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A definition-by-example approach and visual language for activity patterns in engineering disciplines
Authors: Mario Janke aff001; Tobias Kuschke aff001; Patrick Mäder aff001
Authors place of work: Software Engineering for Safety-critical Systems Group, Technische Universität Ilmenau, Ilmenau, Germany aff001
Published in the journal: PLoS ONE 15(1)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0226877Summary
Modeling tools are well established in software development. A model is the result of a series of modeling activities. The ability to recognize when a user is working on a certain modeling activity opens up a range of possibilities for context-sensitive support. One possible way to support the user is offering the auto-completion of the current task. The recognition of modeling activities is typically carried out by matching event patterns against events emitted by a user’s editing operations. A user that intends to add or customize auto-completions must be able to easily understand and create activity definitions. However, defining the currently required complex event patterns is a challenging and error-prone task even for a person with an intensive knowledge of event-processing languages. In this paper, we propose the visual definition language VisPaRec accompanied by a method that allows creating activity definitions in a semi-automated and graphical way. We evaluate our visual definition language in a comparative user study against the generic event-processing language Rapide. We found that the proposed visual representation increases comprehensibility while reducing time for constructing and modifying activity definitions significantly.
Keywords:
Vision – Engines – Language – Syntax – Computer software – Swimming – Programming languages – software development
1 Introduction
Automating repetitive tasks in software engineering processes has become essential for developers. Apart from increasing the efficiency of the development process, it can also improve the quality of the developed product by obviating human errors. For example, software developers, experts and novices alike, benefit from simple automations like auto-completion in an IDE [1]. Researchers demonstrated that automation can be beneficial for graphical modeling tasks as well [2–5]. There are plenty of opportunities to support a developer in recurring activities during model-driven architecture and design (e.g., model refactorings). However, the recognition of these activities is not a trivial task since they include a number of different, related editing operations. Complex event processing (CEP) [6] allows for the recognition of such activities and is the technology we apply for this and previous work. In previous work, we used complex patterns of editing events to update traceability information automatically upon recognizing users’ modeling activities [7] and successfully brought a visual language approach to traceability analysis [8–10]. In a succeeding project, we studied how software modeling activities can be recommended while a developer is editing UML models [11] and how such recommended activities can then be auto-completed [12–14]. Both proposed approaches build upon activity definitions captured as event-processing rules. Reactive to every editing operation carried out by the user, an implementation of the latter approach recommends a ranked set of context-relevant modeling activities for auto-completion. The typical workflow of integrating activity pattern-based completion into a tool includes using a general-purpose CEP language or declarative programming language. Alternatively, simple patters can be hardcoded without a proper CEP framework. However, this comes with serious drawbacks in terms of maintainability and expandability. We have previous developed a prototype architecture of an auto-completion tool based on a textual CEP language, but we hypothesize that a specialized visual language can increase the applicability of this and many other approaches. In general, the usefulness of such automation highly depends on their customizability to users’ needs. However, defining the required event-processing rules is a challenging task because very specific knowledge of the processing platform and its declaration language is required.
This paper presents the visual language VisPaRec accompanied by a definition method allowing non-CEP-experts to create and maintain activity definitions in a semi-automated way. We see multiple application scenarios where lowering the effort and knowledge necessary to work with activity definitions can benefit developers in the software industry. On one hand, tool vendors of model and code editors can develop CEP pattern based support more easily. On the other hand, modelers using modeling tools directly benefit by being able to customize and define their own activity definitions. The modelers may or may not be active programmers, but have full insight into their personal working patterns and customization wishes. Our approach aims to aid users in defining their own patterns and by that supporting their individual workflows. In this sense, pattern specification should require as little knowledge about programming and CEP as possible. Patterns should be comprehensible at a glance, easily maintainable and expandable. Through the definition-by-demonstration method proposed in this work, users can create activity definitions by demonstrating the desired activity within their modeling environment rather than being requested to write complex event processing rules. Thereby, technical and tool-specific aspects are abstracted and mostly hidden from the user.
The remainder of this paper is structured as follows. Section 2 reviews related work on complex event patterns, defining model transformations and programming by example. Section 3 describes the concepts of modeling activity definitions and their relation. Section 4 introduces VisPaRec, the visual definition language that we developed for specifying modeling activity definitions, followed by an analysis and comparison of selected event processing languages. Section 5 presents how VisPaRec can be embedded into a “by-demonstration” approach that automates large parts of creating a definition. Section 6 describes a user experiment that we conducted to evaluate comprehensibility, applicability and usability of VisPaRec. Finally, Section 7 concludes our work and outlines future research.
2 Related work
Supporting development activities in modeling-based environments is a relatively novel research topic. To the best of our knowledge, there exist no approaches that support users in defining their own activities and in employing them in modeling environments for auto-completion. There do, however, exist generic solutions for supporting users in the definition of complex event patterns and model transformation rules. Complex event processing, in general, is a technique to infer high-level knowledge from streams of low-level events. A core principle is the agglomeration of the simple input events into more structured agglomerations called complex events. Another characterizing feature are queries against these events, simple and complex alike. Usually, incremental evaluation is a key feature. Typical applications range from monitoring tasks, such as evaluating sensory data and network monitoring, over gesture detection to business rule engines.
Textually defining complex event patterns
Eckert et al.’s [15] comprehensive survey shows that, driven by varying user needs as well as strengths and weaknesses of the underlying engines, a rather high number of textual CEP languages have been proposed in the past. We exemplarily discuss three languages that follow different approaches in their design. Given the large variation in language features in the early days of rule processing, Rapide [16, 17] was proposed as a language independent of an underlying engine. It has a strong mathematical foundation and was designed as a general language framework. Rapide consists of a comprehensive and expressive set of rule features that has inspired CEP engines since and that is supported by most CEP engines today. The Drools Rules Language (DRL) [18, 19] is one of many production rule languages. It is tightly coupled with its host language Java. In DRL, persistent state is represented as Java objects called facts, which are stored in a Working Memory. Pattern matching happens through rules that specify facts and conditions that single or multiple facts must fulfill. Esper EPL [20] is a data stream query language. Its language design originates from the database query language SQL. Esper EPL abstracts the input as a data stream of tuples. These streams can be queried much like a relational database. Timing as well as sequencing constraints can be formulated in a high-level syntax. Additionally, Esper EPL allows combining data stream queries with pattern matching. We compare the part of these languages’ syntax that is relevant to the presented approach in Section 4.3.2.
Visually defining complex event patterns
In the field of complex event processing, a number of graphical editors, both proprietary tools and academic approaches, for defining patterns and rules exist. The SocEDA project [21] offers an editor for translating high-level definitions of complex event patterns into Esper EPL. The tool supports the pattern definition visually but also requires the user to write code of the underlying event-processing language. The visual representation of a pattern in SocEDA does not contain all information, but rather represents some of it merely within the code. Nowak et al. [22] present an editor based on the Palantir Government platform for creating rules in the event-processing language JESS. Similar to SocEDA, the visual representation does not include all the relevant information. The editor only presents additional information in a panel when requested by the user. Both approaches reduce the visual load by omitting some information and only showing it on demand. While this is effective for a modeling tool, it does not enable visual comprehension of patterns at all. Strelka is a graphical editor for defining rules developed by the REWERSE Working Group I1 [23]. The tool uses the UML based rule modeling language URML that allows users to visually model different types of rules based on UML class models. Boubeta-Puig et al. [24] describe a user-friendly, model-driven approach for specifying complex event patterns. Similar to our proposed method, users are able to design graphical models specifying event patterns. These models are then transformed into platform-specific event-processing code by the use of a corresponding model-to-text transformation. Their editor MEdit4CEP provides all instruments that are necessary to express conditions for recognizing modeling activities. However, even low-level language elements like logical operators are displayed by separate visual elements, which leads to high visual complexity and clutter. In contrast to the first two approaches, MEdit4CEP and Strelka do encode rules completely visually. The drawback of this approach is that the visual pattern definitions become very complex even for small rules, since a lot of information that could be represented very compactly, is displayed in a very explicit way. We further investigate this issue in Section 4.3. The introduced editors allow defining event patterns and rules without explicit knowledge of a platform-specific event-processing language, but they all are developed from the viewpoint of complex event processing. Additionally, these approaches do not provide mechanisms for defining auto-completions of modeling activities.
Defining model transformations
Sun et al. [25] presented an approach that allows users to demonstrate model transformations and to automatically derive transformation rules from this demonstration. In another study, Sun et al. [26] describe how layout information for model transformations can be captured during user demonstrations and effectively used later on. Biermann et al. [27] propose a framework for in-place transformations of EMF-Models. Based on their approach, Arendt et al. [28] developed the transformation language Henshin. In their work, they describe concepts like pre - and post-conditions of model states that have similarities to our work. However, transformation rules are intended to change models upon reaching defined states, whereas our approach regards edits, not state. Specifying the evolution of model elements comprising historic element states and restricting the timing of model changes are not the purpose of model transformation rules.
Graph transformation languages like Story Diagrams [29] can specify patterns similarly to transformation languages. A pattern matches a graph and applies the transformation to it, the outcome is a modified graph. This approach, therefore, cannot be used directly to specify an activity pattern. However, one could try to reinterpret the existing visual notations for graph transformations or augment them. Graph transformations only specify a state before and after the transformation. For the specification of activity patterns, continuous and possibly concurrent changes need to be specified.
Programming by example
Raza et. al. [30] propose a solution to the problem of ambiguity in example-based programming. They use the least general generalization to describe a set of examples. The inherent ambiguity involved in such tasks is a highly important issue our approach faces as well. Their approach aims to express rather small changes using a multitude of examples and was evaluated using a Microsoft Powerpoint add-in.
Conclusions
We conclude that there are approaches that support the graphical specification of rules. However, none of them provides a desirable solution to the problem of specifying event-processing rules in the context of modeling activity recognition. This is what we aim to accomplish with VisPaRec. VisPaRec is not intended to be a general-purpose EPL, but rather a domain-specific language for the representation of modeling activities that is easy to read and write for non-CEP-experts.
3 Concepts of modeling activity definitions
We aim to support a user in developing a model that comprises a set of model elements E. Typical model elements are packages, components, classes, interfaces, attributes, methods, associations, dependencies, and generalizations. The user is evolving this model through editing operations of the types add, modify, or delete. A modify operation changes attributes of an existing model element, e.g., the element’s name or type. This choice of operation types is extendable in nature and may be dependent on the application at hand. For specific applications, it might be useful to formulate more types. However, specific operation types like copying a model element or the act of moving one model element into another can be represented as a pattern of the fundamental types add, delete and modify. We denote the set of all editing operations performed by a user on a model as O. A modeling activity is then defined as a recurring set of editing operations carried out by the user on model elements.
As a running example, we introduce a modeling activity that represents the well-known refactoring “Extract Class” (see Fowler [31]) on a UML class diagram. During this refactoring, an attribute of an existing class is extracted into an independent class. Fig 1 shows the modeling activity performed on an example model of a software system. As a precondition, a class must exist and contain an attribute. In the example, the attribute Engine of the class CarConfiguration is extracted. The ellipses represent editing operations belonging to the modeling activity. The existing attribute is deleted (I) and a new class is added (II) within the same package CarConfigurator. The new class will be renamed (III) according to the deleted attribute Engine. The activity is completed by adding a new association connecting the two classes (IV) and modifying it into a directed aggregation (V). The user may freely decide about the sequence of editing operations. Naturally, some limitations are imposed by the modeling environment, e.g., classes need to be added before they can be connected.
Fig. 1. Editing operations for executing the activity “Extracting attribute as class”. The event-based recognition of a modeling activity requires an activity definition in the set of all activity definitions T. An activity definition specifies: (1) a set of expected editing operations that have to be performed to complete the modeling activity, (2) a set of expected element versions V capturing expected states of model elements during the modeling activity, (3) constraints on model element properties captured in element versions PV and across element versions PR, (4) constraints across editing operations and element versions SR restricting the operation sequence, and (5) an action to be executed upon recognition of the specified modeling activity. It is sufficient to store values of element properties in PV, while PR needs references to multiple element versions. The action part of the definition depends on the usage scenario. There are numerous ways to react to a detected activity, but in the scope of this paper, we illustrate our approach within an auto-completion technique that aims to complete the modeling activity the user started. Information specified in the action part of an activity definition therefore comprises completion actions A to be executed automatically and property defaults D to specify values of editing operations to be auto-completed.
