#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Epidemiological, clinical and laboratory characteristics of the measles resurgence in the Republic of Serbia in 2014-2015


Autoři: Snežana Medić aff001;  Vladimir Petrović aff001;  Goranka Lončarević aff003;  Milena Kanazir aff003;  Ivana Begović Lazarević aff004;  Slavica Rakić Adrović aff005;  Maja Bančević aff006;  Claude P. Muller aff007;  Judith M. Hübschen aff007
Působiště autorů: Center for Disease Control and Prevention, Institute of Public Health of Vojvodina, Novi Sad, Serbia aff001;  Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia aff002;  Department for Disease Control and Prevention, Institute of Public Health of Serbia, Belgrade, Serbia aff003;  Center for Disease Control and Prevention, Institute of Public Health of Belgrade, Belgrade, Serbia aff004;  Institute of Laboratory Medicine, SLK Clinics, Heilbronn, Germany aff005;  National Reference Laboratory for Measles and Rubella, Institute of Virology, Vaccine and Sera ‘Torlak’, Belgrade, Serbia aff006;  WHO European Regional Reference Laboratory for Measles and Rubella, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette and Laboratoire National de Santé, Dudelange, Luxembourg aff007
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0224009

Souhrn

The Republic of Serbia is a country with ongoing endemic transmission of measles. The aim of this study is to summarize the main characteristics of the measles resurgence that occurred in Serbia in 2014–2015. The national surveillance data on measles was analysed in relation to the clinical, epidemiological and laboratory data. Between November 2014 and December 2015 a measles resurgence with 420 cases was observed in Serbia. Measles virus was initially introduced by and spread among citizens of Bosnia and Herzegovina with temporary residence in Serbia, before spreading to the resident population. Of the 223 patients with available medical records, 173 (77.6%) were unvaccinated. The overall measles incidence during the outbreak was 5.8/100.000. The highest age-specific incidence rate was recorded in children aged ≤4 years (25.9/100.000), but most cases (67.9%) were ≥20 years old. Hospitalization rate was high (32.9%) and included two cases of encephalitis associated with measles. In total, 42 health-care workers and 22 related cases including hospitalized patients (n = 13) contracted measles. The overall percentage of laboratory confirmed cases was 81.7% (n = 343/420). All measles virus sequences except one (D9) belonged to genotype D8, suggesting interruption of transmission after the previous outbreak in 2010–2011 caused by genotype D4 viruses. The growing number of adult patients as compared to previous epidemics, suggests an urgent need for supplementary immunization activities targeting susceptible health care workers, unvaccinated or incompletely vaccinated adults as well as people without vaccination records. The comprehensive investigation of the 2014/2015 measles resurgence will contribute to decisions about appropriate countermeasures to stop the future measles resurgences in Serbia.

Klíčová slova:

Epidemiology – Government laboratories – Measles – Measles virus – Romani people – Vaccination and immunization – Serbia – MMR vaccine


Zdroje

1. World Health Organization. Global measles and rubella strategic plan: 2012–2020. 2012. http://apps.who.int/iris/bitstream/10665/44855/1/9789241503396_eng.pdf Accessed 15 February 2018

2. The UN Inter-agency Group for Child Mortality Estimation. Levels & trends in child mortality report 2011: Estimates developed by the UN Inter-agency Group for Child Mortality Estimation. New York, NY, United Nations Children’s Fund. 2011. http://www.childinfo.org/files/Child_Mortality_Report_2011.pdf Accessed 10 January 2018.

3. World Health Organization Regional Office for Europe (WHO Europe). Eliminating measles and rubella: Framework for the verification process in the WHO European Region. Copenhagen: WHO Europe; 2014. http://www.euro.who.int/__data/assets/pdf_file/0009/247356/Eliminating-measles-and-rubella-Framework-for-the-verification-process-in-the-WHO-European-Region.pdf Accessed 21 January 2017.

