memory encoding
Článek cagA gene EPIYA motif genetic characterization from Colombian Helicobacter pylori isolates: Standardization of a molecular test for rapid clinical laboratory detection
Článek Mugharat an-Nachcharini: A specialized sheep-hunting camp reveals high-altitude habitats in the earliest Neolithic of the Central Levant
Článek Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix)
Článek Clinicians’ communication with patients receiving a MCI diagnosis: The ABIDE project
Článek Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling
Článek Fast quantitative time lapse displacement imaging of endothelial cell invasion
Článek Two novel mutations in MSX1 causing oligodontia
Článek 7,200 years old constructions and mudbrick technology: The evidence from Tel Tsaf, Jordan Valley, Israel
Článek Tuberculosis recurrences and predictive factors in a vulnerable population in Catalonia
Článek Dome-shaped macula in children and adolescents
Článek Barriers in the access, diagnosis and treatment completion for tuberculosis patients in central and western Nepal: A qualitative study among patients, community members and health care workers
Článek Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer
Článek Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34
Článek Preliminary evidences of the presence of extracellular DNA single stranded forms in soil
Článek A comparison of quality of life between patients treated with different dialysis modalities in Taiwan
Článek The effectiveness of substance use interventions for homeless and vulnerably housed persons:  A systematic review of systematic reviews on supervised consumption facilities, managed alcohol programs, and pharmacological agents for opioid use disorder
Článek Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis
Článek Morphological association between the muscles and bones in the craniofacial region
Článek Transcriptome analysis of Actinidia chinensis in response to Botryosphaeria dothidea infection
Článek Evaluating two decision aids for Australian men supporting informed decisions about prostate cancer screening: A randomised controlled trial
Článek Serum galectins as potential biomarkers of inflammatory bowel diseases
Článek Linguistic Z-number weighted averaging operators and their application to portfolio selection problem
Článek Comparative study on skin protection activity of polyphenol-rich extract and polysaccharide-rich extract from Sargassum vachellianum
Článek Real-world data about emotional stress, disability and need for social care in a German IBD patient cohort
Článek The regenerative compatibility: A synergy between healthy ecosystems, environmental attitudes, and restorative experiences
Článek Fusion of augmented reality imaging with the endoscopic view for endonasal skull base surgery; a novel application for surgical navigation based on intraoperative cone beam computed tomography and optical tracking
Článek Functional characterization of NK cells in Mexican pediatric patients with acute lymphoblastic leukemia: Report from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia
Článek Radiomics signature for prediction of lateral lymph node metastasis in conventional papillary thyroid carcinoma
Článek Antenatal depression and its association with adverse birth outcomes in low and middle-income countries: A systematic review and meta-analysis
Článek Perceptions of risk and influences of choice in pregnant women with obesity. An evidence synthesis of qualitative research
Článek The role of refugee and migrant migration status on medication adherence: Mediation through illness perceptions
Článek Job stress and emotional exhaustion at work in Spanish workers: Does unhealthy work affect the decision to drive?
Článek Correction: Amphibians on the hotspot: Molecular biology and conservation in the South American Atlantic Rainforest
Článek Sexual risk classes among youth experiencing homelessness: Relation to childhood adversities, current mental symptoms, substance use, and HIV testing
Článek Time for change is now: Experiences of participants in a community-based approach for iron and folic acid supplementation in a rural county in Kenya, a qualitative study
Článek Non-invasive genetic monitoring for the threatened valley elderberry longhorn beetle
Článek Statistical learning for turboshaft helicopter accidents using logistic regression
Článek The effect of various metal-salts on the sedimentation of soil in a water-based suspension
Článek Using electronic health record system triggers to target delivery of a patient-centered intervention to improve venous thromboembolism prevention for hospitalized patients: Is there a differential effect by race?
Článek Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells
Článek Novel broad-spectrum activity-based probes to profile malarial cysteine proteases
Článek Environmental tobacco smoke (ETS) and hyperlipidemia modified by perceived work stress
Článek Association between opioid analgesic therapy and initiation of buprenorphine management: An analysis of prescription drug monitoring program data
Článek Effect of a community-based approach of iron and folic acid supplementation on compliance by pregnant women in Kiambu County, Kenya: A quasi-experimental study
Článek Radiocarbon dating of two old African baobabs from India
Článek Improvement project in higher education institutions: A BPEP-based model
Článek An updated evaluation of serum sHER2, CA15.3, and CEA levels as biomarkers for the response of patients with metastatic breast cancer to trastuzumab-based therapies
Článek Genome-wide association study of metabolic syndrome in Korean populations
Článek The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis
Článek Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia
Článek Short- & long-term effects of monetary and non-monetary incentives to cooperate in public good games: An experiment
Článek Niche modeling reveals life history shifts in birds at La Brea over the last twenty millennia
Článek Distributed flux balance analysis simulations of serial biomass fermentation by two organisms
Článek Plasma kynurenines and prognosis in patients with heart failure
Článek Occurrence and distribution of anthropogenic persistent organic pollutants in coastal sediments and mud shrimps from the wetland of central Taiwan
Článek Intensified visual clutter induces increased sympathetic signalling, poorer postural control, and faster torsional eye movements during visual rotation
Článek Restoration of cortical symmetry and binaural function: Cortical auditory evoked responses in adult cochlear implant users with single sided deafness
Článek A smartphone-enabled wireless and batteryless implantable blood flow sensor for remote monitoring of prosthetic heart valve function
Článek Gut microbiota composition alterations are associated with the onset of diabetes in kidney transplant recipients
Článek Shock index and TIMI risk index as valuable prognostic tools in patients with acute coronary syndrome complicated by cardiogenic shock
Článek Merit overrules theory of mind when young children share resources with others
Článek Economic burden of maternal morbidity – A systematic review of cost-of-illness studies
Článek Correction: Escherichia coli and Salmonella spp. isolated from Australian meat chickens remain susceptible to critically important antimicrobial agents
Článek Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue
Článek Cell-free DNA donor fraction analysis in pediatric and adult heart transplant patients by multiplexed allele-specific quantitative PCR: Validation of a rapid and highly sensitive clinical test for stratification of rejection probability
Článek Immunopathogenesis of canine chronic ulcerative stomatitis
Článek Correction: Quantification of speech and synchrony in the conversation of adults with autism spectrum disorder
Článek Efficacy and safety of ultrasonic circular cyclocoagulation with second-generation probe in glaucoma: A retrospective study
Článek Generalizing findings from a randomized controlled trial to a real-world study of the iLookOut, an online education program to improve early childhood care and education providers’ knowledge and attitudes about reporting child maltreatment
Článek Comparative proteomic analysis of different stages of breast cancer tissues using ultra high performance liquid chromatography tandem mass spectrometer
Článek A cross-sectional study of psychopathy and khat abuse among prisoners in the correctional institution in Jimma, Ethiopia
Článek Head impulse compensatory saccades: Visual dependence is most evident in bilateral vestibular loss