Based on the introduced initial concepts, we developed a meta-model for activity definitions (see Fig 2). Whenever a rule matches, the result must be kept in a structured way to be usable for a possible auto-completion. It must specify editing operations already done, and how to complete the ones not done yet. An example is contained in the experimental replication package (accessible at https://dataverse.harvard.edu/dataset.xhtml?persistentId=doi%3A10.7910%2FDVN%2FFTPF3Z, cp. R1T on page 32) showing how to specify the necessary information using three arrays. Explicit specification is necessary in any general-purpose language.
Fig. 2. The meta-model for activity definitions. 4 VisPaRec—A language for activity definitions
Based on the meta-model introduced in the previous section, we developed a visual representation for each concept. We followed Moody’s principles for creating efficient visual software engineering notations [32]. Moody argues that the basis for a “good visual notation” is having a clear design goal that specifies what kind of information needs to be presented, what audience is using this information (theory of cognitive fit), and what visual dialect is suitable for that purpose. Moody lists fundamental principles that a notation should fulfill. Referring to the principles of semiotic clarity, perceptual discriminability, semantic transparency, visual expressiveness and dual coding, the basic notation elements should exhibit the following characteristics. They should correspond 1 : 1 to their semantic construct. Therefore, we mapped each meta-model element to an individual visual notation element while keeping their number cognitively manageable (graphic economy). Furthermore, notation elements should be clearly distinguishable from each other by using the full range and capacity of visual variables like shape, color and size. Also, text should be used redundantly to support graphic elements. In the following, we introduce the notation elements of our visual definition language and explain them on examples.
4.1 Language concepts
Model element (C1)
Each model element involved in an activity is represented by an open ended swim lane, much like in UML (see Fig 3). A vertical label on the left hand side of this swim lane contains the element type. The swim lane is a container that groups different versions of an evolving model element and the editing operations that transition from one version into the following.
Fig. 3. Visual representation: Model element (C1). Decision: Group versions of an element via swim lanes. Rationale: We see an object over its lifetime as a semantic construct on its own. Swim lanes help to reach the goal of representing each semantic construct 1 : 1 as they are a single notation element for a single construct. The commonly used alternative is to encode the edited model element through a guard of the object’s ID, which corresponds n:1 to the semantic construct. The swim lane concept also contributes towards graphic economy.
Element version (C2)
An element version uses the notation of classes from a UML class diagram. We distinguish three types of element versions (see Fig 4): First, Existent specifies that a certain model element must exist before the modeling activity is started. Second, Non-Existent specifies that a certain model element may not exist before the start of an activity or after it is being deleted during an activity. Third, ordinary element versions specify certain states in the model element’s evolution. Different background colors are used within swim lanes to visually highlight the existence and the non-existence of a model element. Elements within the same swim lane have an implicit sequence constraint (see Sequence Constraints (C5)) among them, while no sequencing between swim lanes is enforced. This allows for more flexible patterns, as concurrency can be formulated.
Fig. 4. Visual representation: Element versions (C2). Editing operation (C3)
Editing operations are represented with a circular outline. According to the principle of dual coding, we visualize the operation types add, modify, delete, within the circle textually and additionally as a colored symbol (see Fig 5). An editing operation must be connected to a previous element version that specifies the state of the element before the operation is performed and to a resulting element version that specifies the element’s state after the operation. Two dashed arrows visualize these relations. The direction of those arrows points from the previous element version to the operation and from the operation to the resulting element version. The visual representation of model elements, element versions and editing operations all differ in shape and size. The graphical grouping of versions and operations into swim lanes is intended to clearly visualize the involved model elements and their evolution throughout a modeling activity.
Fig. 5. Visual representation: Editing operations (C3). Decision: Each operation type has its own icon distinguished by color and shape. Rationale: As the operation type has a huge impact on the interpretation of an edit, it must represent the types in a clearly distinguishable way ensuring semiotic clarity. Varying color and shape ensure perceptual discriminability. We expect this design to ease comprehension compared to all current solutions, which represent these concepts solely by a different name or id of the change type.
Property constraint (C4)
Property constraints specify values of element properties and are expressed as logical terms. To keep the graphical complexity manageable, we chose to not represent logical expressions in a graphical way. Instead, we specify these expressions textually by using operators like those shown in Fig 6. Property constraints are partitioned into static and dynamic ones. Static constraints PV specify constraints on concrete values of element properties and are therefore defined within an element version. A very common static property constraint is the specification of the type of an element. Dynamic constraints PR are defined as references across properties of versions of the same or different model elements involved in an activity. These references are visualized as directed connectors that point from the constrained to the referenced element version. Two elements having the same name, or one element being the child of another one are typical dynamic property constraints. The left hand part of Fig 6 shows the two visual representations of property constraints. Property constraints can be applied to restrict all element versions except those of the type Non-Existent. We do not check for syntactical or semantical mistakes within property constraints at modeling time. However, at a later point, the transformation into executable event processing rules (cp. Section 5.4) does check syntax.
Fig. 6. Visual representations: Property constraints (C4) (left) and possible constraint operators (right). Decision: Represent static and dynamic property constraints differently. Rationale: A fixed parameter and a reference between multiple model elements are semantically rather different. Separate visual representations help to uncover and visualize dependencies between model elements to the user and contribute to better perceptual discriminability of concepts.
Sequence constraints (C5)
Sequence constraints express timing and order conditions. They start and end at element versions or editing operations (see Section 3). We decided to visually distinguish sequence constraints from property constraints.
Sequence constraints use orange connectors instead of blue ones and squares as source symbols instead of dots. Fig 7 shows two examples of sequence constraints. The operator “>” means “after” and “TimeStamp > Created” (upper example) expresses that the editing operation must be performed after the model element has been created. In contrast “<” means “before” and the lower example specifies that the class has to be added before the interface is added.
Fig. 7. Visual representation: Sequence constraints (C5). Decision: Distinguish property constraints from sequence constraints. Rationale: We regard sequence constraints, which manage event order, and property constraints, which manage event content relations, as semantically different. Accordingly, we represent them differently increasing perceptual discriminability.
Completion actions (C6)
Completion actions serve as replacements for those editing operations that have not been performed manually. An activity definition comprises completion actions for all specified editing operations. Each completion action contains property value assignments that correspond to the property constraints of its editing operation. As such, it can be automatically retrieved from the editing operation definition. For that reason, completion actions are not explicitly expressed in a visual activity definition. Instead, each editing operation and the resulting element version visualize the corresponding completion action.
Completion defaults (C7)
Completion defaults specify default values for element properties that are applied when the auto-completion of a modeling activity is executed. Completion actions can comprise completion defaults that must be defined explicitly. We integrate the completion defaults into the resulting element versions of editing operations as shown in Fig 8. The example in the figure specifies that a user must add an association of subtype aggregation or composition to match. If this operation is auto-completed rather than manually executed, an association of subtype composition will be added.
Fig. 8. Visual representation: Completion defaults (C7). 4.2 VisPaRec’s expressiveness and scope
At the core, all EPLs are used to specify patterns by describing participating objects as variables and how they are related as guards, as well as what should happen whenever a pattern is matched as an action [33]. VisPaRec allows users to specify the variables in multiple different ways, tailored to the domain. Both, element versions as well as editing operations, serve as variables. As element versions are allowed to have arbitrary properties, they have full expressiveness. Sequence constraints, property constraints and model elements represent the guard concept. Model elements and sequence constraints, however, can only express specialized relations and are not as expressive as general guards. Property constraints can specify arbitrary relations between elements, and therefore are as expressive as the guard concept. This has the consequence that model elements and sequence constraints can be expressed as property constraints, but doing so results in massively harder to read and write descriptions. One can therefore see them as an abbreviating syntax construct. The completion actions are the equivalent of the action of a CEP pattern. One should note that the action of a CEP rule is only activated when the whole pattern is matched, while completion actions are applied whenever a single variable is matched. The behavior of completion actions is at least as expressive, as one can perform the desired action in the completion action of the object matched last. Table 1 summarizes the mapping between the basic CEP concepts and the visual concepts in VisPaRec implementing them. The table shows that for every CEP concept a VisPaRec element with the same expressiveness exist, concepts with full expressiveness are marked in italic. Therefore, VisPaRec can be used to express arbitrary complex events patterns.
Tab. 1. Mapping between CEP and VisPaRec concepts. 4.3 Comparison of event processing languages
Now, we take a closer look into how different EPLs specify the basic CEP concepts discussed in Section 4.2 as well as the domain specific concepts described in Section 3. Fig 9 shows an example pattern in VisPaRec that we will refer to as the example activity. It is a simplified version of the pattern shown in Fig 12 that we reduced for space reasons. We formulate this pattern in various CEP languages in order to compare them with each other. The pattern matches when an attribute is deleted and a class is added, which is then renamed to the name of the deleted attribute. No additional explicit order between these events is enforced. Figs 9, 10 and 11 show the implementation of this activity in the respective languages.
Fig. 9. Example activity modeled in our VisPaRec language. Fig. 10. Fig. 11. Fig. 12. VisPaRec definition of the modeling activity “Extracting attribute as class”. 4.3.1 Evaluation of visual event processing languages
Strelka. Fig 10 shows how the example activity can be modeled with Strelka, using URML. The variables are represented by classes following the UML notation. The blue arrows pointing from a class to the rule are so-called ClassificationConditions, specifying what a single class has to fulfill in order to fit the pattern. The blue arrows pointing from an association to the rule are AssociationConditions, specifying how classes must be related in order to fit the pattern. These two concepts represent guards.
MEdit4CEP. The model depicted in Fig 11 represents the example activity modeled in MEdit4CEP. Simple events serve as variables and are represented as rectangles with a green “E” on the top left corner. If an event has properties, these are listed within the event’s rectangle as separate rectangles with a green “P” on the top left corner. Constant values are visualized as black rectangles with rounded corners and a broad border. Any comparison operator is represented by a single model element that is a pink circle containing the comparison symbol. It must have two incoming arrows to specify the arguments, which need to be ordered explicitly by the numbers “1” and “2”. Comparison operators together with constants represent the guard concept. Any pattern must contain a complex event that must have at least one property that is connected to a property of a simple event. Complex events are represented much like simple events, but use red labeling.
Comparison. The example shows that in Strelka and MEdit4CEP manyfold relations must be explicitly specified. This is the result of the very general nature of both languages. These relations could actually be formulated more intuitively and more compactly. The main problem is that one must explicitly specify which operations and element versions refer to the same object, which happens very frequently in our application. Additionally, the order of editing operations must be specified by enforcing an order between time stamps. Furthermore, MEdit4CEP displays all event properties at all times, which is not necessary for the given application, where the same two event types are used over and over. Note that we left out properties not relevant to the small pattern presented, and more properties are relevant in general. Both diagrams reach the limit of what is comfortably displayable on one screen even for this very small example. We therefore come to the conclusion that the presented unspecialized visual languages are not applicable for larger patterns within our application.
VisPaRec differentiates itself through several design choices of which we regard the following ones as most significant.
VisPaRec uses swim lanes to keep track of element versions as well as editing operations regarding the same object. The other two considered visual languages use the guard concept to model this. While guards prevent introducing a new concept, they require encoding the semantic of referring to the same object numerous times.
VisPaRec gives editing operations a specialized visualization, whereas Strelka and MEdit4CEP use their respective guard syntax. Thereby, VisPaRec can reduce the number of elements to a more manageable amount and differentiates the semantically very different editing operations visually as well.
VisPaRec colors sequence constraints and property constraints differently, which again keeps semantically different concepts also visually distinguishable.
