Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis
Autoři:
Tara C. Bouton aff001; Margaretha de Vos aff002; Elizabeth J. Ragan aff004; Laura F. White aff005; Leonie Van Zyl aff006; Danie Theron aff006; C. Robert Horsburgh aff007; Robin M. Warren aff002; Karen R. Jacobson aff004
Působiště autorů:
Division of Infectious Diseases, Brown University Alpert School of Medicine, Providence, RI, United States of America
aff001; Department of Science and Technology, National Research Foundation Centre of Excellence in Biomedical Tuberculosis Research, South Africa Medical Research Council for Tuberculosis Research, Cape Town, South Africa
aff002; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
aff003; Section of Infectious Diseases, Boston University School of Medicine, Boston, MA, United States of America
aff004; Department of Biostatistics Boston University School of Public Health, Boston, MA, United States of America
aff005; Brewelskloof Hospital, Worcester, South Africa
aff006; Department of Medicine, Boston University School of Medicine, Boston, MA, United States of America
aff007; Departments of Epidemiology, Biostatistics and Global Health, Boston University School of Public Health, Boston, MA, United States of America
aff008
Vyšlo v časopise:
PLoS ONE 14(10)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0223308
Souhrn
South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysfunction) rather than drug resistance.
Klíčová slova:
Deafness – Drug screening – Drug therapy – Extensively drug-resistant tuberculosis – Multi-drug-resistant tuberculosis – Toxicity – Tuberculosis
Zdroje
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Článek vyšel v časopise
PLOS One
2019 Číslo 10
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