Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study

English version

Autoři: Charbél Talani ^aff001; Antti Mäkitie ^aff003; Martin Beran ^aff006; Erik Holmberg ^aff007; Göran Laurell ^aff008; Lovisa Farnebo ^aff001
Působiště autorů: Division of Speech language pathology, Audiology and Otorhinolaryngology, Department of Clinical and Experimental medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden ^aff001; Department of Otorhinolaryngology in Linköping, Anaesthetics, Operations and Specialty Surgery Center, Region Östergötland, Linköping, Sweden ^aff002; Department of Otorhinolaryngology–Head and Neck Surgery, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland ^aff003; Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden ^aff004; Research Programme in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland ^aff005; Department of ENT and Maxillofacial Surgery, NAL Medical Center Hospital, Trollhattan, Sweden ^aff006; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden ^aff007; Department of Clinical Sciences, ENT, Uppsala University, Uppsala, Sweden ^aff008
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0223154

Souhrn

Background

Cancers of the head and neck have a high mortality rate, and roughly 10% of the patients die within six months of diagnosis. To our knowledge little has been written about this group.

We wished to identify risk factors for early death, to predict and monitor patients at risk better and, if possible, avoid unjustified major treatment.

Methods and findings

This population-based nationwide study from the Swedish Head and Neck Cancer Register (SweHNCR) included data from 2008–2015 and 9733 patients at potential risk of early death.

A total of 925 (9.5%) patients died within six months. For every year older the patients became, the risk of early death increased by 2.3% (p<0.001). The relative risk of death was 3.37 times higher (237%) for patients with WHO score 1 compared with WHO score 0. A primary tumour in the hypopharynx correlated with a 24% increased risk over the oral cavity (p<0.024). Patients with stage IV disease had a 3.7 times greater risk of early death than those with stage I (p<0.001). As expected, a 12 times increased risk of early death was noted in the palliative treatment group, compared to the curative group.

Limitations to this study were that the actual cause of death was not recorded in the SweHNCR, and that socioeconomic factors, alcohol consumption, smoking habits, and HPV status, were not reported in SweHNCR until 2015. However, the fact that this is a population-based nationwide study including 9733 patients compensates for some of these limitations.

Conclusions

Identification of patients at increased risk of early death shows that older patients with advanced disease, increased WHO score, primary tumour in the hypopharynx, and those given palliative treatment, are more likely than the others to die from head and neck cancer within six months of diagnosis.

Klíčová slova:

Cancer detection and diagnosis – Cancer treatment – Head – Head and neck cancers – Neck – Surgical and invasive medical procedures – Sweden – Salivary glands

Zdroje

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Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study

Souhrn

Background

Methods and findings

Conclusions

Klíčová slova:

Zdroje

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