Regarding graphic economy, Strelka uses a very low number of different symbols. VisPaRec does introduce more symbols than Strelka, as it is necessary to cover the range of semantic constructs deducted from the metamodel in Fig 2. MEdit4CEP uses some symbols that we find too excessive for the application, and simply inflate the number of symbols. Examples for this are the element naming, the differentiation between element and properties, as well as the numbers identifying the inputs of the = relation (even though it does not matter since = is a symmetric relation).
4.3.2 Evaluation of textual event processing languages
To analyze the similarities and differences of common EPLs applicable for the definition of activity patterns, we discuss main language concepts on an example activity written in Rapide, DRL, and Esper EPL (cp. Section 2). The resulting specifications are shown in Listing 1, 2 and 3, respectively. For brevity and readability, we are omitting surrounding parts of the pattern specification like rule declaration, variable declarations, rules’ action part etc. and focus on the core pattern definitions.
Listing 1. Example activity written in Rapide.
1 EditingOperation(Element_Version is ? V3) where
2 ( ? V3.Type = “attribute”)
3 ? 01(Element_Version is ? V4, Operation_Type is “delete”) where
4 ( ? V4.ID = ? V3.ID)
5 ? 02(Element_Version is ? V5, Operation_Type is “add”) where
6 ( ? V5.Type = “class”)
7 ? 03(Element_Version is ? V6, Operation_Type is “modify”) where
8 ( ? V6.ID = ? V5.ID and ? V6.Name = ? V3.Name)
Listing 2. Example activity written in DRL.
1 EditingOperation( $ V3 : Element_Version, $ V3.Type == “attribute”)
2 $ 01 : EditingOperation( $ V4 : Element_Version,
3 Operation_Type == “delete”, $ V4.ID == $ V3.ID)
4 $ 02 : EditingOperation( $ V5 : Element_Version,
5 Operation_Type == “add”, $ V5.Type == “class”)
6 $ 03 : EditingOperation(V6 : Element_Version,
7 Operation_Type == “modify”, $ V6.ID == $ V5.ID,
8 $ V6. Name == $ V3. Name)
Listing 3. Example activity written in Esper EPL.
1 ( EO3 = EditingOperation (Element_Version.Type = “attribute”) ->
2 01 = EditingOperation (Operation_Type = “delete”,
3 Element_Version.ID = EO3.Element_Version.ID) ) and
4 ( 02 = EditingOperation (Operation_Type = “add”,
5 Element_Version.Type = “class”) ->
6 03 = EditingOperation(Operation_Type = “modify”,
7 03. ElementVersion.ID = 02.ElementVersion.ID) )
8 where 03.ElementVersion.Name = 01.ElementVersion.Name
Assignments. In the Listings 1, 2 and 3, assignment operators are colored blue, while comparison operators are colored red. A comparison shows that the languages differ in how they mark assignments, how they express relations to constants and how they express relations to variable parts. Rapide uses the keyword “is” for variable assignments as well as comparisons with constants. It uses “=” for comparisons between variables. DRL uses “:” for all assignments, but “=” for both types of comparison. In Esper EPL, assignments as well as comparisons use “=”. All three ways of specification are reasonable, as the separation of syntactically different operators is important but it also is valuable to keep the number of syntactical elements of a language manageable. Furthermore, Esper EPL is missing a syntax construct that allows assignments of attributes to variables. While the syntax for this can be seen in line 1 for Rapide and DRL, Esper EPL needs to refer to the attribute using the object every time. This can be rather clunky when using a sub-object often, or when referring to an attribute of a sub-object.
Variables. All variables are colored green in the examples. The type of editing operations like O1 and O2 must be declared on every use in DRL and Esper EPL, while Rapide declares all variables at the start of the file. Rapide, therefore, is very compact in specifications where object types are often reused. Variables are typically marked with the prefix “?” in Rapide and “$” in DRL, while Esper EPL usually does not use such a prefix. Although a prefix adds an extra character that may look confusing at first, it helps differentiating variables from constant expressions. The prefix “?” stresses the variable nature and thus has a somewhat plausible association with a variable. Anyway those are merely conventions.
Sequencing. All sequencing related language elements are colored purple in the examples. In Esper EPL, the sequencing of events is specified through the “ − >” operator, which is used whenever the left hand side event happens before the right hand side event. It binds weaker than the “and” operator. The keyword “where” is used to filter the matches of a pattern after it is completed. This is necessary because the example activity has two concurrent streams of events that must be connected by the constraint of identical names. While Esper EPL’s syntax allows the user to specify the sequence of events in a very compact way, the user must explicitly specify every detail of the sequence. On the one hand, this makes the user more aware of the event flow than the syntax of Rapide or DRL, on the other hand, we found it surprisingly hard to get the sequencing right for examples within our application. The other two languages formulate sequencing constraints just like any other property constraint, while the internal matching order is determined by the order of the statements from top to bottom.
In conclusion, all three textual languages were able to express the example within a similar amount of space. We discuss their applicability in regards to modeling activity patterns within the context of our evaluation in Section 6.1.
5 Defining modeling activities by example
We now propose a semi-automated definition process that comprises three steps: (1) demonstrating the modeling activity and deriving an initial activity definition, (2) manually refining the activity definition, and (3) generating platform-specific event-processing rules from the activity definition. The following subsections describe these three processing steps in detail.
5.1 Step 1: Demonstrating the modeling activity
The first step is often the hardest. Therefore, providing an intuitive way for creating an activity definition rather than starting to construct it from scratch is highly desired. A state-of-the-art way to address this goal is the definition “by-demonstration”, which allows a user to simply execute a desired behavior within a familiar working environment and to automatically derive an initial description based on that demonstration. This demonstration step starts on an empty diagram of a supported model type, e.g., a UML class diagram, and comprises two phases: (1a) modeling the activity preconditions and (1b) performing the editing operations. The following paragraphs describe these two phases and the transformation rules that are applied to create an activity definition that conforms to the meta-model depicted in Fig 2.
Step 1a: Modeling the activity preconditions
The preconditions of a modeling activity comprise model elements that have to be present before the modeling activity may be performed. In order to demonstrate the preconditions, the user adds the model elements to an empty diagram and defines their important properties. The preconditions for our example activity can be seen in Fig 1. Before starting the activity, a class must exist containing an attribute to be extracted. While the user is modeling the activity preconditions, Rule 1 to Rule 4 are applied. This step leads to at least one element version for each modeled element, specifying all relevant property constraints. Once all activity preconditions have been modeled, the user approves them and thereby enters phase (1b): the demonstration of the editing operations.
Rule 1: Add new model element
1 Trigger: editing operation o of type add for a model element e (o ∈ O, e∈E|o=add(e))
2 create an element version v0, where v0 specifies the state before o: v0 = pre(o)
3 define the non-existence of e by setting v0 to type Non-Existent
4 create an element version v1, where v1 specifies the resulting state of o: v1 = result(o)
5 forall non-empty properties x of v1, except ID and Name do
6 define a property constraint of the type (identifier(xi) = value(xi))
Rule 2: Modify existing model element
1 Trigger: editing operation o of type modify for a model element e (o ∈ O, e∈E|o=modify(e))
2 retrieve an element version vn, where vn is the last version of e preliminary to o (vn = last(e))
3 create an element version vn+1, where vn+1 specifies the state of e subsequent to o (vn+1 = result(o))
4 forall properties x of vn+1 do
5 if value(x(vn)) ≠ value(x(vn+1)) then
6 define a property constraint of the type (identifier(x) = value(x))
Rule 3: Delete existing model element
1 Trigger: editing operation o of type delete for a model element e (o ∈ O, e∈E|o=delete(e))
2 retrieve an element version vn, where vn is the last version of e preliminary to the model element deletion operation o: vn = last(e)
3 create an element version vn+1, where vn+1 specifies the state of e subsequent to the model element deletion operation o: vn+1 = result(o)
4 define the non-existence of e by setting vn+1 to type Non-Existent
Step 1b: Performing the editing operations
Upon approving the preconditions, Rule 5 is applied. This removes obsolete element versions and editing operations and leads to exactly one element version of type Existent for each preexisting model element. The user then performs the editing operations of the modeling activity involving preexisting and newly created model elements. Again, Rule 1 to 4 are applied in order to create the corresponding objects in the activity definition. To demonstrate a delete operation, a preexisting model element is deleted from the diagram. For demonstrating an add operation, a new model element can be added from the toolbox without the need to change any property. The user only needs to edit those element properties that shall be transformed into property constraints of the activity definition (Rule 2). Our activity recognition approach handles the undo of editing operations within the modeling tool, i.e., a user may use this functionality upon mistakes in performing editing operations and modeling preconditions without impact on the resulting activity definition. Fig 1 shows that Class2 has been modified to express a property constraint: the name of Class2 must be set to the name of the extracted attribute. Most of these property constraints can be derived automatically during the demonstration step by applying Rule 6. Rule 6 replaces identical constant property values with references to the corresponding model elements, making the static property constraints dynamic. Fig 12 illustrates such an initial definition that was obtained by demonstrating the example activity shown in Fig 1.
The presented set of transformation rules is independent of the model type that an activity is applied to. The set is meant as a basic rule set for creating initial activity definitions according to the specified meta-model. However, the set may be adjusted or enhanced for other types of models.
5.2 Limitations of rule definition by example
Rule definition by example essentially uses a bit of event data, in our case a stream of editing operations, to infer matching rules. A rule can therefore be abstracted as one way to interpret correlations contained in the given bit of data. Unfortunately, the derivation process is inherently ambiguous, no matter how many demonstrations are given. As an illustrating example, two different element versions a and b may have the name “Factory”. The property constraints shown in Listing 4, as well as infinitely many other ones, would fit that state of data.
Rule 4: Create version for preexisting model elements
1 Trigger: model element e that have not assigned any element version (e∈E|last(e)=∅)
2 create an element version v0, where v0 specifies the initial state of e
3 define the existence of e by setting v0 to type Existent
Rule 5: Remove obsolete versions and operations of model elements
1 Trigger: model element e
2 if the model element e has been deleted already (∃v∈V:∧v=last(element(v))∧element(v)∉E)) then
3 delete all editing operations: operation(e) and all element versions: version(e) of the deleted model element e
4 else
5 delete all editing operations: operation(e) and all element versions: version(e) of the model element e except the last version vn: vn = last(e)
6 define the existence of e by setting vn to type Existent
Rule 6: Create property constraint reference by identifier
1 Trigger: element version v
2 forall property constraints p of v do
3 if value(p) contains the identifier of a model element e, where element(v) ≠ e then
4 create a property constraint reference pr pointing from v to the first existing version of e: exist(e)
5 define a logical expression of the type (identifier(pr) = ID) where ID references the identifier of e
6 delete p
Listing 4. Possible Constraints based on the same demonstration
1 a.name == b.name
2 a.name == “Factory” && b.name == “Factory”
3 a.name.startsWith(“Fac”) && b.name.endsWith(“tory”)
4 a.name.startsWith(“Fac”) && b.name == “Factory”
An example based rule definition must therefore aim to find rules that are simple and likely. As there can always be cases where the simple and likely interpretation is not the correct one, manual refinement of rules can be necessary. For example, the rule definer might have wanted to demonstrate rule number 3 of Listing 4, but since rule number 1 is simpler it will generally be preferred. Furthermore, a single example defines a very specific chronological order between all editing operations. As a large number of highly different demonstrations would be necessary to determine relevant sequence constraints, those must be excluded from our automatic detection. For the activity “Extracting attribute as class”, all of the relevant ID equivalencies and name equivalencies will be detected. But there is no way to know from a single example if any of the detected equivalencies are false positives. An interesting extension would be keeping some of the demonstrations to check whether a refinement done in the next step would lead to a contradiction.
5.3 Step 2: Manually refining the activity definition
In the second step of the process, the user manually refines the initial activity definition generated in Step 1. This step is required to generalize the activity definition and to add information that cannot be derived automatically. Refinements that need to be applied are of three generic types discussed below.
Edit constraints
Refinements can be done in order to (1) add additional property constraints that have not been captured during demonstration, to (2) relax or extend constraints that have been captured already, and to (3) add sequence constraints that restrict the order of editing operations for performing an activity if necessary. For example, during the demonstration of the activity in Fig 1, an editing operation referred to the modification of the associations’ subtype into aggregation, but the intention of the user is to also allow the subtype composition for this activity. To do this refinement, the user needs to extend the existing constraint SubType = aggregation into SubType = aggregation, composition (see Fig 12, RI).
