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proLékaře.cz / Odborné časopisy / PLOS One / 2020 - 1

Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration

English version

Autoři: Jeanette M. Metzger aff001;  Helen N. Matsoff aff001;  Alexandra D. Zinnen aff001;  Rachel A. Fleddermann aff001;  Viktoriya Bondarenko aff001;  Heather A. Simmons aff001;  Andres Mejia aff001;  Colleen F. Moore aff003;  Marina E. Emborg aff001
Působiště autorů: Wisconsin National Primate Research Center, University of Wisconsin–Madison, Madison, WI, United States of America aff001;  Cellular and Molecular Pathology Graduate Program, University of Wisconsin–Madison, Madison, WI, United States of America aff002;  Department of Psychology, University of Wisconsin–Madison, Madison, WI, United States of America aff003;  Department of Medical Physics, University of Wisconsin–Madison, Madison, WI, United States of America aff004
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226999

Souhrn

Cardiac dysautonomia is a common nonmotor symptom of Parkinson’s disease (PD) associated with loss of sympathetic innervation to the heart and decreased plasma catecholamines. Disease-modifying strategies for PD cardiac neurodegeneration are not available, and biomarkers of target engagement are lacking. Systemic administration of the catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) recapitulates PD cardiac dysautonomia pathology. We recently used positron emission tomography (PET) to visualize and quantify cardiac sympathetic innervation, oxidative stress, and inflammation in adult male rhesus macaques (Macaca mulatta; n = 10) challenged with 6-OHDA (50mg/kg; i.v.). Twenty-four hours post-intoxication, the animals were blindly and randomly assigned to receive daily doses of the peroxisome proliferator-activated receptor gamma (PPARγ) agonist pioglitazone (n = 5; 5mg/kg p.o.) or placebo (n = 5). Quantification of PET radioligand uptake showed increased oxidative stress and inflammation one week after 6-OHDA which resolved to baseline levels by twelve weeks, at which time pioglitazone-treated animals showed regionally preserved sympathetic innervation. Here we report post mortem characterization of heart and adrenal tissue in these animals compared to age and sex matched normal controls (n = 5). In the heart, 6-OHDA-treated animals showed a significant loss of sympathetic nerve fibers density (tyrosine hydroxylase (TH)-positive fibers). The anatomical distribution of markers of sympathetic innervation (TH) and inflammation (HLA-DR) significantly correlated with respective in vivo PET findings across left ventricle levels and regions. No changes were found in alpha-synuclein immunoreactivity. Additionally, CD36 protein expression was increased at the cardiomyocyte intercalated discs following PPARγ-activation compared to placebo and control groups. Systemic 6-OHDA decreased adrenal medulla expression of catecholamine producing enzymes (TH and aromatic L-amino acid decarboxylase) and circulating levels of norepinephrine, which were attenuated by PPARγ-activation. Overall, these results validate in vivo PET findings of cardiac sympathetic innervation, oxidative stress, and inflammation and illustrate cardiomyocyte CD36 upregulation as a marker of PPARγ target engagement.

Klíčová slova:

Cardiac ventricles – Cardiomyocytes – Heart – Inflammation – Nerve fibers – Oxidative stress – Parkinson disease – Positron emission tomography

Zdroje

1. Kashihara K, Imamura T, Shinya T. Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease. Parkinsonism Relat Disord. 2010;16(4):252–5. Epub 2010/01/26. doi: 10.1016/j.parkreldis.2009.12.010 20097595.

2. Li ST, Dendi R, Holmes C, Goldstein DS. Progressive loss of cardiac sympathetic innervation in Parkinson's disease. Ann Neurol. 2002;52(2):220–3. Epub 2002/09/05. doi: 10.1002/ana.10236 12210793.

3. Wong KK, Raffel DM, Bohnen NI, Altinok G, Gilman S, Frey KA. 2-Year Natural Decline of Cardiac Sympathetic Innervation in Idiopathic Parkinson Disease Studied with 11C-Hydroxyephedrine PET. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 2017;58(2):326–31. Epub 2016/08/20. doi: 10.2967/jnumed.116.176891 27539837; PubMed Central PMCID: PMC5288743.

4. Nagayama H, Hamamoto M, Ueda M, Nagashima J, Katayama Y. Reliability of MIBG myocardial scintigraphy in the diagnosis of Parkinson's disease. J Neurol Neurosurg Psychiatry. 2005;76(2):249–51. Epub 2005/01/18. doi: 10.1136/jnnp.2004.037028 15654042; PubMed Central PMCID: PMC1739515.

5. Wong KK, Raffel DM, Koeppe RA, Frey KA, Bohnen NI, Gilman S. Pattern of cardiac sympathetic denervation in idiopathic Parkinson disease studied with 11C hydroxyephedrine PET. Radiology. 2012;265(1):240–7. Epub 2012/07/31. doi: 10.1148/radiol.12112723 22843766; PubMed Central PMCID: PMC3447171.

6. Orimo S, Uchihara T, Nakamura A, Mori F, Kakita A, Wakabayashi K, et al. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain. 2008;131(Pt 3):642–50. Epub 2007/12/15. doi: 10.1093/brain/awm302 18079166.

7. Mitsui J, Saito Y, Momose T, Shimizu J, Arai N, Shibahara J, et al. Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease. J Neurol Sci. 2006;243(1–2):101–4. Epub 2006/01/31. doi: 10.1016/j.jns.2005.11.034 16442563.

8. Amino T, Orimo S, Itoh Y, Takahashi A, Uchihara T, Mizusawa H. Profound cardiac sympathetic denervation occurs in Parkinson disease. Brain pathology (Zurich, Switzerland). 2005;15(1):29–34. Epub 2005/03/23. doi: 10.1111/j.1750-3639.2005.tb00097.x 15779234.

9. Nakamura T, Hirayama M, Hara T, Hama T, Watanabe H, Sobue G. Does cardiovascular autonomic dysfunction contribute to fatigue in Parkinson's disease? Movement Disorders. 2011;26(10):1869–74. doi: 10.1002/mds.23744 21542023

10. Nakamura T, Hirayama M, Hara T, Mizutani Y, Suzuki J, Watanabe H, et al. Role of cardiac sympathetic nerves in preventing orthostatic hypotension in Parkinson's disease. Parkinsonism Relat Disord. 2014;20(4):409–14. Epub 2014/01/28. doi: 10.1016/j.parkreldis.2014.01.003 24462345.

11. Nakamura T, Hirayama M, Yamashita F, Uchida K, Hama T, Watanabe H, et al. Lowered cardiac sympathetic nerve performance in response to exercise in Parkinson's disease. Mov Disord. 2010;25(9):1183–9. Epub 2010/07/16. doi: 10.1002/mds.23127 20629159.

12. Velseboer DC, de Haan RJ, Wieling W, Goldstein DS, de Bie RM. Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis. Parkinsonism Relat Disord. 2011;17(10):724–9. doi: 10.1016/j.parkreldis.2011.04.016 21571570.

13. Goldstein DS. Dysautonomia in Parkinson's disease: neurocardiological abnormalities. Lancet Neurol. 2003;2(11):669–76. Epub 2003/10/24. doi: 10.1016/s1474-4422(03)00555-6 14572735.

14. Jain S, Goldstein DS. Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis. Neurobiol Dis. 2012;46(3):572–80. doi: 10.1016/j.nbd.2011.10.025 22094370; PubMed Central PMCID: PMC3299874.

15. Goldstein DS, Holmes CS, Dendi R, Bruce SR, Li ST. Orthostatic hypotension from sympathetic denervation in Parkinson's disease. Neurology. 2002;58(8):1247–55. Epub 2002/04/24. doi: 10.1212/wnl.58.8.1247 11971094.

16. Hirsch EC, Vyas S, Hunot S. Neuroinflammation in Parkinson's disease. Parkinsonism Relat Disord. 2012;18 Suppl 1:S210–2. doi: 10.1016/S1353-8020(11)70065-7 22166438.

17. Blesa J, Trigo-Damas I, Quiroga-Varela A, Jackson-Lewis VR. Oxidative stress and Parkinson's disease. Front Neuroanat. 2015;9:91. doi: 10.3389/fnana.2015.00091 26217195; PubMed Central PMCID: PMC4495335.

18. Kapadia R, Yi JH, Vemuganti R. Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Frontiers in bioscience: a journal and virtual library. 2008;13:1813–26. Epub 2007/11/06. doi: 10.2741/2802 17981670; PubMed Central PMCID: PMC2734868.

19. Swanson CR, Joers V, Bondarenko V, Brunner K, Simmons HA, Ziegler TE, et al. The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys. J Neuroinflammation. 2011;8:91. doi: 10.1186/1742-2094-8-91 21819568; PubMed Central PMCID: PMC3166925.

20. Pisanu A, Lecca D, Mulas G, Wardas J, Simbula G, Spiga S, et al. Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-gamma agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease. Neurobiol Dis. 2014;71:280–91. Epub 2014/08/20. doi: 10.1016/j.nbd.2014.08.011 25134730.

21. Joers V, Dilley K, Rahman S, Jones C, Shultz J, Simmons H, et al. Cardiac sympathetic denervation in 6-OHDA-treated nonhuman primates. PLoS One. 2014;9(8):e104850. doi: 10.1371/journal.pone.0104850 25133405; PubMed Central PMCID: PMC4136781.

22. Joers V, Seneczko K, Goecks NC, Kamp TJ, Hacker TA, Brunner KG, et al. Nonuniform cardiac denervation observed by 11C-meta-hydroxyephedrine PET in 6-OHDA-treated monkeys. PLoS One. 2012;7(4):e35371. doi: 10.1371/journal.pone.0035371 22539969; PubMed Central PMCID: PMC3335153.

23. Rodriguez-Pallares J, Parga JA, Muñoz A, Rey P, Guerra MJ, Labandeira-Garcia JL. Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons. J Neurochem. 2007;103(1):145–56. doi: 10.1111/j.1471-4159.2007.04699.x 17573824.

24. Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol. 2001;65(2):135–72. doi: 10.1016/s0301-0082(01)00003-x 11403877.

25. Rocha NP, de Miranda AS, Teixeira AL. Insights into Neuroinflammation in Parkinson's Disease: From Biomarkers to Anti-Inflammatory Based Therapies. BioMed research international. 2015;2015:628192–. Epub 2015/07/29. doi: 10.1155/2015/628192 26295044.

26. Metzger JM, Moore CF, Boettcher CA, Brunner KG, Fleddermann RA, Matsoff HN, et al. In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration. NPJ Parkinsons Dis. 2018;4:22. Epub 2018/07/25. doi: 10.1038/s41531-018-0057-1 30038956; PubMed Central PMCID: PMC6045637.

27. Bakdash JZ, Marusich LR. Repeated Measures Correlation. Frontiers in psychology. 2017;8:456. Epub 2017/04/26. doi: 10.3389/fpsyg.2017.00456 28439244; PubMed Central PMCID: PMC5383908.

28. Simmons HA. Age-Associated Pathology in Rhesus Macaques (Macaca mulatta). Veterinary pathology. 2016;53(2):399–416. Epub 2016/02/13. doi: 10.1177/0300985815620628 26864889.

29. Joers V, Emborg ME. Modeling and imaging cardiac sympathetic neurodegeneration in Parkinson's disease. Am J Nucl Med Mol Imaging. 2014;4(2):125–59. 24753981; PubMed Central PMCID: PMC3992208.

30. Daubner SC, Le T, Wang S. Tyrosine hydroxylase and regulation of dopamine synthesis. Arch Biochem Biophys. 2011;508(1):1–12. doi: 10.1016/j.abb.2010.12.017 21176768; PubMed Central PMCID: PMC3065393.

31. Orimo S, Ozawa E, Nakade S, Sugimoto T, Mizusawa H. (123)I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. 1999;67(2):189–94. doi: 10.1136/jnnp.67.2.189 10406987.

32. Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord. 2015;30(12):1591–601. Epub 2015/10/17. doi: 10.1002/mds.26424 26474316.

33. Pysz MA, Gambhir SS, Willmann JK. Molecular imaging: current status and emerging strategies. Clinical radiology. 2010;65(7):500–16. Epub 2010/06/15. doi: 10.1016/j.crad.2010.03.011 20541650; PubMed Central PMCID: PMC3150531.

34. Tai YC, Ruangma A, Rowland D, Siegel S, Newport DF, Chow PL, et al. Performance evaluation of the microPET focus: a third-generation microPET scanner dedicated to animal imaging. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 2005;46(3):455–63. Epub 2005/03/08. 15750159.

35. Obata A, Yoshimi E, Waki A, Lewis JS, Oyama N, Welch MJ, et al. Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells. Annals of nuclear medicine. 2001;15(6):499–504. Epub 2002/02/08. doi: 10.1007/bf02988502 11831397.

