Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients
Autoři:
Claas Baier aff001; Lena Linke aff001; Matthias Eder aff002; Frank Schwab aff003; Iris Freya Chaberny aff004; Ralf-Peter Vonberg aff001; Ella Ebadi aff001
Působiště autorů:
Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany
aff001; Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
aff002; Institute of Hygiene and Environmental Medicine, Charité - University Medicine, Berlin, Germany
aff003; Institute of Hygiene, Hospital Epidemiology and Environmental Medicine, Leipzig University Hospital, Leipzig, Germany
aff004
Vyšlo v časopise:
PLoS ONE 15(1)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0227772
Souhrn
Non-implanted central vascular catheters (CVC) are frequently required for therapy in hospitalized patients with hematological malignancies or solid tumors. However, CVCs may represent a source for bloodstream infections (central line-associated bloodstream infections, CLABSI) and, thus, may increase morbidity and mortality of these patients. A retrospective cohort study over 3 years was performed. Risk factors were determined and evaluated by a multivariable logistic regression analysis. Healthcare costs of CLABSI were analyzed in a matched case-control study. In total 610 patients got included with a CLABSI incidence of 10.6 cases per 1,000 CVC days. The use of more than one CVC per case, CVC insertion for conditioning for stem cell transplantation, acute myeloid leukemia, leukocytopenia (≤ 1000/μL), carbapenem therapy and pulmonary diseases were independent risk factors for CLABSI. Hospital costs directly attributed to the onset of CLABSI were 8,810 € per case. CLABSI had a significant impact on the overall healthcare costs. Knowledge about risk factors and infection control measures for CLABSI prevention is crucial for best clinical practice.
Klíčová slova:
Acute myeloid leukemia – Bloodstream infections – Cancer risk factors – Catheters – Hematology – Jugular vein – Medical risk factors – Nosocomial infections
Zdroje
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