Článek Complementarity of empirical and process-based approaches to modelling mosquito population dynamics with Aedes albopictus as an example—Application to the development of an operational mapping tool of vector populations
Článek Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation
Článek When and what to test for: A cost-effectiveness analysis of febrile illness test-and-treat strategies in the era of responsible antibiotic use
Článek Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials
Článek The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice
Článek Seroepidemiological study of rubella in Vojvodina, Serbia: 24 years after the introduction of the MMR vaccine in the national immunization programme
Článek Efficacy of a mitochondrion-targeting agent for reducing the level of urinary protein in rats with puromycin aminonucleoside-induced minimal-change nephrotic syndrome
Článek Association of endothelial nitric oxide synthase (NOS3) gene polymorphisms with primary open-angle glaucoma in a Saudi cohort
Článek Antitrust analysis with upward pricing pressure and cost efficiencies
Článek Machine learning models for identifying preterm infants at risk of cerebral hemorrhage
Článek Natural selection contributes to food web stability
Článek Pyramiding QTLs controlling tolerance against drought, salinity, and submergence in rice through marker assisted breeding
Článek Diversity and plant growth-promoting functions of diazotrophic/N-scavenging bacteria isolated from the soils and rhizospheres of two species of Solanum
Článek Sustainability effects of motor control stabilisation exercises on pain and function in chronic nonspecific low back pain patients: A systematic review with meta-analysis and meta-regression
Článek Sofosbuvir-based regimen for genotype 2 HCV infected patients in Taiwan: A real world experience
Článek The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function
Článek Sequencing artifacts derived from a library preparation method using enzymatic fragmentation
Článek Analysis of the Rdr1 gene family in different Rosaceae genomes reveals an origin of an R-gene cluster after the split of Rubeae within the Rosoideae subfamily
Článek Concomitant phytonutrient and transcriptome analysis of mature fruit and leaf tissues of tomato (Solanum lycopersicum L. cv. Oregon Spring) grown using organic and conventional fertilizer
Článek Quantitative analysis of adsorption and desorption of volatile organic compounds on reusable zeolite filters using gas chromatography
Článek Comparing bioinformatic pipelines for microbial 16S rRNA amplicon sequencing
Článek TMEM98 is a negative regulator of FRAT mediated Wnt/ß-catenin signalling
Článek Modeling migration patterns in the USA under sea level rise
Článek Quo vadis Pantanal? Expected precipitation extremes and drought dynamics from changing sea surface temperature
Článek Cloud-computing and machine learning in support of country-level land cover and ecosystem extent mapping in Liberia and Gabon
Článek An exploratory study on the quality of patient screening and counseling for hypertension management in Tanzania
Článek Relation of fibroblast growth factor receptor 2 expression to hepatocellular carcinoma recurrence after liver resection
Článek The Brief Measure of Emotional Preoperative Stress (B-MEPS) as a new predictive tool for postoperative pain: A prospective observational cohort study
Článek The impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis
Článek Correction: Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition
Článek Clinical and pathological features of thrombotic microangiopathy influencing long-term kidney transplant outcomes
Článek Multidisciplinary investigation of two Egyptian child mummies curated at the University of Tartu Art Museum, Estonia (Late/Graeco-Roman Periods)
Článek Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season
Článek Morphological adjustment in free-living Steinernema feltiae infective juveniles to increasing concentration of Nemafric-BL phytonematicide
Článek Murine Surf4 is essential for early embryonic development
Článek Using mHealth to improve health care delivery in India: A qualitative examination of the perspectives of community health workers and beneficiaries
Článek Algorithmic handwriting analysis of the Samaria inscriptions illuminates bureaucratic apparatus in biblical Israel
Článek Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis
Článek Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome
Článek Short treatment with antalarmin alters adrenal gland receptors in the rat model of endometriosis
Článek Is it really always only the others who are to blame? GP’s view on medical overuse. A questionnaire study
Článek Serum visfatin and vaspin levels in hepatocellular carcinoma (HCC)
Článek Retraction: SDR9C7 Promotes Lymph Node Metastases in Patients with Esophageal Squamous Cell Carcinoma
Článek iTRAQ proteomics reveals the regulatory response to Magnaporthe oryzae in durable resistant vs. susceptible rice genotypes
Článek A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients
Článek Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
Článek Point-of-care diagnostic (POCD) method for detecting Bursaphelenchus xylophilus in pinewood using recombinase polymerase amplification (RPA) with the portable optical isothermal device (POID)
Článek Bioluminescent imaging of Arabidopsis thaliana using an enhanced Nano-lantern luminescence reporter system
Článek Biosynthetic pathway of indole-3-acetic acid in ectomycorrhizal fungi collected from northern Thailand
Článek Clinical implications of elevated serum interleukin-6 in IgG4-related disease
Článek Downscaling NLDAS-2 daily maximum air temperatures using MODIS land surface temperatures
Článek Sex-specific and opposite modulatory aspects revealed by PPI network and pathway analysis of ischemic stroke in humans
Článek Plasma Trimethylamine-N-oxide and impaired glucose regulation: Results from The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS)
Článek Self-esteem and other risk factors for depressive symptoms among adolescents in United Arab Emirates
Článek Control of the microsporidian parasite Nosema ceranae in honey bees (Apis mellifera) using nutraceutical and immuno-stimulatory compounds
Článek The effect of storage conditions on microbial communities in stool
Článek Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates
Článek Influence of flow on phosphorus-dynamics and particle size in agricultural drainage ditch sediments
Článek A prospective, randomized, double-blind trial to compare body weight-adjusted and fixed doses of palonosetron for preventing postoperative nausea and vomiting in obese female patients
Článek Application of computerized 3D-CT texture analysis of pancreas for the assessment of patients with diabetes
Článek Predictive validation and forecasts of short-term changes in healthcare expenditure associated with changes in smoking behavior in the United States
Článek An information-based approach to handle various types of uncertainty in fuzzy bodies of evidence
Článek Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial
Článek Health care professionals’ knowledge of commonly used sedative, analgesic and neuromuscular drugs: A single center (Rambam Health Care Campus), prospective, observational survey
Článek Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
Článek OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model
Článek Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
Článek Novel method to measure temporal windows based on eye movements during viewing of the Necker cube
Článek Whole blood transcriptomic analysis of beef cattle at arrival identifies potential predictive molecules and mechanisms that indicate animals that naturally resist bovine respiratory disease
Článek Effects of smoke flavoring using different wood chips and barbecuing on the formation of polycyclic aromatic hydrocarbons and heterocyclic aromatic amines in salmon fillets
Článek Sleep quality and sex modify the relationships between trait energy and fatigue on state energy and fatigue
Článek The role of peer, parental, and school norms in predicting adolescents’ attitudes and behaviours of majority and different minority ethnic groups in Croatia
Článek Filtered beauty in Oslo and Tokyo: A spatial frequency analysis of facial attractiveness
Článek The impact of rehabilitation frequency on the risk of stroke in patients with rheumatoid arthritis
Článek Availability, prices and affordability of selected antibiotics and medicines against non-communicable diseases in western Cameroon and northeast DR Congo
Článek The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation
Článek Detection of posttraumatic pneumothorax using electrical impedance tomography—An observer-blinded study in pigs with blunt chest trauma
Článek Educators’ perceptions of organisational readiness for implementation of a pre-adolescent transdisciplinary school health intervention for inter-generational outcomes
Článek Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA
Článek The effects of sport expertise and shot results on basketball players’ action anticipation
Článek Framework and algorithms for identifying honest blocks in blockchain
Článek Efficacy and safety of anti-viral therapy for Hepatitis B virus-associated glomerulonephritis: A meta-analysis
Článek Selective transmission of some HIV-1 subtype C variants might depend on Envelope stimulating dendritic cells to secrete IL-10
Článek Noise reduction and quantification of fiber orientations in greyscale images
Článek Exploring the impact of terminology differences in blood and organ donor decision making
Článek Ontogenetic similarities between giraffe and sauropod neck osteological mobility
Článek Load transfer mechanism and critical length of anchorage zone for anchor bolt
Článek Income inequalities in stroke incidence and mortality: Trends in stroke-free and stroke-affected life years based on German health insurance data
Článek Community’s perception, experiences and health seeking behavior towards newborn illnesses in Debre Libanos District, North Shoa, Oromia, Ethiopia: Qualitative study
Článek Platelet indices significantly correlate with liver fibrosis in HCV-infected patients
Článek Reanalysis of the Bridge et al. study of suicide following release of 13 Reasons Why
Článek Validation of the easyscreen flavivirus dengue alphavirus detection kit based on 3base amplification technology and its application to the 2016/17 Vanuatu dengue outbreak
Článek The nitrate content of fresh and cooked vegetables and their health-related risks
Článek Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
Článek Implicit task switching in Parkinson’s disease is preserved when on medication
Článek Root treatment with oxathiapiprolin, benthiavalicarb or their mixture provides prolonged systemic protection against oomycete foliar pathogens
Článek Real-world effectiveness and safety of ranibizumab for the treatment of myopic choroidal neovascularization: Results from the LUMINOUS study
Článek Non-gradient and genotype-dependent patterns of RSV gene expression
Článek Multiplex real-time PCR for the detection of Clavibacter michiganensis subsp. michiganensis, Pseudomonas syringae pv. tomato and pathogenic Xanthomonas species on tomato plants
Článek The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis
Článek Parasites modulate the gut-microbiome in insects: A proof-of-concept study
Článek The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature
Článek Vascularization and biocompatibility of poly(ε-caprolactone) fiber mats for rotator cuff tear repair
Článek The shield of self-compassion: A buffer against disordered eating risk from physical appearance perfectionism
Článek Disease-specific out-of-pocket healthcare expenditure in urban Bangladesh: A Bayesian analysis
Článek Advanced biofilm analysis in streams receiving organic deicer runoff
Článek Upregulation of long non-coding RNA ROR1-AS1 promotes cell growth and migration in bladder cancer by regulation of miR-504
Článek Method development and validation for rapid identification of epigallocatechin gallate using ultra-high performance liquid chromatography
Článek Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study
Článek Same-day antiretroviral therapy initiation for HIV-infected adults in South Africa: Analysis of routine data
Článek Health-related quality of life among patients with type 2 diabetes mellitus in Eastern Province, Saudi Arabia: A cross-sectional study
Článek Photocatalytic biocidal effect of copper doped TiO2 nanotube coated surfaces under laminar flow, illuminated with UVA light on Legionella pneumophila
Článek The interoceptive hippocampus: Mouse brain endocrine receptor expression highlights a dentate gyrus (DG)–cornu ammonis (CA) challenge–sufficiency axis
Článek Educational attainment and HIV testing and counselling service utilisation during antenatal care in Ghana: Analysis of Demographic and Health Surveys
Článek Centromeres of Cucumis melo L. comprise Cmcent and two novel repeats, CmSat162 and CmSat189
Článek “I like the way I am, but I feel like I could get a little bit bigger”: Perceptions of body image among adolescents and youth living with HIV in Durban, South Africa
Článek Nanoparticle-based ‘turn-on’ scattering and post-sample fluorescence for ultrasensitive detection of water pollution in wider window
Článek The relationship of moral sensitivity and patient safety attitudes with nursing students’ perceptions of disclosure of patient safety incidents: A cross-sectional study
Článek Insights into the strategy of micro-environmental adaptation: Transcriptomic analysis of two alvinocaridid shrimps at a hydrothermal vent
Článek Thirty-day readmission after medical-surgical hospitalization for people who experience imprisonment in Ontario, Canada: A retrospective cohort study
Článek The effect of long-term brine discharge from desalination plants on benthic foraminifera
Článek Hyper-spectral response and estimation model of soil degradation in Kenli County, the Yellow River Delta
Článek Prescribing trends of glaucoma drugs in six major cities of China from 2013 to 2017
Článek Significant changes in synovial fluid microRNAs after high tibial osteotomy in medial compartmental knee osteoarthritis: Identification of potential prognostic biomarkers
Článek Reassortment and adaptive mutations of an emerging avian influenza virus H7N4 subtype in China
Článek Ischemia and reperfusion injury in superficial inferior epigastric artery-based vascularized lymph node flaps
Článek High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania – A prospective cohort study
Článek Mitochondrial DNA variations and mitochondrial dysfunction in Fanconi anemia
Článek Extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing Escherichia coli isolates causing bacteremia in the Netherlands (2014 – 2016) differ in clonal distribution, antimicrobial resistance gene and virulence gene content
Článek Molecular characterization of blaKHM-1 encoding plasmid in an Enterobacter hormaechei subsp. hoffmannii isolate from blood culture
Článek PR3 levels are impaired in plasma and PBMCs from Arabs with cardiovascular diseases
Článek Sex differences in self-regulation in early, middle and late adolescence: A large-scale cross-sectional study
Článek Interaction between elevated temperature and different types of Na-salicylate treatment in Brachypodium dystachion
Článek A highway crash risk assessment method based on traffic safety state division
Článek A brain connectivity characterization of children with different levels of mathematical achievement based on graph metrics
Článek Quantifying the level of difficulty to treat major depressive disorder with antidepressants: Treatment Resistance to Antidepressants Evaluation Scale
Článek Occupational gender segregation and economic growth in U.S. local labor markets, 1980 through 2010
Článek The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome
Článek Construction of a high-density genetic map and fine mapping of a candidate gene locus for a novel branched-spike mutant in barley
Článek Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease
Článek Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer
Článek Deep2Full: Evaluating strategies for selecting the minimal mutational experiments for optimal computational predictions of deep mutational scan outcomes
Článek Economic compensation interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review and meta-analysis
Článek Distinctive effect of anesthetics on the effect of limb remote ischemic postconditioning following ischemic stroke
Článek Natural hybridization between Phyllagathis and Sporoxeia species produces a hybrid without reproductive organs
Článek Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder
Článek The impact of peer attachment on prosocial behavior, emotional difficulties and conduct problems in adolescence: The mediating role of empathy
Článek Spatial and climatic variables independently drive elevational gradients in ant species richness in the Eastern Himalaya
Článek What is the qualitative evidence concerning the risks, diagnosis, management and consequences of gastrointestinal infections in the community in the United Kingdom? A systematic review and meta-ethnography
Článek Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress
Článek Key barriers and enablers associated with uptake and continuation of oral pre-exposure prophylaxis (PrEP) in the public sector in Zimbabwe: Qualitative perspectives of general population clients at high risk for HIV
Článek Characterizing the University of California’s tenure-track teaching position from the faculty and administrator perspectives
Článek Patient preferences for maintenance therapy in Crohn’s disease: A discrete-choice experiment
Článek Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
Článek Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation
Článek Accuracy of intraocular lens power calculation formulas using a swept-source optical biometer
Článek Characterization of black patina from the Tiber River embankments using Next-Generation Sequencing
Článek Comparison of blood lactate and perceived exertion responses in two matched time-under-tension protocols
Článek Fibrin hydrogels are safe, degradable scaffolds for sub-retinal implantation
Článek Post-translational modifications of Drosophila melanogaster HOX protein, Sex combs reduced
Článek Problem gambling, associations with comorbid health conditions, substance use, and behavioural addictions: Opportunities for pathways to treatment
Článek Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production
Článek Characterization of METTL16 as a cytoplasmic RNA binding protein
Článek Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples
Článek Nanosheet wrapping-assisted coverslip-free imaging for looking deeper into a tissue at high resolution
Článek Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
Článek Early diagnosis of sepsis in emergency departments, time to treatment, and association with mortality: An observational study
Článek Validity of cerebrovascular ICD-9-CM codes in healthcare administrative databases. The Umbria Data-Value Project
Článek Tuberculoid leprosy: An in vivo microvascular evaluation of cutaneous lesions
Článek Neuromuscular blockers in the acute respiratory distress syndrome: A meta-analysis
Článek Identification of putative Type-I sex pheromone biosynthesis-related genes expressed in the female pheromone gland of Streltzoviella insularis
Článek A bushel of viruses: Identification of seventeen novel putative viruses by RNA-seq in six apple trees
Článek Torque teno virus viral load is related to age, CMV infection and HLA type but not to Alzheimer's disease
Článek The variability of bacterial communities in both the endosphere and ectosphere of different niches in Chinese chives (Allium tuberosum)
Článek Tripartite factors leading to molecular divergence between human and murine smooth muscle
Článek Characterization of dermal skin innervation in fibromyalgia syndrome
Článek A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy
Článek A scoping review of importation and predictive models related to vector-borne diseases, pathogens, reservoirs, or vectors (1999–2016)
Článek Assessment of climate change impact on the malaria vector Anopheles hyrcanus, West Nile disease, and incidence of melanoma in the Vojvodina Province (Serbia) using data from a regional climate model
Článek Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship
Článek Healthcare utilization of Mexican-American Medicare beneficiaries with and without Alzheimer’s disease and related dementias
Článek Evaluation of questionnaire as an instrument to measure the level of nutritional and weight gain knowledge in pregnant women in Poland. A pilot study
Článek TranCEP: Predicting the substrate class of transmembrane transport proteins using compositional, evolutionary, and positional information
Článek Expression of acyl-CoA-binding protein 5 from Rhodnius prolixus and its inhibition by RNA interference
Článek Transforming assessment of speech in children with cleft palate via online crowdsourcing
Článek High prevalence of off-label and unlicensed paediatric prescribing in a hospital in Indonesia during the period Aug.—Oct. 2014
Článek General practice management of rotator cuff related shoulder pain: A reliance on ultrasound and injection guided care
Článek Estimating the population size of female sex workers and transgender women  in Sri Lanka
Článek Can helmet decrease mortality of craniocerebral trauma patients in a motorcycle accident?: A propensity score matching
Článek Obesity, smoking habits, and serum phosphate levels predicts mortality after life-style intervention
Článek Treatment of children under 4 years of age with medulloblastoma and ependymoma in the HIT2000/HIT-REZ 2005 trials: Neuropsychological outcome 5 years after treatment
Článek Can a semi-quantitative method replace the current quantitative method for the annual screening of microalbuminuria in patients with diabetes? Diagnostic accuracy and cost-saving analysis considering the potential health burden
Článek A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1)
Článek Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age
Článek Burden and risk factors of cutaneous leishmaniasis in a peri-urban settlement in Kenya, 2016
Článek Embryonic thermal manipulation has short and long-term effects on the development and the physiology of the Japanese quail
Článek High-order radiomics features based on T2 FLAIR MRI predict multiple glioma immunohistochemical features: A more precise and personalized gliomas management
Článek Human-raptor conflict in rural settlements of Colombia
Článek Regional adaptations and parallel mutations in Feline panleukopenia virus strains from China revealed by nearly-full length genome analysis
Článek Long-term ecological research in southern Brazil grasslands: Effects of grazing exclusion and deferred grazing on plant and arthropod communities
Článek Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer
Článek Survival analysis of 230 patients with unresectable hepatocellular carcinoma treated with bland transarterial embolization
Článek Adverse drug reaction reporting practice and associated factors among medical doctors in government hospitals in Addis Ababa, Ethiopia
Článek TaWAK6 encoding wall-associated kinase is involved in wheat resistance to leaf rust similar to adult plant resistance
Článek Deficiency syndromes in top predators associated with large-scale changes in the Baltic Sea ecosystem
Článek Allele specific expression of Dof genes responding to hormones and abiotic stresses in sugarcane
Článek Perceived relative social status and cognitive load influence acceptance of unfair offers in the Ultimatum Game
Článek Quantitative evaluation of choriocapillaris using optical coherence tomography and optical coherence tomography angiography in patients with central serous chorioretinopathy after half-dose photodynamic therapy
Článek Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties
Článek Extracting lung function measurements to enhance phenotyping of chronic obstructive pulmonary disease (COPD) in an electronic health record using automated tools
Článek Multiple fragmented habitat-patch use in an urban breeding passerine, the Short-toed Treecreeper
Článek Histological and immunohistochemical characterization of the porcine ocular surface
Článek Household environmental tobacco smoke exposure in healthy young children in Hong Kong: Prevalence and risk factors
Článek Wind energy development and wildlife conservation in Lithuania: A mapping tool for conflict assessment
Článek Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study
Článek Peer distribution of HIV self-test kits to men who have sex with men to identify undiagnosed HIV infection in Uganda: A pilot study
Článek Error rates of human reviewers during abstract screening in systematic reviews
Článek Faecal analyses and alimentary tracers reveal the foraging ecology of two sympatric bats
Článek Urethral realignment with maximal urethral length and bladder neck preservation in robot-assisted radical prostatectomy: Urinary continence recovery
Článek Error metrics determination in functionally approximated circuits using SAT solvers
Článek Spatial movement pattern recognition in soccer based on relative player movements
Článek The importance of transporters and cell polarization for the evaluation of human stem cell-derived hepatic cells
Článek Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: A nationwide study
Článek Morphological and functional characteristics of mitral annular calcification and their relationship to stroke
Článek And the nominees are: Using design-awards datasets to build computational aesthetic evaluation model
Článek Service delivery interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review
