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Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study


Autoři: Yi-Hao Peng aff001;  Yu-Sheng Lin aff004;  Chia-Hung Chen aff005;  Kun-Yuan Tsai aff006;  Yi-Chih Hung aff007;  Hsuan-Ju Chen aff009;  Wei-Chih Liao aff005;  Wen-Chao Ho aff001
Působiště autorů: Department of Public Health, China Medical University, Taichung, Taiwan aff001;  Department of Respiratory Therapy, Asia University Hospital, Asia University, Taichung, Taiwan aff002;  Department of Respiratory Therapy, China Medical University, Taichung, Taiwan aff003;  Department of Chest Medicine, Division of Internal Medicine, Asia University Hospital, Asia University, Taichung, Taiwan aff004;  Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan aff005;  Division of Endocrinology and Metabolism, Chung-Hsin Clinic, New Taipei, Taiwan aff006;  Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan aff007;  Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan aff008;  Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan aff009;  Department of Nursing, Asia University, Taichung, Taiwan aff010
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226997

Souhrn

Background

It has been unclear whether diabetes mellitus (DM) is positively associated with a risk of venous thromboembolism (VTE). In addition, whether the risk of VTE is altered in patients with type 1 diabetes (T1DM) has rarely been explored.

Aim

We investigated whether patients with T1DM are at a relatively high risk of VTE development.

Methods

We retrieved data from the National Health Insurance Research Database of Taiwan to conduct this retrospective cohort study. The T1DM group consisted of 4967 patients diagnosed as having T1DM before 2003. The non-T1DM group comprised 19 868 age- and sex-matched enrollees without T1DM. Cox proportional hazard regression analysis was used to investigate the hazard ratio of VTE in patients with T1DM relative to those without T1DM.

Results

During a mean follow-up period of 8.61 years, the risk of VTE in the T1DM group was 5.33-fold higher than in the non-T1DM group after adjusting for dyslipidemia, hypertension, stroke, lower leg fracture or surgery, and obesity. Further stratified analysis revealed that the risk of VTE was significantly high in both sexes and in all age groups below the age of 60.

Conclusion

T1DM appears to be an independent risk factor for VTE development.

Klíčová slova:

Age groups – diabetes mellitus – Heart failure – Hypertension – Obesity – Surgical and invasive medical procedures – Venous thromboembolism


Zdroje

1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes care. 2004;27(5):1047–53. doi: 10.2337/diacare.27.5.1047 15111519.

2. Creager MA, Luscher TF, Cosentino F, Beckman JA. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I. Circulation. 2003;108(12):1527–32. doi: 10.1161/01.CIR.0000091257.27563.32 14504252.

3. Luscher TF, Creager MA, Beckman JA, Cosentino F. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part II. Circulation. 2003;108(13):1655–61. doi: 10.1161/01.CIR.0000089189.70578.E2 14517152.

4. Diabetes C, Complications Trial Research G, Nathan DM, Genuth S, Lachin J, Cleary P, et al. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329(14):977–86. Epub 1993/09/30. doi: 10.1056/NEJM199309303291401 8366922.

5. Epidemiology of Diabetes Interventions and Complications (EDIC). Design, implementation, and preliminary results of a long-term follow-up of the Diabetes Control and Complications Trial cohort. Diabetes Care. 1999;22(1):99–111. Epub 1999/05/20. doi: 10.2337/diacare.22.1.99 10333910; PubMed Central PMCID: PMC2745938.

6. Ou HT, Yang CY, Wang JD, Hwang JS, Wu JS. Life Expectancy and Lifetime Health Care Expenditures for Type 1 Diabetes: A Nationwide Longitudinal Cohort of Incident Cases Followed for 14 Years. Value in health: the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2016;19(8):976–84. doi: 10.1016/j.jval.2016.05.017 27987648.

7. Pompili M, Forte A, Lester D, Erbuto D, Rovedi F, Innamorati M, et al. Suicide risk in type 1 diabetes mellitus: A systematic review. Journal of psychosomatic research. 2014;76(5):352–60. doi: 10.1016/j.jpsychores.2014.02.009 24745775.

8. Michota FA. Bridging the gap between evidence and practice in venous thromboembolism prophylaxis: the quality improvement process. Journal of general internal medicine. 2007;22(12):1762–70. doi: 10.1007/s11606-007-0369-z 17891516; PubMed Central PMCID: PMC2219822.

9. Heit JA, Spencer FA, White RH. The epidemiology of venous thromboembolism. Journal of thrombosis and thrombolysis. 2016;41(1):3–14. doi: 10.1007/s11239-015-1311-6 26780736; PubMed Central PMCID: PMC4715842.

10. White RH. The epidemiology of venous thromboembolism. Circulation. 2003;107(23 Suppl 1):I4–8. doi: 10.1161/01.CIR.0000078468.11849.66 12814979.

11. Ageno W, Becattini C, Brighton T, Selby R, Kamphuisen PW. Cardiovascular risk factors and venous thromboembolism: a meta-analysis. Circulation. 2008;117(1):93–102. Epub 2007/12/19. doi: 10.1161/CIRCULATIONAHA.107.709204 18086925.