Define completion defaults
Completion actions are automatically retrieved from specified editing operations and the property constraints of their resulting element versions (see Section 4). Additionally, the user can define completion defaults that ensure desired values of element properties after the auto-completion of a modeling activity. Referring to the previous example, when allowing two options for the association subtype, a completion default could define which subtype is used when auto-completing the activity (Fig 12, RII).
Merge captured editing operations
In the demonstration phase, an editing operation is captured for each performed and accepted modification of a model element. If a user edits the properties of an element in a chain of subsequent edits, multiple element versions are created for a model element. For recognizing and auto-completing the modeling activity, often not all captured editing operations and element versions are required. Multiple sequentially performed modify operations on the same model element can be merged into a single editing operation and resulting element version, defining all required constraints in one place. For example, if the user demonstrates the modification of the association by two editing operations, modifying the subtype and modifying the navigability, these can be merged into a single operation as shown in Fig 12.
5.4 Step 3: Generating event-processing rules
In the third processing step, a refined activity definition is transformed into event-processing rules that can be evaluated by a rule engine. This is necessary because our visual language cannot be understood by a CEP engine like Drools or Esper directly. The transformation is done in two stages. The first stage can be regarded as a preprocessing where implicit information is defined explicitly which is required for correctly working event patterns. This preprocessing is done automatically as follows.
Type constraints
In the visual language, information about element types is captured in the label of a swim lane. In the textual representation, these type restrictions have to be specified explicitly to ensure a correct recognition of model elements. Rule 7 creates a type constraint for the first existing version of each model element.
Rule 7: Create model element type constraints
1 Trigger: model element e
2 retrieve an element version v, where v is the first existing version of e (v = exist(e))
3 define a property constraint of the type (Type = type(e)) for v
Connecting element versions
Element versions that refer to the same model element are grouped into a swim lane in the visual representation. This grouping requires extra effort in the textual notation. Therefore, Rule 8 adds ID-equality constraints to all versions of a model element.
Rule 8: Bind element versions of a model element
1 Trigger: element versions v of a model element e (v∈V,e∈E|v=version(e))
2 retrieve an element version v0, where v0 is the first existing version of e (v0 = exist(e))
3 forall previous element versions w ≠ v0 of v do
4 cretae a property constraint reference pointing from w to v0
5 define a logical expression of the type (ID = ID) expressing the equality of the model elements: element(v0) = element(w)
Preventing multi-matching
An activity may contain multiple add operations for elements of the same type, e.g., creating new classes. It is essential to ensure that the first editing operation cannot match multiple times. Rule 9 adds an ID-inequality constraint requesting that the identifiers of such model elements are different.
Rule 9: Differentiate model elements of the same type
1 Trigger: element version v resulting from editing operation o on an model element e of the type add: (v∈V,o∈O,e∈E|o=add(e)∧v=version(e))
2 if the value of the property constraint Type of v is equal to the value of an element version vj: value(type(v)) = value(type(vj)), where element(v) ≠ element(vj) then
3 create a property constraint reference pointing from v to vj
4 define a logical term of the type (ID ≠ ID) expressing the inequality of the model elements: element(v) ≠ element(vj)
Rule 10: Create sequence constraints to add-operations
1 Trigger: editing operation o
2 retrieve all element versions v of V, where type of v is Existent (type(v) = Existent)
3 if the operation type of o is add type(oi)) = add then
4 forall element versions vj of v do
5 create a property constraint reference pointing from o to vj
6 define a logical expression of the type (TimeStamp > Created) expressing that o must be performed after vj was created
Sequence constraints
Sequence constraints are required to ensure that preexisting model elements were not created after editing operations of the activity already took place. Rule 10 adds a sequence constraint between all add-operations and the preexisting elements of a modeling activity.
In the second stage, a model-to-text transformation uses the preprocessed activity definition as input for generating event-processing rules. This transformation is platform-specific and will not be discussed here. A variety of event-processing rule engines may be utilized for recognizing modeling activities.
6 Evaluation
We decided to perform a comparative user study of VisPaRec. As a baseline for comparison, we selected the textual language Rapide. As the benefit of by-demonstration approaches in general has been already studied by other authors [25], we decided to restrict our study to the evaluation of VisPaRec in comparison to Rapide.
In this user experiment, we aim to answer the following research questions:
- RQ1
How well can a user comprehend VisPaRec’s visual activity definitions in contrast to Rapide’s textual definitions? (Comprehensibility)
- RQ2
Does the use of VisPaRec result in a faster and more correct definition of modeling activities compared to Rapide’s textual definitions? (Applicability)
- RQ3
How do users judge the usability of VisPaRec in contrast to textual Rapide definitions? (Usability)
6.1 Choice of a baseline event processing language
All above discussed event processing languages are suitable for defining modeling activities (cp. Section 2 and 4.3). Both Strelka, as well as MEdit4CEP, display a large number of model elements, even for the reduced example. This is problematic because we intend to use practically relevant refactorings for the study, which are much more extensive. Based on that we doubt that the activity definition in any of the two languages scales well in space and visual complexity. We settled for a textual language as baseline for the following reasons: First, textual languages are the more standard way to work with CEP, given that many tools like Drools and Esper do not support visual languages. Second, tasks of a moderate complexity level still fit into a manageable amount of space being roughly a standard letter size.
Considering the three presented textual languages, we found that pattern definitions are rather similar syntactically (cp. Listing 1,2, and 3). We found the most noticeable syntactical difference within the event sequencing of Esper EPL. For our presented auto-completion application, the very explicit sequencing quickly resulted in complicated nested sequencing constructs. Based on that, we argue that Esper EPL will be more difficult to deal with than the sequencing syntax of Rapide and DRL.
Besides this, their largest syntactical differences lying within language parts that are not relevant to our modeling approach. Especially DRL and Rapide were very close for the given example. As Rapide is somewhat closer to natural language than the other discussed EPLs, we considered it the easier language to explain to a user who is not a CEP expert. It is also not bound to a certain rule engine or project. We do have substantial experience in writing readable Rapide code, as we used it to formulate patterns for our auto-completion prototype, which was implemented before we designed VisPaRec. We therefore decided to compare VisPaRec with Rapide.
6.2 Experimental set-up
Subjects
The participants comprised 16 researchers, PhD students, and masters students experienced in software engineering and knowledgeable in model-based development with UML. All of them were studying or working at the TU Ilmenau and had a computer science background. We recruited them through an email to university-wide mailing lists. Participants had 4 years of software and system development experience on average. Their self-proclaimed skill level ranged from low to very high, with an average of 2.4 on a scale from 0 to 4. The participants had much less experience with complex event processing, averaging at 0.75 years. No participant answered to have a very high skill level, and only a single participant had a high skill level in complex event processing. The study took place from April 21 to May 5, 2015. We recruited researchers and PhD students through an open call at the faculty of computer science. We also invited students attending our software engineering classes. In this way, we approached about 100 researchers and about 50 students. We required the participants to have experience in software development or complex event processing. There were no dropouts during the study. Verbal informed consent was obtained from all participants. Ethics approval was waived by the Vice President for Research of the Technical University of Ilmenau as the responsible department.
Procedure
The experiment was controlled using a computer that presented instructions and recorded times for completing tasks. The computer was configured into a kiosk mode preventing participants from leaving the experimental software. Participants’ answers were gathered on a paper-based questionnaire and in a structured debriefing interview where the interviewer recorded participants’ answers. First, participants filled-in an initial part on the questionnaire that inquired about a subject’s experience and skill level in system and software development, model-based development, UML modeling and complex event processing. Second, each participant was asked to study the extensive tutorial on defining modeling activities textually and visually in Rapide and VisPaRec. Third, participants were given two different activity specifications, one in Rapide and one in VisPaRec, and had to answer six questions that required understanding these specifications. Fourth, each participant had to specify an activity pattern from scratch and had to refine another one. Fifth, in a structured interview we asked subjects to rate the usability of VisPaRec’s seven definition concepts (cp. Section 4.1) in contrast to their representation in Rapide. Sixth, subjects were structurally interviewed by the experimenter about their impressions and comments regarding the visual definition language and the experiment in general. Each interview sequentially inquired about the seven concepts C1–C7 (cp. Section 4.1) and how difficult a participant perceived their comprehension and application in both notations. We used the interview guide contained in the supplementary material. Seventh, we asked participants for general feedback and improvement ideas.
Tasks
The experiment comprised VisPaRec and Rapide definitions of four common modeling activities: “Extracting attribute into class” (also seen in Fig 12), “Resolving many-to-many association”, “Replacing association by interface”, and “Resolving association class”. These patterns describe typical model refactorings, using five up to eight different model elements to be edited zero to two times. Therefore, they generate multiple element versions related to the same model element. Participants were given seven questions and four corresponding multiple-choice statements per question and asked to check the correct statements. The questions R1–R6 dealt with deriving the number of model elements, identifying the number of model elements existing at the start and end of the pattern, identifying and classifying the editing operations, detailing whether specific elements had certain completion actions, recognizing connections between model elements as well as understanding property constraints. These tasks aimed to establish an appropriate background knowledge of the textual as well as the visual representation before applying these notations in two tasks W1 and W2. While W1 required to construct an activity definition, W2 asked for the modification of an existing definition.
Participant’s tasks and VisPaRec’s main design decisions (see Section 4.1) are related as follows:
- R1
is directly influenced by the swim lane concept, so is R2.
- R3
asks for the type of editing operations and therefore interacts with the decision to encode the types visually.
- R4
interacts with properties, sequencing, swim lanes and editing operation types.
- R5
asks participants about property constraints, editing operations (default values) and swim lanes.
- R6
interacts with all of the design choices, as it requires the participants to understand editing types, properties, sequencing and their life cycle.
In the same manner, the writing tasks W1 and W2 require interaction with all of the presented decisions.
In all tasks, the duration was dominated by the effort to understand and solve the problem, not by the physical actions made. This is due to the tasks being difficult but not requiring a lot of actions to complete: R1–R4 each required the ticking of a box, R5 and R6 required to tick two boxes. W1 is the task with the most physical effort by far, requiring the participants to finish a started activity definition. One group was required to write up to 600 characters while the other group drew a small diagram of less than 20 elements as well as less than 15 connections between them. The task W2 only required correcting a given activity definition by striking and correcting the parts participants saw as incorrect. Therefore, the amount of writing work does not have a substantial influence on the duration of tasks.
Treatments and measures
The experiment had one independent variable, the definition language, and two treatments, the visual and the textual representation of an activity definition in VisPaRec and Rapide, respectively. Subjects were randomly assigned to one of two groups. The comprehension tasks (R1–R6) always were related to a visual or a textual pattern definition. One group answered questions R1, R3 and R5 for the visual definition in VisPaRec and the other questions regarding the definition in Rapide, while the second group answered R1, R3 and R5 for the definition in Rapide and the remaining for the visual definition in VisPaRec. For the application tasks, the first group performed W1 using Rapide and W2 using VisPaRec, while the other group did W2 using VisPaRec and W1 using Rapide. The comprehensibility and applicability were measured quantitatively in terms of time to solve a task and correctness of the result. We assessed usability qualitatively within structured interviews, where participants were asked for a comparative rating of activity definition concepts on a Likert scale from 1 (very hard) to 4 (very easy).
