#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Magnetic resonance imaging presentation of deep infiltrating endometriosis nodules before and after pregnancy: A case series


Autoři: Anne Elodie Millischer aff001;  Louis Marcellin aff002;  Pietro Santulli aff002;  Chloe Maignien aff002;  Mathilde Bourdon aff002;  Bruno Borghese aff002;  François Goffinet aff005;  Charles Chapron aff002
Působiště autorů: Centre de Radiologie IMPC Bachaumont Pole femme-mere-enfant, Paris, France aff001;  Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Assistance Publique–Hôpitaux de Paris (AP-HP), Service de Chirurgie Gynécologie Obstétrique II et Médecine de la Reproduction, Hôpital Universitaire Paris Centre (HUPC), Centre Hospital aff002;  Equipe Stress Oxydant, Prolifération Cellulaire et Inflammation, Département Développement, Reproduction, Cancer, Inserm U1016, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, AP-HP, HUPC, CHU Cochin, Paris, France aff003;  Equipe Génomique, Epigénétique et Physiopathologie de la Reproduction, Département Développement, Reproduction, Cancer, Inserm U1016, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, AP-HP, HUPC, CHU Cochin, Paris, France aff004;  Port Royal Maternity Unit, Cochin Hospital, Assistance Publique des Hôpitaux de Paris, DHU Risks and Pregnancy, Paris Descartes University, Paris, France aff005
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0223330

Souhrn

Objective

To compare the magnetic resonance imaging (MRI) features of deep infiltrating endometriosis (DIE) lesions before and after pregnancy.

Design

Retrospective study.

Setting

A single French university tertiary referral hospital.

Patients

Twenty-one women without a prior history of surgery for endometriosis with a radiological diagnosis by MRI with two sets of examinations performed before and after pregnancy.

Interventions

The volumes of the lesions were compared using the same protocol before and after pregnancy based on MRI (1.5 T) examinations by a single experienced radiologist who is a referring practitioner for image-based diagnosis of endometriosis.

Main outcome measure(s)

The DIE lesion volume.

Measurements and main results

Between October 2012 and December 2016, a total of 21 patients (67 lesions) were included and compared before and after pregnancy. The mean time interval between the MRI before pregnancy and delivery was 19.6 ± 8.5 months (median: 17.6, IQR 13.5–25.2 months). The mean time interval between delivery and the MRI after pregnancy was 11.0 ± 6.4 months (median: 8.3, IQR 6–15.2 months). The mean overall DIE lesion volume by MRI was significantly higher before pregnancy compared to after pregnancy (2,552 ± 3,315 mm3 vs. 1,708 ± 3,266 mm3, respectively, p < 0.01). The mean volume by MRI of the largest lesion of each patient was significantly higher before pregnancy compared to after pregnancy (4,728 ± 4,776 mm3 vs. 3165 ± 5299 mm3; p < 0.01).

Conclusion

Our data indicate a favorable impact of pregnancy on DIE lesion volumes as measured by MRI.

Klíčová slova:

Bladder – Hypertensive disorders in pregnancy – Labor and delivery – Lesions – Magnetic resonance imaging – Obstetric procedures – Pregnancy – Surgical and invasive medical procedures


Zdroje

1. de Ziegler D, Borghese B, Chapron C. Endometriosis and infertility: pathophysiology and management. Lancet. 2010;376(9742):730–8. Epub 2010/08/31. S0140-6736(10)60490-4 [pii] doi: 10.1016/S0140-6736(10)60490-4 20801404.

2. Giudice LC. Clinical practice. Endometriosis. The New England journal of medicine. 2010;362(25):2389–98. Epub 2010/06/25. doi: 10.1056/NEJMcp1000274 20573927; PubMed Central PMCID: PMC3108065.

3. Sampson JA. Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation. The American journal of pathology. 1927;3(2):93–110 43. 19969738; PubMed Central PMCID: PMC1931779.

4. Tammaa A, Fritzer N, Lozano P, Krell A, Salzer H, Salama M, et al. Interobserver agreement and accuracy of non-invasive diagnosis of endometriosis by transvaginal sonography. Ultrasound Obstet Gynecol. 2015;46(6):737–40. doi: 10.1002/uog.14843 25766661.

5. Nisenblat V, Bossuyt PM, Farquhar C, Johnson N, Hull ML. Imaging modalities for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev. 2016;2:CD009591. doi: 10.1002/14651858.CD009591.pub2 26919512.