36. Fujibayashi Y, Taniuchi H, Yonekura Y, Ohtani H, Konishi J, Yokoyama A. Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 1997;38(7):1155–60. Epub 1997/07/01. 9225812.

37. Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. Journal of environmental science and health Part C, Environmental carcinogenesis & ecotoxicology reviews. 2009;27(2):120–39. Epub 2009/05/05. doi: 10.1080/10590500902885684 19412858.

38. Bird JL, Izquierdo-Garcia D, Davies JR, Rudd JH, Probst KC, Figg N, et al. Evaluation of translocator protein quantification as a tool for characterising macrophage burden in human carotid atherosclerosis. Atherosclerosis. 2010;210(2):388–91. Epub 2010/01/09. doi: 10.1016/j.atherosclerosis.2009.11.047 20056222; PubMed Central PMCID: PMC2884178.

39. Turkheimer FE, Rizzo G, Bloomfield PS, Howes O, Zanotti-Fregonara P, Bertoldo A, et al. The methodology of TSPO imaging with positron emission tomography. Biochemical Society transactions. 2015;43(4):586–92. Epub 2015/11/10. doi: 10.1042/BST20150058 26551697; PubMed Central PMCID: PMC4613512.

40. Owen DR, Yeo AJ, Gunn RN, Song K, Wadsworth G, Lewis A, et al. An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism. 2012;32(1):1–5. Epub 2011/10/20. doi: 10.1038/jcbfm.2011.147 22008728; PubMed Central PMCID: PMC3323305.

41. Hondares E, Mora O, Yubero P, Rodriguez de la Concepcion M, Iglesias R, Giralt M, et al. Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation. Endocrinology. 2006;147(6):2829–38. Epub 2006/03/04. doi: 10.1210/en.2006-0070 16513826.

42. Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 1998;93(2):241–52. Epub 1998/05/06. doi: 10.1016/s0092-8674(00)81575-5 9568716.

43. Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, et al. Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)gamma-DEPENDENT MECHANISM. J Biol Chem. 2016;291(33):16977–89. Epub 2016/07/01. doi: 10.1074/jbc.M116.740092 27358406; PubMed Central PMCID: PMC5016103.

44. Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell. 1998;93(2):229–40. Epub 1998/05/06. doi: 10.1016/s0092-8674(00)81574-3 9568715.

45. Fernandez-Marcos PJ, Auwerx J. Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis. The American journal of clinical nutrition. 2011;93(4):884s–90. Epub 2011/02/04. doi: 10.3945/ajcn.110.001917 21289221; PubMed Central PMCID: PMC3057551.

46. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A. 2003;100(14):8466–71. Epub 2003/07/02. doi: 10.1073/pnas.1032913100 12832613; PubMed Central PMCID: PMC166252.

47. Hamza AA, Fikry EM, Abdallah W, Amin A. Mechanistic insights into the augmented effect of bone marrow mesenchymal stem cells and thiazolidinediones in streptozotocin-nicotinamide induced diabetic rats. Sci Rep. 2018;8(1):9827. Epub 2018/07/01. doi: 10.1038/s41598-018-28029-1 29959408; PubMed Central PMCID: PMC6026169.

48. Hammarstedt A, Pihlajamaki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, et al. High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naive type 2 diabetic subjects. J Intern Med. 2008;263(4):440–9. Epub 2008/03/08. doi: 10.1111/j.1365-2796.2007.01914.x 18324929; PubMed Central PMCID: PMC2676866.

49. Bogacka I, Xie H, Bray GA, Smith SR. Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes. 2005;54(5):1392–9. Epub 2005/04/28. doi: 10.2337/diabetes.54.5.1392 15855325.

50. Pagel-Langenickel I, Bao J, Joseph JJ, Schwartz DR, Mantell BS, Xu X, et al. PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle. J Biol Chem. 2008;283(33):22464–72. Epub 2008/06/27. doi: 10.1074/jbc.M800842200 18579525; PubMed Central PMCID: PMC2504883.

51. Simon DK, Simuni T, Elm J, Clark-Matott J, Graebner AK, Baker L, et al. Peripheral Biomarkers of Parkinson's Disease Progression and Pioglitazone Effects. J Parkinsons Dis. 2015. Epub 2015/10/08. doi: 10.3233/jpd-150666 26444095.

52. Garcia-Ruiz I, Solis-Munoz P, Fernandez-Moreira D, Munoz-Yague T, Solis-Herruzo JA. Pioglitazone leads to an inactivation and disassembly of complex I of the mitochondrial respiratory chain. BMC biology. 2013;11:88. Epub 2013/08/07. doi: 10.1186/1741-7007-11-88 23915000; PubMed Central PMCID: PMC3751493.

53. Ahn HY, Kim HH, Hwang JY, Park C, Cho BY, Park YJ. Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression. PPAR Res. 2018;2018:9568269. Epub 2018/10/27. doi: 10.1155/2018/9568269 30363699; PubMed Central PMCID: PMC6181001.

54. Silverstein RL, Febbraio M. CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. Science signaling. 2009;2(72):re3. Epub 2009/05/28. doi: 10.1126/scisignal.272re3 19471024; PubMed Central PMCID: PMC2811062.

55. Umbarawan Y, Syamsunarno M, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, et al. Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure. Sci Rep. 2018;8(1):12035. Epub 2018/08/15. doi: 10.1038/s41598-018-30616-1 30104639; PubMed Central PMCID: PMC6089997.

56. Glatz JF, Luiken JJ. From fat to FAT (CD36/SR-B2): Understanding the regulation of cellular fatty acid uptake. Biochimie. 2017;136:21–6. Epub 2016/12/26. doi: 10.1016/j.biochi.2016.12.007 28013071.

57. Aguer C, Foretz M, Lantier L, Hebrard S, Viollet B, Mercier J, et al. Increased FAT/CD36 cycling and lipid accumulation in myotubes derived from obese type 2 diabetic patients. PLoS One. 2011;6(12):e28981. Epub 2011/12/24. doi: 10.1371/journal.pone.0028981 22194967; PubMed Central PMCID: PMC3241688.

58. Greenwalt DE, Scheck SH, Rhinehart-Jones T. Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet. The Journal of clinical investigation. 1995;96(3):1382–8. Epub 1995/09/01. doi: 10.1172/JCI118173 7544802; PubMed Central PMCID: PMC185760.

59. Peng J, Huan Y, Jiang Q, Sun SJ, Jia CM, Shen ZF. Effects and Potential Mechanisms of Pioglitazone on Lipid Metabolism in Obese Diabetic KKAy Mice. PPAR Res. 2014;2014:538183. Epub 2014/05/07. doi: 10.1155/2014/538183 24799887; PubMed Central PMCID: PMC3988943.

60. Ouwens DM, Diamant M, Fodor M, Habets DDJ, Pelsers M, El Hasnaoui M, et al. Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification. Diabetologia. 2007;50(9):1938–48. Epub 2007/07/20. doi: 10.1007/s00125-007-0735-8 17639306; PubMed Central PMCID: PMC2039861.

61. van Oort MM, van Doorn JM, Bonen A, Glatz JF, van der Horst DJ, Rodenburg KW, et al. Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4. Biochim Biophys Acta. 2008;1781(1–2):61–71. Epub 2008/01/03. doi: 10.1016/j.bbalip.2007.11.006 18167317.

62. Yang KJ, Noh JR, Kim YH, Gang GT, Hwang JH, Yang SJ, et al. Differential modulatory effects of rosiglitazone and pioglitazone on white adipose tissue in db/db mice. Life sciences. 2010;87(13–14):405–10. Epub 2010/08/21. doi: 10.1016/j.lfs.2010.08.002 20723549.

63. Motojima K, Passilly P, Peters JM, Gonzalez FJ, Latruffe N. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. J Biol Chem. 1998;273(27):16710–4. Epub 1998/06/27. doi: 10.1074/jbc.273.27.16710 9642225.

64. Bogacka I, Gettys TW, de Jonge L, Nguyen T, Smith JM, Xie H, et al. The effect of beta-adrenergic and peroxisome proliferator-activated receptor-gamma stimulation on target genes related to lipid metabolism in human subcutaneous adipose tissue. Diabetes care. 2007;30(5):1179–86. Epub 2007/03/14. doi: 10.2337/dc06-1962 17351280.

65. Wilmsen HM, Ciaraldi TP, Carter L, Reehman N, Mudaliar SR, Henry RR. Thiazolidinediones upregulate impaired fatty acid uptake in skeletal muscle of type 2 diabetic subjects. Am J Physiol Endocrinol Metab. 2003;285(2):E354–62. Epub 2003/04/18. doi: 10.1152/ajpendo.00491.2001 12700163.

66. Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, et al. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002;22(8):2607–19. Epub 2002/03/23. doi: 10.1128/MCB.22.8.2607-2619.2002 11909955; PubMed Central PMCID: PMC133709.

67. Eto M, Sumi H, Fujimura H, Yoshikawa H, Sakoda S. Pioglitazone promotes peripheral nerve remyelination after crush injury through CD36 upregulation. Journal of the peripheral nervous system: JPNS. 2008;13(3):242–8. Epub 2008/10/11. doi: 10.1111/j.1529-8027.2008.00183.x 18844791.

68. Gosset P, Charbonnier AS, Delerive P, Fontaine J, Staels B, Pestel J, et al. Peroxisome proliferator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells. European journal of immunology. 2001;31(10):2857–65. Epub 2001/10/10. doi: 10.1002/1521-4141(2001010)31:10<2857::aid-immu2857>3.0.co;2-x 11592060.

69. Hirakata M, Tozawa R, Imura Y, Sugiyama Y. Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation. Biochem Biophys Res Commun. 2004;323(3):782–8. Epub 2004/09/24. doi: 10.1016/j.bbrc.2004.08.151 15381068.

70. Yamanaka M, Ishikawa T, Griep A, Axt D, Kummer MP, Heneka MT. PPARgamma/RXRalpha-induced and CD36-mediated microglial amyloid-beta phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J Neurosci. 2012;32(48):17321–31. Epub 2012/12/01. doi: 10.1523/JNEUROSCI.1569-12.2012 23197723.

71. Da Silva Morais A, Abarca-Quinones J, Horsmans Y, Starkel P, Leclercq IA. Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice. International journal of molecular medicine. 2007;19(1):105–12. Epub 2006/12/05. 17143554.

72. Qi N, Kazdova L, Zidek V, Landa V, Kren V, Pershadsingh HA, et al. Pharmacogenetic evidence that cd36 is a key determinant of the metabolic effects of pioglitazone. J Biol Chem. 2002;277(50):48501–7. Epub 2002/10/18. doi: 10.1074/jbc.M206655200 12384507.

73. Rasouli N, Yao-Borengasser A, Varma V, Spencer HJ, McGehee RE Jr., Peterson CA, et al. Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans. Arteriosclerosis, thrombosis, and vascular biology. 2009;29(9):1328–35. Epub 2009/08/12. doi: 10.1161/ATVBAHA.109.186957 19667111; PubMed Central PMCID: PMC2755066.

74. Wierzbicki M, Chabowski A, Zendzian-Piotrowska M, Gorski J. Differential effects of in vivo PPAR alpha and gamma activation on fatty acid transport proteins expression and lipid content in rat liver. Journal of physiology and pharmacology: an official journal of the Polish Physiological Society. 2009;60(1):99–106. Epub 2009/05/15. 19439812.

75. Barbieri M, Di Filippo C, Esposito A, Marfella R, Rizzo MR, D'Amico M, et al. Effects of PPARs agonists on cardiac metabolism in littermate and cardiomyocyte-specific PPAR-gamma-knockout (CM-PGKO) mice. PLoS One. 2012;7(4):e35999. Epub 2012/05/09. doi: 10.1371/journal.pone.0035999 22563432; PubMed Central PMCID: PMC3338561.

76. Goldstein DS, Holmes C, Lopez GJ, Wu T, Sharabi Y. Cardiac sympathetic denervation predicts PD in at-risk individuals. Parkinsonism Relat Disord. 2017. Epub 2017/10/17. doi: 10.1016/j.parkreldis.2017.10.003 29032895.

77. Courbon F, Brefel-Courbon C, Thalamas C, Alibelli MJ, Berry I, Montastruc JL, et al. Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease. Mov Disord. 2003;18(8):890–7. Epub 2003/07/31. doi: 10.1002/mds.10461 12889078.

78. Münch G, Nguyen NT, Nekolla S, Ziegler S, Muzik O, Chakraborty P, et al. Evaluation of sympathetic nerve terminals with [(11)C]epinephrine and [(11)C]hydroxyephedrine and positron emission tomography. Circulation. 2000;101(5):516–23. doi: 10.1161/01.cir.101.5.516 10662749.

