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Prevalence of Trypanosoma cruzi infection in active military population of The Colombian National Army gathered in five departments


Autoři: Claudia Méndez aff001;  Maria Clara Duque aff001;  Yanira Romero aff001;  Julie Pérez aff001;  Omaira Rodríguez aff001;  Camilo A. Correa-Cárdenas aff001;  Maria Teresa Alvarado aff001;  Omar Cantillo-Barraza aff001
Působiště autorů: Grupo de Investigación en Enfermedades Tropicales del Ejército (GINETEJ), Laboratorio de Referencia e Investigación, Dirección de Sanidad, Bogotá, Colombia aff001
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0223611

Souhrn

Background

The National Army of Colombia is present in all of the national territory, focused in sylvatic zones where they are exposed continually to potential risk of transmission of Trypanosoma cruzi, the etiological agent of the Chagas disease. People of this study were active personal that were born and lived during their first years in endemic areas of transmission through domiciled vectors as Rhodnius prolixus.

Aim

The main aim of this study was to estimate the prevalence of Chagas disease in the active military population of the National Army, gathered in five departments.

Methods

An observational and descriptive study with cross-sectional analysis was carried out. Blood sample each patient in order to apply serological diagnosis by two different Enzyme Linked ImmunoSorbent Assay tests, following the algorithm of National Institute of Health, Colombia. In cases of serum results with inconsistencies, a Hemagglutination Inhibition test and Indirect Immunofluorescence assay test were performed to solve inconclusiveness. Positive samples by two different tests were considered seropositive. Additionally, to each positive sample by at least one serological test, we did extraction of DNA for molecular diagnosis.

Results

295 serums were analyzed and two of them were positive in order to get a prevalence of 0.68%. Two samples analyzed by molecular diagnosis were negative.

Conclusion

The prevalence was < 1% It is probable the infection in the seropositive individuals occurred before enlisting in the military service due to origin locations with transmission such as Casanare and Boyacá. These findings allow defining the prevention and control programs of chronic cases and reduction in the disease burden.

Klíčová slova:

Armed forces – Colombia – Leishmaniasis – Parasitic diseases – Serology – Trypanosoma cruzi – Chagas disease – Vector-borne diseases


Zdroje

1. Chagas C. Nova tripanozomiaze humana: estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., ajente etiolojico de nova entidade morbida do homem. Memórias do Instituto Oswaldo Cruz. 1909;1:159–218. doi: 10.1590/S0074-02761909000200008

2. Lee BY, Bacon KM, Bottazzi ME, Hotez PJ. Global economic burden of Chagas disease: a computational simulation model. Lancet Infect Dis. 2013;13(4):342–8. Epub 2013/02/12. doi: 10.1016/S1473-3099(13)70002-1. 23395248; PubMed Central PMCID: PMC3763184.

3. Guhl F, Aguilera G, Pinto N, Vergara D. Updated geographical distribution and ecoepidemiology of the triatomine fauna (Reduviidae: Triatominae) in Colombia. Biomedica. 2007;27 Suppl 1:143–62. doi: S0120-41572007000500016. 18154255.

4. Cantillo-Barraza O, Gómez-Palacio A, Salazar D, Mejía-Jaramillo AM, Calle J, Triana O. Distribution and ecoepidemiology of the triatomine fauna (Hemiptera: Reduviidae) in Margarita Island, Bolívar, Colombia. Biomedica. 2010;30(3):382–9. doi: S0120-41572010000300011. 21713340.

5. Parra G.J. FMYAVM. Vigilancia d Triatominae (Hemiptera: Reduviidae) en Colombia. (1era Ed. pp127) ed: Bogotá D.C. Colombia. Editorial Sic Editorial Ltda; 2015. 127 p.

6. Guhl F, Restrepo M, Angulo VM, Antunes CM, Campbell-Lendrum D, Davies CR. Lessons from a national survey of Chagas disease transmission risk in Colombia. Trends Parasitol. 2005;21(6):259–62. S1471-4922(05)00104-2 doi: 10.1016/j.pt.2005.04.011. 15922243.

7. Ramirez JD, Guhl F, Messenger LA, Lewis MD, Montilla M, Cucunuba Z, et al. Contemporary cryptic sexuality in Trypanosoma cruzi. Mol Ecol. 2012;21(17):4216–26. Epub 2012/07/11. doi: 10.1111/j.1365-294X.2012.05699.x. 22774844.