4. World Health Organization Regional Office for Europe (WHO Europe). Fifth Meeting of the European Regional Verification Commission for Measles and Rubella Elimination (RVC). 24–26 October 2016, Copenhagen, Denmark. http://www.euro.who.int/__data/assets/pdf_file/0005/330917/5th-RVC-meeting-report.pdf?ua=1 Accessed 15 July 2019.

5. World Health Organization. Regional office for Europe. The European Vaccine Action Plan 2015–2020. http://www.euro.who.int/__data/assets/pdf_file/0007/255679/WHO_EVAP_UK_v30_WEBx.pdf?ua=1 Accessed 20 August 2019.

6. World Health Organization. Global Vaccine Action Plan 2012–2020. http://file:///C:/Users/Korisnik/Downloads/9789241503396_eng.pdf Accessed 12 August 2019.

7. World Health Organization Regional Office for Europe (WHO Europe). WHO EpiBrief. A report on the epidemiology of selected vaccine-preventable diseases in the European Region. No. 1/2016. http://www.euro.who.int/__data/assets/pdf_file/0009/313020/EpiBrief_EpiData_1_2016-rev1.pdf?ua=1 Accessed 09 November 2017.

8. Statistical Office of the Republic of Serbia. Statistical year book of Republic of Serbia, 2015. [In Serbian/English]. http://webrzs.stat.gov.rs/WebSite/userFiles/file/Aktuelnosti/StatGod2015.pdf. Accessed 10 December 2018.

9. Institute of Public Health of Serbia. Guideline for epidemiological surveillance of Measles, Rubella and Congenital Rubella Syndrome Serbian. [In Serbian] Belgrade. 2008.

10. Official Gazette of the Republic of Serbia No. 11/06. Regulation on Immunization and Manner of Protection by Medications. [In Serbian]. http://www.paragraf.rs/propisi/pravilnik_o_imunizaciji_i_nacinu_zastite_lekovima.html Accessed 03 November 2017.

11. The Institute of Public Health of Serbia. The results of conducted immunization in the Republic of Serbia in the period from 2001 to 2014. 2014. [In Serbian]. http://www.batut.org.rs/index.php?content=1230 Accessed 08 October 2017.

12. The Institute of Public Health of Serbia. The results of conducted immunization in the Republic of Serbia in 2015. 2016. [In Serbian]. http://www.batut.org.rs/download/izvestaji/Imunizacija%202015.pdf Accessed 20 October 2017.

13. Šeguljev Z, Đurić P, Petrović V, Stefanović S, Ćosić G, Hrnjaković I, et al. Current measles outbreak in Serbia: a preliminary report. Euro Surveill. 2007;12(11):pii = 3155. https://doi.org/10.2807/esw.12.11.03155-en

14. Nedeljković J, Rakić Adrović S, Tasić G, Kovačević-Jovanović V, Lončarević G, et al. Resurgence of measles in Serbia 2010–2011 highlights the need for supplementary immunization activities. Epidemiol Infect. 2016. Apr;144(5):1121–8. doi: 10.1017/S0950268815002277 26449667

15. World Health Organization Regional Office for Europe (WHO Europe). Guidelines for measles and rubella outbreak investigation and response in the WHO European Region. 2013. http://www.euro.who.int/__data/assets/pdf_file/0003/217164/OutbreakGuidelines-updated.pdf Accessed 12 August 2017.

16. Hall TA. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl Acids Symp Ser 1999;41:95–8.

17. Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA 6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol. 2013 Dec; 30(12):2725–9. doi: 10.1093/molbev/mst197 24132122 Epub 2013 Oct 16.

18. World Health Organization. Weekly Epidemiological Record (WER). No 30/ 2015. Vol. 90. (pp. 373–380). http://www.who.int/wer/2015/wer9030.pdf?ua=1 Accessed 22 August 2017.