6. Bazot M, Bharwani N, Huchon C, Kinkel K, Cunha TM, Guerra A, et al. European society of urogenital radiology (ESUR) guidelines: MR imaging of pelvic endometriosis. Eur Radiol. 2017;27(7):2765–75. doi: 10.1007/s00330-016-4673-z 27921160; PubMed Central PMCID: PMC5486785.

7. Medeiros LR, Rosa MI, Silva BR, Reis ME, Simon CS, Dondossola ER, et al. Accuracy of magnetic resonance in deeply infiltrating endometriosis: a systematic review and meta-analysis. Arch Gynecol Obstet. 2015;291(3):611–21. doi: 10.1007/s00404-014-3470-7 25288268.

8. Bazot M, Lafont C, Rouzier R, Roseau G, Thomassin-Naggara I, Darai E. Diagnostic accuracy of physical examination, transvaginal sonography, rectal endoscopic sonography, and magnetic resonance imaging to diagnose deep infiltrating endometriosis. Fertil Steril. 2009;92(6):1825–33. doi: 10.1016/j.fertnstert.2008.09.005 19019357.

9. Lessey BA, Kim JJ. Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why. Fertil Steril. 2017;108(1):19–27. Epub 2017/06/13. doi: 10.1016/j.fertnstert.2017.05.031 28602477; PubMed Central PMCID: PMC5629018.

10. Miravet-Valenciano J, Ruiz-Alonso M, Gomez E, Garcia-Velasco JA. Endometrial receptivity in eutopic endometrium in patients with endometriosis: it is not affected, and let me show you why. Fertil Steril. 2017;108(1):28–31. Epub 2017/07/03. doi: 10.1016/j.fertnstert.2017.06.002 28668152.

11. Leeners B, Damaso F, Ochsenbein-Kolble N, Farquhar C. The effect of pregnancy on endometriosis-facts or fiction? Hum Reprod Update. 2018;24(3):290–9. Epub 2018/02/23. doi: 10.1093/humupd/dmy004 29471493.

12. Beecham CT. Surgical treatment of endometriosis with special reference to conservative surgery in young women. J Am Med Assoc. 1949;139(15):971. doi: 10.1001/jama.1949.02900320001001 18113902.

13. Leone Roberti Maggiore U, Ferrero S, Mangili G, Bergamini A, Inversetti A, Giorgione V, et al. A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes. Hum Reprod Update. 2016;22(1):70–103. doi: 10.1093/humupd/dmv045 26450609.

14. Santulli P, Marcellin L, Menard S, Thubert T, Khoshnood B, Gayet V, et al. Increased rate of spontaneous miscarriages in endometriosis-affected women. Hum Reprod. 2016;31(5):1014–23. doi: 10.1093/humrep/dew035 26965434.

15. Kortelahti M, Anttila MA, Hippelainen MI, Heinonen ST. Obstetric outcome in women with endometriosis—a matched case-control study. Gynecol Obstet Invest. 2003;56(4):207–12. doi: 10.1159/000074815 14614250.

16. Fernando S, Breheny S, Jaques AM, Halliday JL, Baker G, Healy D. Preterm birth, ovarian endometriomata, and assisted reproduction technologies. Fertil Steril. 2009;91(2):325–30. doi: 10.1016/j.fertnstert.2008.01.096 18384780.

17. Stephansson O, Kieler H, Granath F, Falconer H. Endometriosis, assisted reproduction technology, and risk of adverse pregnancy outcome. Hum Reprod. 2009;24(9):2341–7. Epub 2009/05/15. doi: 10.1093/humrep/dep186 19439428.

18. Benaglia L, Bermejo A, Somigliana E, Scarduelli C, Ragni G, Fedele L, et al. Pregnancy outcome in women with endometriomas achieving pregnancy through IVF. Hum Reprod. 2012;27(6):1663–7. doi: 10.1093/humrep/des054 22447627.

19. Vercellini P, Parazzini F, Pietropaolo G, Cipriani S, Frattaruolo MP, Fedele L. Pregnancy outcome in women with peritoneal, ovarian and rectovaginal endometriosis: a retrospective cohort study. BJOG. 2012;119(12):1538–43. doi: 10.1111/j.1471-0528.2012.03466.x 22900995.

20. Harada T, Taniguchi F, Onishi K, Kurozawa Y, Hayashi K, Harada T, et al. Obstetrical Complications in Women with Endometriosis: A Cohort Study in Japan. PLoS One. 2016;11(12):e0168476. doi: 10.1371/journal.pone.0168476 28005934; PubMed Central PMCID: PMC5179019.