6.3 Results and discussion
Comprehensibility (RQ1)
Table 2 shows the results that participants achieved in the six comprehension tasks for the textual as well as the visual language. The results of a two-tailed t-test with independent samples and unequal variances are shown on the right. The upper part of the table shows the average time needed to perform the tasks, while the lower part shows the achieved correctness. The average correctness for participants working with VisPaRec was 72.0% and 60.8% for those working with Rapide. The time needed varied greatly between questions and methods. On average, comprehending VisPaRec activity patterns was 22.5% faster than comprehending their Rapide equivalent. However, there are two questions that were answered wrong more often by participants using VisPaRec than by those using Rapide (R1 and R3). These were also the questions where participants had the highest time saving using VisPaRec. We hypothesize that there is in fact a time-correctness trade off. R1 and R3 simply ask the participants to count model elements/editing operations, therefore they might have seemed misleadingly easy and participants may have jumped to a conclusion too fast. The textual description of Rapide may have forced participants to examine the activity patterns more closely, giving them more time to think about the question as a side effect. Overall, participants working with VisPaRec worked faster and more accurate on average. We suppose that the main reason for improvement is the lifeline concept, because it displays clearly which element versions belong to the same model element. This information is rather hard to grasp without lifelines, because the user must follow a chain of ID-equivalencies to group the different element versions together.
Tab. 2. Average time spent and correctness achieved in performing the comprehension tasks R1–R6. Applicability (RQ2)
Table 3 shows mean, standard deviation, difference in percent, effect significance and the results of a two-tailed t-test with independent samples and unequal variances for both application tasks and notations. The upper part of the table shows the average time that participants spent on solving the task, while the lower part shows the achieved correctness. Constructing activity definitions fully manually (task W1) is not the intended use case of our visual definition language, as the demonstration step can create an initial definition (see Section 5.1). However, W1 was intended to allow for a direct comparison with the writing of definitions in Rapide. Defining the described modeling activity in VisPaRec reduced the required time significantly, on average by 43% (cp. Table 3). Task W2 required participants to understand a given activity definition and to modify certain editing operations and related information. This understanding and adjusting is a common use case especially when creating definitions by example. In this task, subjects working with VisPaRec were on average 47% faster than subjects working with Rapide. These results show that the use of VisPaRec can reduce the time for defining and editing modeling activities significantly. Concerning the correctness, no significant effect could be determined. Table 3 shows that subjects achieved on average almost equal correctness results with both methods. A possible reason could be that all subjects where new to the definition of event patterns for recognizing modeling activities. The measured incorrectness may rather reflect a missing familiarity with the topic than a difference in the two representations. This part of the research question can only be answered properly in a more extensive long-term study.
Tab. 3. Average time spent and correctness achieved in performing the application tasks W1 and W2. Usability (RQ3)
Table 4 aggregates users’ qualitative ratings of VisPaRec’s seven core concepts in contrast to their representation in Rapide in terms of usability (cp. Section 4.1). The results of a two-tailed t-test with independent samples and unequal variances are shown on the right. Participants rated each concept on a Likert scale from 1 (very hard) to 4 (very easy). The visual representation of model elements (C1) significantly effects the comprehensibility (cp. Table 4). Finding out what elements are comprised in a modeling activity using VisPaRec’s representation was rated as very easy. In contrast, subjects reported that performing this task in Rapide is very hard because information about model elements must be retrieved by understanding textual constraint statements. A similar effect is visible for element versions (C2). This is understandable because comprehending the Rapide representation requires resolving references in mind to find out which versions elements undergo throughout an activity. Especially the visual grouping of evolving element versions into one element swim lane was reported as highly beneficial by most subjects. The comprehension of (C3) was reported as very easy in VisPaRec, but also as easy in Rapide. This is much less of a difference than regarding C1 und C2. We hypothesize that the reason for this finding may be that a well structured textual definition makes it easy to find the operation types “add”,“modify” and “delete”.
Tab. 4. Usability of activity definition concepts (cp. Section 4). Nevertheless, subjects liked the clearly distinguishable visual representation of editing operations. Also not significant was the effect of VisPaRec’s visual representation of property constraints (C4). One reason is that static property constraints are represented textually in both Rapide and VisPaRec, and thus the representations are rather similar. Another reason is the representation of dynamic constraints as connectors. Subjects liked to see what model elements are related instead of resolving textual references but struggled initially with tracing the connectors from source to target. This was reported as a question of familiarization. In addition, suggestions were made to support the usage of connectors in active editors through highlighting and out-fading on “mouse-over”. This was also mentioned for sequence constraints (C5). In contrast, subjects rated the Rapide representation of sequence constraints as hard to understand. On average, completion actions (C6) were rated to be easily comprehensible in VisPaRec, but hard to understand in Rapide. It can be seen in Table 4 that both ratings have a high standard deviation, meaning that subject had very different views on it. While some subjects liked to be able to automatically retrieve completion actions, reducing redundant information, the other part liked the clear overview of writing down completion actions explicitly. We believe that eliminating redundant information in an activity definition can reduce error-proneness in the long run. Completion defaults (C7) were understood very easily in VisPaRec. The visualization of completion defaults separated from property constraints was reported as very beneficial. In contrast, defining them textually within completion actions makes it hard to distinguish between conditional and default values. When we asked participants whether they prefer reading textual languages or visual languages in general, 94% of the participants preferred reading visual activity definitions, 84% of participants preferred writing visual activity definitions over textual ones. Participants also gave us valuable feedback for future iterations of the language. Most feedback referred to visual details, e.g., one participant found the orange color of time constraints rather close to the red we use for deletion operations, while another participant advised to make the arrow starting symbols more clear in favor of color blind users. Participants also envisioned VisPaRec to be supported by active editor features, like sorting swim lanes by type and collapsing swim lanes as well as element version stacks.
6.4 Limitations
The experiment aimed to evaluate VisPaRec in comparison to the generic textual language Rapide for defining complex event-processing rules. We chose Rapide as a platform-independent textual definition language for the reasons elaborated in Section 6.1. While the fundamental concepts of CEP are represented across all event-processing languages, we cannot claim that our results are generalizable across all those languages, even though we do not expect substantially different results regarding different general purpose EPLs. Still, this can only be confirmed by further experiments to study other languages. Additionally, our visual language should be also compared to a textual domain specific language which is specialized for the definition of activity patterns. As we are not aware of any language specifically built for this domain, such a comparison is impossible at this time. We consider engineers, working in a model-driven software and systems development process as main audience for the proposed approach. Therefore, we requested that subjects participating in our experiment had to fit this role. All subjects had a mature level of education and at least some experience in model-driven development and UML modeling. The tasks used in the experiment were based on modeling activities commonly known from literature and often occurring in practice. However, the low number of data points does not allow to draw general conclusions. To ensure that subjects had a consistent fundamental knowledge in concepts of the experiment, we asked all subjects to work through an extensive tutorial that also included different comprehension tasks. We expect that replications of the experiment under the described conditions will offer similar results, leading to similar findings. For that purpose, we provide our material in a replication package (accessible at https://dataverse.harvard.edu/dataset.xhtml?persistentId=doi%3A10.7910%2FDVN%2FFTPF3Z).
7 Conclusions and future work
This paper proposed a novel way to define event-processing rules for recognizing and auto-completing modeling activities during model-driven software and systems development. By using VisPaRec, event-patterns and corresponding completion actions can be graphically modeled instead of written as textual patterns. Along with this visual language, we proposed a three-step semi-automated activity definition process. This process builds upon a by-example step that provides the user with an initial activity definition to be refined. After manual refinement, required event-processing rules can then be automatically generated. A user experiment showed that participants achieved on average higher correctness in less time when asked to understand visual activity definitions and were able to define and edit activities in significantly less time (-43%, -47%) at comparable correctness. When asked about the usability of the approach, participants rated the visual activity definitions as easy to very easy to understand in contrast to the textual baseline definition language Rapide. Almost every participant (94%) preferred reading visual activity definitions over textual. Although we embed the language into a by-example approach, 81% of the participants would also prefer writing visual definitions in a solely manual manner. The approach has been implemented as an add-in to the Sparx Enterprise Architect modeling tool [34]. Screenshots of the definition process are part of the supplementary material. Interviews with study participants provided various ideas for additional supporting functionality in this process.
Future work will comprise the evaluation of the prototype in a larger industrial study to gain more results, especially concerning the capability of reducing error-proneness. Another interesting extension point would be an evaluation of the applicability of VisPaRec’s main design choices to general-purpose CEP languages. The concept of special time and ordering constraints may be applicable as-is. However, the concept of swim lanes most likely needs to be generalized in order to support other attributes than object identification and to be useful in different scenarios. Regarding the activity definition by example, presumably higher accuracy can be achieved through the use of multiple demonstrations. We currently evaluate graph-based methods in order to support an arbitrarily amount of definitions and make the method more flexible. Another possibility is to implement VisPaRec as an interactive editor that could supply dynamic features, such as those desired by some participants of our study.
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- The validation of the Beijing version of the Montreal Cognitive Assessment in Chinese patients undergoing hemodialysis
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- Engaging with change: Information and communication technology professionals’ perspectives on change at the mid-point in the UK/EU Brexit process
- Adherence to iron-folic acid supplement and associated factors among antenatal care attending pregnant mothers in governmental health institutions of Adwa town, Tigray, Ethiopia: Cross-sectional study
- Flower, seed, and fruit development in three Tunisian species of Polygonum: Implications for their taxonomy and evolution of distyly in Polygonaceae
- Development of a risk score for prediction of poor treatment outcomes among patients with multidrug-resistant tuberculosis
- Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus
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- Marine seafood production via intense exploitation and cultivation in China: Costs, benefits, and risks
- Signatures of medical student applicants and academic success
- Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia
- The effects of extended photoperiod and warmth on hair growth in ponies and horses at different times of year
- Modeling the effect of prolonged ethanol exposure on global gene expression and chromatin accessibility in normal 3D colon organoids
- Clinical, cytogenetic and molecular genetic characterization of a tandem fusion translocation in a male Holstein cattle with congenital hypospadias and a ventricular septal defect
- Severity of misophonia symptoms is associated with worse cognitive control when exposed to misophonia trigger sounds
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- The evolution of secondary flow phenomena and their effect on primary shock conditions in shock tubes: Experimentation and numerical model
- Estimating the basic reproduction number of a pathogen in a single host when only a single founder successfully infects
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- Catchment-scale export of antibiotic resistance genes and bacteria from an agricultural watershed in central Iowa
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- Impact of scion/rootstock reciprocal effects on metabolomics of fruit juice and phloem sap in grafted Citrus reticulata
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- Color discrimination and gas chromatography-mass spectrometry fingerprint based on chemometrics analysis for the quality evaluation of Schizonepetae Spica
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- Gene expression noise in a complex artificial toxin expression system
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- Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2
- Copper to Tuscany – Coals to Newcastle? The dynamics of metalwork exchange in early Italy
- The Brazilian TP53 mutation (R337H) and sarcomas
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- Impact of viral disease hypophagia on pig jejunal function and integrity
- Enzyme response of activated sludge to a mixture of emerging contaminants in continuous exposure
- Molecular evidence for horizontal transmission of chelonid alphaherpesvirus 5 at green turtle (Chelonia mydas) foraging grounds in Queensland, Australia