19. World Health Organization. Weekly epidemiological record (WER). No. 9/ 2012. Vol 87. (pp. 73–80) https://www.who.int/wer/2012/wer8709.pdf Accessed 09 December 2018

20. Rota PA, Brown K, Mankertz A, Santibanez S, Shulga S, Muller P, et al. Global Distribution of Measles Genotypes and Measles Molecular Epidemiology, The Journal of Infectious Diseases, Volume 204, Issue suppl 1, 1 July 2011, Pages S514–S523. https://doi.org/10.1093/infdis/jir118 21666208

21. Salimović-Bešić I, Šeremet M, Hübschen JM, Hukić M, Tihić N, Ahmetagić S, et al. Epidemiologic and laboratory surveillance of the measles outbreak in the Federation of Bosnia and Herzegovina, February 2014-April 2015. Clin Microbiol Infect. 2016;22(6):563.e1–7. https://doi.org/10.1016/j.cmi.2016.02.005 26928202

22. Hukić M, Ravlija J, Karakas S, Mulaomerović M, Dedeić, Ljubović A, et al. An ongoing measles outbreak in the Federation of Bosnia and Herzegovina, 2014 to 2015. Euro Surveill.2015;20(9):pii = 21047.https://doi.org/10.2807/1560-7917.ES2015.20.9.21047 25764186

23. Werber D, Hoffmann A, Santibanez S, Mankertz A, Sagebiel D. Large measles outbreak introduced by asylum seekers and spread among the insufficiently vaccinated resident population, Berlin, October 2014 to August 2015. Euro Surveill. 2017;22(34):pii = 30599. https://doi.org/10.2807/1560-7917.ES.2017.22.34.30599 28857043

24. World Health Organization Regional Office for Europe (WHO Europe). WHO-UNHCR-UNICEF joint technical guidance: general principles of vaccination of refugees, asylum-seekers and migrants in the WHO European Region. Copenhagen: WHO Europe; 23 Nov 2015. http://www.euro.who.int/en/health-topics/health-determinants/migration-and-health/news/news/2015/11/who,-unicef-and-unhcr-call-for-equitable-access-to-vaccines-for-refugees-and-migrants/who-unhcr-unicef-joint-technical-guidance-general-principles-of-vaccination-of-refugees,-asylum-seekers-and-migrants-in-the-who-european-region Accessed 18 January 2018.

25. European Centre for Disease Prevention and Control (ECDC). Rapid Risk Assessment. Communicable disease risks associated with the movement of refugees in Europe during the winter season. Stockholm: ECDC; 10 Nov 2015. http://ecdc.europa.eu/en/publications/Publications/refugee-migrant-health-in-european-winter-rapid-risk-assessment.pdf Accessed 10 September 2017.

26. UNICEF Belgrade. Research, knowledge, attitudes and practices in relation to immunization of children in Serbia 2017. 2018.: https://www.unicef.org/serbia/media/9146/file/Knowledge,%20attitudes%20and%20practices.pdf Accessed 20 July 2019.

27. Radovanovic Z. Anti-vaccinationists and their arguments in the Balkan countries that share the same language January 2017. Serbian Archives of Medicine 145 (00): 46–46.

28. Institute for Health Protection Novi Sad. Communicable diseases in Autonomous Province of Vojvodina, 1983. 1984. [In Serbian]. Institute for Health Protection Novi Sad.

29. Statistical Office of the Republic of Serbia and UNICEF. Research on Multiple Indicators of the Position of Women and Children in Serbia 2014, and Research on Multiple Indicators of the Position of Women and Children in Roma Settlements in Serbia 2014. Main findings. 2014. Belgrade, Serbia: Statistical Office of the Republic of Serbia and UNICEF p. 10. https://www.unicef.org/serbia/MICS5_2014_SERBIA_Key_Findings_and_Roma_Settlements.pdf Accessed 17 December 2017.