79. Asghar O, Arumugam P, Armstrong I, Ray S, Schmitt M, Malik RA. Iodine-123 metaiodobenzylguanidine scintigraphy for the assessment of cardiac sympathetic innervation and the relationship with cardiac autonomic function in healthy adults using standardized methods. Nucl Med Commun. 2017;38(1):44–50. Epub 2016/11/30. doi: 10.1097/MNM.0000000000000608 27898646; PubMed Central PMCID: PMC5131722.

80. Kawano H, Okada R, Yano K. Histological study on the distribution of autonomic nerves in the human heart. Heart Vessels. 2003;18(1):32–9. Epub 2003/03/20. doi: 10.1007/s003800300005 12644879.

81. Stoddard SL. The adrenal medulla and Parkinson's disease. Reviews in the neurosciences. 1994;5(4):293–307. Epub 1994/10/01. doi: 10.1515/revneuro.1994.5.4.293 7697198.

82. Stoddard SL, Merkel GJ, Cook JA, Zinsmeister AR, Carmichael SW. Adrenal medulla and Parkinson's disease. Microscopy research and technique. 1994;29(2):151–4. Epub 1994/10/01. doi: 10.1002/jemt.1070290212 7812036.

83. Stoddard SL, Tyce GM, Ahlskog JE, Zinsmeister AR, Carmichael SW. Decreased catecholamine content in parkinsonian adrenal medullae. Experimental neurology. 1989;104(1):22–7. doi: 10.1016/0014-4886(89)90004-6 2924866.

84. Senard JM, Rascol O, Durrieu G, Tran MA, Berlan M, Rascol A, et al. Effects of yohimbine on plasma catecholamine levels in orthostatic hypotension related to Parkinson disease or multiple system atrophy. Clinical neuropharmacology. 1993;16(1):70–6. Epub 1993/02/01. doi: 10.1097/00002826-199302000-00008 8422659.

85. Mannelli M, Cantini G, Poli G, Mangoni M, Nesi G, Canu L, et al. Role of the PPAR-gamma system in normal and tumoral pituitary corticotropic cells and adrenal cells. Neuroendocrinology. 2010;92 Suppl 1:23–7. Epub 2010/09/21. doi: 10.1159/000314312 20829614.

86. Pan ZQ, Xie D, Choudhary V, Seremwe M, Tsai YY, Olala L, et al. The effect of pioglitazone on aldosterone and cortisol production in HAC15 human adrenocortical carcinoma cells. Molecular and cellular endocrinology. 2014;394(1–2):119–28. Epub 2014/07/20. doi: 10.1016/j.mce.2014.07.007 25038520; PubMed Central PMCID: PMC4237224.

87. Uruno A, Matsuda K, Noguchi N, Yoshikawa T, Kudo M, Satoh F, et al. Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production. Journal of molecular endocrinology. 2011;46(1):37–49. Epub 2010/11/26. doi: 10.1677/JME-10-0088 21106862.

88. Simuni T, Kieburtz K, Tilley B, Elm J, Ravina B, Babcock D, et al. Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial. Lancet Neurol. 2015;14(8):795–803. Epub 2015/06/28. doi: 10.1016/S1474-4422(15)00144-1 26116315; PubMed Central PMCID: PMC4574625.

89. Kordower JH, Olanow CW, Dodiya HB, Chu Y, Beach TG, Adler CH, et al. Disease duration and the integrity of the nigrostriatal system in Parkinson's disease. Brain. 2013;136(Pt 8):2419–31. Epub 2013/07/26. doi: 10.1093/brain/awt192 23884810; PubMed Central PMCID: PMC3722357.

90. Cheng HC, Ulane CM, Burke RE. Clinical progression in Parkinson disease and the neurobiology of axons. Ann Neurol. 2010;67(6):715–25. Epub 2010/06/03. doi: 10.1002/ana.21995 20517933; PubMed Central PMCID: PMC2918373.

91. Brauer R, Bhaskaran K, Chaturvedi N, Dexter DT, Smeeth L, Douglas I. Glitazone Treatment and Incidence of Parkinson's Disease among People with Diabetes: A Retrospective Cohort Study. PLoS medicine. 2015;12(7):e1001854. Epub 2015/07/22. doi: 10.1371/journal.pmed.1001854 26196151; PubMed Central PMCID: PMC4511413.