Článek Multidimensional Scales of Perceived Self-Efficacy (MSPSE): Measurement invariance across Italian and Colombian adolescents
Článek Diversity of Mycobacteriaceae from aquatic environment at the São Paulo Zoological Park Foundation in Brazil
Článek Parents’ underestimation of their child’s weight status. Moderating factors and change over time: A cross-sectional study
Článek Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs
Článek Spatial variation in fertilizer prices in Sub-Saharan Africa
Článek Knowledge, beliefs, and concerns about bone health from a systematic review and metasynthesis of qualitative studies
Článek Successful isolation of Treponema pallidum strains from patients’ cryopreserved ulcer exudate using the rabbit model
Článek Effects of size and elasticity on the relation between flow velocity and wall shear stress in side-wall aneurysms: A lattice Boltzmann-based computer simulation study
Článek Pupil response to noxious corneal stimulation
Článek The impact of computed radiography and teleradiology on patients’ diagnosis and treatment in Mweso, the Democratic Republic of Congo
Článek Differential effects of synthetic psychoactive cathinones and amphetamine stimulants on the gut microbiome in mice
Článek Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in Chile: A cross-sectional serosurvey
Článek Increased episodes of aspiration on videofluoroscopic swallow study in children with nasogastric tube placement
Článek Obstructive sleep apnea and hypopnea syndrome in patients admitted in a tertiary hospital in Cameroon: Prevalence and associated factors
Článek Association of single nucleotide polymorphisms with dyslipidemia in antiretroviral exposed HIV patients in a Ghanaian population: A case-control study
Článek Sonic Hedgehog upregulation does not enhance the survival and engraftment of stem cell-derived cardiomyocytes in infarcted hearts
Článek Blind method for discovering number of clusters in multidimensional datasets by regression on linkage hierarchies generated from random data
Článek Predictive factors of first dosage intravenous immunoglobulin-related adverse effects in children
Článek Description and characterization of the artisanal elasmobranch fishery on Guatemala’s Caribbean coast
Článek Individual and community level determinants of short birth interval in Ethiopia: A multilevel analysis
Článek Effects of rejection intensity and rejection sensitivity on social approach behavior in women
Článek The development and validation of a measurement instrument to investigate determinants of health care utilisation for low back pain in Ethiopia
Článek Validity of the French version of the Autonomy Preference Index and its adaptation for patients with advanced cancer
Článek The epidemiological characteristics and spatio-temporal analysis of childhood hand, foot and mouth disease in Korea, 2011-2017
Článek Exponential random graph model parameter estimation for very large directed networks
Článek The implementation of community-based diabetes and hypertension management care program in Indonesia
Článek Effect of temperature variation on hospital admissions and outcomes in dogs with myxomatous mitral valve disease and new onset pulmonary edema
Článek A capability approach to assess aquaculture sustainability standard compliance
Článek Pre-collecting lymphatic vessels form detours following obstruction of lymphatic flow and function as collecting lymphatic vessels
Článek Construct validity and reliability of the Talent Development Environment Questionnaire in Caribbean youth track and field athletes
Článek Optimization of cytotoxic activity of Nocardia sp culture broths using a design of experiments
Článek Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during substance P-mediated neurogenic inflammation ex vivo
Článek Microbiota in foods from Inuit traditional hunting
Článek Investigating Italian disinformation spreading on Twitter in the context of 2019 European elections
Článek In vivo expression of peptidylarginine deiminase in Drosophila melanogaster
Článek Modelling zero-truncated overdispersed antenatal health care count data of women in Bangladesh
Článek Detection and density of breeding marsh birds in Iowa wetlands
Článek A lineage-specific rapid diagnostic test (Chagas Sero K-SeT) identifies Brazilian Trypanosoma cruzi II/V/VI reservoir hosts among diverse mammalian orders
Článek Aromatase deficiency in hematopoietic cells improves glucose tolerance in male mice through skeletal muscle-specific effects
Článek If host is refractory, insistent parasite goes berserk: Trypanosomatid Blastocrithidia raabei in the dock bug Coreus marginatus
Článek Antimicrobial resistance patterns and molecular resistance markers of Campylobacter jejuni isolates from human diarrheal cases
Článek Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients
Článek Prevalence of antiphospholipid antibodies in Behçet's disease: A systematic review and meta-analysis
Článek Chemical analysis of snus products from the United States and northern Europe
Článek Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry
Článek Aggregation of CAT tails blocks their degradation and causes proteotoxicity in S. cerevisiae
Článek Expression of concern: Compensatory increase of transglutaminase 2 is responsible for resistance to mTOR inhibitor treatment
Článek Common mental illness among epilepsy patients in Bahir Dar city, Ethiopia: A cross-sectional study
Článek Staging dementia based on caregiver reported patient symptoms: Implications from a latent class analysis
Článek Health-related quality of life and its determinants among ambulatory patients with epilepsy at Ambo General Hospital, Ethiopia: Using WHOQOL-BREF
Článek In silico analysis and high-risk pathogenic phenotype predictions of non-synonymous single nucleotide polymorphisms in human Crystallin beta A4 gene associated with congenital cataract
Článek Referral decisions and its predictors related to orthopaedic care.  A retrospective study in a novel primary care setting
Článek Influence of gelation on the retention of purple cactus pear extract in microencapsulated double emulsions
Článek Factors related to met needs for rehabilitation 6 years after stroke
Článek Association of cataract and sun exposure in geographically diverse populations of India: The CASE study. First Report of the ICMR-EYE SEE Study Group
Článek Investigation of injury severity in urban expressway crashes: A case study from Beijing
Článek Morphometric study of the diaphragmatic surface of the liver in the human fetus
Článek Food insecurity and dietary diversity among lactating mothers in the urban municipality in the mountains of Nepal
Článek Genetic characterization of Bacillus anthracis strains circulating in Italy from 1972 to 2018
Článek Promising antifungal activity of new oxadiazole against Candida krusei
Článek An atlas of personality, emotion and behaviour
Článek Long-term effects of intracranial islet grafting on cognitive functioning in a rat metabolic model of sporadic Alzheimer's disease-like dementia
Článek Compartmentalized profiling of amniotic fluid cytokines in women with preterm labor
Článek Comparison of the myometrial transcriptome from singleton and twin pregnancies by RNA-Seq
Článek Adverse reproductive effects of S100A9 on bovine sperm and early embryonic development in vitro
Článek Astrocyte senescence promotes glutamate toxicity in cortical neurons
Článek Primary ciliary dyskinesia and psychological well-being in adolescence
Článek Dipeptidyl peptidase-4 is increased in the abdominal aortic aneurysm vessel wall and is associated with aneurysm disease processes
Článek Primary care physician knowledge, attitudes, and diagnostic testing practices for norovirus and acute gastroenteritis
Článek Microfluidic-prepared DOTAP nanoparticles induce strong T-cell responses in mice
Článek Intraocular scattering as a predictor of driving performance in older adults with cataracts
Článek Reduced bone mineral density among HIV infected patients on anti-retroviral therapy in Blantyre, Malawi: Prevalence and associated factors
Článek Correction: Extraversion personality, perceived health and activity participation among community-dwelling aging adults in Hong Kong
Článek A rainwater control optimization design approach for airports based on a self-organizing feature map neural network model
Článek 18F-FDG-PET/MRI in the diagnostic work-up of limbic encephalitis
Článek The socioeconomic impact of orthopaedic trauma: A systematic review and meta-analysis
Článek Treatment patterns among patients with moderate-to-severe ulcerative colitis in the United States and Europe
Článek City to city learning and knowledge exchange for climate resilience in southern Africa