21. Glavind MT, Forman A, Arendt LH, Nielsen K, Henriksen TB. Endometriosis and pregnancy complications: a Danish cohort study. Fertil Steril. 2017;107(1):160–6. doi: 10.1016/j.fertnstert.2016.09.020 27743699.

22. Saraswat L, Ayansina DT, Cooper KG, Bhattacharya S, Miligkos D, Horne AW, et al. Pregnancy outcomes in women with endometriosis: a national record linkage study. BJOG. 2017;124(3):444–52. Epub 2016/02/19. doi: 10.1111/1471-0528.13920 26887349.

23. Brosens I, Pijnenborg R, Benagiano G. Defective myometrial spiral artery remodelling as a cause of major obstetrical syndromes in endometriosis and adenomyosis. Placenta. 2013;34(2):100–5. doi: 10.1016/j.placenta.2012.11.017 23232321.

24. Brosens I, Pijnenborg R, Vercruysse L, Romero R. The "Great Obstetrical Syndromes" are associated with disorders of deep placentation. Am J Obstet Gynecol. 2011;204(3):193–201. Epub 2010/11/26. doi: 10.1016/j.ajog.2010.08.009 21094932; PubMed Central PMCID: PMC3369813.

25. Marcellin L, Santulli P, Gogusev J, Lesaffre C, Jacques S, Chapron C, et al. Endometriosis also affects the decidua in contact with the fetal membranes during pregnancy. Hum Reprod. 2015;30(2):392–405. doi: 10.1093/humrep/deu321 25432921.

26. Brosens JJ, Parker MG, McIndoe A, Pijnenborg R, Brosens IA. A role for menstruation in preconditioning the uterus for successful pregnancy. Am J Obstet Gynecol. 2009;200(6):615 e1–6. Epub 2009/01/13. doi: 10.1016/j.ajog.2008.11.037 19136085.

27. Sammour RN, Leibovitz Z, Shapiro I, Degani S, Levitan Z, Aharoni A, et al. Decidualization of ovarian endometriosis during pregnancy mimicking malignancy. J Ultrasound Med. 2005;24(9):1289–94. doi: 10.7863/jum.2005.24.9.1289 16123189

28. Schatz F, Guzeloglu-Kayisli O, Arlier S, Kayisli UA, Lockwood CJ. The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. Hum Reprod Update. 2016;22(4):497–515. doi: 10.1093/humupd/dmw004 26912000; PubMed Central PMCID: PMC4917742.

29. Gellersen B, Brosens JJ. Cyclic decidualization of the human endometrium in reproductive health and failure. Endocr Rev. 2014;35(6):851–905. Epub 2014/08/21. doi: 10.1210/er.2014-1045 25141152.

30. Coccia ME, Rizzello F, Palagiano A, Scarselli G. The effect of the hormonal milieu of pregnancy on deep infiltrating endometriosis: serial ultrasound assessment of changes in size and pattern of deep endometriotic lesions. Eur J Obstet Gynecol Reprod Biol. 2012;160(1):35–9. doi: 10.1016/j.ejogrb.2011.10.004 22099535.

31. Vannuccini S, Clifton VL, Fraser IS, Taylor HS, Critchley H, Giudice LC, et al. Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome. Hum Reprod Update. 2016;22(1):104–15. Epub 2015/09/24. doi: 10.1093/humupd/dmv044 26395640.

32. Ueda Y, Enomoto T, Miyatake T, Fujita M, Yamamoto R, Kanagawa T, et al. A retrospective analysis of ovarian endometriosis during pregnancy. Fertil Steril. 2010;94(1):78–84. doi: 10.1016/j.fertnstert.2009.02.092 19356751.

33. Maignien C, Santulli P, Gayet V, Lafay-Pillet MC, Korb D, Bourdon M, et al. Prognostic factors for assisted reproductive technology in women with endometriosis-related infertility. Am J Obstet Gynecol. 2017;216(3):280 e1–e9. doi: 10.1016/j.ajog.2016.11.1042 27899313.

34. Cabrol D, Goffinet F. Protocoles cliniques en obstétrique. 4ème édition ed2013.

35. Kinkel K, Frei KA, Balleyguier C, Chapron C. Diagnosis of endometriosis with imaging: a review. Eur Radiol. 2006;16(2):285–98. doi: 10.1007/s00330-005-2882-y 16155722.

36. Millischer AE, Salomon LJ, Santulli P, Borghese B, Dousset B, Chapron C. Fusion imaging for evaluation of deep infiltrating endometriosis: feasibility and preliminary results. Ultrasound Obstet Gynecol. 2015;46(1):109–17. doi: 10.1002/uog.14712 25358293.