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Článek Extreme mortality and reproductive failure of common murres resulting from the northeast Pacific marine heatwave of 2014-2016
Článek Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil
Článek Fecal transplant prevents gut dysbiosis and anxiety-like behaviour after spinal cord injury in rats
Článek High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle
Článek Effect of classroom intervention on student food selection and plate waste: Evidence from a randomized control trial
Článek Cytomegalovirus-specific CD8+ T-cell responses are associated with arterial blood pressure in people living with HIV
Článek In-depth hepatoprotective mechanistic study of Phyllanthus niruri: In vitro and in vivo studies and its chemical characterization
Článek Content shared on social media for national cancer survivors day 2018
Článek Cost-effectiveness of alectinib compared to crizotinib for the treatment of first-line ALK+ advanced non-small-cell lung cancer in France
Článek Preventing HIV and HSV-2 through knowledge and attitudes: A replication study of a multi-component community-based intervention in Zimbabwe
Článek MLST-based genetic relatedness of Campylobacter jejuni isolated from chickens and humans in Poland
Článek Unraveling the polychromy and antiquity of the Pachacamac Idol, Pacific coast, Peru
Článek Hypertension prevalence but not control varies across the spectrum of risk in patients with atrial fibrillation: A RE-LY atrial fibrillation registry sub-study
Článek Valuing natural habitats for enhancing coastal resilience: Wetlands reduce property damage from storm surge and sea level rise
Článek Universal coverage but unmet need: National and regional estimates of attrition across the diabetes care continuum in Thailand
Článek A systematic review and meta-analysis of acute kidney injury in the intensive care units of developed and developing countries
Článek Phylogeographic analyses point to long-term survival on the spot in micro-endemic Lycian salamanders
Článek A randomized trial of a behavioral intervention to decrease hospital length of stay by decreasing bedrest
Článek Genlisea hawkingii (Lentibulariaceae), a new species from Serra da Canastra, Minas Gerais, Brazil
Článek Structural variation and its potential impact on genome instability: Novel discoveries in the EGFR landscape by long-read sequencing
Článek Assessment of forest cover and carbon stock changes in sub-tropical pine forest of Azad Jammu & Kashmir (AJK), Pakistan using multi-temporal Landsat satellite data and field inventory
Článek Color image segmentation using adaptive hierarchical-histogram thresholding
Článek The association between nonalcoholic fatty liver disease and esophageal, stomach, or colorectal cancer: National population-based cohort study
Článek Effects in spite of tough constraints - A theory of change based investigation of contextual and implementation factors affecting the results of a performance based financing scheme extended to malnutrition in Burundi
Článek Comparison of motif-based and whole-unique-sequence-based analyses of phage display library datasets generated by biopanning of anti-Borrelia burgdorferi immune sera
Článek Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho
Článek Research performance and age explain less than half of the gender pay gap in New Zealand universities
Článek Do bumblebees have signatures? Demonstrating the existence of a speed-curvature power law in Bombus terrestris locomotion patterns
Článek A primary healthcare information intervention for communicating cardiovascular risk to patients with poorly controlled hypertension: The Education and Coronary Risk Evaluation (Educore) study—A pragmatic, cluster-randomized trial
Článek “I did not know it was a medical condition”: Predictors, severity and help seeking behaviors of women with female sexual dysfunction in the Volta region of Ghana
Článek The role of services content for manufacturing competitiveness: A network analysis
Článek Mortality and demographic recovery in early post-black death epidemics: Role of recent emigrants in medieval Dijon
Článek Modelling the impact of migrants on the success of the HIV care and treatment program in Botswana
Článek Does squatting need attention?—A dual-task study on cognitive resources in resistance exercise
Článek A human mission to Mars: Predicting the bone mineral density loss of astronauts
Článek Drug-target interaction prediction using Multi Graph Regularized Nuclear Norm Minimization
Článek A preliminary study of resting brain metabolism in treatment-resistant depression before and after treatment with olanzapine-fluoxetine combination
Článek Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation
Článek Gait asymmetry in glucocerebrosidase mutation carriers with Parkinson’s disease
Článek Radioiodine therapy and Graves’ disease – Myths and reality
Článek pyKNEEr: An image analysis workflow for open and reproducible research on femoral knee cartilage
Článek Creatinine versus cystatin C for renal function-based mortality prediction in an elderly cohort: The Northern Manhattan Study
Článek Population-based estimates of humoral autoimmunity from the U.S. National Health and Nutrition Examination Surveys, 1960–2014
Článek Circulating CTRP9 correlates with the prevention of aortic calcification in renal allograft recipients
Článek Potential socioeconomic impacts from ocean acidification and climate change effects on Atlantic Canadian fisheries
Článek Kinematic analysis of motor learning in upper limb body-powered bypass prosthesis training
Článek The treeness of the tree of historical trees of life
Článek Female finches prefer courtship signals indicating male vigor and neuromuscular ability
Článek The effect of spatial position and age within an egg-clutch on embryonic development and key metabolic enzymes in two clownfish species, Amphiprion ocellaris and Amphiprion frenatus
Článek Egg donors’ motivations, experiences, and opinions: A survey of egg donors in South Africa
Článek Polymer-free sirolimus-eluting stent use in Europe and Asia: Ethnic differences in demographics and clinical outcomes
Článek How “simple” methodological decisions affect interpretation of population structure based on reduced representation library DNA sequencing: A case study using the lake whitefish
Článek The impact of translated reminder letters and phone calls on mammography screening booking rates: Two randomised controlled trials
Článek Application of a genetic algorithm to the keyboard layout problem
Článek Design and evaluation of a laboratory-based wheelchair castor testing protocol using community data
Článek Relationship between diabetic macular edema and choroidal layer thickness
Článek Evaluation of the predictive ability of ultrasound-based assessment of breast cancer using BI-RADS natural language reporting against commercial transcriptome-based tests
Článek A Comprehensive Data Gathering Network Architecture in Large-Scale Visual Sensor Networks
Článek Recovery of health-related quality of life after burn injuries: An individual participant data meta-analysis
Článek Modeling aggressive market order placements with Hawkes factor models
Článek Higher prevalence of splenic artery aneurysms in hereditary hemorrhagic telangiectasia: Vascular implications and risk factors
Článek Measuring the diffusion of innovations with paragraph vector topic models
Článek Neandertals on the beach: Use of marine resources at Grotta dei Moscerini (Latium, Italy)
Článek Allergic inflammation is initiated by IL-33–dependent crosstalk between mast cells and basophils
Článek High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer
Článek Wattpad as a resource for literary studies. Quantitative and qualitative examples of the importance of digital social reading and readers’ comments in the margins
Článek Constructing and influencing perceived authenticity in science communication: Experimenting with narrative
Článek Immune recovery markers in a double blind clinical trial comparing dolutegravir and raltegravir based regimens as initial therapy (SPRING-2)
Článek A non-canonical role for p27Kip1 in restricting proliferation of corneal endothelial cells during development
Článek Combined fiscal policies to promote healthier diets: Effects on purchases and consumer welfare
Článek Estimating the impact of drug use on US mortality, 1999-2016
Článek Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction
Článek Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies
Článek Digging the diversity of Iberian bait worms Marphysa (Annelida, Eunicidae)
Článek MESSAR: Automated recommendation of metabolite substructures from tandem mass spectra
Článek Temporal ordering of input modulates connectivity formation in a developmental neuronal network model of the cortex
Článek Healthy lifestyle index and its association with hypertension among community adults in Sri Lanka: A cross-sectional study
Článek Manual dexterity of mice during food-handling involves the thumb and a set of fast basic movements
Článek Research on an evolutionary game model and simulation of a cluster innovation network based on fairness preference
Článek Reconstructing Krassilovia mongolica supports recognition of a new and unusual group of Mesozoic conifers
Článek Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy
Článek From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis
Článek Training interval in cardiopulmonary resuscitation
Článek Quantum isomer search
Článek Ultrastructure of light-activated axons following optogenetic stimulation to produce late-phase long-term potentiation
Článek Optimization of tissue sampling for Borrelia burgdorferi in white-footed mice (Peromyscus leucopus)
Článek Symmetric core-cohesive blockmodel in preschool children’s interaction networks
Článek Predicting antibacterial activity from snake venom proteomes
Článek An investigation of transportation practices in an Ontario swine system using descriptive network analysis
Článek Comparison of gridded precipitation datasets for rainfall-runoff and inundation modeling in the Mekong River Basin
Článek PCR for the detection of pathogens in neonatal early onset sepsis
Článek Mercury and selenium concentrations in fishes of the Upper Colorado River Basin, southwestern United States: A retrospective assessment
Článek The effects of dual-task cognitive interference on gait and turning in Huntington’s disease
Článek Effects of Allium hookeri on gut microbiome related to growth performance in young broiler chickens
Článek Novel imaging biomarkers for mapping the impact of mild mitochondrial uncoupling in the outer retina in vivo
Článek Hyperkalemia treatment modalities: A descriptive observational study focused on medication and healthcare resource utilization
Článek Age and altitude of residence determine anemia prevalence in Peruvian 6 to 35 months old children
Článek Web service QoS prediction using improved software source code metrics
Článek Comparison of post-transplantation diabetes mellitus incidence and risk factors between kidney and liver transplantation patients
Článek Mothers’ oral health literacy and children’s oral health status in Pikine, Senegal: A pilot study
Článek A definition-by-example approach and visual language for activity patterns in engineering disciplines
Článek A network analysis revealed the essential and common downstream proteins related to inguinal hernia
Článek Use of conventional cardiac troponin assay for diagnosis of non-ST-elevation myocardial infarction: ‘The Ottawa Troponin Pathway’
Článek Low risk pregnancies after a cesarean section: Determinants of trial of labor and its failure
Článek Exploratory analysis of the potential for advanced diagnostic testing to reduce healthcare expenditures of patients hospitalized with meningitis or encephalitis
Článek Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models
Článek Identification and characterization of miRNAs involved in cold acclimation of zebrafish ZF4 cells
Článek Research on motion planning for an indoor spray arm based on an improved potential field method
Článek Camera-traps are a cost-effective method for surveying terrestrial squamates: A comparison with artificial refuges and pitfall traps
Článek Detailed analysis of the transverse arch of hallux valgus feet with and without pain using weightbearing ultrasound imaging and precise force sensors
Článek The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC
Článek Filling the human resource gap through public-private partnership: Can private, community-based skilled birth attendants improve maternal health service utilization and health outcomes in a remote region of Bangladesh?
Článek HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells
Článek Still standing: Recent patterns of post-fire conifer refugia in ponderosa pine-dominated forests of the Colorado Front Range
Článek Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling
Článek Biogeographic study of human gut-associated crAssphage suggests impacts from industrialization and recent expansion
Článek Treating patients with driving phobia by virtual reality exposure therapy – a pilot study
Článek The impact of race relations on NFL attendance: An econometric analysis
Článek The potential impact of the Affordable Care Act and Medicaid expansion on reducing colorectal cancer screening disparities in African American males
Článek Efficient processing of raster and vector data
Článek Rewilding with large herbivores: Positive direct and delayed effects of carrion on plant and arthropod communities
Článek Early life experience and alterations of group composition shape the social grooming networks of former pet and entertainment chimpanzees (Pan troglodytes)
Článek Muscarinic modulation of M and h currents in gerbil spherical bushy cells
Článek Therapeutic hypothermia after out of hospital cardiac arrest improve 1-year survival rate for selective patients
Článek Subterranean Deuteraphorura Absolon, 1901, (Hexapoda, Collembola) of the Western Carpathians — Troglomorphy at the northern distributional limit in Europe
Článek Fragmentation and inefficiencies in US equity markets: Evidence from the Dow 30
Článek Aqueous ethanol extract of Libidibia ferrea (Mart. Ex Tul) L.P. Queiroz (juca) exhibits antioxidant and migration-inhibiting activity in human gastric adenocarcinoma (ACP02) cells
Článek Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy
Článek Proportions of CD4 test results indicating advanced HIV disease remain consistently high at primary health care facilities across four high HIV burden countries
Článek Single-modal and multi-modal false arrhythmia alarm reduction using attention-based convolutional and recurrent neural networks
Článek Eye-gaze information input based on pupillary response to visual stimulus with luminance modulation
Článek Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation
Článek Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study
Článek Were ancient foxes far more carnivorous than recent ones?—Carnassial morphological evidence
Článek Disruption in daily eating-fasting and activity-rest cycles in Indian adolescents attending school
Článek Association between baseline abundance of Peptoniphilus, a Gram-positive anaerobic coccus, and wound healing outcomes of DFUs
Článek The earliest farming communities north of the Carpathians: The settlement at Gwoździec site 2
Článek Trends of the prevalence and incidence of hypertrophic cardiomyopathy in Korea: A nationwide population-based cohort study
Článek Designing information provision to serve as a reminder of altruistic benefits: A case study of the risks of air pollution caused by industrialization
Článek Are changes in depressive symptoms, general health and residential area socio-economic status associated with trajectories of waist circumference and body mass index?
Článek Extracellular vesicles of U937 macrophage cell line infected with DENV-2 induce activation in endothelial cells EA.hy926
Článek FlexGraph: Flexible partitioning and storage for scalable graph mining
Článek Post-weaning infant-to-mother bonding in nutritionally independent female mice
Článek A little good is good enough: Ethical consumption, cheap excuses, and moral self-licensing
Článek Multimodal hand gesture recognition using single IMU and acoustic measurements at wrist
Článek Variance based weighting of multisensory head rotation signals for verticality perception
Článek Eligibility for hepatitis B antiviral therapy among adults in the general population in Zambia
Článek Drivers of the opioid crisis: An appraisal of financial conflicts of interest in clinical practice guideline panels at the peak of opioid prescribing
Článek Nutritional inadequacies in commercial vegan foods for dogs and cats
Článek LTA1 and dmLT enterotoxin-based proteins activate antigen-presenting cells independent of PKA and despite distinct cell entry mechanisms
Článek The Shapley value for a fair division of group discounts for coordinating cooling loads
Článek Comparison and evaluation of the morphology of crowns generated by biogeneric design technique with CEREC chairside system
Článek Assessing risk factors and impact of cyberbullying victimization among university students in Myanmar: A cross-sectional study
Článek Incidence of hospital-acquired pressure ulcers in patients with "minimal risk" according to the "Norton-MI" scale
Článek Intra-host symbiont diversity in eastern Pacific cold seep tubeworms identified by the 16S-V6 region, but undetected by the 16S-V4 region
Článek Lipoprotein(a) plasma levels are not associated with survival after acute coronary syndromes: An observational cohort study