Článek Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer
Článek Molecular sequencing and morphological identification reveal similar patterns in native bee communities across public and private grasslands of eastern North Dakota
Článek Cryo-focused ion beam preparation of perovskite based solar cells for atom probe tomography
Článek Physiological and transcriptomic responses of Lanzhou Lily (Lilium davidii, var. unicolor) to cold stress
Článek Estimating associations between antidepressant use and incident mild cognitive impairment in older adults with depression
Článek The use of telephone communication between nurse navigators and their patients
Článek CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction
Článek Retraction: Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis
Článek Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use
Článek Observation and quantification of the morphological effect of trypan blue rupturing dead or dying cells
Článek The visual perception of emotion from masks
Článek Hexavalent chromium removal and total chromium biosorption from aqueous solution by Quercus crassipes acorn shell in a continuous up-flow fixed-bed column: Influencing parameters, kinetics, and mechanism
Článek The predictive value of anthropometric indices for cardiometabolic risk factors in Chinese children and adolescents: A national multicenter school-based study
Článek Lean back and wait for the alarm? Testing an automated alarm system for nosocomial outbreaks to provide support for infection control professionals
Článek Regional disparities in health care resources in traditional Chinese medicine county hospitals in China
Článek Development and use of a scale to assess gender differences in appraisal of mistreatment during childbirth among Ethiopian midwifery students
Článek Factors for starting biosimilar TNF inhibitors in patients with rheumatic diseases in the real world
Článek Correction: Force field generalization and the internal representation of motor learning
Článek Prevalence and foetomaternal effects of iron deficiency anaemia among pregnant women in Lagos, Nigeria
Článek Socioeconomic risk factors for fatal opioid overdoses in the United States: Findings from the Mortality Disparities in American Communities Study (MDAC)
Článek Microbiome signatures in neonatal central line associated bloodstream infections
Článek Interventions for incarcerated adults with opioid use disorder in the United States: A systematic review with a focus on social determinants of health
Článek Opening gap width influences distal tibial rotation below the osteotomy site following open wedge high tibial osteotomy
Článek Surveys of knowledge and awareness of antibiotic use and antimicrobial resistance in general population: A systematic review
Článek Managerial capacity among district health managers and its association with district performance: A comparative descriptive study of six districts in the Eastern Region of Ghana
Článek Knee joint distraction in regular care for treatment of knee osteoarthritis: A comparison with clinical trial data
Článek Cochlear dysfunction is associated with styrene exposure in humans
Článek Association between regular exercise and asthma control among adults: The population-based Northern Finnish Asthma Study
Článek Pharyngeal microbiome alterations during Neisseria gonorrhoeae infection
Článek Assessment of the clinical utility of four NGS panels in myeloid malignancies. Suggestions for NGS panel choice or design
Článek Assessment of time management practice and associated factors among primary hospitals employees in north Gondar, northwest Ethiopia
Článek Genetic diversity and population structure of feral rapeseed (Brassica napus L.) in Japan
Článek Difference between physical therapist estimation and psychological patient-reported outcome measures in patients with low back pain
Článek Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness
Článek Investigating cumulative effects of pre-performance routine interventions in beach volleyball serving
Článek Dispensing of antibiotics without prescription and associated factors in drug retail outlets of Eritrea: A simulated client method
Článek MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma
Článek Cytoplasmic factories, virus assembly, and DNA replication kinetics collectively constrain the formation of poxvirus recombinants
Článek The wavelet power spectrum of perfusion weighted MRI correlates with tumor vascularity in biopsy-proven glioblastoma samples
Článek Neural effects of acute stress on appetite: A magnetoencephalography study
Článek Use of magnetic resonance imaging to determine laterality of meniscal size in healthy volunteers
Článek Co-prevalence of extracranial carotid aneurysms differs between European intracranial aneurysm cohorts
Článek From the host's point of view: Effects of variation in burying beetle brood care and brood size on the interaction with parasitic mites
Článek Kernel-based Gaussian process for anomaly detection in sparse gamma-ray data
Článek Unmet care needs of children with ADHD
Článek Accelerometer-assessed outdoor physical activity is associated with meteorological conditions among older adults: Cross-sectional results from the OUTDOOR ACTIVE study
Článek Identification of Korean cancer survivors’ unmet needs and desired psychosocial assistance: A focus group study
Článek Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A
Článek The role of moral reasoning & personality in explaining lyrical preferences
Článek Correction: Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
Článek Challenges associated with homologous directed repair using CRISPR-Cas9 and TALEN to edit the DMD genetic mutation in canine Duchenne muscular dystrophy
Článek Integrated targeted serum metabolomic profile and its association with gender, age, disease severity, and pattern identification in acne
Článek Global depth perception alters local timing sensitivity
Článek Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing
Článek Recombinant human soluble thrombomodulin is associated with attenuation of sepsis-induced renal impairment by inhibition of extracellular histone release
Článek Human and climatic drivers affect spatial fishing patterns in a multiple-use marine protected area: The Galapagos Marine Reserve
Článek Correction: Leisure-time physical activity and sports in the Brazilian population: A social disparity analysis
Článek Application of the mixture item response theory model to the Self-Administered Food Security Survey Module for Children
Článek Genome-wide association and epistatic interactions of flowering time in soybean cultivar
Článek Correction: Association between workplace bullying and burnout, professional quality of life, and turnover intention among clinical nurses
Článek Correction: Estimation of membrane bending modulus of stiffness tuned human red blood cells from micropore filtration studies
Článek Correction: Limited indirect effects of an infant pneumococcal vaccination program in an aging population
Článek Correction: Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats
Článek Fieldwork-based determination of design priorities for point-of-use drinking water quality sensors for use in resource-limited environments
Článek Young women’s reproductive health conversations: Roles of maternal figures and clinical practices
Článek Correction: Differential recordings of local field potential: A genuine tool to quantify functional connectivity
Článek Novel MscL agonists that allow multiple antibiotics cytoplasmic access activate the channel through a common binding site
Článek Changes in oak (Quercus robur) photosynthesis after winter moth (Operophtera brumata) herbivory are not explained by changes in chemical or structural leaf traits
Článek Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study
Článek Sugar, amino acid and inorganic ion profiling of the honeydew from different hemipteran species feeding on Abies alba and Picea abies
Článek Correction: Comprehensive genome-wide analysis of the pear (Pyrus bretschneideri) laccase gene (PbLAC) family and functional identification of PbLAC1 involved in lignin biosynthesis
Článek Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model
Článek Water consumption and prevalence of irritable bowel syndrome among adults
Článek Correction: Health conditions associated with overweight in climacteric women
Článek Correction: Determining Glomerular Filtration Rate in Homozygous Sickle Cell Disease: Utility of Serum Creatinine Based Estimating Equations
Článek Modelling the number of antenatal care visits in Bangladesh to determine the risk factors for reduced antenatal care attendance
