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Associative responses to visual shape stimuli in the mouse auditory cortex


Autoři: Manabu Ogi aff001;  Tatsuya Yamagishi aff001;  Hiroaki Tsukano aff001;  Nana Nishio aff001;  Ryuichi Hishida aff001;  Kuniyuki Takahashi aff002;  Arata Horii aff002;  Katsuei Shibuki aff001
Působiště autorů: Department of Neurophysiology, Brain Research Institute, Niigata University, Asahi-machi, Chuo-ku, Niigata, Japan aff001;  Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Asahi-machi, Chuo-ku, Niigata, Japan aff002
Vyšlo v časopise: PLoS ONE 14(10)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0223242

Souhrn

Humans can recall various aspects of a characteristic sound as a whole when they see a visual shape stimulus that has been intimately associated with the sound. In subjects with audio-visual associative memory, auditory responses that code the associated sound may be induced in the auditory cortex in response to presentation of the associated visual shape stimulus. To test this possibility, mice were pre-exposed to a combination of an artificial sound mimicking a cat’s “meow” and a visual shape stimulus of concentric circles or stars for more than two weeks, since such passive exposure is known to be sufficient for inducing audio-visual associative memory in mice. After the exposure, we anesthetized the mice, and presented them with the associated visual shape stimulus. We found that associative responses in the auditory cortex were induced in response to the visual stimulus. The associative auditory responses were observed when complex sounds such as “meow” were used for formation of audio-visual associative memory, but not when a pure tone was used. These results suggest that associative auditory responses in the auditory cortex represent the characteristics of the complex sound stimulus as a whole.

Klíčová slova:

Fluorescence imaging – Imaging techniques – Memory – Memory recall – Neurons – Vision – Auditory cortex – Audio equipment


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