Článek Use of Nanotrap particles for the capture and enrichment of Zika, chikungunya and dengue viruses in urine
Článek Pancreatic secretory trypsin inhibitor reduces multi-organ injury caused by gut ischemia/reperfusion in mice
Článek The effect of diet on the gastrointestinal microbiome of juvenile rehabilitating green turtles (Chelonia mydas)
Článek Biochemical characterization of Ty1 retrotransposon protease
Článek Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1
Článek The validation of the Beijing version of the Montreal Cognitive Assessment in Chinese patients undergoing hemodialysis
Článek All of gene expression (AOE): An integrated index for public gene expression databases
Článek Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease
Článek Inflammasome expression is higher in ovarian tumors than in normal ovary
Článek Adherence to iron-folic acid supplement and associated factors among antenatal care attending pregnant mothers in governmental health institutions of Adwa town, Tigray, Ethiopia: Cross-sectional study
Článek Flower, seed, and fruit development in three Tunisian species of Polygonum: Implications for their taxonomy and evolution of distyly in Polygonaceae
Článek Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus
Článek Marine seafood production via intense exploitation and cultivation in China: Costs, benefits, and risks
Článek Signatures of medical student applicants and academic success
Článek The effects of extended photoperiod and warmth on hair growth in ponies and horses at different times of year
Článek Modeling the effect of prolonged ethanol exposure on global gene expression and chromatin accessibility in normal 3D colon organoids
Článek Clinical, cytogenetic and molecular genetic characterization of a tandem fusion translocation in a male Holstein cattle with congenital hypospadias and a ventricular septal defect
Článek Severity of misophonia symptoms is associated with worse cognitive control when exposed to misophonia trigger sounds
Článek Detection of Torque Teno Virus (TTV) and TTV-Like Minivirus in patients with presumed infectious endophthalmitis in India
Článek The evolution of secondary flow phenomena and their effect on primary shock conditions in shock tubes: Experimentation and numerical model
Článek Estimating the basic reproduction number of a pathogen in a single host when only a single founder successfully infects
Článek What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson’s disease? A preliminary pharmacoepidemiologic study
Článek Community- and trophic-level responses of soil nematodes to removal of a non-native tree at different stages of invasion
Článek Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging
Článek Sonographic measurement of normal common bile duct diameter and associated factors at the University of Gondar comprehensive specialized hospital and selected private imaging center in Gondar town, North West Ethiopia
Článek Catchment-scale export of antibiotic resistance genes and bacteria from an agricultural watershed in central Iowa
Článek Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis
Článek Characterization of a universal screening approach for congenital CMV infection based on a highly-sensitive, quantitative, multiplex real-time PCR assay
Článek Multiregional origins of the domesticated tetraploid wheats
Článek Racism against Totonaco women in Veracruz: Intercultural competences for health professionals are necessary
Článek Increased inflammation and endothelial markers in patients with late severe post-thrombotic syndrome
Článek Genes associated with body weight gain and feed intake identified by meta-analysis of the mesenteric fat from crossbred beef steers
Článek Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations
Článek Multiple paedomorphic lineages of soft-substrate burrowing invertebrates: parallels in the origin of Xenocratena and Xenoturbella
Článek Simple non-mydriatic retinal photography is feasible and demonstrates retinal microvascular dilation in Chronic Obstructive Pulmonary Disease (COPD)
Článek Evaluating poverty alleviation strategies in a developing country
Článek RNAmountAlign: Efficient software for local, global, semiglobal pairwise and multiple RNA sequence/structure alignment
Článek Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter?
Článek Pan-cancer analysis of somatic mutations and epigenetic alterations in insulated neighbourhood boundaries
Článek Prevalence and characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) isolated from chicken meat in the province of Quebec, Canada
Článek HIV treatment response among female sex workers participating in a treatment as prevention demonstration project in Cotonou, Benin
Článek Soluble AXL as a marker of disease progression and survival in melanoma
Článek Using machine learning methods to determine a typology of patients with HIV-HCV infection to be treated with antivirals
Článek Quantifying tourism booms and the increasing footprint in the Arctic with social media data
Článek Gender differences influence over insomnia in Korean population: A cross-sectional study
Článek Impact of scion/rootstock reciprocal effects on metabolomics of fruit juice and phloem sap in grafted Citrus reticulata
Článek Adapting cognitive diagnosis computerized adaptive testing item selection rules to traditional item response theory
Článek Usability assessment of seven HIV self-test devices conducted with lay-users in Johannesburg, South Africa
Článek Management of veterinary anaesthesia in small animals: A survey of current practice in Quebec
Článek Genetic structure of the European hedgehog (Erinaceus europaeus) in Denmark
Článek Molecular karyotyping of Siberian wild rye (Elymus sibiricus L.) with oligonucleotide fluorescence in situ hybridization (FISH) probes
Článek Umbilical cord separation time, predictors and healing complications in newborns with dry care
Článek The strain distribution in the lumbar anterior longitudinal ligament is affected by the loading condition and bony features: An in vitro full-field analysis
Článek Marine resource congestion in China: Identifying, measuring, and assessing its impact on sustainable development of the marine economy
Článek Analysis of attitudinal components towards statistics among students from different academic degrees
Článek Effects of fatigue induced by repeated-sprint on kicking accuracy and velocity in female soccer players
Článek A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB
Článek Clinical correlates associated with the long-term response of bipolar disorder patients to lithium, valproate or lamotrigine: A retrospective study
Článek Determinants of change in long-acting or permanent contraceptives use in Ethiopia; A multivariate decomposition analysis of data from the Ethiopian demographic and health survey
Článek On the genus Crossaster (Echinodermata: Asteroidea) and its distribution
Článek Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme
Článek Optogenetically induced cellular habituation in non-neuronal cells
Článek An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect
Článek The effect of strontium and silicon substituted hydroxyapatite electrochemical coatings on bone ingrowth and osseointegration of selective laser sintered porous metal implants
Článek Modeling the Theory of Planned Behaviour to predict adherence to preventive dental visits in preschool children
Článek Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States
Článek Color discrimination and gas chromatography-mass spectrometry fingerprint based on chemometrics analysis for the quality evaluation of Schizonepetae Spica
Článek Comparisons of recurrence-free survival and overall survival between microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: A multiple centers retrospective cohort study with propensity score matching
Článek Transcriptome-wide identification of novel circular RNAs in soybean in response to low-phosphorus stress
Článek Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial
Článek The association between dietary patterns before and in early pregnancy and the risk of gestational diabetes mellitus (GDM): Data from the Malaysian SECOST cohort
Článek Gene expression noise in a complex artificial toxin expression system
Článek Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution
Článek Prediction of Uropathogens by Flow Cytometry and Dip-stick Test Results of Urine Through Multivariable Logistic Regression Analysis
Článek Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2
Článek Copper to Tuscany – Coals to Newcastle? The dynamics of metalwork exchange in early Italy
Článek The Brazilian TP53 mutation (R337H) and sarcomas
Článek Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance
Článek Detection of amitraz resistance and reduced treatment efficacy in the Varroa Mite, Varroa destructor, within commercial beekeeping operations
Článek Impact of viral disease hypophagia on pig jejunal function and integrity
Článek Enzyme response of activated sludge to a mixture of emerging contaminants in continuous exposure
Článek Molecular evidence for horizontal transmission of chelonid alphaherpesvirus 5 at green turtle (Chelonia mydas) foraging grounds in Queensland, Australia
Článek Technology anxiety and resistance to change behavioral study of a wearable cardiac warming system using an extended TAM for older adults
Článek Age-related differences in the temporal dynamics of spectral power during memory encoding
Článek cagA gene EPIYA motif genetic characterization from Colombian Helicobacter pylori isolates: Standardization of a molecular test for rapid clinical laboratory detection
Článek Mugharat an-Nachcharini: A specialized sheep-hunting camp reveals high-altitude habitats in the earliest Neolithic of the Central Levant
Článek Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix)
Článek Clinicians’ communication with patients receiving a MCI diagnosis: The ABIDE project
Článek Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling
Článek Fast quantitative time lapse displacement imaging of endothelial cell invasion
Článek Two novel mutations in MSX1 causing oligodontia
Článek 7,200 years old constructions and mudbrick technology: The evidence from Tel Tsaf, Jordan Valley, Israel
Článek Tuberculosis recurrences and predictive factors in a vulnerable population in Catalonia
Článek Dome-shaped macula in children and adolescents
Článek Barriers in the access, diagnosis and treatment completion for tuberculosis patients in central and western Nepal: A qualitative study among patients, community members and health care workers
Článek Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer
Článek Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34
Článek Preliminary evidences of the presence of extracellular DNA single stranded forms in soil
Článek The effectiveness of substance use interventions for homeless and vulnerably housed persons:  A systematic review of systematic reviews on supervised consumption facilities, managed alcohol programs, and pharmacological agents for opioid use disorder
Článek Spatiotemporal characteristics and driving forces of construction land expansion in Yangtze River economic belt, China
Článek Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis
Článek Morphological association between the muscles and bones in the craniofacial region
Článek Transcriptome analysis of Actinidia chinensis in response to Botryosphaeria dothidea infection
Článek Evaluating two decision aids for Australian men supporting informed decisions about prostate cancer screening: A randomised controlled trial
Článek Serum galectins as potential biomarkers of inflammatory bowel diseases
Článek Linguistic Z-number weighted averaging operators and their application to portfolio selection problem
Článek Comparative study on skin protection activity of polyphenol-rich extract and polysaccharide-rich extract from Sargassum vachellianum
Článek Fusion of augmented reality imaging with the endoscopic view for endonasal skull base surgery; a novel application for surgical navigation based on intraoperative cone beam computed tomography and optical tracking
Článek Functional characterization of NK cells in Mexican pediatric patients with acute lymphoblastic leukemia: Report from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia
Článek Radiomics signature for prediction of lateral lymph node metastasis in conventional papillary thyroid carcinoma
Článek Antenatal depression and its association with adverse birth outcomes in low and middle-income countries: A systematic review and meta-analysis
Článek The role of refugee and migrant migration status on medication adherence: Mediation through illness perceptions
Článek Job stress and emotional exhaustion at work in Spanish workers: Does unhealthy work affect the decision to drive?
Článek Correction: Amphibians on the hotspot: Molecular biology and conservation in the South American Atlantic Rainforest
Článek Time for change is now: Experiences of participants in a community-based approach for iron and folic acid supplementation in a rural county in Kenya, a qualitative study
Článek Non-invasive genetic monitoring for the threatened valley elderberry longhorn beetle
Článek Statistical learning for turboshaft helicopter accidents using logistic regression
Článek Vegetation change over seven years in the largest protected Pacific Northwest Bunchgrass Prairie remnant
Článek The effect of various metal-salts on the sedimentation of soil in a water-based suspension
Článek Using electronic health record system triggers to target delivery of a patient-centered intervention to improve venous thromboembolism prevention for hospitalized patients: Is there a differential effect by race?
Článek Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells
Článek Novel broad-spectrum activity-based probes to profile malarial cysteine proteases
Článek Health-related quality of life in cancer patients treated with immune checkpoint inhibitors: A systematic review on reporting of methods in randomized controlled trials
Článek Environmental tobacco smoke (ETS) and hyperlipidemia modified by perceived work stress
Článek Association between opioid analgesic therapy and initiation of buprenorphine management: An analysis of prescription drug monitoring program data
Článek Effect of a community-based approach of iron and folic acid supplementation on compliance by pregnant women in Kiambu County, Kenya: A quasi-experimental study
Článek Radiocarbon dating of two old African baobabs from India
Článek The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis
Článek Short- & long-term effects of monetary and non-monetary incentives to cooperate in public good games: An experiment
Článek Niche modeling reveals life history shifts in birds at La Brea over the last twenty millennia
Článek Morphological consequences of artificial cranial deformation: Modularity and integration
Článek Distributed flux balance analysis simulations of serial biomass fermentation by two organisms
Článek Plasma kynurenines and prognosis in patients with heart failure
Článek Occurrence and distribution of anthropogenic persistent organic pollutants in coastal sediments and mud shrimps from the wetland of central Taiwan
Článek Restoration of cortical symmetry and binaural function: Cortical auditory evoked responses in adult cochlear implant users with single sided deafness
Článek A smartphone-enabled wireless and batteryless implantable blood flow sensor for remote monitoring of prosthetic heart valve function
Článek Gut microbiota composition alterations are associated with the onset of diabetes in kidney transplant recipients
Článek Economic burden of maternal morbidity – A systematic review of cost-of-illness studies
Článek Comparison of balance changes after inspiratory muscle or Otago exercise training
Článek Correction: Escherichia coli and Salmonella spp. isolated from Australian meat chickens remain susceptible to critically important antimicrobial agents
Článek Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue
Článek Cell-free DNA donor fraction analysis in pediatric and adult heart transplant patients by multiplexed allele-specific quantitative PCR: Validation of a rapid and highly sensitive clinical test for stratification of rejection probability
Článek Immunopathogenesis of canine chronic ulcerative stomatitis
Článek Correction: Quantification of speech and synchrony in the conversation of adults with autism spectrum disorder
Článek Efficacy and safety of ultrasonic circular cyclocoagulation with second-generation probe in glaucoma: A retrospective study
Článek Generalizing findings from a randomized controlled trial to a real-world study of the iLookOut, an online education program to improve early childhood care and education providers’ knowledge and attitudes about reporting child maltreatment
Článek Self-selection of food ingredients and agricultural by-products by the house cricket, Acheta domesticus (Orthoptera: Gryllidae): A holistic approach to develop optimized diets
Článek Machine learning detection of Atrial Fibrillation using wearable technology
Článek Comparative proteomic analysis of different stages of breast cancer tissues using ultra high performance liquid chromatography tandem mass spectrometer
Článek A cross-sectional study of psychopathy and khat abuse among prisoners in the correctional institution in Jimma, Ethiopia
Článek Head impulse compensatory saccades: Visual dependence is most evident in bilateral vestibular loss