- Technology anxiety and resistance to change behavioral study of a wearable cardiac warming system using an extended TAM for older adults
- Evaluation and validation of 2D biomechanical models of the knee for radiograph-based preoperative planning in total knee arthroplasty
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- Age-related differences in the temporal dynamics of spectral power during memory encoding
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- Tuberculosis recurrences and predictive factors in a vulnerable population in Catalonia
- Dome-shaped macula in children and adolescents
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- The effectiveness of substance use interventions for homeless and vulnerably housed persons: A systematic review of systematic reviews on supervised consumption facilities, managed alcohol programs, and pharmacological agents for opioid use disorder
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- Evaluating two decision aids for Australian men supporting informed decisions about prostate cancer screening: A randomised controlled trial
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- Time for change is now: Experiences of participants in a community-based approach for iron and folic acid supplementation in a rural county in Kenya, a qualitative study
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- Statistical learning for turboshaft helicopter accidents using logistic regression
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- The effect of various metal-salts on the sedimentation of soil in a water-based suspension
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- Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells
- Novel broad-spectrum activity-based probes to profile malarial cysteine proteases
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- Effect of a community-based approach of iron and folic acid supplementation on compliance by pregnant women in Kiambu County, Kenya: A quasi-experimental study
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- The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis
- Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia
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- Intensified visual clutter induces increased sympathetic signalling, poorer postural control, and faster torsional eye movements during visual rotation
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- Correction: Quantification of speech and synchrony in the conversation of adults with autism spectrum disorder
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- A cross-sectional study of psychopathy and khat abuse among prisoners in the correctional institution in Jimma, Ethiopia
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- Quantitative analysis of adsorption and desorption of volatile organic compounds on reusable zeolite filters using gas chromatography
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- TMEM98 is a negative regulator of FRAT mediated Wnt/ß-catenin signalling
- Modeling migration patterns in the USA under sea level rise
- Quo vadis Pantanal? Expected precipitation extremes and drought dynamics from changing sea surface temperature
- Cloud-computing and machine learning in support of country-level land cover and ecosystem extent mapping in Liberia and Gabon
- An exploratory study on the quality of patient screening and counseling for hypertension management in Tanzania
- Relation of fibroblast growth factor receptor 2 expression to hepatocellular carcinoma recurrence after liver resection
- The Brief Measure of Emotional Preoperative Stress (B-MEPS) as a new predictive tool for postoperative pain: A prospective observational cohort study
- The impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis
- Correction: Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition
- Clinical and pathological features of thrombotic microangiopathy influencing long-term kidney transplant outcomes
- Multidisciplinary investigation of two Egyptian child mummies curated at the University of Tartu Art Museum, Estonia (Late/Graeco-Roman Periods)
- Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season
- Morphological adjustment in free-living Steinernema feltiae infective juveniles to increasing concentration of Nemafric-BL phytonematicide
- Murine Surf4 is essential for early embryonic development
- Using mHealth to improve health care delivery in India: A qualitative examination of the perspectives of community health workers and beneficiaries
- Algorithmic handwriting analysis of the Samaria inscriptions illuminates bureaucratic apparatus in biblical Israel
- Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis
- Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome
- Short treatment with antalarmin alters adrenal gland receptors in the rat model of endometriosis
- Is it really always only the others who are to blame? GP’s view on medical overuse. A questionnaire study
- Serum visfatin and vaspin levels in hepatocellular carcinoma (HCC)
- Retraction: SDR9C7 Promotes Lymph Node Metastases in Patients with Esophageal Squamous Cell Carcinoma
- iTRAQ proteomics reveals the regulatory response to Magnaporthe oryzae in durable resistant vs. susceptible rice genotypes
- A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients
- Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
- Incidence and predictors of loss to follow up among adult HIV patients on antiretroviral therapy in University of Gondar Comprehensive Specialized Hospital: A competing risk regression modeling
- Point-of-care diagnostic (POCD) method for detecting Bursaphelenchus xylophilus in pinewood using recombinase polymerase amplification (RPA) with the portable optical isothermal device (POID)
- Bioluminescent imaging of Arabidopsis thaliana using an enhanced Nano-lantern luminescence reporter system
- Biosynthetic pathway of indole-3-acetic acid in ectomycorrhizal fungi collected from northern Thailand
- Clinical implications of elevated serum interleukin-6 in IgG4-related disease
- Downscaling NLDAS-2 daily maximum air temperatures using MODIS land surface temperatures
- Sex-specific and opposite modulatory aspects revealed by PPI network and pathway analysis of ischemic stroke in humans
- Plasma Trimethylamine-N-oxide and impaired glucose regulation: Results from The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS)
- Self-esteem and other risk factors for depressive symptoms among adolescents in United Arab Emirates
- Control of the microsporidian parasite Nosema ceranae in honey bees (Apis mellifera) using nutraceutical and immuno-stimulatory compounds
- The effect of storage conditions on microbial communities in stool
- Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates
- Influence of flow on phosphorus-dynamics and particle size in agricultural drainage ditch sediments
- A prospective, randomized, double-blind trial to compare body weight-adjusted and fixed doses of palonosetron for preventing postoperative nausea and vomiting in obese female patients
- Application of computerized 3D-CT texture analysis of pancreas for the assessment of patients with diabetes
- Predictive validation and forecasts of short-term changes in healthcare expenditure associated with changes in smoking behavior in the United States
- An information-based approach to handle various types of uncertainty in fuzzy bodies of evidence
- Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial
- Health care professionals’ knowledge of commonly used sedative, analgesic and neuromuscular drugs: A single center (Rambam Health Care Campus), prospective, observational survey
- Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
- OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model
- Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
- Novel method to measure temporal windows based on eye movements during viewing of the Necker cube
- Whole blood transcriptomic analysis of beef cattle at arrival identifies potential predictive molecules and mechanisms that indicate animals that naturally resist bovine respiratory disease
- Effects of smoke flavoring using different wood chips and barbecuing on the formation of polycyclic aromatic hydrocarbons and heterocyclic aromatic amines in salmon fillets
- Sleep quality and sex modify the relationships between trait energy and fatigue on state energy and fatigue
- The role of peer, parental, and school norms in predicting adolescents’ attitudes and behaviours of majority and different minority ethnic groups in Croatia
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- The impact of rehabilitation frequency on the risk of stroke in patients with rheumatoid arthritis
- Availability, prices and affordability of selected antibiotics and medicines against non-communicable diseases in western Cameroon and northeast DR Congo
- The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation
- Detection of posttraumatic pneumothorax using electrical impedance tomography—An observer-blinded study in pigs with blunt chest trauma
- Educators’ perceptions of organisational readiness for implementation of a pre-adolescent transdisciplinary school health intervention for inter-generational outcomes
- Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA
- The effects of sport expertise and shot results on basketball players’ action anticipation
- Framework and algorithms for identifying honest blocks in blockchain
- Efficacy and safety of anti-viral therapy for Hepatitis B virus-associated glomerulonephritis: A meta-analysis
- Selective transmission of some HIV-1 subtype C variants might depend on Envelope stimulating dendritic cells to secrete IL-10
- Noise reduction and quantification of fiber orientations in greyscale images
- Exploring the impact of terminology differences in blood and organ donor decision making
- Ontogenetic similarities between giraffe and sauropod neck osteological mobility
- Load transfer mechanism and critical length of anchorage zone for anchor bolt
- Income inequalities in stroke incidence and mortality: Trends in stroke-free and stroke-affected life years based on German health insurance data
- Community’s perception, experiences and health seeking behavior towards newborn illnesses in Debre Libanos District, North Shoa, Oromia, Ethiopia: Qualitative study
- Platelet indices significantly correlate with liver fibrosis in HCV-infected patients
- Reanalysis of the Bridge et al. study of suicide following release of 13 Reasons Why
- Validation of the easyscreen flavivirus dengue alphavirus detection kit based on 3base amplification technology and its application to the 2016/17 Vanuatu dengue outbreak
- The nitrate content of fresh and cooked vegetables and their health-related risks
- Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
- Serotonin transporter dependent modulation of food-seeking behavior
- Implicit task switching in Parkinson’s disease is preserved when on medication
- Root treatment with oxathiapiprolin, benthiavalicarb or their mixture provides prolonged systemic protection against oomycete foliar pathogens
- Real-world effectiveness and safety of ranibizumab for the treatment of myopic choroidal neovascularization: Results from the LUMINOUS study
- Non-gradient and genotype-dependent patterns of RSV gene expression
- Multiplex real-time PCR for the detection of Clavibacter michiganensis subsp. michiganensis, Pseudomonas syringae pv. tomato and pathogenic Xanthomonas species on tomato plants
- The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis
- Parasites modulate the gut-microbiome in insects: A proof-of-concept study
- The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature
- Vascularization and biocompatibility of poly(ε-caprolactone) fiber mats for rotator cuff tear repair
- The shield of self-compassion: A buffer against disordered eating risk from physical appearance perfectionism
- Disease-specific out-of-pocket healthcare expenditure in urban Bangladesh: A Bayesian analysis
- Advanced biofilm analysis in streams receiving organic deicer runoff
- Upregulation of long non-coding RNA ROR1-AS1 promotes cell growth and migration in bladder cancer by regulation of miR-504
- Method development and validation for rapid identification of epigallocatechin gallate using ultra-high performance liquid chromatography
- Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens
- Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study
- Same-day antiretroviral therapy initiation for HIV-infected adults in South Africa: Analysis of routine data
- Health-related quality of life among patients with type 2 diabetes mellitus in Eastern Province, Saudi Arabia: A cross-sectional study
- Photocatalytic biocidal effect of copper doped TiO2 nanotube coated surfaces under laminar flow, illuminated with UVA light on Legionella pneumophila
- The interoceptive hippocampus: Mouse brain endocrine receptor expression highlights a dentate gyrus (DG)–cornu ammonis (CA) challenge–sufficiency axis
- Educational attainment and HIV testing and counselling service utilisation during antenatal care in Ghana: Analysis of Demographic and Health Surveys
- Dissection of flag leaf metabolic shifts and their relationship with those occurring simultaneously in developing seed by application of non-targeted metabolomics
- Centromeres of Cucumis melo L. comprise Cmcent and two novel repeats, CmSat162 and CmSat189
- Acute high-intensity and moderate-intensity interval exercise do not change corticospinal excitability in low fit, young adults
- “I like the way I am, but I feel like I could get a little bit bigger”: Perceptions of body image among adolescents and youth living with HIV in Durban, South Africa
- Nanoparticle-based ‘turn-on’ scattering and post-sample fluorescence for ultrasensitive detection of water pollution in wider window
- The relationship of moral sensitivity and patient safety attitudes with nursing students’ perceptions of disclosure of patient safety incidents: A cross-sectional study
- Insights into the strategy of micro-environmental adaptation: Transcriptomic analysis of two alvinocaridid shrimps at a hydrothermal vent
- Thirty-day readmission after medical-surgical hospitalization for people who experience imprisonment in Ontario, Canada: A retrospective cohort study
- The effect of long-term brine discharge from desalination plants on benthic foraminifera
- Hyper-spectral response and estimation model of soil degradation in Kenli County, the Yellow River Delta
- Prescribing trends of glaucoma drugs in six major cities of China from 2013 to 2017
- Significant changes in synovial fluid microRNAs after high tibial osteotomy in medial compartmental knee osteoarthritis: Identification of potential prognostic biomarkers
- Reassortment and adaptive mutations of an emerging avian influenza virus H7N4 subtype in China
- Ischemia and reperfusion injury in superficial inferior epigastric artery-based vascularized lymph node flaps
- High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania – A prospective cohort study
- Switchable resolution in soft x-ray tomography of single cells
- Mitochondrial DNA variations and mitochondrial dysfunction in Fanconi anemia
- Extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing Escherichia coli isolates causing bacteremia in the Netherlands (2014 – 2016) differ in clonal distribution, antimicrobial resistance gene and virulence gene content
- Molecular characterization of blaKHM-1 encoding plasmid in an Enterobacter hormaechei subsp. hoffmannii isolate from blood culture
- PR3 levels are impaired in plasma and PBMCs from Arabs with cardiovascular diseases
- Sex differences in self-regulation in early, middle and late adolescence: A large-scale cross-sectional study
- Interaction between elevated temperature and different types of Na-salicylate treatment in Brachypodium dystachion
