Echocardiography overestimates LV mass in the elderly as compared to cardiac CT
Autoři:
Joshua Stokar aff001; David Leibowitz aff002; Ronen Durst aff002; Dorith Shaham aff003; Donna R. Zwas aff002
Působiště autorů:
Division of Endocrinology, Hadassah University Medical Center, Jerusalem, Israel
aff001; Division of Cardiology, Hadassah University Medical Center, Jerusalem, Israel
aff002; Division of Radiology, Hadassah University Medical Center, Jerusalem, Israel
aff003
Vyšlo v časopise:
PLoS ONE 14(10)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0224104
Souhrn
Purpose
Echocardiographic studies have shown an increase in LV mass with advanced age. However, autopsy and MRI studies demonstrate that with aging, LV mass is unchanged or slightly decreased, with a decrease in LV volume and an increase in wall thickness consistent with concentric remodeling. LV structural remodeling with aging may lead to an overestimation of LV mass in older adults when using standard echocardiography measurements and calculations. This study compared CT and echocardiographic LV mass calculation in younger and older patients and parameters associated with age-related LV remodeling.
Methods
Same subject modality comparison of echocardiographic and cardiac CT LV measurement with derivation of LV mass was performed retrospectively. Echocardiographic measurements were performed by a single observer in accordance with European Association of Cardiovascular Imaging (EACI)/American Society of Echocardiography (ASE) guidelines. CT measurements were performed in end-diastole on multiplanar reformatted image planes corresponding to those typically used in echocardiography. Calculated CT measurements were based on automatic segmentation of heart chambers via edge-tracing algorithms.
Results
129 patients were identified. In patients age 65 and older, LV mass was significantly higher when calculated using echocardiographic measurements compared to CT. Patients 65 years of age and older were found to have increased average wall thickness measurements with echocardiography but not with CT. The discrepancy between calculated echo and CT LV mass was reduced when using the mid-septal instead of proximal wall width for the EACI convention.
Conclusion
In the elderly, increased echo-derived LV mass may reflect remodeling rather than a true increase in LV mass.
Klíčová slova:
Age groups – Aging – Computed axial tomography – Echocardiography – Elderly – Geriatrics – Magnetic resonance imaging
Zdroje
1. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study. New England Journal of Medicine. 1990;322(22):1561–6. doi: 10.1056/NEJM199005313222203 2139921
2. Haider AW, Larson MG, Benjamin EJ, Levy D. Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. Journal of the American College of Cardiology. 1998;32(5):1454–9. doi: 10.1016/s0735-1097(98)00407-0 9809962
3. Vakili BA, Okin PM, Devereux RB. Prognostic implications of left ventricular hypertrophy. American heart journal. 2001;141(3):334–41. doi: 10.1067/mhj.2001.113218 11231428
4. Schillaci G, Verdecchia P, Porcellati C, Cuccurullo O, Cosco C, Perticone F. Continuous Relation Between Left Ventricular Mass and Cardiovascular Risk in Essential Hypertension. Hypertension. 2000;35(2):580–6. doi: 10.1161/01.hyp.35.2.580 10679501
5. Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH. Relation of Left Ventricular Mass and Geometry to Morbidity and Mortality in Uncomplicated Essential Hypertension. Annals of Internal Medicine. 1991;114(5):345–52. doi: 10.7326/0003-4819-114-5-345 1825164
6. Devereux RB, Bella JN, Palmieri V, Oberman A, Kitzman DW, Hopkins PN, et al. Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults: The HyperGEN Study. Hypertension. 2001;38(3):417–23. doi: 10.1161/01.hyp.38.3.417 11566915
7. Bella JN, Palmieri V, Liu JE, Kitzman DW, Oberman A, Hunt SC, et al. Relationship Between Left Ventricular Diastolic Relaxation and Systolic Function in Hypertension: The Hypertension Genetic Epidemiology Network (HyperGEN) Study. Hypertension. 2001;38(3):424–8. doi: 10.1161/01.hyp.38.3.424 11566916
8. Devereux RB, Wachtell K, Gerdts E, et al. PRognostic significance of left ventricular mass change during treatment of hypertension. JAMA. 2004;292(19):2350–6. doi: 10.1001/jama.292.19.2350 15547162
9. Myerson SG, Bellenger NG, Pennell DJ. Assessment of Left Ventricular Mass by Cardiovascular Magnetic Resonance. Hypertension. 2002;39(3):750–5. doi: 10.1161/hy0302.104674 11897757
10. Katz J, Milliken MC, Stray-Gundersen J, Buja LM, Parkey RW, Mitchell JH, et al. Estimation of human myocardial mass with MR imaging. Radiology. 1988;169(2):495–8. doi: 10.1148/radiology.169.2.2971985 2971985.