Článek Complementarity of empirical and process-based approaches to modelling mosquito population dynamics with Aedes albopictus as an example—Application to the development of an operational mapping tool of vector populations
Článek Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation
Článek When and what to test for: A cost-effectiveness analysis of febrile illness test-and-treat strategies in the era of responsible antibiotic use
Článek Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials
Článek The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice
Článek Seroepidemiological study of rubella in Vojvodina, Serbia: 24 years after the introduction of the MMR vaccine in the national immunization programme
Článek Association of endothelial nitric oxide synthase (NOS3) gene polymorphisms with primary open-angle glaucoma in a Saudi cohort
Článek Antitrust analysis with upward pricing pressure and cost efficiencies
Článek Machine learning models for identifying preterm infants at risk of cerebral hemorrhage
Článek Natural selection contributes to food web stability
Článek Diversity and plant growth-promoting functions of diazotrophic/N-scavenging bacteria isolated from the soils and rhizospheres of two species of Solanum
Článek Sustainability effects of motor control stabilisation exercises on pain and function in chronic nonspecific low back pain patients: A systematic review with meta-analysis and meta-regression
Článek Sofosbuvir-based regimen for genotype 2 HCV infected patients in Taiwan: A real world experience
Článek The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function
Článek Analysis of the Rdr1 gene family in different Rosaceae genomes reveals an origin of an R-gene cluster after the split of Rubeae within the Rosoideae subfamily
Článek Concomitant phytonutrient and transcriptome analysis of mature fruit and leaf tissues of tomato (Solanum lycopersicum L. cv. Oregon Spring) grown using organic and conventional fertilizer
Článek Quantitative analysis of adsorption and desorption of volatile organic compounds on reusable zeolite filters using gas chromatography
Článek Comparing bioinformatic pipelines for microbial 16S rRNA amplicon sequencing
Článek TMEM98 is a negative regulator of FRAT mediated Wnt/ß-catenin signalling
Článek Modeling migration patterns in the USA under sea level rise
Článek Cloud-computing and machine learning in support of country-level land cover and ecosystem extent mapping in Liberia and Gabon
Článek An exploratory study on the quality of patient screening and counseling for hypertension management in Tanzania
Článek Relation of fibroblast growth factor receptor 2 expression to hepatocellular carcinoma recurrence after liver resection
Článek The Brief Measure of Emotional Preoperative Stress (B-MEPS) as a new predictive tool for postoperative pain: A prospective observational cohort study
Článek The impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis
Článek Correction: Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition
Článek Clinical and pathological features of thrombotic microangiopathy influencing long-term kidney transplant outcomes
Článek Multidisciplinary investigation of two Egyptian child mummies curated at the University of Tartu Art Museum, Estonia (Late/Graeco-Roman Periods)
Článek Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season
Článek Murine Surf4 is essential for early embryonic development
Článek Using mHealth to improve health care delivery in India: A qualitative examination of the perspectives of community health workers and beneficiaries
Článek Algorithmic handwriting analysis of the Samaria inscriptions illuminates bureaucratic apparatus in biblical Israel
Článek Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome
Článek Short treatment with antalarmin alters adrenal gland receptors in the rat model of endometriosis
Článek Is it really always only the others who are to blame? GP’s view on medical overuse. A questionnaire study
Článek Serum visfatin and vaspin levels in hepatocellular carcinoma (HCC)
Článek iTRAQ proteomics reveals the regulatory response to Magnaporthe oryzae in durable resistant vs. susceptible rice genotypes
Článek A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients
Článek Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
Článek Incidence and predictors of loss to follow up among adult HIV patients on antiretroviral therapy in University of Gondar Comprehensive Specialized Hospital: A competing risk regression modeling
Článek Point-of-care diagnostic (POCD) method for detecting Bursaphelenchus xylophilus in pinewood using recombinase polymerase amplification (RPA) with the portable optical isothermal device (POID)
Článek Clinical implications of elevated serum interleukin-6 in IgG4-related disease
Článek Downscaling NLDAS-2 daily maximum air temperatures using MODIS land surface temperatures
Článek Plasma Trimethylamine-N-oxide and impaired glucose regulation: Results from The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS)
Článek Self-esteem and other risk factors for depressive symptoms among adolescents in United Arab Emirates
Článek Control of the microsporidian parasite Nosema ceranae in honey bees (Apis mellifera) using nutraceutical and immuno-stimulatory compounds
Článek The effect of storage conditions on microbial communities in stool
Článek Influence of flow on phosphorus-dynamics and particle size in agricultural drainage ditch sediments
Článek A prospective, randomized, double-blind trial to compare body weight-adjusted and fixed doses of palonosetron for preventing postoperative nausea and vomiting in obese female patients
Článek Application of computerized 3D-CT texture analysis of pancreas for the assessment of patients with diabetes
Článek Predictive validation and forecasts of short-term changes in healthcare expenditure associated with changes in smoking behavior in the United States
Článek An information-based approach to handle various types of uncertainty in fuzzy bodies of evidence
Článek Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial
Článek Health care professionals’ knowledge of commonly used sedative, analgesic and neuromuscular drugs: A single center (Rambam Health Care Campus), prospective, observational survey
Článek Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
Článek OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model
Článek Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
Článek Novel method to measure temporal windows based on eye movements during viewing of the Necker cube
Článek Whole blood transcriptomic analysis of beef cattle at arrival identifies potential predictive molecules and mechanisms that indicate animals that naturally resist bovine respiratory disease
Článek Effects of smoke flavoring using different wood chips and barbecuing on the formation of polycyclic aromatic hydrocarbons and heterocyclic aromatic amines in salmon fillets
Článek Sleep quality and sex modify the relationships between trait energy and fatigue on state energy and fatigue
Článek The role of peer, parental, and school norms in predicting adolescents’ attitudes and behaviours of majority and different minority ethnic groups in Croatia
Článek Filtered beauty in Oslo and Tokyo: A spatial frequency analysis of facial attractiveness
Článek The impact of rehabilitation frequency on the risk of stroke in patients with rheumatoid arthritis
Článek The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation
Článek Detection of posttraumatic pneumothorax using electrical impedance tomography—An observer-blinded study in pigs with blunt chest trauma
Článek Educators’ perceptions of organisational readiness for implementation of a pre-adolescent transdisciplinary school health intervention for inter-generational outcomes
Článek Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA
Článek Framework and algorithms for identifying honest blocks in blockchain
Článek Efficacy and safety of anti-viral therapy for Hepatitis B virus-associated glomerulonephritis: A meta-analysis
Článek Selective transmission of some HIV-1 subtype C variants might depend on Envelope stimulating dendritic cells to secrete IL-10
Článek Noise reduction and quantification of fiber orientations in greyscale images
Článek Exploring the impact of terminology differences in blood and organ donor decision making
Článek Ontogenetic similarities between giraffe and sauropod neck osteological mobility
Článek Load transfer mechanism and critical length of anchorage zone for anchor bolt
Článek Income inequalities in stroke incidence and mortality: Trends in stroke-free and stroke-affected life years based on German health insurance data
Článek Community’s perception, experiences and health seeking behavior towards newborn illnesses in Debre Libanos District, North Shoa, Oromia, Ethiopia: Qualitative study
Článek Platelet indices significantly correlate with liver fibrosis in HCV-infected patients
Článek Reanalysis of the Bridge et al. study of suicide following release of 13 Reasons Why
Článek Validation of the easyscreen flavivirus dengue alphavirus detection kit based on 3base amplification technology and its application to the 2016/17 Vanuatu dengue outbreak
Článek The nitrate content of fresh and cooked vegetables and their health-related risks
Článek Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
Článek Serotonin transporter dependent modulation of food-seeking behavior
Článek Implicit task switching in Parkinson’s disease is preserved when on medication
Článek Root treatment with oxathiapiprolin, benthiavalicarb or their mixture provides prolonged systemic protection against oomycete foliar pathogens
Článek Real-world effectiveness and safety of ranibizumab for the treatment of myopic choroidal neovascularization: Results from the LUMINOUS study
Článek Non-gradient and genotype-dependent patterns of RSV gene expression
Článek The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis
Článek Parasites modulate the gut-microbiome in insects: A proof-of-concept study
Článek The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature
Článek Vascularization and biocompatibility of poly(ε-caprolactone) fiber mats for rotator cuff tear repair
Článek The shield of self-compassion: A buffer against disordered eating risk from physical appearance perfectionism
Článek Disease-specific out-of-pocket healthcare expenditure in urban Bangladesh: A Bayesian analysis
Článek Advanced biofilm analysis in streams receiving organic deicer runoff
Článek Upregulation of long non-coding RNA ROR1-AS1 promotes cell growth and migration in bladder cancer by regulation of miR-504
Článek Method development and validation for rapid identification of epigallocatechin gallate using ultra-high performance liquid chromatography
Článek Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens
Článek Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study
Článek Same-day antiretroviral therapy initiation for HIV-infected adults in South Africa: Analysis of routine data
Článek Health-related quality of life among patients with type 2 diabetes mellitus in Eastern Province, Saudi Arabia: A cross-sectional study
Článek Photocatalytic biocidal effect of copper doped TiO2 nanotube coated surfaces under laminar flow, illuminated with UVA light on Legionella pneumophila
Článek The interoceptive hippocampus: Mouse brain endocrine receptor expression highlights a dentate gyrus (DG)–cornu ammonis (CA) challenge–sufficiency axis
Článek Educational attainment and HIV testing and counselling service utilisation during antenatal care in Ghana: Analysis of Demographic and Health Surveys
Článek Dissection of flag leaf metabolic shifts and their relationship with those occurring simultaneously in developing seed by application of non-targeted metabolomics
Článek Centromeres of Cucumis melo L. comprise Cmcent and two novel repeats, CmSat162 and CmSat189
Článek Acute high-intensity and moderate-intensity interval exercise do not change corticospinal excitability in low fit, young adults
Článek “I like the way I am, but I feel like I could get a little bit bigger”: Perceptions of body image among adolescents and youth living with HIV in Durban, South Africa
Článek Nanoparticle-based ‘turn-on’ scattering and post-sample fluorescence for ultrasensitive detection of water pollution in wider window
Článek The relationship of moral sensitivity and patient safety attitudes with nursing students’ perceptions of disclosure of patient safety incidents: A cross-sectional study
Článek Insights into the strategy of micro-environmental adaptation: Transcriptomic analysis of two alvinocaridid shrimps at a hydrothermal vent
Článek Thirty-day readmission after medical-surgical hospitalization for people who experience imprisonment in Ontario, Canada: A retrospective cohort study
Článek The effect of long-term brine discharge from desalination plants on benthic foraminifera
Článek Hyper-spectral response and estimation model of soil degradation in Kenli County, the Yellow River Delta
Článek Prescribing trends of glaucoma drugs in six major cities of China from 2013 to 2017
Článek Significant changes in synovial fluid microRNAs after high tibial osteotomy in medial compartmental knee osteoarthritis: Identification of potential prognostic biomarkers
Článek Reassortment and adaptive mutations of an emerging avian influenza virus H7N4 subtype in China
Článek Ischemia and reperfusion injury in superficial inferior epigastric artery-based vascularized lymph node flaps
Článek High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania – A prospective cohort study
Článek Switchable resolution in soft x-ray tomography of single cells
Článek Mitochondrial DNA variations and mitochondrial dysfunction in Fanconi anemia
Článek Extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing Escherichia coli isolates causing bacteremia in the Netherlands (2014 – 2016) differ in clonal distribution, antimicrobial resistance gene and virulence gene content
Článek Molecular characterization of blaKHM-1 encoding plasmid in an Enterobacter hormaechei subsp. hoffmannii isolate from blood culture
Článek PR3 levels are impaired in plasma and PBMCs from Arabs with cardiovascular diseases
Článek Sex differences in self-regulation in early, middle and late adolescence: A large-scale cross-sectional study
Článek Interaction between elevated temperature and different types of Na-salicylate treatment in Brachypodium dystachion
Článek A highway crash risk assessment method based on traffic safety state division
Článek A brain connectivity characterization of children with different levels of mathematical achievement based on graph metrics
Článek Quantifying the level of difficulty to treat major depressive disorder with antidepressants: Treatment Resistance to Antidepressants Evaluation Scale
Článek Occupational gender segregation and economic growth in U.S. local labor markets, 1980 through 2010
Článek The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome
Článek Construction of a high-density genetic map and fine mapping of a candidate gene locus for a novel branched-spike mutant in barley
Článek Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease
Článek Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer
Článek Deep2Full: Evaluating strategies for selecting the minimal mutational experiments for optimal computational predictions of deep mutational scan outcomes
Článek Economic compensation interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review and meta-analysis
Článek Distinctive effect of anesthetics on the effect of limb remote ischemic postconditioning following ischemic stroke
Článek Natural hybridization between Phyllagathis and Sporoxeia species produces a hybrid without reproductive organs
Článek Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder
Článek The impact of peer attachment on prosocial behavior, emotional difficulties and conduct problems in adolescence: The mediating role of empathy
Článek Spatial and climatic variables independently drive elevational gradients in ant species richness in the Eastern Himalaya
Článek What is the qualitative evidence concerning the risks, diagnosis, management and consequences of gastrointestinal infections in the community in the United Kingdom? A systematic review and meta-ethnography
Článek Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress
Článek Key barriers and enablers associated with uptake and continuation of oral pre-exposure prophylaxis (PrEP) in the public sector in Zimbabwe: Qualitative perspectives of general population clients at high risk for HIV
Článek Characterizing the University of California’s tenure-track teaching position from the faculty and administrator perspectives
Článek Restoration of Mal overcomes the defects of apoptosis in lung cancer cells
Článek Patient preferences for maintenance therapy in Crohn’s disease: A discrete-choice experiment
Článek Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
Článek Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation
Článek Accuracy of intraocular lens power calculation formulas using a swept-source optical biometer
Článek Characterization of black patina from the Tiber River embankments using Next-Generation Sequencing
Článek Comparison of blood lactate and perceived exertion responses in two matched time-under-tension protocols
Článek Fibrin hydrogels are safe, degradable scaffolds for sub-retinal implantation
Článek Post-translational modifications of Drosophila melanogaster HOX protein, Sex combs reduced
Článek Problem gambling, associations with comorbid health conditions, substance use, and behavioural addictions: Opportunities for pathways to treatment
Článek Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production
