Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007
Autoři:
Jian-Te Lee aff001; Ting-Yu Yen aff002; Wei-Liang Shih aff003; Chun-Yi Lu aff002; Ding-Ping Liu aff004; Yi-Chuan Huang aff006; Luan-Yin Chang aff002; Li-Min Huang aff002; Tzou-Yien Lin aff007
Působiště autorů:
Department of Pediatrics, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan
aff001; Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
aff002; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University and Infectious Diseases Research and Education Center, Ministry of Health and Welfare and National Taiwan University, Taipei, Taiwan
aff003; Epidemic Intelligence Center, Centers for Disease Control, Taipei, Taiwan
aff004; National Taipei University of Nursing and Health Sciences, Taipei, Taiwan
aff005; Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
aff006; Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan
aff007; The National Health Research Institutes, Miaoli, Taiwan
aff008
Vyšlo v časopise:
PLoS ONE 14(10)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0224110
Souhrn
Background
During recent 20 years, enterovirus 71 (EV71) has emerged as a major concern among children, particularly in the Asia-Pacific region. To understand current EV71 serostatus, to find risk factors associated with EV71 infection and to establish future EV71 vaccine policy, we performed a seroepidemiology study in Taiwan in 2017.
Methods
After informed consent was obtained, we enrolled preschool children, 6–15-year-old students, 16–50-year-old people. They received a questionnaire and a blood sample was collected to measure the EV71 neutralization antibody.
Results
Altogether, 920 subjects were enrolled with a male-to-female ratio of 1.03. The EV71 seropositive rate was 10% (8/82) in infants, 4% (6/153) in 1-year-old children, 8% (7/83) in 2-year-old children, 8% (13/156) in 3–5-year-old children, 31% (38/122) in 6–11-year-old primary school students, 45% (54/121) in 12–15-year-old high school students and 75% (152/203) in 16-50-year-old people. Risk factors associated with EV71 seropositivity in preschool children were female gender, having siblings, more siblings, and contact with herpangina or hand-foot-and-mouth disease. The risk factor with EV71 seropositivity in 16–50-year-old people was having children in their families in addition to older age (p<0.001). Compared with the rates in 1997, 1999 and 2007, the rates in children were significantly lower in 2017.
Conclusion
EV71 seropositive rates were very low, at 4% to 10%, in preschool children and not high, at 31%, in primary school students. Preschool children are highly susceptible and need EV71 vaccine most.
Klíčová slova:
Human families – Children – Medical risk factors – Rural areas – Schools – Taiwan – Urban areas – Hand, foot and mouth disease
Zdroje
1. Schmidt NJ, Lennette EH, Ho HH. An apparently new enterovirus isolated from patients with disease of the central nervous system. J Infect Dis. 1974;129:304–309. doi: 10.1093/infdis/129.3.304 4361245
2. Shindarov LM, Chumakov MP, Voroshilova MK, Bojinov S, Vasilenko SM, Iordanov I, et al. Epidemiological, clinical and pathomorphological characteristics of epidemic poliomyelitis-like disease caused by enterovirus 71. J Hyg Epidemiol Microbiol Immunol. 1979;23:284–295. 231067
3. Nagy G, Takatsy S, Kukan E, Mihaly I, Domok I. Virological diagnosis of enterovirus type 71 infections: experiences gained during an epidemic of acute CNS diseases in Hungary in 1978. Arch Virol. 1982;71:217–227. doi: 10.1007/bf01314873 6285858
4. Chan LG, Parashar UD, Lye MS, Ong FG, Zaki SR, Alexander JP, et al. Deaths of children during an outbreak of hand, foot, and mouth disease in Sarawak, Malaysia: clinical and pathological characteristics of the disease. Clin Infect Dis. 2000;31:678–683. doi: 10.1086/314032 11017815
5. Centers for Diseases Control and Prevention. Deaths among children during an outbreak of hand, foot, and mouth disease—Taiwan, Republic of China, April-July 1998. MMWR Morb Mortal Wkly Rep. 1998;47:629–632. 9704628
6. Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis. 2010;10(11):778–790. doi: 10.1016/S1473-3099(10)70194-8 20961813
7. Yang B, Liu F, Liao Q, Wu P, Chang Z, Huang J, et al. Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine. Euro Surveill. 2017;22(50).
8. Ho M, Chen ER, Hsu KH, Twu SJ, Chen KT, Tsai SF, et al. An epidemic of enterovirus 71 infection in Taiwan. N Eng J Med. 1999;341:929–935.
9. Wu TN, Tsai SF, Li SF, Lee TF, Huang TM, Wang ML, et al. Sentinel surveillance for enterovirus 71, Taiwan, 1998. Emerg Infect Dis. 1999;5:458–460. doi: 10.3201/eid0503.990321 10341187
10. Chang LY, Lin TY, Hsu KH, Huang YC, Lin KL, Hsueh C, et al. Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease. Lancet. 1999;354:1682–1686. doi: 10.1016/S0140-6736(99)04434-7 10568570
11. Lin TY, Chang LY, Hsia SH, Huang YC, Chiu CH, Hsueh C, et al. The 1998 enterovirus 71 outbreak in Taiwan: pathogenesis and management. Clin Infect Dis. 2002;34 Suppl 2:S52–57.
