Clinical implications of elevated serum interleukin-6 in IgG4-related disease

English version

Autoři: Satoshi Tsukuda ^aff001; Tsukasa Ikeura ^aff001; Takashi Ito ^aff001; Koh Nakamaru ^aff001; Masataka Masuda ^aff001; Yuichi Hori ^aff001; Manami Ikemune ^aff001; Masato Yanagawa ^aff001; Toshihiro Tanaka ^aff001; Takashi Tomiyama ^aff001; Takashi Yamaguchi ^aff001; Yugo Ando ^aff001; Kazushige Uchida ^aff002; Toshiro Fukui ^aff001; Akiyoshi Nishio ^aff001; Rika Terasawa ^aff003; Noboru Tanigawa ^aff003; Kazuichi Okazaki ^aff001
Působiště autorů: Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka, Japan ^aff001; Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan ^aff002; Department of Radiology, Kansai Medical University, Hirakata, Osaka, Japan ^aff003
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0227479

Souhrn

Introduction

Some patients with IgG4-related disease (IgG4-RD) exhibit elevated serum interleukin (IL)-6 with excessive inflammatory reactions or with repeating relapse. To date few reports pertaining to clinical implications of elevated serum IL-6 in IgG4-RD patients have been published. The aims of the current retrospective study were to investigate the clinical implications of elevated serum IL-6 in IgG4-RD patients, and to examine whether IL-6 can predict the activity and/or relapse of the disease.

Materials and methods

We examined the clinical picture at the onset of 43 patients who were diagnosed with IgG4-RD in our hospital and were able to measure serum IL-6 before steroid treatment.

Results

The median level of serum IL-6 was 2.2 pg/mL. There was a significant correlation between IL-6 and C-reactive protein (CRP) level (r = 0.397, p = 0.008), hemoglobin level (r = -0.390, p = 0.010) and albumin level (r = -0.556, p < 0.001). When 43 patients were divided into two groups by using a cut-off IL-6 of 4 pg/mL, the high IL-6 group showed higher age, lower albumin, higher CRP and higher aspartate aminotransferase (AST) (age p = 0.014, albumin p = 0.006, CRP p <0.001, AST p = 0.009). Hepatic swelling and splenomegaly were significantly more prevalent in the high IL-6 group than it was in the low IL-6 group (liver p < 0.001, spleen p = 0.020). Biliary tract involvement tended to admit more in the high IL-6 group (p = 0.060).

Conclusion

Serum IL-6 level at the onset of IgG4-RD may be significantly correlated with clinical inflammatory parameters and it may also be associated with involvement of the bile duct, liver, and spleen.

Klíčová slova:

Albumins – Diagnostic medicine – Hemoglobin – Kidneys – Pancreas – Spleen – Steroid therapy – Splenomegaly

Zdroje

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Clinical implications of elevated serum interleukin-6 in IgG4-related disease

Souhrn

Introduction

Materials and methods

Results

Conclusion

Klíčová slova:

Zdroje

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