- A highway crash risk assessment method based on traffic safety state division
- A brain connectivity characterization of children with different levels of mathematical achievement based on graph metrics
- Quantifying the level of difficulty to treat major depressive disorder with antidepressants: Treatment Resistance to Antidepressants Evaluation Scale
- Occupational gender segregation and economic growth in U.S. local labor markets, 1980 through 2010
- The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome
- Construction of a high-density genetic map and fine mapping of a candidate gene locus for a novel branched-spike mutant in barley
- Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease
- Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer
- Deep2Full: Evaluating strategies for selecting the minimal mutational experiments for optimal computational predictions of deep mutational scan outcomes
- Economic compensation interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review and meta-analysis
- Distinctive effect of anesthetics on the effect of limb remote ischemic postconditioning following ischemic stroke
- Natural hybridization between Phyllagathis and Sporoxeia species produces a hybrid without reproductive organs
- Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder
- The impact of peer attachment on prosocial behavior, emotional difficulties and conduct problems in adolescence: The mediating role of empathy
- Spatial and climatic variables independently drive elevational gradients in ant species richness in the Eastern Himalaya
- What is the qualitative evidence concerning the risks, diagnosis, management and consequences of gastrointestinal infections in the community in the United Kingdom? A systematic review and meta-ethnography
- Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress
- Key barriers and enablers associated with uptake and continuation of oral pre-exposure prophylaxis (PrEP) in the public sector in Zimbabwe: Qualitative perspectives of general population clients at high risk for HIV
- Characterizing the University of California’s tenure-track teaching position from the faculty and administrator perspectives
- Restoration of Mal overcomes the defects of apoptosis in lung cancer cells
- Patient preferences for maintenance therapy in Crohn’s disease: A discrete-choice experiment
- Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
- Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation
- Accuracy of intraocular lens power calculation formulas using a swept-source optical biometer
- Characterization of black patina from the Tiber River embankments using Next-Generation Sequencing
- Comparison of blood lactate and perceived exertion responses in two matched time-under-tension protocols
- Fibrin hydrogels are safe, degradable scaffolds for sub-retinal implantation
- Post-translational modifications of Drosophila melanogaster HOX protein, Sex combs reduced
- Problem gambling, associations with comorbid health conditions, substance use, and behavioural addictions: Opportunities for pathways to treatment
- Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production
- Characterization of METTL16 as a cytoplasmic RNA binding protein
- Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples
- Nanosheet wrapping-assisted coverslip-free imaging for looking deeper into a tissue at high resolution
- Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
- Early diagnosis of sepsis in emergency departments, time to treatment, and association with mortality: An observational study
- Validity of cerebrovascular ICD-9-CM codes in healthcare administrative databases. The Umbria Data-Value Project
- Tuberculoid leprosy: An in vivo microvascular evaluation of cutaneous lesions
- Neuromuscular blockers in the acute respiratory distress syndrome: A meta-analysis
- Identification of putative Type-I sex pheromone biosynthesis-related genes expressed in the female pheromone gland of Streltzoviella insularis
- Redefining transcriptional regulation of the APOE gene and its association with Alzheimer’s disease
- Disease-relevant mutations alter amino acid co-evolution networks in the second nucleotide binding domain of CFTR
- A bushel of viruses: Identification of seventeen novel putative viruses by RNA-seq in six apple trees
- Torque teno virus viral load is related to age, CMV infection and HLA type but not to Alzheimer's disease
- The variability of bacterial communities in both the endosphere and ectosphere of different niches in Chinese chives (Allium tuberosum)
- Tripartite factors leading to molecular divergence between human and murine smooth muscle
- Characterization of dermal skin innervation in fibromyalgia syndrome
- A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy
- A scoping review of importation and predictive models related to vector-borne diseases, pathogens, reservoirs, or vectors (1999–2016)
- Assessment of climate change impact on the malaria vector Anopheles hyrcanus, West Nile disease, and incidence of melanoma in the Vojvodina Province (Serbia) using data from a regional climate model
- Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship
- Healthcare utilization of Mexican-American Medicare beneficiaries with and without Alzheimer’s disease and related dementias
- Evaluation of questionnaire as an instrument to measure the level of nutritional and weight gain knowledge in pregnant women in Poland. A pilot study
- TranCEP: Predicting the substrate class of transmembrane transport proteins using compositional, evolutionary, and positional information
- Non-Invasive Functional-Brain-Imaging with an OPM-based Magnetoencephalography System
- Expression of acyl-CoA-binding protein 5 from Rhodnius prolixus and its inhibition by RNA interference
- Transforming assessment of speech in children with cleft palate via online crowdsourcing
- High prevalence of off-label and unlicensed paediatric prescribing in a hospital in Indonesia during the period Aug.—Oct. 2014
- General practice management of rotator cuff related shoulder pain: A reliance on ultrasound and injection guided care
- Estimating the population size of female sex workers and transgender women in Sri Lanka
- Can helmet decrease mortality of craniocerebral trauma patients in a motorcycle accident?: A propensity score matching
- Obesity, smoking habits, and serum phosphate levels predicts mortality after life-style intervention
- Treatment of children under 4 years of age with medulloblastoma and ependymoma in the HIT2000/HIT-REZ 2005 trials: Neuropsychological outcome 5 years after treatment
- Can a semi-quantitative method replace the current quantitative method for the annual screening of microalbuminuria in patients with diabetes? Diagnostic accuracy and cost-saving analysis considering the potential health burden
- A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1)
- Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age
- Burden and risk factors of cutaneous leishmaniasis in a peri-urban settlement in Kenya, 2016
- Predicting strike susceptibility and collision patterns of the common buzzard at wind turbine structures in the federal state of Brandenburg, Germany
- Embryonic thermal manipulation has short and long-term effects on the development and the physiology of the Japanese quail
- High-order radiomics features based on T2 FLAIR MRI predict multiple glioma immunohistochemical features: A more precise and personalized gliomas management
- Human-raptor conflict in rural settlements of Colombia
- Regional adaptations and parallel mutations in Feline panleukopenia virus strains from China revealed by nearly-full length genome analysis
- Long-term ecological research in southern Brazil grasslands: Effects of grazing exclusion and deferred grazing on plant and arthropod communities
- Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer
- Survival analysis of 230 patients with unresectable hepatocellular carcinoma treated with bland transarterial embolization
- Adverse drug reaction reporting practice and associated factors among medical doctors in government hospitals in Addis Ababa, Ethiopia
- TaWAK6 encoding wall-associated kinase is involved in wheat resistance to leaf rust similar to adult plant resistance
- Deficiency syndromes in top predators associated with large-scale changes in the Baltic Sea ecosystem
- The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice
- Allele specific expression of Dof genes responding to hormones and abiotic stresses in sugarcane
- Perceived relative social status and cognitive load influence acceptance of unfair offers in the Ultimatum Game
- Quantitative evaluation of choriocapillaris using optical coherence tomography and optical coherence tomography angiography in patients with central serous chorioretinopathy after half-dose photodynamic therapy
- Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties
- Extracting lung function measurements to enhance phenotyping of chronic obstructive pulmonary disease (COPD) in an electronic health record using automated tools
- Multiple fragmented habitat-patch use in an urban breeding passerine, the Short-toed Treecreeper
- Histological and immunohistochemical characterization of the porcine ocular surface
- Household environmental tobacco smoke exposure in healthy young children in Hong Kong: Prevalence and risk factors
- Wind energy development and wildlife conservation in Lithuania: A mapping tool for conflict assessment
- Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study
- Effect of epoch length on intensity classification and on accuracy of measurement under controlled conditions on treadmill: Towards a better understanding of accelerometer measurement
- Peer distribution of HIV self-test kits to men who have sex with men to identify undiagnosed HIV infection in Uganda: A pilot study
- Error rates of human reviewers during abstract screening in systematic reviews
- Faecal analyses and alimentary tracers reveal the foraging ecology of two sympatric bats
- Urethral realignment with maximal urethral length and bladder neck preservation in robot-assisted radical prostatectomy: Urinary continence recovery
- Error metrics determination in functionally approximated circuits using SAT solvers
- Spatial movement pattern recognition in soccer based on relative player movements
- A novel visual ranking system based on arterial spin labeling perfusion imaging for evaluating perfusion disturbance in patients with ischemic stroke
- Prospective Validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score for Necrotizing Fasciitis of the Extremities
- The importance of transporters and cell polarization for the evaluation of human stem cell-derived hepatic cells
- Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: A nationwide study
- Morphological and functional characteristics of mitral annular calcification and their relationship to stroke
- And the nominees are: Using design-awards datasets to build computational aesthetic evaluation model
- Service delivery interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review
- Multidimensional Scales of Perceived Self-Efficacy (MSPSE): Measurement invariance across Italian and Colombian adolescents
- Diversity of Mycobacteriaceae from aquatic environment at the São Paulo Zoological Park Foundation in Brazil
- A graph-based algorithm for RNA-seq data normalization
- Parents’ underestimation of their child’s weight status. Moderating factors and change over time: A cross-sectional study
- Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs
- Spatial variation in fertilizer prices in Sub-Saharan Africa
- Knowledge, beliefs, and concerns about bone health from a systematic review and metasynthesis of qualitative studies
- Successful isolation of Treponema pallidum strains from patients’ cryopreserved ulcer exudate using the rabbit model
- Effects of size and elasticity on the relation between flow velocity and wall shear stress in side-wall aneurysms: A lattice Boltzmann-based computer simulation study
- Pupil response to noxious corneal stimulation
- Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients
- The impact of computed radiography and teleradiology on patients’ diagnosis and treatment in Mweso, the Democratic Republic of Congo
- Differential effects of synthetic psychoactive cathinones and amphetamine stimulants on the gut microbiome in mice
- Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in Chile: A cross-sectional serosurvey
- Increased episodes of aspiration on videofluoroscopic swallow study in children with nasogastric tube placement
- Obstructive sleep apnea and hypopnea syndrome in patients admitted in a tertiary hospital in Cameroon: Prevalence and associated factors
- Association of single nucleotide polymorphisms with dyslipidemia in antiretroviral exposed HIV patients in a Ghanaian population: A case-control study
- Sonic Hedgehog upregulation does not enhance the survival and engraftment of stem cell-derived cardiomyocytes in infarcted hearts
- The pharmacokinetic parameters and the effect of a single and repeated doses of memantine on gastric myoelectric activity in experimental pigs
- Blind method for discovering number of clusters in multidimensional datasets by regression on linkage hierarchies generated from random data
- Predictive factors of first dosage intravenous immunoglobulin-related adverse effects in children
- Description and characterization of the artisanal elasmobranch fishery on Guatemala’s Caribbean coast
- Individual and community level determinants of short birth interval in Ethiopia: A multilevel analysis
- Effects of rejection intensity and rejection sensitivity on social approach behavior in women
- The impact of IoT security labelling on consumer product choice and willingness to pay
- The development and validation of a measurement instrument to investigate determinants of health care utilisation for low back pain in Ethiopia
- Validity of the French version of the Autonomy Preference Index and its adaptation for patients with advanced cancer
- The epidemiological characteristics and spatio-temporal analysis of childhood hand, foot and mouth disease in Korea, 2011-2017
- Exponential random graph model parameter estimation for very large directed networks
- The implementation of community-based diabetes and hypertension management care program in Indonesia
- Effect of temperature variation on hospital admissions and outcomes in dogs with myxomatous mitral valve disease and new onset pulmonary edema
- The development of the Police Practices Scale: Understanding policing approaches towards street-based female sex workers in a U.S. City
- A capability approach to assess aquaculture sustainability standard compliance
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- Construct validity and reliability of the Talent Development Environment Questionnaire in Caribbean youth track and field athletes
- Optimization of cytotoxic activity of Nocardia sp culture broths using a design of experiments
- Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during substance P-mediated neurogenic inflammation ex vivo
- Microbiota in foods from Inuit traditional hunting
- Investigating Italian disinformation spreading on Twitter in the context of 2019 European elections
- In vivo expression of peptidylarginine deiminase in Drosophila melanogaster
- Modelling zero-truncated overdispersed antenatal health care count data of women in Bangladesh
- Detection and density of breeding marsh birds in Iowa wetlands
- A lineage-specific rapid diagnostic test (Chagas Sero K-SeT) identifies Brazilian Trypanosoma cruzi II/V/VI reservoir hosts among diverse mammalian orders
- Aromatase deficiency in hematopoietic cells improves glucose tolerance in male mice through skeletal muscle-specific effects