30. Institute of Public Health of Vojvodina. Communicable diseases in Autonomous Province of Vojvodina in 2007. 2008. Novi Sad: Institute of Public Health of Vojvodina; p.19–20. [In Serbian]. http://izjzv.org.rs/publikacije/ZarazneBolesti/ZB_2007.pdf Accessed 20 January 2018.

31. The Institute of Public Health of Serbia. The results of conducted immunization in the Republic of Serbia in 2010. 2011. [In Serbian]. http://www.batut.org.rs/download/izvestaji/Izvestaj%20o%20sprovedenoj%20imunizaciji%202011.pdf Accessed 01 January 2018.

32. Official Gazette of the Republic of Serbia No. 14/18. Regulation on Immunization and Manner of Protection by Medications. [In Serbian]. https://www.paragraf.rs/propisi/pravilnik_o_imunizaciji_i_nacinu_zastite_lekovima.html Accessed 01 June 2018.

33. Official Gazette of the Republic of Serbia No. 11/18. Rulebook on a program of mandatory and recommended immunization of the population against certain infectious diseases. [In Serbian]. http://www.pravno-informacionisistem.rs/SlGlasnikPortal/reg/viewAct/748406ec-f0ad-43bc-b673-59d44e08f3f8 Accessed 15 June 2018.

34. Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine-Preventable Diseases. Hamborsky J, Kroger A, Wolfe S, eds. 13th ed. Washington D.C. Public Health Foundation, 2015. https://www.cdc.gov/vaccines/pubs/pinkbook/downloads/table-of-contents.pdf Accessed 09 May 2018.

35. World Health Organization Regional Office for Europe. Guidance on conducting serosurveys in support of measles and rubella elimination in the WHO European Region. 2013. http://www.euro.who.int/__data/assets/pdf_file/0011/236648/Guidance-on-conducting-serosurveys-in-support-of-measles-and-rubella-elimination-in-the-WHO-European-Region.pdf Accessed 04 November 2017.

36. Fiebelkorn AP, Seward JF, Orenstein W. A Global Perspective of Vaccination of Healthcare Personnel against Measles: Systematic Review. Vaccine. 2014;32(38):4823–4839. doi: 10.1016/j.vaccine.2013.11.005 24280280

37. Maltezou HC, Poland GA. Immunization of Health-Care Providers: Necessity and Public Health Policies. Leggat PA, Smith DR, eds. Healthcare. 2016;4(3):47. doi: 10.3390/healthcare4030047 27490580

38. Mercader S, Garcia P, Bellini WJ. Measles virus IgG avidity assay for use in classification of measles vaccine failure in measles elimination settings. Clin Vaccine Immunol. 2012 Nov;19(11):1810–7. doi: 10.1128/CVI.00406-12 22971778

39. Sowers SB, Rota JS, Hickman CJ, Mercader S, Redd S, McNall RJ, et al. High Concentrations of Measles Neutralizing Antibodies and High-Avidity Measles IgG Accurately Identify Measles Reinfection Cases. Edwards KM, ed. Clinical and Vaccine Immunology : CVI. 2016;23(8):707–716. doi: 10.1128/CVI.00268-16 27335386

40. European Centre for Disease Prevention and Control. Communicable diseases threats report- Week 50, 9–15 December 2018 Stockholm, ECDC. https://ecdc.europa.eu/sites/portal/files/documents/communicable-disease-threats-report-15-december-2018.pdf Accessed 17 December 2018.


Článek vyšel v časopise

PLOS One


2019 Číslo 10
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

Současné pohledy na riziko v parodontologii
nový kurz
Autoři: MUDr. Ladislav Korábek, CSc., MBA

Svět praktické medicíny 3/2024 (znalostní test z časopisu)

Kardiologické projevy hypereozinofilií
Autoři: prof. MUDr. Petr Němec, Ph.D.

Střevní příprava před kolonoskopií
Autoři: MUDr. Klára Kmochová, Ph.D.

Aktuální možnosti diagnostiky a léčby litiáz
Autoři: MUDr. Tomáš Ürge, PhD.

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#