12. Bai J, Ding X, Du X, Zhao X, Wang Z, Ma Z. Diabetes is associated with increased risk of venous thromboembolism: a systematic review and meta-analysis. Thromb Res. 2015;135(1):90–5. Epub 2014/12/02. doi: 10.1016/j.thromres.2014.11.003 25434631.

13. Bell EJ, Folsom AR, Lutsey PL, Selvin E, Zakai NA, Cushman M, et al. Diabetes mellitus and venous thromboembolism: A systematic review and meta-analysis. Diabetes Res Clin Pract. 2016;111:10–8. Epub 2015/11/28. doi: 10.1016/j.diabres.2015.10.019 26612139; PubMed Central PMCID: PMC4752919.

14. White RH, Keenan CR. Effects of race and ethnicity on the incidence of venous thromboembolism. Thromb Res. 2009;123 Suppl 4:S11–7. Epub 2009/06/13. doi: 10.1016/S0049-3848(09)70136-7 19303496.

15. Liao S, Woulfe T, Hyder S, Merriman E, Simpson D, Chunilal S. Incidence of venous thromboembolism in different ethnic groups: a regional direct comparison study. J Thromb Haemost. 2014;12(2):214–9. Epub 2013/11/29. doi: 10.1111/jth.12464 24283769.

16. Stein PD, Goldman J, Matta F, Yaekoub AY. Diabetes mellitus and risk of venous thromboembolism. Am J Med Sci. 2009;337(4):259–64. Epub 2009/04/15. doi: 10.1097/MAJ.0b013e31818bbb8b 19365171.

17. Singh TP, Groehn H, Kazmers A. Vascular function and carotid intimal-medial thickness in children with insulin-dependent diabetes mellitus. J Am Coll Cardiol. 2003;41(4):661–5. Epub 2003/02/25. doi: 10.1016/s0735-1097(02)02894-2 12598080.

18. Dogra G, Rich L, Stanton K, Watts GF. Endothelium-dependent and independent vasodilation studies at normoglycaemia in type I diabetes mellitus with and without microalbuminuria. Diabetologia. 2001;44(5):593–601. Epub 2001/05/31. doi: 10.1007/s001250051665 11380077.

19. Jarvisalo MJ, Raitakari M, Toikka JO, Putto-Laurila A, Rontu R, Laine S, et al. Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes. Circulation. 2004;109(14):1750–5. Epub 2004/03/17. doi: 10.1161/01.CIR.0000124725.46165.2C 15023875.

20. Singh A, Boden G, Homko C, Gunawardana J, Rao AK. Whole-blood tissue factor procoagulant activity is elevated in type 1 diabetes: effects of hyperglycemia and hyperinsulinemia. Diabetes Care. 2012;35(6):1322–7. Epub 2012/03/14. doi: 10.2337/dc11-2114 22410811; PubMed Central PMCID: PMC3357241.

21. Hess K, Alzahrani SH, Mathai M, Schroeder V, Carter AM, Howell G, et al. A novel mechanism for hypofibrinolysis in diabetes: the role of complement C3. Diabetologia. 2012;55(4):1103–13. Epub 2011/09/16. doi: 10.1007/s00125-011-2301-7 21918806.

22. Ajjan RA, Gamlen T, Standeven KF, Mughal S, Hess K, Smith KA, et al. Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity. Blood. 2013;122(1):134–42. Epub 2013/05/24. doi: 10.1182/blood-2013-04-494641 23699598.

23. Agren A, Jorneskog G, Elgue G, Henriksson P, Wallen H, Wiman B. Increased incorporation of antiplasmin into the fibrin network in patients with type 1 diabetes. Diabetes Care. 2014;37(7):2007–14. Epub 2014/04/25. doi: 10.2337/dc13-1776 24760258.

24. Waden J, Forsblom C, Thorn LM, Saraheimo M, Rosengard-Barlund M, Heikkila O, et al. Physical activity and diabetes complications in patients with type 1 diabetes: the Finnish Diabetic Nephropathy (FinnDiane) Study. Diabetes Care. 2008;31(2):230–2. Epub 2007/10/26. doi: 10.2337/dc07-1238 17959867.

25. Kennedy A, Narendran P, Andrews RC, Daley A, Greenfield SM, Group E. Attitudes and barriers to exercise in adults with a recent diagnosis of type 1 diabetes: a qualitative study of participants in the Exercise for Type 1 Diabetes (EXTOD) study. BMJ Open. 2018;8(1):e017813. Epub 2018/01/27. doi: 10.1136/bmjopen-2017-017813 29371269; PubMed Central PMCID: PMC5786070.

26. Samama MM. An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study. Arch Intern Med. 2000;160(22):3415–20. Epub 2000/12/09. doi: 10.1001/archinte.160.22.3415 11112234.

27. White RH, Gettner S, Newman JM, Trauner KB, Romano PS. Predictors of rehospitalization for symptomatic venous thromboembolism after total hip arthroplasty. N Engl J Med. 2000;343(24):1758–64. Epub 2000/12/15. doi: 10.1056/NEJM200012143432403 11114314.

28. Huang L, Li J, Jiang Y. Association between hypertension and deep vein thrombosis after orthopedic surgery: a meta-analysis. Eur J Med Res. 2016;21:13. Epub 2016/03/24. doi: 10.1186/s40001-016-0207-z 27004410; PubMed Central PMCID: PMC4802612.


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