8. Parra-Henao G, Cardona AS, Quiros-Gomez O, Angulo V, Alexander N. House-level risk factors for Triatoma dimidiata infestation in Colombia. Am J Trop Med Hyg. 92. United States: The American Society of Tropical Medicine and Hygiene.; 2015. p. 193–200. doi: 10.4269/ajtmh.14-0273 25349372

9. Cantillo-Barraza O, Garces E, Gomez-Palacio A, Cortes LA, Pereira A, Marcet PL, et al. Eco-epidemiological study of an endemic Chagas disease region in northern Colombia reveals the importance of Triatoma maculata (Hemiptera: Reduviidae), dogs and Didelphis marsupialis in Trypanosoma cruzi maintenance. Parasit Vectors. 2015;8:482. Epub 2015/09/24. doi: 10.1186/s13071-015-1100-2. 26394766; PubMed Central PMCID: PMC4580378.

10. Hernandez C, Vera MJ, Cucunuba Z, Florez C, Cantillo O, Buitrago LS, et al. High-Resolution Molecular Typing of Trypanosoma cruzi in 2 Large Outbreaks of Acute Chagas Disease in Colombia. J Infect Dis. 2016;214(8):1252–5. Epub 2016/08/12. doi: 10.1093/infdis/jiw360. 27511897; PubMed Central PMCID: PMC5034963.

11. Hernandez C, Salazar C, Brochero H, Teheran A, Buitrago LS, Vera M, et al. Untangling the transmission dynamics of primary and secondary vectors of Trypanosoma cruzi in Colombia: parasite infection, feeding sources and discrete typing units. Parasit Vectors. 2016;9(1):620. Epub 2016/12/03. doi: 10.1186/s13071-016-1907-5. 27903288; PubMed Central PMCID: PMC5131512.

12. Nicholls R. Chagas disease as foodborne illness: The experience in Colombia. Parasitology Group National Institute of Health, Colombia. In: Final Report Technical Consultation and Epidemiology, Prevention and Management of Transmission of Chagas Disease as Foodborne Disease (ETA); 4–5 May 2006; Rio de Janeiro. Pp. 13–4.

13. Ramirez JD, Montilla M, Cucunuba ZM, Florez AC, Zambrano P, Guhl F. Molecular epidemiology of human oral Chagas disease outbreaks in Colombia. PLoS Negl Trop Dis. 2013;7(2):e2041. Epub 2013/02/26. doi: 10.1371/journal.pntd.0002041. 23437405; PubMed Central PMCID: PMC3578743.

14. Dib J, Barnabe C, Tibayrenc M, Triana O. Incrimination of Eratyrus cuspidatus (Stal) in the transmission of Chagas' disease by molecular epidemiology analysis of Trypanosoma cruzi isolates from a geographically restricted area in the north of Colombia. Acta Trop. 2009;111(3):237–42. S0001-706X(09)00109-0. doi: 10.1016/j.actatropica.2009.05.004. 19442641.

15. Olivera MJ, Fory JA, Porras JF, Buitrago G. Prevalence of Chagas disease in Colombia: A systematic review and meta-analysis. PLoS One. 2019;14(1):e0210156. Epub 2019/01/08. doi: 10.1371/journal.pone.0210156. 30615644; PubMed Central PMCID: PMC6322748.

16. Llau AF, Tejada CE, Ahmed NU. Chagas Disease Prevalence in Colombia: A Meta-Analysis and Systematic Review. Vector Borne Zoonotic Dis. 2019;19(2):81–9. Epub 2018/08/30. doi: 10.1089/vbz.2018.2308. 30156473.

17. Castillo-Riquelme M, Guhl F, Turriago B, Pinto N, Rosas F, Martínez MF, et al. The costs of preventing and treating chagas disease in Colombia. PLoS Negl Trop Dis. 2008;2(11):e336. doi: 10.1371/journal.pntd.0000336. 19015725; PubMed Central PMCID: PMC2581604.