Článek Characterization of METTL16 as a cytoplasmic RNA binding protein
Článek Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples
Článek Nanosheet wrapping-assisted coverslip-free imaging for looking deeper into a tissue at high resolution
Článek Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
Článek Early diagnosis of sepsis in emergency departments, time to treatment, and association with mortality: An observational study
Článek Validity of cerebrovascular ICD-9-CM codes in healthcare administrative databases. The Umbria Data-Value Project
Článek Tuberculoid leprosy: An in vivo microvascular evaluation of cutaneous lesions
Článek Neuromuscular blockers in the acute respiratory distress syndrome: A meta-analysis
Článek Identification of putative Type-I sex pheromone biosynthesis-related genes expressed in the female pheromone gland of Streltzoviella insularis
Článek Redefining transcriptional regulation of the APOE gene and its association with Alzheimer’s disease
Článek Disease-relevant mutations alter amino acid co-evolution networks in the second nucleotide binding domain of CFTR
Článek A bushel of viruses: Identification of seventeen novel putative viruses by RNA-seq in six apple trees
Článek Torque teno virus viral load is related to age, CMV infection and HLA type but not to Alzheimer's disease
Článek The variability of bacterial communities in both the endosphere and ectosphere of different niches in Chinese chives (Allium tuberosum)
Článek Tripartite factors leading to molecular divergence between human and murine smooth muscle
Článek Characterization of dermal skin innervation in fibromyalgia syndrome
Článek A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy
Článek A scoping review of importation and predictive models related to vector-borne diseases, pathogens, reservoirs, or vectors (1999–2016)
Článek Assessment of climate change impact on the malaria vector Anopheles hyrcanus, West Nile disease, and incidence of melanoma in the Vojvodina Province (Serbia) using data from a regional climate model
Článek Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship
Článek Healthcare utilization of Mexican-American Medicare beneficiaries with and without Alzheimer’s disease and related dementias
Článek Evaluation of questionnaire as an instrument to measure the level of nutritional and weight gain knowledge in pregnant women in Poland. A pilot study
Článek TranCEP: Predicting the substrate class of transmembrane transport proteins using compositional, evolutionary, and positional information
Článek Non-Invasive Functional-Brain-Imaging with an OPM-based Magnetoencephalography System
Článek Expression of acyl-CoA-binding protein 5 from Rhodnius prolixus and its inhibition by RNA interference
Článek Transforming assessment of speech in children with cleft palate via online crowdsourcing
Článek High prevalence of off-label and unlicensed paediatric prescribing in a hospital in Indonesia during the period Aug.—Oct. 2014
Článek General practice management of rotator cuff related shoulder pain: A reliance on ultrasound and injection guided care
Článek Estimating the population size of female sex workers and transgender women  in Sri Lanka
Článek Can helmet decrease mortality of craniocerebral trauma patients in a motorcycle accident?: A propensity score matching
Článek Obesity, smoking habits, and serum phosphate levels predicts mortality after life-style intervention
Článek Treatment of children under 4 years of age with medulloblastoma and ependymoma in the HIT2000/HIT-REZ 2005 trials: Neuropsychological outcome 5 years after treatment
Článek Can a semi-quantitative method replace the current quantitative method for the annual screening of microalbuminuria in patients with diabetes? Diagnostic accuracy and cost-saving analysis considering the potential health burden
Článek A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1)
Článek Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age
Článek Burden and risk factors of cutaneous leishmaniasis in a peri-urban settlement in Kenya, 2016
Článek Predicting strike susceptibility and collision patterns of the common buzzard at wind turbine structures in the federal state of Brandenburg, Germany
Článek Embryonic thermal manipulation has short and long-term effects on the development and the physiology of the Japanese quail
Článek High-order radiomics features based on T2 FLAIR MRI predict multiple glioma immunohistochemical features: A more precise and personalized gliomas management
Článek Human-raptor conflict in rural settlements of Colombia
Článek Regional adaptations and parallel mutations in Feline panleukopenia virus strains from China revealed by nearly-full length genome analysis
Článek Long-term ecological research in southern Brazil grasslands: Effects of grazing exclusion and deferred grazing on plant and arthropod communities
Článek Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer
Článek Survival analysis of 230 patients with unresectable hepatocellular carcinoma treated with bland transarterial embolization
Článek Adverse drug reaction reporting practice and associated factors among medical doctors in government hospitals in Addis Ababa, Ethiopia
Článek TaWAK6 encoding wall-associated kinase is involved in wheat resistance to leaf rust similar to adult plant resistance
Článek Deficiency syndromes in top predators associated with large-scale changes in the Baltic Sea ecosystem
Článek The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice
Článek Allele specific expression of Dof genes responding to hormones and abiotic stresses in sugarcane
Článek Perceived relative social status and cognitive load influence acceptance of unfair offers in the Ultimatum Game
Článek Quantitative evaluation of choriocapillaris using optical coherence tomography and optical coherence tomography angiography in patients with central serous chorioretinopathy after half-dose photodynamic therapy
Článek Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties
Článek Extracting lung function measurements to enhance phenotyping of chronic obstructive pulmonary disease (COPD) in an electronic health record using automated tools
Článek Multiple fragmented habitat-patch use in an urban breeding passerine, the Short-toed Treecreeper
Článek Histological and immunohistochemical characterization of the porcine ocular surface
Článek Household environmental tobacco smoke exposure in healthy young children in Hong Kong: Prevalence and risk factors
Článek Wind energy development and wildlife conservation in Lithuania: A mapping tool for conflict assessment
Článek Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study
Článek Effect of epoch length on intensity classification and on accuracy of measurement under controlled conditions on treadmill: Towards a better understanding of accelerometer measurement
Článek Peer distribution of HIV self-test kits to men who have sex with men to identify undiagnosed HIV infection in Uganda: A pilot study
Článek Error rates of human reviewers during abstract screening in systematic reviews
Článek Faecal analyses and alimentary tracers reveal the foraging ecology of two sympatric bats
Článek Urethral realignment with maximal urethral length and bladder neck preservation in robot-assisted radical prostatectomy: Urinary continence recovery
Článek Error metrics determination in functionally approximated circuits using SAT solvers
Článek Spatial movement pattern recognition in soccer based on relative player movements
Článek A novel visual ranking system based on arterial spin labeling perfusion imaging for evaluating perfusion disturbance in patients with ischemic stroke
Článek Prospective Validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score for Necrotizing Fasciitis of the Extremities
Článek The importance of transporters and cell polarization for the evaluation of human stem cell-derived hepatic cells
Článek Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: A nationwide study
Článek Morphological and functional characteristics of mitral annular calcification and their relationship to stroke
Článek And the nominees are: Using design-awards datasets to build computational aesthetic evaluation model
Článek Service delivery interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review
Článek Multidimensional Scales of Perceived Self-Efficacy (MSPSE): Measurement invariance across Italian and Colombian adolescents
Článek Diversity of Mycobacteriaceae from aquatic environment at the São Paulo Zoological Park Foundation in Brazil
Článek A graph-based algorithm for RNA-seq data normalization
Článek Parents’ underestimation of their child’s weight status. Moderating factors and change over time: A cross-sectional study
Článek Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs
Článek Spatial variation in fertilizer prices in Sub-Saharan Africa
Článek Knowledge, beliefs, and concerns about bone health from a systematic review and metasynthesis of qualitative studies
Článek Successful isolation of Treponema pallidum strains from patients’ cryopreserved ulcer exudate using the rabbit model
Článek Effects of size and elasticity on the relation between flow velocity and wall shear stress in side-wall aneurysms: A lattice Boltzmann-based computer simulation study
Článek Pupil response to noxious corneal stimulation
Článek Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients
Článek The impact of computed radiography and teleradiology on patients’ diagnosis and treatment in Mweso, the Democratic Republic of Congo
Článek Differential effects of synthetic psychoactive cathinones and amphetamine stimulants on the gut microbiome in mice
Článek Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in Chile: A cross-sectional serosurvey
Článek Increased episodes of aspiration on videofluoroscopic swallow study in children with nasogastric tube placement
Článek Obstructive sleep apnea and hypopnea syndrome in patients admitted in a tertiary hospital in Cameroon: Prevalence and associated factors
Článek Association of single nucleotide polymorphisms with dyslipidemia in antiretroviral exposed HIV patients in a Ghanaian population: A case-control study
Článek Sonic Hedgehog upregulation does not enhance the survival and engraftment of stem cell-derived cardiomyocytes in infarcted hearts
Článek The pharmacokinetic parameters and the effect of a single and repeated doses of memantine on gastric myoelectric activity in experimental pigs
Článek Blind method for discovering number of clusters in multidimensional datasets by regression on linkage hierarchies generated from random data
Článek Predictive factors of first dosage intravenous immunoglobulin-related adverse effects in children
Článek Description and characterization of the artisanal elasmobranch fishery on Guatemala’s Caribbean coast
Článek Individual and community level determinants of short birth interval in Ethiopia: A multilevel analysis
Článek Effects of rejection intensity and rejection sensitivity on social approach behavior in women
Článek The impact of IoT security labelling on consumer product choice and willingness to pay
Článek The development and validation of a measurement instrument to investigate determinants of health care utilisation for low back pain in Ethiopia
Článek Validity of the French version of the Autonomy Preference Index and its adaptation for patients with advanced cancer
Článek The epidemiological characteristics and spatio-temporal analysis of childhood hand, foot and mouth disease in Korea, 2011-2017
Článek Exponential random graph model parameter estimation for very large directed networks
Článek The implementation of community-based diabetes and hypertension management care program in Indonesia
Článek Effect of temperature variation on hospital admissions and outcomes in dogs with myxomatous mitral valve disease and new onset pulmonary edema
Článek The development of the Police Practices Scale: Understanding policing approaches towards street-based female sex workers in a U.S. City
Článek A capability approach to assess aquaculture sustainability standard compliance
Článek Pre-collecting lymphatic vessels form detours following obstruction of lymphatic flow and function as collecting lymphatic vessels
Článek Construct validity and reliability of the Talent Development Environment Questionnaire in Caribbean youth track and field athletes
Článek Optimization of cytotoxic activity of Nocardia sp culture broths using a design of experiments
Článek Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during substance P-mediated neurogenic inflammation ex vivo
Článek Microbiota in foods from Inuit traditional hunting
Článek Investigating Italian disinformation spreading on Twitter in the context of 2019 European elections
Článek In vivo expression of peptidylarginine deiminase in Drosophila melanogaster
Článek Modelling zero-truncated overdispersed antenatal health care count data of women in Bangladesh
Článek Detection and density of breeding marsh birds in Iowa wetlands
Článek A lineage-specific rapid diagnostic test (Chagas Sero K-SeT) identifies Brazilian Trypanosoma cruzi II/V/VI reservoir hosts among diverse mammalian orders
Článek Aromatase deficiency in hematopoietic cells improves glucose tolerance in male mice through skeletal muscle-specific effects
Článek If host is refractory, insistent parasite goes berserk: Trypanosomatid Blastocrithidia raabei in the dock bug Coreus marginatus
Článek Antimicrobial resistance patterns and molecular resistance markers of Campylobacter jejuni isolates from human diarrheal cases
Článek Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients
Článek An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury
Článek Prevalence of antiphospholipid antibodies in Behçet's disease: A systematic review and meta-analysis
Článek Chemical analysis of snus products from the United States and northern Europe
Článek Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry
Článek Impact of early-onset persistent stunting on cognitive development at 5 years of age: Results from a multi-country cohort study
Článek Aggregation of CAT tails blocks their degradation and causes proteotoxicity in S. cerevisiae
Článek Expression of concern: Compensatory increase of transglutaminase 2 is responsible for resistance to mTOR inhibitor treatment
Článek Common mental illness among epilepsy patients in Bahir Dar city, Ethiopia: A cross-sectional study
Článek Staging dementia based on caregiver reported patient symptoms: Implications from a latent class analysis
Článek Health-related quality of life and its determinants among ambulatory patients with epilepsy at Ambo General Hospital, Ethiopia: Using WHOQOL-BREF
Článek In silico analysis and high-risk pathogenic phenotype predictions of non-synonymous single nucleotide polymorphisms in human Crystallin beta A4 gene associated with congenital cataract
Článek Fungal diversity in canopy soil of silver beech, Nothofagus menziesii (Nothofagaceae)
Článek Referral decisions and its predictors related to orthopaedic care.  A retrospective study in a novel primary care setting
Článek Readiness to prescribe: Using educational design to untie the Gordian Knot
Článek Influence of gelation on the retention of purple cactus pear extract in microencapsulated double emulsions
Článek Factors related to met needs for rehabilitation 6 years after stroke
Článek Association of cataract and sun exposure in geographically diverse populations of India: The CASE study. First Report of the ICMR-EYE SEE Study Group
Článek Investigation of injury severity in urban expressway crashes: A case study from Beijing
Článek Clinical outcomes of incident peritoneal dialysis patients coming from kidney transplantation program: A case-control study
Článek Evaluation of the factors influencing the housing safety awareness of residents in Shanghai
Článek Morphometric study of the diaphragmatic surface of the liver in the human fetus
Článek Food insecurity and dietary diversity among lactating mothers in the urban municipality in the mountains of Nepal
Článek Genetic characterization of Bacillus anthracis strains circulating in Italy from 1972 to 2018
Článek Promising antifungal activity of new oxadiazole against Candida krusei
Článek An atlas of personality, emotion and behaviour
Článek Long-term effects of intracranial islet grafting on cognitive functioning in a rat metabolic model of sporadic Alzheimer's disease-like dementia
Článek Compartmentalized profiling of amniotic fluid cytokines in women with preterm labor
Článek Comparison of the myometrial transcriptome from singleton and twin pregnancies by RNA-Seq
Článek Adverse reproductive effects of S100A9 on bovine sperm and early embryonic development in vitro
Článek Functional dynamics of bacterial species in the mouse gut microbiome revealed by metagenomic and metatranscriptomic analyses
Článek Astrocyte senescence promotes glutamate toxicity in cortical neurons
Článek Primary ciliary dyskinesia and psychological well-being in adolescence
Článek Dipeptidyl peptidase-4 is increased in the abdominal aortic aneurysm vessel wall and is associated with aneurysm disease processes
Článek Primary care physician knowledge, attitudes, and diagnostic testing practices for norovirus and acute gastroenteritis
Článek Microfluidic-prepared DOTAP nanoparticles induce strong T-cell responses in mice
Článek Intraocular scattering as a predictor of driving performance in older adults with cataracts
Článek Reduced bone mineral density among HIV infected patients on anti-retroviral therapy in Blantyre, Malawi: Prevalence and associated factors