Článek Correction: Cumulative viral load as a predictor of CD4+ T-cell response to antiretroviral therapy using Bayesian statistical models
Článek Dominant negative effects by inactive Spa47 mutants inhibit T3SS function and Shigella virulence
Článek Physiology education for intensive care medicine residents: A 15-minute interactive peer-led flipped classroom session
Článek Strengthening capacity for natural sciences research: A qualitative assessment to identify good practices, capacity gaps and investment priorities in African research institutions
Článek Correction: A handy method to remove bacterial contamination from fungal cultures
Článek Correction: Effect of statin on life prognosis in Japanese patients undergoing hemodialysis
Článek Retraction: Outer Membrane Protein A (OmpA) of Shigella flexneri 2a Induces TLR2-Mediated Activation of B Cells: Involvement of Protein Tyrosine Kinase, ERK and NF-κB
Článek Retraction: Biofabrication of streptomycin-conjugated calcium phosphate nanoparticles using red ginseng extract and investigation of their antibacterial potential
Článek Correction: Drivers of deforestation in the basin of the Usumacinta River: Inference on process from pattern analysis using generalised additive models
Článek Retraction: MiR-30a-5p Antisense Oligonucleotide Suppresses Glioma Cell Growth by Targeting SEPT7
Článek Correction: Dynamics of plasma micronutrient concentrations and their correlation with serum proteins and thyroid hormones in patients with paracoccidioidomycosis
Článek Correction: Prevalence of damaged and missing teeth among women in the southern plains of Nepal: Findings of a simplified assessment tool
Článek Retraction: Immunoglobulin G Expression in Lung Cancer and Its Effects on Metastasis
Článek Correction: Dynamic mechanical and nanofibrous topological combinatory cues designed for periodontal ligament engineering
Článek From seed to flour: Sowing sustainability in the use of cantaloupe melon residue (Cucumis melo L. var. reticulatus)
Článek Core Scientific Dataset Model: A lightweight and portable model and file format for multi-dimensional scientific data
Článek Accounting for measurement error to assess the effect of air pollution on omic signals
Článek Leucine zipper transcription factor-like 1 binds adaptor protein complex-1 and 2 and participates in trafficking of transferrin receptor 1
Článek Barriers for tuberculosis case finding in Southwest Ethiopia: A qualitative study
Článek Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia
Článek A lower psoas muscle volume was associated with a higher rate of recurrence in male clear cell renal cell carcinoma
Článek Two angles of overqualification-the deviant behavior and creative performance: The role of career and survival job
Článek Cost-utility analysis of de-escalating biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis
Článek Efficient estimation of stereo thresholds: What slope should be assumed for the psychometric function?
Článek Learning efficient haptic shape exploration with a rigid tactile sensor array
Článek Effects of dietary supplementation with a microalga (Schizochytrium sp.) on the hemato-immunological, and intestinal histological parameters and gut microbiota of Nile tilapia in net cages
Článek Regional versus local wind speed and direction at a narrow beach with a high and steep foredune
Článek Fragmented QRS complex in patients with systemic lupus erythematosus at the time of diagnosis and its relationship with disease activity
Článek Severe thiamine deficiency in eastern Baltic cod (Gadus morhua)
Článek Transfer entropy as a variable selection methodology of cryptocurrencies in the framework of a high dimensional predictive model
Článek Psychometric validation of Czech version of the Sport Motivation Scale
Článek Correction: Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
Článek Recognition of personality disorder and anxiety disorder comorbidity in patients treated for depression in secondary psychiatric care
Článek Correction: Strategies for achieving high sequencing accuracy for low diversity samples and avoiding sample bleeding using illumina platform
Článek Best compromise nutritional menus for childhood obesity
Článek Bund removal to re-establish tidal flow, remove aquatic weeds and restore coastal wetland services—North Queensland, Australia
Článek The impact of body posture on intrinsic brain activity: The role of beta power at rest
Článek Retraction: DJ-1 Modulates α-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70
Článek Infants without health insurance: Racial/ethnic and rural/urban disparities in infant households’ insurance coverage
Článek A LAMP at the end of the tunnel: A rapid, field deployable assay for the kauri dieback pathogen, Phytophthora agathidicida
Článek Performance of Qure.ai automatic classifiers against a large annotated database of patients with diverse forms of tuberculosis
Článek Real-world cost-effectiveness of rivaroxaban compared with vitamin K antagonists in the context of stroke prevention in atrial fibrillation in France
Článek Spatial risk assessment of global change impacts on Swedish seagrass ecosystems
Článek Prevalence of anaemia and low intake of dietary nutrients in pregnant women living in rural and urban areas in the Ashanti region of Ghana
Článek MLST-based genetic relatedness of Campylobacter jejuni isolated from chickens and humans in Poland
Článek The association between nonalcoholic fatty liver disease and esophageal, stomach, or colorectal cancer: National population-based cohort study
Článek Gait asymmetry in glucocerebrosidase mutation carriers with Parkinson’s disease
Článek pyKNEEr: An image analysis workflow for open and reproducible research on femoral knee cartilage
Článek Kinematic analysis of motor learning in upper limb body-powered bypass prosthesis training
Článek How “simple” methodological decisions affect interpretation of population structure based on reduced representation library DNA sequencing: A case study using the lake whitefish
Článek PCR for the detection of pathogens in neonatal early onset sepsis
Článek Association between baseline abundance of Peptoniphilus, a Gram-positive anaerobic coccus, and wound healing outcomes of DFUs
Článek Drivers of the opioid crisis: An appraisal of financial conflicts of interest in clinical practice guideline panels at the peak of opioid prescribing
Článek All of gene expression (AOE): An integrated index for public gene expression databases
Článek Sonographic measurement of normal common bile duct diameter and associated factors at the University of Gondar comprehensive specialized hospital and selected private imaging center in Gondar town, North West Ethiopia
Článek RNAmountAlign: Efficient software for local, global, semiglobal pairwise and multiple RNA sequence/structure alignment
Článek The Brazilian TP53 mutation (R337H) and sarcomas
Článek Spatiotemporal characteristics and driving forces of construction land expansion in Yangtze River economic belt, China
Článek Vegetation change over seven years in the largest protected Pacific Northwest Bunchgrass Prairie remnant
Článek Health-related quality of life in cancer patients treated with immune checkpoint inhibitors: A systematic review on reporting of methods in randomized controlled trials
Článek Morphological consequences of artificial cranial deformation: Modularity and integration
Článek Comparison of balance changes after inspiratory muscle or Otago exercise training
Článek Self-selection of food ingredients and agricultural by-products by the house cricket, Acheta domesticus (Orthoptera: Gryllidae): A holistic approach to develop optimized diets
Článek Machine learning detection of Atrial Fibrillation using wearable technology
Článek Incidence and predictors of loss to follow up among adult HIV patients on antiretroviral therapy in University of Gondar Comprehensive Specialized Hospital: A competing risk regression modeling
Článek Serotonin transporter dependent modulation of food-seeking behavior
Článek Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens
Článek Dissection of flag leaf metabolic shifts and their relationship with those occurring simultaneously in developing seed by application of non-targeted metabolomics
Článek Acute high-intensity and moderate-intensity interval exercise do not change corticospinal excitability in low fit, young adults
Článek Switchable resolution in soft x-ray tomography of single cells
Článek Restoration of Mal overcomes the defects of apoptosis in lung cancer cells
Článek Redefining transcriptional regulation of the APOE gene and its association with Alzheimer’s disease