18. Cucunuba ZM, Nouvellet P, Conteh L, Vera MJ, Angulo VM, Dib JC, et al. Modelling historical changes in the force-of-infection of Chagas disease to inform control and elimination programmes: application in Colombia. BMJ Glob Health. 2017;2(3):e000345. Epub 2017/11/18. doi: 10.1136/bmjgh-2017-000345. 29147578; PubMed Central PMCID: PMC5680445.

19. Suescún-Carrero SH, García-Artunduaga C, Bohórquez SV-. Prevalencia de anticuerpos contra Trypanosoma cruzi en mujeres embarazadas de zonas endémicas del departamento de Boyacá, Colombia. Iatreia. 2017;30:361–8.

20. Zuleta-Duenas LP, Lopez-Quiroga AJ, Torres-Torres F, Castaneda-Porras O. Possible oral transmission of Chagas disease among hydrocarbons sector workers in Casanare, Colombia, 2014. Biomedica. 2017;37(2):218–32. Epub 2017/05/21. doi: 10.7705/biomedica.v37i3.3153. 28527286.

21. de Bilhão N. V., de Árias A. R., Vera C. A., Riego A., de Tomassone M., & Sanabria L. Seroprevalencia de la enfermedad de chagas en conscriptos del servicio militar de lãs fuerzas armadas del Paraguay. Clase 1977–1980. Revista de Patologia Tropical/Journal of Tropical Pathology. 2001; 30(2): 183–192. doi: 10.5216/rpt.v30i2.15146

22. Peña V, Fernández G, Gómez-Palacio A, Mejía-Jaramillo A, Cantillo O, Triana-Chávez O. High-Resolution Melting (HRM) of the Cytochrome B Gene: a Powerful Approach to Identify Blood-Meal Sources in Chagas Disease Vectors. PLoS Negl Trop Dis. 2012;6(2):e1530. doi: 10.1371/journal.pntd.0001530. 22389739. PubMed Central PMCID: PMC3289613.

23. Moser DR, Kirchhoff LV, Donelson JE. Detection of Trypanosoma cruzi by DNA amplification using the polymerase chain reaction. J Clin Microbiol. 1989;27(7):1477–82. 2504769; PubMed Central PMCID: PMC267598.

24. World Health Organization. Reporte del grupo de trabajo científico sobre la enfermedad de Chagas. Buenos Aires, Argentina WHO; 2005, 1-96pp. Available from: https://apps.who.int/iris/bitstream/handle/10665/69724/TDR_SWG_09_spa.pdf;jsessionid = C59AFBB65A1CD6857F928111529A10F4?sequence = 1.

25. Villamil-Gomez WE, Echeverria LE, Ayala MS, Munoz L, Mejia L, Eyes-Escalante M, et al. Orally transmitted acute Chagas disease in domestic travelers in Colombia. J Infect Public Health. 2017;10(2):244–6. Epub 2016/06/04. doi: 10.1016/j.jiph.2016.05.002. 27256221.

26. Bedoya JA, Cortes Marquez MM, Cardona Arias JA. Seroprevalence of markers of transfusion transmissible infections in blood bank in Colombia. Rev Saude Publica. 2012;46(6):950–9. Epub 2013/03/19. 23503536.

27. Rocha-Muñoz L, Hernández-Peñaranda I, Martínez-Pedraza D, Castellanos-Dominguez Y. Trypanosoma cruzi: prevalence and risk factors for seropositivity in blood donors of Hemocentro y Unidad de Aféresis… de riesgo de seropositividad en donantes de. Med Lab. 2014;20:529–42.

28. Instituto Nacional de Salud Informe final, enfermedad de Chagas, Colombia, 2013. Grupo Enfermedades Transmitidas por Vectores (ETV). Subdirección de Vigilancia y Control en Salud Pública. 2013;1: 14pp. Available from: https://www.ins.gov.co/buscador-eventos/Paginas/Info-Evento.aspx.

29. Bohórquez R, Blanco M, Nicholls S, Hernández C, Gualdrón L. Estudio de una epidemia de carditis aguda en población adulta. Act Med Col. 1992;17(4).

30. Webber BJ, Pawlak MT, Valtier S, Daniels CC, Tully CC, Wozniak EJ, et al. Prevalence and Seroprevalence of Trypanosoma cruzi Infection in a Military Population in Texas. Am J Trop Med Hyg. 2017;97(5):1477–81. Epub 2017/08/19. doi: 10.4269/ajtmh.17-0109. 28820695; PubMed Central PMCID: PMC5817750.