37. Millischer AE, Salomon LJ, Porcher R, Brasseur-Daudruy M, Gourdier AL, Hornoy P, et al. Magnetic resonance imaging for abnormally invasive placenta: the added value of intravenous gadolinium injection. BJOG. 2017;124(1):88–95. Epub 2016/06/28. doi: 10.1111/1471-0528.14164 27346286.

38. de Venecia C, Ascher SM. Pelvic Endometriosis: Spectrum of Magnetic Resonance Imaging Findings. Semin Ultrasound CT MR. 2015;36(4):385–93. Epub 2015/08/25. doi: 10.1053/j.sult.2015.05.001 26296488.

39. Togashi K, Nishimura K, Kimura I, Tsuda Y, Yamashita K, Shibata T, et al. Endometrial cysts: diagnosis with MR imaging. Radiology. 1991;180(1):73–8. Epub 1991/07/01. doi: 10.1148/radiology.180.1.2052726 2052726.

40. Siegelman ES, Oliver ER. MR imaging of endometriosis: ten imaging pearls. Radiographics. 2012;32(6):1675–91. Epub 2012/10/16. doi: 10.1148/rg.326125518 23065164.

41. Yoon JH, Choi D, Jang KT, Kim CK, Kim H, Lee SJ, et al. Deep rectosigmoid endometriosis: "mushroom cap" sign on T2-weighted MR imaging. Abdom Imaging. 2010;35(6):726–31. Epub 2010/09/08. doi: 10.1007/s00261-010-9643-3 20820774.

42. Chapron C, Chopin N, Borghese B, Foulot H, Dousset B, Vacher-Lavenu MC, et al. Deeply infiltrating endometriosis: pathogenetic implications of the anatomical distribution. Hum Reprod. 2006;21(7):1839–45. doi: 10.1093/humrep/del079 16543256.

43. Tomayko MM, Reynolds CP. Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol. 1989;24(3):148–54. doi: 10.1007/bf00300234 2544306.

44. Saba L, Guerriero S, Sulcis R, Ajossa S, Melis G, Mallarini G. Agreement and reproducibility in identification of endometriosis using magnetic resonance imaging. Acta Radiol. 2010;51(5):573–80. Epub 2010/04/13. doi: 10.3109/02841851003657343 20380608.

45. Hans Evers JL. Is adolescent endometriosis a progressive disease that needs to be diagnosed and treated? Hum Reprod. 2013;28(8):2023. Epub 2013/07/19. doi: 10.1093/humrep/det298 23861497.

46. Fedele L, Bianchi S, Zanconato G, Raffaelli R, Berlanda N. Is rectovaginal endometriosis a progressive disease? Am J Obstet Gynecol. 2004;191(5):1539–42. Epub 2004/11/18. doi: 10.1016/j.ajog.2004.06.104 15547522.

47. Vigano P, Candiani M, Monno A, Giacomini E, Vercellini P, Somigliana E. Time to redefine endometriosis including its pro-fibrotic nature. Hum Reprod. 2018;33(3):347–52. Epub 2017/12/06. doi: 10.1093/humrep/dex354 29206943.

48. Guo SW. Fibrogenesis resulting from cyclic bleeding: the Holy Grail of the natural history of ectopic endometrium. Hum Reprod. 2018;33(3):353–6. Epub 2018/02/09. doi: 10.1093/humrep/dey015 29420711.

49. Huhtinen K, Desai R, Stahle M, Salminen A, Handelsman DJ, Perheentupa A, et al. Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels. J Clin Endocrinol Metab. 2012;97(11):4228–35. Epub 2012/09/13. doi: 10.1210/jc.2012-1154 22969138; PubMed Central PMCID: PMC3485603.

50. Bulun SE, Zeitoun K, Takayama K, Noble L, Michael D, Simpson E, et al. Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis. Endocr Relat Cancer. 1999;6(2):293–301. Epub 2000/03/24. 10731122.

51. Vercellini P, Buggio L, Somigliana E. Role of medical therapy in the management of deep rectovaginal endometriosis. Fertil Steril. 2017;108(6):913–30. Epub 2017/12/06. doi: 10.1016/j.fertnstert.2017.08.038 29202965.

52. Brown J, Crawford TJ, Datta S, Prentice A. Oral contraceptives for pain associated with endometriosis. Cochrane Database Syst Rev. 2018;5:CD001019. Epub 2018/05/23. doi: 10.1002/14651858.CD001019.pub3 29786828; PubMed Central PMCID: PMC6494634.