11. Ostrzega E, Maddahi J, Honma H, Crues Iii JV, Resser KJ, Charuzi Y, et al. Quantification of left ventricular myocardial mass in humans by nuclear magnetic resonance imaging. American Heart Journal. 1989;117(2):444–52. doi: 10.1016/0002-8703(89)90791-6 2916415
12. Fieno DS, Jaffe WC, Simonetti OP, Judd RM, Finn JP. TrueFISP: Assessment of accuracy for measurement of left ventricular mass in an animal model. Journal of Magnetic Resonance Imaging. 2002;15(5):526–31. doi: 10.1002/jmri.10107 11997893
13. Schmermund A, Rensing BJ, Sheedy PF, Rumberger JA. Reproducibility of right and left ventricular volume measurements by electron-beam CT in patients with congestive heart failure. International journal of cardiac imaging. 1998;14(3):201–9. Epub 1998/11/14. 9813757.
14. Mousseaux E, Beygui F, Fornes P, Chatellier G, Hagege A, Desnos M, et al. Determination of left ventricular mass with electron beam computed tomography in deformed, hypertrophic human hearts. European heart journal. 1994;15(6):832–41. Epub 1994/06/01. doi: 10.1093/oxfordjournals.eurheartj.a060592 8088273.
15. Levy D, Anderson KM, Savage DD, Kannel WB, Christiansen JC, Castelli WP. Echocardiographically detected left ventricular hypertrophy: prevalence and risk factors. The Framingham Heart Study. Ann Intern Med. 1988;108(1):7–13. Epub 1988/01/01. doi: 10.7326/0003-4819-108-1-7 2962527.
16. Leibowitz D, Stessman-Lande I, Jacobs J, Cohen A, Weiss AT, Ein-Mor E, et al. Cardiac structure and function in persons 85 years of age. The American journal of cardiology. 2011;108(3):465–70. Epub 2011/05/24. doi: 10.1016/j.amjcard.2011.03.070 21600542.
17. Hees PS, Fleg JL, Lakatta EG, Shapiro EP. Left ventricular remodeling with age in normal men versus women: Novel insights using three-dimensional magnetic resonance imaging. The American journal of cardiology. 2002;90(11):1231–6. doi: 10.1016/s0002-9149(02)02840-0 12450604
18. Cheng S, Fernandes VRS, Bluemke DA, McClelland RL, Kronmal RA, Lima JAC. Age-Related Left Ventricular Remodeling and Associated Risk for Cardiovascular Outcomes / CLINICAL PERSPECTIVE. Circulation: Cardiovascular Imaging. 2009;2(3):191–8. doi: 10.1161/circimaging.108.819938 19808592
19. Olivetti G, Giordano G, Corradi D, Melissari M, Lagrasta C, Gambert SR, et al. Gender differences and aging: Effects on the human heart. Journal of the American College of Cardiology. 1995;26(4):1068–79. doi: 10.1016/0735-1097(95)00282-8 7560601
20. Nikitin NP, Huan Loh P, de Silva R, Witte KKA, Lukaschuk EI, Parker A, et al. Left ventricular morphology, global and longitudinal function in normal older individuals: A cardiac magnetic resonance study. International journal of cardiology. 2006;108(1):76–83. doi: 10.1016/j.ijcard.2005.04.009 16516701
21. Chuang ML, Gona P, Hautvast GLTF, Salton CJ, Breeuwer M, O'Donnell CJ, et al. CMR reference values for left ventricular volumes, mass, and ejection fraction using computer-aided analysis: The Framingham Heart Study. Journal of Magnetic Resonance Imaging. 2013:n/a-n/a. doi: 10.1002/jmri.24239 24123369
22. Diaz T, Pencina MJ, Benjamin EJ, Aragam J, Fuller DL, Pencina KM, et al. Prevalence, Clinical Correlates, and Prognosis of Discrete Upper Septal Thickening on Echocardiography: The Framingham Heart Study. Echocardiography. 2009;26(3):247–53. doi: 10.1111/j.1540-8175.2008.00806.x 19175779
23. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography. 2015;28(1):1–39.e14. doi: 10.1016/j.echo.2014.10.003 25559473
24. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;1(8476):307–10. Epub 1986/02/08. 2868172.