31. McPhatter L, Roachell W, Mahmood F, Hoffman L, Lockwood N, Osuna A, et al. Vector surveillance to determine species composition and occurrence of Trypanosoma cruzi at three military installations in San Antonio, Texas. US Army Med Dep J. 2012:12–21. Epub 2012/07/21. 22815160.

32. Caicedo-Díaz R. A. C., Forsyth C., Bernal O. A., Marchiol A., Duran M. B., Batista, et al. Comparative Evaluation of Immunoassays to Improve Access to Diagnosis for Chagas Disease in Colombia. International Journal of Infectious Diseases. 2019;S1201–9712(19)30307-8. doi: 10.1016/j.ijid.2019.07.022. 31357062.

33. Carvalho A, Mendes TAO, Coelho EAF, Duarte MC, Menezes-Souza D. New antigens for the serological diagnosis of human visceral leishmaniasis identified by immunogenomic screening. PLoS One. 2018;13(12):e0209599. Epub 2018/12/21. doi: 10.1371/journal.pone.0209599. 30571783; PubMed Central PMCID: PMC6301785.

34. Berrizbeitia M, Ndao M, Bubis J, Gottschalk M, Aché A, Lacouture S, et al. Purified excreted-secreted antigens from Trypanosoma cruzi trypomastigotes as tools for diagnosis of Chagas' disease. Journal of Clinical Microbiology. 2006;44(2):291–6. doi: 10.1128/JCM.44.2.291-296.2006. 16455872; PubMed Central PMCID: PMC1392643.

35. Caballero ZC, Sousa OE, Marques WP, Saez-Alquezar A, Umezawa ES. Evaluation of serological tests to identify Trypanosoma cruzi infection in humans and determine cross-reactivity with Trypanosoma rangeli and Leishmania spp. Clin Vaccine Immunol. 2007;14(8):1045–9. Epub 2007/05/25. doi: 10.1128/CVI.00127-07. 17522327; PubMed Central PMCID: PMC2044488.

36. Toledo-Machado CM, de Avila RA, C NG, Granier C, Bueno LL, Carneiro CM, et al. Immunodiagnosis of canine visceral leishmaniasis using mimotope peptides selected from phage displayed combinatorial libraries. Biomed Res Int. 2015;2015:401509. Epub 2015/02/25. doi: 10.1155/2015/401509. 25710003; PubMed Central PMCID: PMC4325972.

37. Elisei RMT, Matos CS, Carvalho A, Chaves AT, Medeiros FAC, Barbosa R, et al. Immunogenomic screening approach to identify new antigens for the serological diagnosis of chronic Chagas' disease. Appl Microbiol Biotechnol. 2018;102(14):6069–80. Epub 2018/05/08. doi: 10.1007/s00253-018-8992-7. 29736822.

38. Patino LH, Mendez C, Rodriguez O, Romero Y, Velandia D, Alvarado M, et al. Spatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian army. PLoS Negl Trop Dis. 2017;11(8):e0005876. Epub 2017/08/30. doi: 10.1371/journal.pntd.0005876. 28850603; PubMed Central PMCID: PMC5593196.

39. Cantillo-Barraza Omar, et al. Hacia el desarrollo de una cultura científica local para hacer frente a la problemática del Chagas. Revista Iberoamericana de Educación. 2012; 58(1):119–33.

40. Cucunuba ZM, Florez AC, Cardenas A, Pavia P, Montilla M, Aldana R, et al. Prevalence and risk factors for Chagas disease in pregnant women in Casanare, Colombia. Am J Trop Med Hyg. 2012;87(5):837–42. Epub 2012/10/04. doi: 10.4269/ajtmh.2012.12-0086. 23033397; PubMed Central PMCID: PMC3516258.

41. de Moraes M. H., Guarneri A. A., Girardi F. P., Rodrigues J. B., Eger I., Tyler K., et al. Different serological cross-reactivity of Trypanosoma rangeli forms in Trypanosoma cruzi-infected patients sera. Parasites & vectors. 2008; 1(1), 20. doi: 10.1186/1756-3305-1-20. 18611261; PubMed Central PMCID: PMC2475519.


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