12. Lin TY, Twu SJ, Ho MS, Chang LY, Lee CY. Enterovirus 71 Outbreaks in Taiwan: Occurrence and Recognition. Emerg Infect Dis. 2003;9:291–293. doi: 10.3201/eid0903.020285 12643822
13. Chen SC, Chang HL, Yan TR, Cheng YT, Chen KT. An eight-year study of epidemiologic features of enterovirus 71 infection in Taiwan. Am J Trop Med Hyg. 2007;77:188–191. 17620652
14. Chen KT, Chang HL, Wang ST, Cheng YT, Yang JY. Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998–2005. Pediatrics. 2007;120:e244–252. doi: 10.1542/peds.2006-3331 17671037
15. Chang LY. Enterovirus 71 in Taiwan. Pediatr Neonatol. 2008;49:103−112. doi: 10.1016/S1875-9572(08)60023-6 19054914
16. Chia MY, Chiang PS, Chung WY, Luo ST, Lee MS. Epidemiology of enterovirus 71 infections in Taiwan. Pediatr Neonatol. 2014;55(4):243–249. doi: 10.1016/j.pedneo.2013.07.007 24120535
17. Liu DP, Wang TA, Huang WT, Chang LY, Wang ET, Cheng SH, et al. Disease burden of enterovirus infection in Taiwan: Implications for vaccination policy. Vaccine. 2016;34(7):974–980. doi: 10.1016/j.vaccine.2015.12.026 26768128
18. Lee MS, Chang LY. Development of enterovirus 71 vaccines. Expert Review of Vaccines. 2010;9:149−156. doi: 10.1586/erv.09.152 20109026
19. Chang LY, King CC, Hsu KH, Ning HC, Tsao KC, Li CC, et al. Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan. Pediatrics. 2002;109:e88. doi: 10.1542/peds.109.6.e88 12042582
20. Lu CY, Lee CY, Kao CL, Shao WY, Lee PI, Twu SJ, et al. Incidence and case–fatality rates resulting from the 1998 enterovirus 71 outbreak in Taiwan. J Med Virol. 2002;67:217−223. doi: 10.1002/jmv.2210 11992582
21. Jian SW, Chen CM, Lee CY, Liu DP. Real-Time surveillance of infectious diseases: Taiwan’s experience. Health Secur. 2017;15(2):144–153. doi: 10.1089/hs.2016.0107 28418738
22. Chang LY, Tsao KC, Hsia SH, Shih SR, Huang CG, Chan WK, et al. Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan. JAMA. 2004;291:222−227. doi: 10.1001/jama.291.2.222 14722149
23. Central Intelligence Agent. The world Fact Book-country comparison: birth rate. [cited 2018 Dec 20]. https://www.cia.gov/library/publications/resources/the-world-factbook/fields/345rank.html
24. Huang WC, Shih WL, Yang SC, Yen TY, Lee JT, Huang YC, et al. Predicting severe enterovirus 71 infection: age, comorbidity, and parental behavior matter. J Microbiol Immunol Infect. 2017;50:10−16. doi: 10.1016/j.jmii.2014.11.013 25678038
25. Lee KM, Gong YN, Hsieh TH, Woodman A, Dekker NH, Cameron CE, et al. Discovery of Enterovirus A71-like nonstructural genomes in recent circulating viruses of the Enterovirus A species. Emerg Microbes Infect. 2018;7(1):111. doi: 10.1038/s41426-018-0107-0 29930332
26. Hamaguchi T, Fujisawa H, Sakai K, Okino S, Kurosaki N, Nishimura Y, et al. Acute encephalitis caused by intrafamilial transmission of enterovirus 71 in adult. Emerg Infect Dis. 2008;14(5):828–30. doi: 10.3201/eid1405.071121 18439374
27. Zhang D, Chen Y, Chen X, He Z, Zhu X, Hao Y. Enterovirus 71 neutralizing antibodies seroepidemiological research among children in Guangzhou, China between 2014 and 2015: a cross-sectional study. Int J Environ Res Public Health. 2017;14:319.
28. Ang LW, Tay J, Phoon MC, Hsu JP, Cutter J, James L, et al. Seroepidemiology of coxsackievirus A6, coxsackievirus A16, and enterovirus 71 infections among children and adolescents in Singapore, 2008–2010. PLoS One. 2015;10:e0127999. doi: 10.1371/journal.pone.0127999 26011735
29. Akhmadishina LV, Eremeeva TP, Trotsenko OE, Ivanova OE, Mikhailov MI, Lukashev AN. Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia. PLoS One. 2014;9:e97404. doi: 10.1371/journal.pone.0097404 24819617
30. Linsuwanon P, Puenpa J, Huang SW, Wang YF, Mauleekoonphairoj J, Wang JR, et al. Epidemiology and seroepidemiology of human enterovirus 71 among Thai populations. J Biomed Sci. 2014;21:16. doi: 10.1186/1423-0127-21-16 24548776
31. Horwood PF, Andronico A, Tarantola A, Salje H, Duong V, Mey C, et al. Seroepidemiology of human enterovirus 71 infection among children, Cambodia. Emerg Infect Dis. 2016;22:92−95 doi: 10.3201/eid2201.151323 26690000
32. Xing W, Liao Q, Viboud C, Zhang J, Sun J, Wu JT, et al. Hand, foot, and mouth disease in China, 2008–12: an epidemiological study. Lancet Infect Dis. 2014;14:308–318. doi: 10.1016/S1473-3099(13)70342-6 24485991
33. Duong V, Mey C, Eloit M, Zhu H, Danet L, Huang Z, et al. Molecular epidemiology of human enterovirus 71 at the origin of an epidemic of fatal hand, foot and mouth disease cases in Cambodia. Emerg Microbes Infect. 2016;5:e104. doi: 10.1038/emi.2016.101 27651091
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