Článek Disease-relevant mutations alter amino acid co-evolution networks in the second nucleotide binding domain of CFTR
Článek Non-Invasive Functional-Brain-Imaging with an OPM-based Magnetoencephalography System
Článek Predicting strike susceptibility and collision patterns of the common buzzard at wind turbine structures in the federal state of Brandenburg, Germany
Článek The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice
Článek Effect of epoch length on intensity classification and on accuracy of measurement under controlled conditions on treadmill: Towards a better understanding of accelerometer measurement
Článek A novel visual ranking system based on arterial spin labeling perfusion imaging for evaluating perfusion disturbance in patients with ischemic stroke
Článek Prospective Validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score for Necrotizing Fasciitis of the Extremities
Článek A graph-based algorithm for RNA-seq data normalization
Článek Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients
Článek The pharmacokinetic parameters and the effect of a single and repeated doses of memantine on gastric myoelectric activity in experimental pigs
Článek The impact of IoT security labelling on consumer product choice and willingness to pay
Článek The development of the Police Practices Scale: Understanding policing approaches towards street-based female sex workers in a U.S. City
Článek An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury
Článek Impact of early-onset persistent stunting on cognitive development at 5 years of age: Results from a multi-country cohort study
Článek Fungal diversity in canopy soil of silver beech, Nothofagus menziesii (Nothofagaceae)
Článek Readiness to prescribe: Using educational design to untie the Gordian Knot
Článek Clinical outcomes of incident peritoneal dialysis patients coming from kidney transplantation program: A case-control study
Článek Evaluation of the factors influencing the housing safety awareness of residents in Shanghai
Článek Functional dynamics of bacterial species in the mouse gut microbiome revealed by metagenomic and metatranscriptomic analyses
Článek Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility
Článek Activity-dependent switches between dynamic regimes of extracellular matrix expression
Článek A mathematical model for assessing the effectiveness of controlling relapse in Plasmodium vivax malaria endemic in the Republic of Korea
Článek Unusual genome expansion and transcription suppression in ectomycorrhizal Tricholoma matsutake by insertions of transposable elements
Článek HIV RNA measurement in dried blood spots of HIV-infected patients in Thailand using Abbott m2000 system
Článek Ultra-rapid cooling of ibex sperm by spheres method does not induce a vitreous extracellular state and increases the membrane damages
Článek Analysis on hydraulic characteristics of improved sandy soil with soft rock
Článek The impact of lowbush blueberry (Vaccinium angustifolium Ait.) and cranberry (Vaccinium macrocarpon Ait.) pollination on honey bee (Apis mellifera L.) colony health status
Článek Reconstruction of a regulated two-cell metabolic model to study biohydrogen production in a diazotrophic cyanobacterium Anabaena variabilis ATCC 29413
Článek Intra-individual variation of particles in exhaled air and of the contents of Surfactant protein A and albumin
Článek Revisits, readmissions, and outcomes for pediatric traumatic brain injury in California, 2005-2014
Článek Enhanced handover mechanism using mobility prediction in wireless networks
Článek Are the current gRNA ranking prediction algorithms useful for genome editing in plants?
Článek Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies
Článek Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression—An in vitro study
Článek Agreement between cardiovascular disease risk assessment tools: An application to the United Arab Emirates population
Článek Constructing HLM to examine multi-level poverty-contributing factors of farmer households: Why and how?
Článek Patterns of symptoms possibly indicative of cancer and associated help-seeking behaviour in a large sample of United Kingdom residents—The USEFUL study
Článek An automated alarm system for food safety by using electronic invoices
Článek Thermal biology of two tropical lizards from the Ecuadorian Andes and their vulnerability to climate change
Článek When weight is an encumbrance; avoidance of stairs by different demographic groups
Článek Non-mycosis fungoides cutaneous lymphomas in a referral center in Taiwan: A retrospective case series and literature review
Článek Would you like to participate in this trial? The practice of informed consent in intrapartum research in the last 30 years
Článek Forward lunge before and after anterior cruciate ligament reconstruction: Faster movement but unchanged knee joint biomechanics
Článek A prospective case-control study on miRNA circulating levels in subjects born small for gestational age (SGA) evaluated from childhood into young adulthood
Článek Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings
Článek How to detect a polytrauma patient at risk of complications: A validation and database analysis of four published scales
Článek Reduced gray matter volume and cortical thickness associated with traffic-related air pollution in a longitudinally studied pediatric cohort
Článek Numerical simulation of atmospheric CO2 concentration and flux over the Korean Peninsula using WRF-VPRM model during Korus-AQ 2016 campaign
Článek Feline irradiated diet-induced demyelination; a model of the neuropathology of sub-acute combined degeneration?
Článek Improved multi-parametric prediction of tissue outcome in acute ischemic stroke patients using spatial features
Článek Survival of medial versus lateral unicompartmental knee arthroplasty: A meta-analysis
Článek Is it time to stop sweeping data cleaning under the carpet? A novel algorithm for outlier management in growth data
Článek Evaluation of liposomal ciprofloxacin formulations in a murine model of anthrax
Článek Analysis of cholesterol in mouse brain by HPLC with UV detection
Článek Exploring prior diseases associated with incident late-onset Alzheimer’s disease dementia
Článek Hypertension prevalence in patients attending tertiary pain management services, a registry-based Australian cohort study
Článek SRL pathogenicity island contributes to the metabolism of D-aspartate via an aspartate racemase in Shigella flexneri YSH6000
Článek Mixed evidence for the relationship between periodontitis and Alzheimer’s disease: A bidirectional Mendelian randomization study
Článek ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain
Článek Diel patterns in swimming behavior of a vertically migrating deepwater shark, the bluntnose sixgill (Hexanchus griseus)
Článek Life history of northern Gulf of Mexico Warsaw grouper Hyporthodus nigritus inferred from otolith radiocarbon analysis
Článek Systematic scoping review of the concept of ‘genetic identity’ and its relevance for germline modification
Článek Height of overburden fracture based on key strata theory in longwall face
Článek Laboratory strains of Bacillus anthracis lose their ability to rapidly grow and sporulate compared to wildlife outbreak strains
Článek Improvement of classification performance of Parkinson’s disease using shape features for machine learning on dopamine transporter single photon emission computed tomography
Článek Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey
Článek Receiver operating characteristic curve analysis of clinical signs for screening of convergence insufficiency in young adults
Článek Efficacy of fertilizing method for different potash sources in cotton (Gossypium hirsutum L.) nutrition under arid climatic conditions
Článek Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome
Článek Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome
Článek Impact of lower limb osteoarthritis on health-related quality of life: A cross-sectional study to estimate the expressed loss of utility in the Spanish population
Článek Correction: Tissue-Specific Expressed Antibody Variable Gene Repertoires
Článek Correction: Causal knowledge promotes behavioral self-regulation: An example using climate change dynamics
Článek Retraction: Use of Granulocyte Colony-Stimulating Factor for the Treatment of Thin Endometrium in Experimental Rats
Článek Correction: Evaluating the foundations that help avert antimicrobial resistance: Performance of essential water sanitation and hygiene functions in hospitals and requirements for action in Kenya
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