Článek Correction: Extraversion personality, perceived health and activity participation among community-dwelling aging adults in Hong Kong
Článek A rainwater control optimization design approach for airports based on a self-organizing feature map neural network model
Článek Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility
Článek 18F-FDG-PET/MRI in the diagnostic work-up of limbic encephalitis
Článek The socioeconomic impact of orthopaedic trauma: A systematic review and meta-analysis
Článek Treatment patterns among patients with moderate-to-severe ulcerative colitis in the United States and Europe
Článek City to city learning and knowledge exchange for climate resilience in southern Africa
Článek Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer
Článek Activity-dependent switches between dynamic regimes of extracellular matrix expression
Článek Molecular sequencing and morphological identification reveal similar patterns in native bee communities across public and private grasslands of eastern North Dakota
Článek A mathematical model for assessing the effectiveness of controlling relapse in Plasmodium vivax malaria endemic in the Republic of Korea
Článek Cryo-focused ion beam preparation of perovskite based solar cells for atom probe tomography
Článek Physiological and transcriptomic responses of Lanzhou Lily (Lilium davidii, var. unicolor) to cold stress
Článek Unusual genome expansion and transcription suppression in ectomycorrhizal Tricholoma matsutake by insertions of transposable elements
Článek Estimating associations between antidepressant use and incident mild cognitive impairment in older adults with depression
Článek The use of telephone communication between nurse navigators and their patients
Článek CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction
Článek HIV RNA measurement in dried blood spots of HIV-infected patients in Thailand using Abbott m2000 system
Článek Retraction: Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis
Článek Ultra-rapid cooling of ibex sperm by spheres method does not induce a vitreous extracellular state and increases the membrane damages
Článek Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use
Článek Observation and quantification of the morphological effect of trypan blue rupturing dead or dying cells
Článek The visual perception of emotion from masks
Článek Hexavalent chromium removal and total chromium biosorption from aqueous solution by Quercus crassipes acorn shell in a continuous up-flow fixed-bed column: Influencing parameters, kinetics, and mechanism
Článek The predictive value of anthropometric indices for cardiometabolic risk factors in Chinese children and adolescents: A national multicenter school-based study
Článek Lean back and wait for the alarm? Testing an automated alarm system for nosocomial outbreaks to provide support for infection control professionals
Článek Regional disparities in health care resources in traditional Chinese medicine county hospitals in China
Článek Analysis on hydraulic characteristics of improved sandy soil with soft rock
Článek Development and use of a scale to assess gender differences in appraisal of mistreatment during childbirth among Ethiopian midwifery students
Článek Factors for starting biosimilar TNF inhibitors in patients with rheumatic diseases in the real world
Článek Correction: Force field generalization and the internal representation of motor learning
Článek Prevalence and foetomaternal effects of iron deficiency anaemia among pregnant women in Lagos, Nigeria
Článek Socioeconomic risk factors for fatal opioid overdoses in the United States: Findings from the Mortality Disparities in American Communities Study (MDAC)
Článek Microbiome signatures in neonatal central line associated bloodstream infections
Článek Interventions for incarcerated adults with opioid use disorder in the United States: A systematic review with a focus on social determinants of health
Článek Opening gap width influences distal tibial rotation below the osteotomy site following open wedge high tibial osteotomy
Článek The impact of lowbush blueberry (Vaccinium angustifolium Ait.) and cranberry (Vaccinium macrocarpon Ait.) pollination on honey bee (Apis mellifera L.) colony health status
Článek Surveys of knowledge and awareness of antibiotic use and antimicrobial resistance in general population: A systematic review
Článek Managerial capacity among district health managers and its association with district performance: A comparative descriptive study of six districts in the Eastern Region of Ghana
Článek Knee joint distraction in regular care for treatment of knee osteoarthritis: A comparison with clinical trial data
Článek Reconstruction of a regulated two-cell metabolic model to study biohydrogen production in a diazotrophic cyanobacterium Anabaena variabilis ATCC 29413
Článek Cochlear dysfunction is associated with styrene exposure in humans
Článek Intra-individual variation of particles in exhaled air and of the contents of Surfactant protein A and albumin
Článek Revisits, readmissions, and outcomes for pediatric traumatic brain injury in California, 2005-2014
Článek Enhanced handover mechanism using mobility prediction in wireless networks
Článek Association between regular exercise and asthma control among adults: The population-based Northern Finnish Asthma Study
Článek Pharyngeal microbiome alterations during Neisseria gonorrhoeae infection
Článek Assessment of the clinical utility of four NGS panels in myeloid malignancies. Suggestions for NGS panel choice or design
Článek Assessment of time management practice and associated factors among primary hospitals employees in north Gondar, northwest Ethiopia
Článek Genetic diversity and population structure of feral rapeseed (Brassica napus L.) in Japan
Článek Are the current gRNA ranking prediction algorithms useful for genome editing in plants?
Článek Difference between physical therapist estimation and psychological patient-reported outcome measures in patients with low back pain
Článek Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness
Článek Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies
Článek Investigating cumulative effects of pre-performance routine interventions in beach volleyball serving
Článek Dispensing of antibiotics without prescription and associated factors in drug retail outlets of Eritrea: A simulated client method
Článek MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma
Článek Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression—An in vitro study
Článek Cytoplasmic factories, virus assembly, and DNA replication kinetics collectively constrain the formation of poxvirus recombinants
Článek The wavelet power spectrum of perfusion weighted MRI correlates with tumor vascularity in biopsy-proven glioblastoma samples
Článek Agreement between cardiovascular disease risk assessment tools: An application to the United Arab Emirates population
Článek Constructing HLM to examine multi-level poverty-contributing factors of farmer households: Why and how?
Článek Patterns of symptoms possibly indicative of cancer and associated help-seeking behaviour in a large sample of United Kingdom residents—The USEFUL study
Článek An automated alarm system for food safety by using electronic invoices
Článek Neural effects of acute stress on appetite: A magnetoencephalography study
Článek Use of magnetic resonance imaging to determine laterality of meniscal size in healthy volunteers
Článek Co-prevalence of extracranial carotid aneurysms differs between European intracranial aneurysm cohorts
Článek Thermal biology of two tropical lizards from the Ecuadorian Andes and their vulnerability to climate change
Článek When weight is an encumbrance; avoidance of stairs by different demographic groups
Článek Non-mycosis fungoides cutaneous lymphomas in a referral center in Taiwan: A retrospective case series and literature review
Článek From the host's point of view: Effects of variation in burying beetle brood care and brood size on the interaction with parasitic mites
Článek Kernel-based Gaussian process for anomaly detection in sparse gamma-ray data
Článek Unmet care needs of children with ADHD
Článek Accelerometer-assessed outdoor physical activity is associated with meteorological conditions among older adults: Cross-sectional results from the OUTDOOR ACTIVE study
Článek Identification of Korean cancer survivors’ unmet needs and desired psychosocial assistance: A focus group study
Článek Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A
Článek The role of moral reasoning & personality in explaining lyrical preferences
Článek Would you like to participate in this trial? The practice of informed consent in intrapartum research in the last 30 years
Článek Correction: Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
Článek Forward lunge before and after anterior cruciate ligament reconstruction: Faster movement but unchanged knee joint biomechanics
Článek Challenges associated with homologous directed repair using CRISPR-Cas9 and TALEN to edit the DMD genetic mutation in canine Duchenne muscular dystrophy
Článek Integrated targeted serum metabolomic profile and its association with gender, age, disease severity, and pattern identification in acne
Článek A prospective case-control study on miRNA circulating levels in subjects born small for gestational age (SGA) evaluated from childhood into young adulthood
Článek Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings
Článek Global depth perception alters local timing sensitivity
Článek How to detect a polytrauma patient at risk of complications: A validation and database analysis of four published scales
Článek Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing
Článek Reduced gray matter volume and cortical thickness associated with traffic-related air pollution in a longitudinally studied pediatric cohort
Článek Recombinant human soluble thrombomodulin is associated with attenuation of sepsis-induced renal impairment by inhibition of extracellular histone release
Článek Human and climatic drivers affect spatial fishing patterns in a multiple-use marine protected area: The Galapagos Marine Reserve
Článek Correction: Leisure-time physical activity and sports in the Brazilian population: A social disparity analysis
Článek Application of the mixture item response theory model to the Self-Administered Food Security Survey Module for Children
Článek Numerical simulation of atmospheric CO2 concentration and flux over the Korean Peninsula using WRF-VPRM model during Korus-AQ 2016 campaign
Článek Feline irradiated diet-induced demyelination; a model of the neuropathology of sub-acute combined degeneration?
Článek Improved multi-parametric prediction of tissue outcome in acute ischemic stroke patients using spatial features
Článek Genome-wide association and epistatic interactions of flowering time in soybean cultivar
Článek Correction: Association between workplace bullying and burnout, professional quality of life, and turnover intention among clinical nurses
Článek Correction: Estimation of membrane bending modulus of stiffness tuned human red blood cells from micropore filtration studies
Článek Correction: Limited indirect effects of an infant pneumococcal vaccination program in an aging population
Článek Correction: Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats
Článek Fieldwork-based determination of design priorities for point-of-use drinking water quality sensors for use in resource-limited environments
Článek Young women’s reproductive health conversations: Roles of maternal figures and clinical practices
Článek Correction: Differential recordings of local field potential: A genuine tool to quantify functional connectivity
Článek Survival of medial versus lateral unicompartmental knee arthroplasty: A meta-analysis
Článek Novel MscL agonists that allow multiple antibiotics cytoplasmic access activate the channel through a common binding site
Článek Is it time to stop sweeping data cleaning under the carpet? A novel algorithm for outlier management in growth data
Článek Changes in oak (Quercus robur) photosynthesis after winter moth (Operophtera brumata) herbivory are not explained by changes in chemical or structural leaf traits
Článek Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study
Článek Evaluation of liposomal ciprofloxacin formulations in a murine model of anthrax
Článek Analysis of cholesterol in mouse brain by HPLC with UV detection
Článek Sugar, amino acid and inorganic ion profiling of the honeydew from different hemipteran species feeding on Abies alba and Picea abies
Článek Exploring prior diseases associated with incident late-onset Alzheimer’s disease dementia
Článek Hypertension prevalence in patients attending tertiary pain management services, a registry-based Australian cohort study
Článek SRL pathogenicity island contributes to the metabolism of D-aspartate via an aspartate racemase in Shigella flexneri YSH6000
Článek Correction: Comprehensive genome-wide analysis of the pear (Pyrus bretschneideri) laccase gene (PbLAC) family and functional identification of PbLAC1 involved in lignin biosynthesis
Článek Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model
Článek Water consumption and prevalence of irritable bowel syndrome among adults
Článek Mixed evidence for the relationship between periodontitis and Alzheimer’s disease: A bidirectional Mendelian randomization study
Článek Correction: Health conditions associated with overweight in climacteric women
Článek Correction: Determining Glomerular Filtration Rate in Homozygous Sickle Cell Disease: Utility of Serum Creatinine Based Estimating Equations
Článek Modelling the number of antenatal care visits in Bangladesh to determine the risk factors for reduced antenatal care attendance
Článek Correction: Cumulative viral load as a predictor of CD4+ T-cell response to antiretroviral therapy using Bayesian statistical models
Článek Dominant negative effects by inactive Spa47 mutants inhibit T3SS function and Shigella virulence
Článek ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain
Článek Diel patterns in swimming behavior of a vertically migrating deepwater shark, the bluntnose sixgill (Hexanchus griseus)
Článek Life history of northern Gulf of Mexico Warsaw grouper Hyporthodus nigritus inferred from otolith radiocarbon analysis
Článek Physiology education for intensive care medicine residents: A 15-minute interactive peer-led flipped classroom session
Článek Strengthening capacity for natural sciences research: A qualitative assessment to identify good practices, capacity gaps and investment priorities in African research institutions
Článek Systematic scoping review of the concept of ‘genetic identity’ and its relevance for germline modification
Článek Height of overburden fracture based on key strata theory in longwall face
Článek Laboratory strains of Bacillus anthracis lose their ability to rapidly grow and sporulate compared to wildlife outbreak strains
Článek Improvement of classification performance of Parkinson’s disease using shape features for machine learning on dopamine transporter single photon emission computed tomography
Článek Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey
Článek Correction: A handy method to remove bacterial contamination from fungal cultures
Článek Correction: Effect of statin on life prognosis in Japanese patients undergoing hemodialysis
Článek Retraction: Outer Membrane Protein A (OmpA) of Shigella flexneri 2a Induces TLR2-Mediated Activation of B Cells: Involvement of Protein Tyrosine Kinase, ERK and NF-κB
Článek Retraction: Biofabrication of streptomycin-conjugated calcium phosphate nanoparticles using red ginseng extract and investigation of their antibacterial potential
Článek Receiver operating characteristic curve analysis of clinical signs for screening of convergence insufficiency in young adults
Článek Correction: Drivers of deforestation in the basin of the Usumacinta River: Inference on process from pattern analysis using generalised additive models
Článek Efficacy of fertilizing method for different potash sources in cotton (Gossypium hirsutum L.) nutrition under arid climatic conditions
Článek Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome
Článek Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome
Článek Retraction: MiR-30a-5p Antisense Oligonucleotide Suppresses Glioma Cell Growth by Targeting SEPT7
Článek Correction: Dynamics of plasma micronutrient concentrations and their correlation with serum proteins and thyroid hormones in patients with paracoccidioidomycosis
Článek Impact of lower limb osteoarthritis on health-related quality of life: A cross-sectional study to estimate the expressed loss of utility in the Spanish population
Článek Correction: Prevalence of damaged and missing teeth among women in the southern plains of Nepal: Findings of a simplified assessment tool
Článek Correction: Tissue-Specific Expressed Antibody Variable Gene Repertoires
Článek Retraction: Immunoglobulin G Expression in Lung Cancer and Its Effects on Metastasis
Článek Correction: Causal knowledge promotes behavioral self-regulation: An example using climate change dynamics
Článek Retraction: Use of Granulocyte Colony-Stimulating Factor for the Treatment of Thin Endometrium in Experimental Rats
Článek Correction: Dynamic mechanical and nanofibrous topological combinatory cues designed for periodontal ligament engineering
Článek Correction: Evaluating the foundations that help avert antimicrobial resistance: Performance of essential water sanitation and hygiene functions in hospitals and requirements for action in Kenya
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