Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings

English version

Autoři: Yuanyuan Guo ^aff001; Carl F. Werner ^aff002; Andres Canales ^aff003; Li Yu ^aff004; Xiaoting Jia ^aff003; Polina Anikeeva ^aff003; Tatsuo Yoshinobu ^aff002
Působiště autorů: Frontier Research Institute for Interdisciplinary Sciences (FRIS), Graduate School of Medicine, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Miyagi 9800845, Japan ^aff001; Department of Electronic Engineering, Department of Biomedical Engineering, Tohoku University, Sendai, Miyagi, 9808579, Japan ^aff002; Department of Materials Science and Engineering, Research Laboratory of Electronics, and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 24139, United States of America ^aff003; Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, United States of America ^aff004
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0228076

Souhrn

Electrical recording permits direct readout of neural activity but offers limited ability to correlate it to the network topography. On the other hand, optical imaging reveals the architecture of neural circuits, but relies on bulky optics and fluorescent reporters whose signals are attenuated by the brain tissue. Here we introduce implantable devices to record brain activities based on the field effect, which can be further extended with capability of label-free electrophysiological mapping. Such devices reply on light-addressable potentiometric sensors (LAPS) coupled to polymer fibers with integrated electrodes and optical waveguide bundles. The LAPS utilizes the field effect to convert electrophysiological activity into regional carrier redistribution, and the neural activity is read out in a spatially resolved manner as a photocurrent induced by a modulated light beam. Spatially resolved photocurrent recordings were achieved by illuminating different pixels within the fiber bundles. These devices were applied to record local field potentials in the mouse hippocampus. In conjunction with the raster-scanning via the single modulated beam, this technology may enable fast label-free imaging of neural activity in deep brain regions.

Klíčová slova:

Brain electrophysiology – Electrophysiology – Fiber optics – Fibers – Light – Medical devices and equipment – Neuroimaging – Polymers

Zdroje

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Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings

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