25. Krouwer JS, Monti KL. A simple, graphical method to evaluate laboratory assays. European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies. 1995;33(8):525–7. Epub 1995/08/01. 8547437.
26. Swinne CJ, Shapiro EP, Jamart J, Fleg JL. Age-associated changes in left ventricular outflow tract geometry in normal subjects. The American journal of cardiology. 1996;78(9):1070–3. Epub 1996/11/01. doi: 10.1016/s0002-9149(96)00542-5 8916496.
27. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, et al. Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings. The American journal of cardiology. 1986;57(6):450–8. doi: 10.1016/0002-9149(86)90771-x 2936235
28. Diaz T, Pencina MJ, Benjamin EJ, Aragam J, Fuller DL, Pencina KM, et al. Prevalence, clinical correlates, and prognosis of discrete upper septal thickening on echocardiography: the Framingham Heart Study. Echocardiography (Mount Kisco, NY). 2009;26(3):247–53. Epub 2009/01/30. doi: 10.1111/j.1540-8175.2008.00806.x 19175779; PubMed Central PMCID: PMC2657181.
29. Verdecchia P, Porcellati C, Zampi I, Schillaci G, Gatteschi C, Battistelli M, et al. Asymmetric left ventricular remodeling due to isolated septal thickening in patients with systemic hypertension and normal left ventricular masses. The American journal of cardiology. 1994;73(4):247–52. Epub 1994/02/01. doi: 10.1016/0002-9149(94)90228-3 8296754.
30. Devereux R, Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation. 1977;55(4):613–8. doi: 10.1161/01.cir.55.4.613 138494
31. Woythaler JN, Singer SL, Kwan OL, Meltzer RS, Reubner B, Bommer W, et al. Accuracy of echocardiography versus electrocardiography in detecting left ventricular hypertrophy: Comparison with postmortem mass measurements. Journal of the American College of Cardiology. 1983;2(2):305–11. doi: 10.1016/s0735-1097(83)80167-3 6223063
32. Anversa P, Palackal T, Sonnenblick EH, Olivetti G, Meggs LG, Capasso JM. Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart. Circulation research. 1990;67(4):871–85. Epub 1990/10/01. doi: 10.1161/01.res.67.4.871 2145091.
33. Kajstura J, Cheng W, Sarangarajan R, Li P, Li B, Nitahara JA, et al. Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats. The American journal of physiology. 1996;271(3 Pt 2):H1215–28. Epub 1996/09/01. doi: 10.1152/ajpheart.1996.271.3.H1215 8853362.
34. Song Y, Yao Q, Zhu J, Luo B, Liang S. Age-related variation in the interstitial tissues of the cardiac conduction system; and autopsy study of 230 Han Chinese. Forensic Science International. 1999;104(2–3):133–42. doi: 10.1016/s0379-0738(99)00103-6 10581719
35. Gazoti Debessa CR, Mesiano Maifrino LB, Rodrigues de Souza R. Age related changes of the collagen network of the human heart. Mechanisms of Ageing and Development. 2001;122(10):1049–58. doi: 10.1016/s0047-6374(01)00238-x 11389923
36. Redheuil A, Yu W-C, Mousseaux E, Harouni AA, Kachenoura N, Wu CO, et al. Age-Related Changes in Aortic Arch GeometryRelationship With Proximal Aortic Function and Left Ventricular Mass and Remodeling. Journal of the American College of Cardiology. 2011;58(12):1262–70. doi: 10.1016/j.jacc.2011.06.012 21903061
Článek vyšel v časopise
PLOS One
2019 Číslo 10
- Pomohou nám s detekcí karcinomu plic i včely?
- Duševní onemocnění se u teenagerů přenáší v rámci školní třídy
- Od kostiček k lidské kůži. Jak si postavit 3D biotiskárnu?
- Řekněte mi, co jíte, a já vám řeknu, jaká je úroveň vaší kognice
- Umělá inteligence v mozkovém implantátu pomáhá muži po mrtvici s dvojjazyčnou konverzací
Nejčtenější v tomto čísle
- Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study
- Combining CDK4/6 inhibitors ribociclib and palbociclib with cytotoxic agents does not enhance cytotoxicity
- Prevalence of pectus excavatum (PE), pectus carinatum (PC), tracheal hypoplasia, thoracic spine deformities and lateral heart displacement in thoracic radiographs of screw-tailed brachycephalic dogs
- Risk factors associated with IgA vasculitis with nephritis (Henoch–Schönlein purpura nephritis) progressing to unfavorable outcomes: A meta-analysis
Zvyšte si kvalifikaci online z pohodlí domova
Všechny kurzy