Proof-of-concept for a non-invasive, portable, and wireless device for cardiovascular monitoring in pediatric patients
Autoři:
Jennifer C. Miller aff001; Jennifer Shepherd aff002; Derek Rinderknecht aff004; Andrew L. Cheng aff001; Niema M. Pahlevan aff005
Působiště autorů:
Division of Pediatric Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA, United States of America
aff001; Fetal and Neonatal Institute, Division of Neonatology, Children’s Hospital Los Angeles, Los Angeles, CA, United States of America
aff002; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America
aff003; Chief Technical Officer Avicena, LLC, Pasadena, CA, United States of America
aff004; Department of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA, United States of America
aff005; Department of Medicine, Division of Cardiovascular Medicine, University of Southern California, Los Angeles, CA, United States of America
aff006
Vyšlo v časopise:
PLoS ONE 15(1)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0227145
Souhrn
Measurement of cardiac function is vital for the health of pediatric patients with heart disease. Standard tools to measure function including echocardiogram and magnetic residence imaging are time intensive, costly, and have limited accessibility. The Vivio is a novel, non-invasive, handheld device that screens for cardiac dysfunction by analyzing intrinsic frequencies (IF) ω1 and ω2 of carotid artery waveforms. Prior studies demonstrated that left ventricular ejection fraction can be derived from IFs in adults. This study 1) studies whether the Vivio can capture carotid arterial pulse waveform data in children ages 0–19 years old; 2) tests the performance of two sensor head geometries, one larger and smaller than the standard size used in adults, designed for the pediatric population; 3) compares the IFs between pediatric age groups and adults with normal function. The Vivio successfully measured a carotid artery waveform in all children over 5 years old and 28% of children under the age of five. The small head did not accurately measure a waveform in any age group. One-way analysis of variance (ANOVA) demonstrated a difference in the IF ω1 between the adult and pediatric cohorts (F = 7.3, Prob>F = 0.0001). Post host analysis demonstrated a difference between the adult cohort (ω1 = 99 +/- 5 bpm) and the cohorts ages 0–4 (ω1 = 111 +/- 2 bpm; p = 0.0006) and 15–19 years old (ω1 = 105 +/-5 bpm; p = 0.02). One-way ANOVA demonstrated a difference in the IF ω2 between the adult and pediatric cohorts (F = 4.8, Prob>F = 0.003), specifically between the adult (ω2 = 81 +/- 13 bpm) and age 0–4 cohorts (ω2 = 48 +/- 8 bpm; p = 0.002). These results suggest that the Vivio can be used to capture carotid pulse waveform data in pediatric populations and that the data produced can be used to measure intrinsic frequencies.
Klíčová slova:
Adults – Age groups – Algorithms – Carotid arteries – Echocardiography – Head – Neck – Pediatrics
Zdroje
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