53. Benaglia L, Somigliana E, Calzolari L, Busnelli A, Cardellicchio L, Ragni G, et al. The vanishing endometrioma: the intriguing impact of pregnancy on small endometriotic ovarian cysts. Gynecol Endocrinol. 2013;29(9):863–6. doi: 10.3109/09513590.2013.813476 23844984.

54. Mascilini F, Moruzzi C, Giansiracusa C, Guastafierro F, Savelli L, De Meis L, et al. Imaging in gynecological disease. 10: Clinical and ultrasound characteristics of decidualized endometriomas surgically removed during pregnancy. Ultrasound Obstet Gynecol. 2014;44(3):354–60. doi: 10.1002/uog.13323 24496773.

55. Bailleux M, Bernard JP, Benachi A, Deffieux X. Ovarian endometriosis during pregnancy: a series of 53 endometriomas. Eur J Obstet Gynecol Reprod Biol. 2017;209:100–4. doi: 10.1016/j.ejogrb.2015.09.037 26482730.

56. Santulli P, Borghese B, Noel JC, Fayt I, Anaf V, de Ziegler D, et al. Hormonal therapy deregulates prostaglandin-endoperoxidase synthase 2 (PTGS2) expression in endometriotic tissues. J Clin Endocrinol Metab. 2014;99(3):881–90. doi: 10.1210/jc.2013-2950 24423291.

57. Vercellini P, Crosignani PG, Somigliana E, Berlanda N, Barbara G, Fedele L. Medical treatment for rectovaginal endometriosis: what is the evidence? Hum Reprod. 2009;24(10):2504–14. doi: 10.1093/humrep/dep231 19574277.

58. Busacca M, Chiaffarino F, Candiani M, Vignali M, Bertulessi C, Oggioni G, et al. Determinants of long-term clinically detected recurrence rates of deep, ovarian, and pelvic endometriosis. Am J Obstet Gynecol. 2006;195(2):426–32. doi: 10.1016/j.ajog.2006.01.078 16890551.

59. Porpora MG, Pallante D, Ferro A, Crisafi B, Bellati F, Benedetti Panici P. Pain and ovarian endometrioma recurrence after laparoscopic treatment of endometriosis: a long-term prospective study. Fertil Steril. 2010;93(3):716–21. doi: 10.1016/j.fertnstert.2008.10.018 19061997.

60. Alberico D, Somigliana E, Bracco B, Dhouha D, Roberto A, Mosconi P, et al. Potential benefits of pregnancy on endometriosis symptoms. Eur J Obstet Gynecol Reprod Biol. 2018;230:182–7. Epub 2018/10/12. doi: 10.1016/j.ejogrb.2018.08.576 30308401.

61. Lier M, Malik RF, van Waesberghe J, Maas JW, van Rumpt-van de Geest DA, Coppus SF, et al. Spontaneous haemoperitoneum in pregnancy and endometriosis: a case series. BJOG. 2017;124(2):306–12. Epub 2016/10/06. doi: 10.1111/1471-0528.14371 27704657.

62. Setubal A, Sidiropoulou Z, Torgal M, Casal E, Lourenco C, Koninckx P. Bowel complications of deep endometriosis during pregnancy or in vitro fertilization. Fertil Steril. 2014;101(2):442–6. doi: 10.1016/j.fertnstert.2013.11.001 24360567.

63. Chiodo I, Somigliana E, Dousset B, Chapron C. Urohemoperitoneum during pregnancy with consequent fetal death in a patient with deep endometriosis. J Minim Invasive Gynecol. 2008;15(2):202–4. doi: 10.1016/j.jmig.2007.09.004 18312991.

64. Nirgianakis K, Gasparri ML, Radan AP, Villiger A, McKinnon B, Mosimann B, et al. Obstetric complications after laparoscopic excision of posterior deep infiltrating endometriosis: a case-control study. Fertil Steril. 2018;110(3):459–66. Epub 2018/08/14. doi: 10.1016/j.fertnstert.2018.04.036 30098698


Článek vyšel v časopise

PLOS One


2019 Číslo 10
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

plice
INSIGHTS from European Respiratory Congress
nový kurz

Současné pohledy na riziko v parodontologii
Autoři: MUDr. Ladislav Korábek, CSc., MBA

Svět praktické medicíny 3/2024 (znalostní test z časopisu)

Kardiologické projevy hypereozinofilií
Autoři: prof. MUDr. Petr Němec, Ph.D.

Střevní příprava před kolonoskopií
Autoři: MUDr. Klára Kmochová, Ph.D.

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#