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Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial


Autoři: Carla Adriane Leal de Araújo aff001;  Suélem Barros de Lorena aff002;  Guilherme Camelo de Sousa Cavalcanti aff002;  Gabriel Landim de Souza Leão aff002;  Geraldo Padilha Tenório aff002;  João Guilherme B. Alves aff001
Působiště autorů: Department of Pediatrics, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil aff001;  Department of Pediatrics, Faculdade Pernambucana de Saúde (FPS), Recife, Pernambuco, Brazil aff002
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0227497

Souhrn

Background

Oral magnesium for leg cramps treatment in pregnancy is a controversial issue according to recent Cochrane systematic review. This study aims to evaluate the efficacy of Mg++ supplementation in leg cramps treatment in pregnancy.

Methods

This observational clinical trial studied 132 pregnant women with leg cramps in the first trimester of pregnancy. At baseline, 74 (56.3%) had two leg cramps episodes per week, 28 (21.1%) three episodes, 13 (9.8%) four episodes and 9 (6.8%) five or more episodes. They were randomized 1:1 to 300 mg/day of oral Mg++ citrate (n = 66) or placebo (n = 66). The primary outcome was the frequency of leg cramps episodes per week reported by pregnant women. Secondary outcomes were the ocurrence of leg cramps and oral magnesium side effects.

Results

130 pregnant women completed the study and the two groups were comparable according to some sociodemographic and clinical characteristics. After 4 weeks of intervention it was observed a 28.4% (39/132) (CI 95%: 20.9–37.0) reduction of leg cramps in all participants and no difference between the two groups was found; reduction of 27.2% (18/66) (CI 95%: 17.0–39.6) in Mg++ group and 32.8% (21/66) (CI 95%: 21.6–45.7) in the placebo group. The OR of leg cramps was 1.3 (CI 95%: 0.6–2.9), p = 0.527, taking the placebo group as reference. Among pregnant women who remained with leg cramps the mean of leg cramps episodes per week showed no significance difference between the Mg++ and placebo groups; t-student test: p = 0.408. Four pregnant women showed gastrointestinal side effects; 2 in each group had nauseas and diarrhoea.

Conclusion

Oral magnesium supplementation during pregnancy did not reduce the ocurrence and frequency of episodes of leg cramps.

Klíčová slova:

Diarrhea – Gastrointestinal analysis – Legs – Magnesium – Nausea – Pregnancy – Randomized controlled trials – Systematic reviews


Zdroje

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