- If host is refractory, insistent parasite goes berserk: Trypanosomatid Blastocrithidia raabei in the dock bug Coreus marginatus
- Antimicrobial resistance patterns and molecular resistance markers of Campylobacter jejuni isolates from human diarrheal cases
- Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients
- An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury
- Prevalence of antiphospholipid antibodies in Behçet's disease: A systematic review and meta-analysis
- Chemical analysis of snus products from the United States and northern Europe
- Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry
- Impact of early-onset persistent stunting on cognitive development at 5 years of age: Results from a multi-country cohort study
- Aggregation of CAT tails blocks their degradation and causes proteotoxicity in S. cerevisiae
- Expression of concern: Compensatory increase of transglutaminase 2 is responsible for resistance to mTOR inhibitor treatment
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- Staging dementia based on caregiver reported patient symptoms: Implications from a latent class analysis
- Health-related quality of life and its determinants among ambulatory patients with epilepsy at Ambo General Hospital, Ethiopia: Using WHOQOL-BREF
- In silico analysis and high-risk pathogenic phenotype predictions of non-synonymous single nucleotide polymorphisms in human Crystallin beta A4 gene associated with congenital cataract
- Fungal diversity in canopy soil of silver beech, Nothofagus menziesii (Nothofagaceae)
- Referral decisions and its predictors related to orthopaedic care. A retrospective study in a novel primary care setting
- Readiness to prescribe: Using educational design to untie the Gordian Knot
- Influence of gelation on the retention of purple cactus pear extract in microencapsulated double emulsions
- Factors related to met needs for rehabilitation 6 years after stroke
- Association of cataract and sun exposure in geographically diverse populations of India: The CASE study. First Report of the ICMR-EYE SEE Study Group
- Investigation of injury severity in urban expressway crashes: A case study from Beijing
- Clinical outcomes of incident peritoneal dialysis patients coming from kidney transplantation program: A case-control study
- Evaluation of the factors influencing the housing safety awareness of residents in Shanghai
- Morphometric study of the diaphragmatic surface of the liver in the human fetus
- Food insecurity and dietary diversity among lactating mothers in the urban municipality in the mountains of Nepal
- Genetic characterization of Bacillus anthracis strains circulating in Italy from 1972 to 2018
- Promising antifungal activity of new oxadiazole against Candida krusei
- An atlas of personality, emotion and behaviour
- Long-term effects of intracranial islet grafting on cognitive functioning in a rat metabolic model of sporadic Alzheimer's disease-like dementia
- Compartmentalized profiling of amniotic fluid cytokines in women with preterm labor
- Comparison of the myometrial transcriptome from singleton and twin pregnancies by RNA-Seq
- Adverse reproductive effects of S100A9 on bovine sperm and early embryonic development in vitro
- Functional dynamics of bacterial species in the mouse gut microbiome revealed by metagenomic and metatranscriptomic analyses
- Astrocyte senescence promotes glutamate toxicity in cortical neurons
- Primary ciliary dyskinesia and psychological well-being in adolescence
- Dipeptidyl peptidase-4 is increased in the abdominal aortic aneurysm vessel wall and is associated with aneurysm disease processes
- Primary care physician knowledge, attitudes, and diagnostic testing practices for norovirus and acute gastroenteritis
- Microfluidic-prepared DOTAP nanoparticles induce strong T-cell responses in mice
- Intraocular scattering as a predictor of driving performance in older adults with cataracts
- Reduced bone mineral density among HIV infected patients on anti-retroviral therapy in Blantyre, Malawi: Prevalence and associated factors
- Correction: Extraversion personality, perceived health and activity participation among community-dwelling aging adults in Hong Kong
- A rainwater control optimization design approach for airports based on a self-organizing feature map neural network model
- Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility
- 18F-FDG-PET/MRI in the diagnostic work-up of limbic encephalitis
- The socioeconomic impact of orthopaedic trauma: A systematic review and meta-analysis
- Treatment patterns among patients with moderate-to-severe ulcerative colitis in the United States and Europe
- City to city learning and knowledge exchange for climate resilience in southern Africa
- Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer
- Activity-dependent switches between dynamic regimes of extracellular matrix expression
- Molecular sequencing and morphological identification reveal similar patterns in native bee communities across public and private grasslands of eastern North Dakota
- A mathematical model for assessing the effectiveness of controlling relapse in Plasmodium vivax malaria endemic in the Republic of Korea
- Cryo-focused ion beam preparation of perovskite based solar cells for atom probe tomography
- Physiological and transcriptomic responses of Lanzhou Lily (Lilium davidii, var. unicolor) to cold stress
- Unusual genome expansion and transcription suppression in ectomycorrhizal Tricholoma matsutake by insertions of transposable elements
- Estimating associations between antidepressant use and incident mild cognitive impairment in older adults with depression
- The use of telephone communication between nurse navigators and their patients
- CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction
- HIV RNA measurement in dried blood spots of HIV-infected patients in Thailand using Abbott m2000 system
- Retraction: Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis
- Ultra-rapid cooling of ibex sperm by spheres method does not induce a vitreous extracellular state and increases the membrane damages
- Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use
- Observation and quantification of the morphological effect of trypan blue rupturing dead or dying cells
- The visual perception of emotion from masks
- Hexavalent chromium removal and total chromium biosorption from aqueous solution by Quercus crassipes acorn shell in a continuous up-flow fixed-bed column: Influencing parameters, kinetics, and mechanism
- The predictive value of anthropometric indices for cardiometabolic risk factors in Chinese children and adolescents: A national multicenter school-based study
- Lean back and wait for the alarm? Testing an automated alarm system for nosocomial outbreaks to provide support for infection control professionals
- Regional disparities in health care resources in traditional Chinese medicine county hospitals in China
- Analysis on hydraulic characteristics of improved sandy soil with soft rock
- Development and use of a scale to assess gender differences in appraisal of mistreatment during childbirth among Ethiopian midwifery students
- Factors for starting biosimilar TNF inhibitors in patients with rheumatic diseases in the real world
- Correction: Force field generalization and the internal representation of motor learning
- Prevalence and foetomaternal effects of iron deficiency anaemia among pregnant women in Lagos, Nigeria
- Socioeconomic risk factors for fatal opioid overdoses in the United States: Findings from the Mortality Disparities in American Communities Study (MDAC)
- Microbiome signatures in neonatal central line associated bloodstream infections
- Interventions for incarcerated adults with opioid use disorder in the United States: A systematic review with a focus on social determinants of health
- Opening gap width influences distal tibial rotation below the osteotomy site following open wedge high tibial osteotomy
- The impact of lowbush blueberry (Vaccinium angustifolium Ait.) and cranberry (Vaccinium macrocarpon Ait.) pollination on honey bee (Apis mellifera L.) colony health status
- Surveys of knowledge and awareness of antibiotic use and antimicrobial resistance in general population: A systematic review
- Managerial capacity among district health managers and its association with district performance: A comparative descriptive study of six districts in the Eastern Region of Ghana
- Knee joint distraction in regular care for treatment of knee osteoarthritis: A comparison with clinical trial data
- Reconstruction of a regulated two-cell metabolic model to study biohydrogen production in a diazotrophic cyanobacterium Anabaena variabilis ATCC 29413
- Cochlear dysfunction is associated with styrene exposure in humans
- Intra-individual variation of particles in exhaled air and of the contents of Surfactant protein A and albumin
- Revisits, readmissions, and outcomes for pediatric traumatic brain injury in California, 2005-2014
- Enhanced handover mechanism using mobility prediction in wireless networks
- Association between regular exercise and asthma control among adults: The population-based Northern Finnish Asthma Study
- Pharyngeal microbiome alterations during Neisseria gonorrhoeae infection
- Assessment of the clinical utility of four NGS panels in myeloid malignancies. Suggestions for NGS panel choice or design
- Assessment of time management practice and associated factors among primary hospitals employees in north Gondar, northwest Ethiopia
- Genetic diversity and population structure of feral rapeseed (Brassica napus L.) in Japan
- Are the current gRNA ranking prediction algorithms useful for genome editing in plants?
- Difference between physical therapist estimation and psychological patient-reported outcome measures in patients with low back pain
- Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness
- Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies
- Investigating cumulative effects of pre-performance routine interventions in beach volleyball serving
- Dispensing of antibiotics without prescription and associated factors in drug retail outlets of Eritrea: A simulated client method
- MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma
- Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression—An in vitro study
- Cytoplasmic factories, virus assembly, and DNA replication kinetics collectively constrain the formation of poxvirus recombinants
- The wavelet power spectrum of perfusion weighted MRI correlates with tumor vascularity in biopsy-proven glioblastoma samples
- Agreement between cardiovascular disease risk assessment tools: An application to the United Arab Emirates population
- Constructing HLM to examine multi-level poverty-contributing factors of farmer households: Why and how?
- Patterns of symptoms possibly indicative of cancer and associated help-seeking behaviour in a large sample of United Kingdom residents—The USEFUL study
- An automated alarm system for food safety by using electronic invoices
- Neural effects of acute stress on appetite: A magnetoencephalography study
- Use of magnetic resonance imaging to determine laterality of meniscal size in healthy volunteers
- Co-prevalence of extracranial carotid aneurysms differs between European intracranial aneurysm cohorts
- Thermal biology of two tropical lizards from the Ecuadorian Andes and their vulnerability to climate change
- When weight is an encumbrance; avoidance of stairs by different demographic groups
- Non-mycosis fungoides cutaneous lymphomas in a referral center in Taiwan: A retrospective case series and literature review
- From the host's point of view: Effects of variation in burying beetle brood care and brood size on the interaction with parasitic mites
- Kernel-based Gaussian process for anomaly detection in sparse gamma-ray data
- Unmet care needs of children with ADHD
- Accelerometer-assessed outdoor physical activity is associated with meteorological conditions among older adults: Cross-sectional results from the OUTDOOR ACTIVE study
- Identification of Korean cancer survivors’ unmet needs and desired psychosocial assistance: A focus group study
- Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A
- The role of moral reasoning & personality in explaining lyrical preferences
- Would you like to participate in this trial? The practice of informed consent in intrapartum research in the last 30 years
- Correction: Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
- Forward lunge before and after anterior cruciate ligament reconstruction: Faster movement but unchanged knee joint biomechanics
- Challenges associated with homologous directed repair using CRISPR-Cas9 and TALEN to edit the DMD genetic mutation in canine Duchenne muscular dystrophy
- Integrated targeted serum metabolomic profile and its association with gender, age, disease severity, and pattern identification in acne
- A prospective case-control study on miRNA circulating levels in subjects born small for gestational age (SGA) evaluated from childhood into young adulthood
- Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings
- Global depth perception alters local timing sensitivity
- How to detect a polytrauma patient at risk of complications: A validation and database analysis of four published scales
- Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing
- Reduced gray matter volume and cortical thickness associated with traffic-related air pollution in a longitudinally studied pediatric cohort
- Recombinant human soluble thrombomodulin is associated with attenuation of sepsis-induced renal impairment by inhibition of extracellular histone release
- Human and climatic drivers affect spatial fishing patterns in a multiple-use marine protected area: The Galapagos Marine Reserve
- Correction: Leisure-time physical activity and sports in the Brazilian population: A social disparity analysis
- Application of the mixture item response theory model to the Self-Administered Food Security Survey Module for Children
- Numerical simulation of atmospheric CO2 concentration and flux over the Korean Peninsula using WRF-VPRM model during Korus-AQ 2016 campaign
- Feline irradiated diet-induced demyelination; a model of the neuropathology of sub-acute combined degeneration?
- Improved multi-parametric prediction of tissue outcome in acute ischemic stroke patients using spatial features
- Genome-wide association and epistatic interactions of flowering time in soybean cultivar
- Correction: Association between workplace bullying and burnout, professional quality of life, and turnover intention among clinical nurses
- Correction: Estimation of membrane bending modulus of stiffness tuned human red blood cells from micropore filtration studies
- Correction: Limited indirect effects of an infant pneumococcal vaccination program in an aging population
- Correction: Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats
- Fieldwork-based determination of design priorities for point-of-use drinking water quality sensors for use in resource-limited environments
- Young women’s reproductive health conversations: Roles of maternal figures and clinical practices
- Correction: Differential recordings of local field potential: A genuine tool to quantify functional connectivity
- Survival of medial versus lateral unicompartmental knee arthroplasty: A meta-analysis
- Novel MscL agonists that allow multiple antibiotics cytoplasmic access activate the channel through a common binding site
- Is it time to stop sweeping data cleaning under the carpet? A novel algorithm for outlier management in growth data
- Changes in oak (Quercus robur) photosynthesis after winter moth (Operophtera brumata) herbivory are not explained by changes in chemical or structural leaf traits
- Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study
- Evaluation of liposomal ciprofloxacin formulations in a murine model of anthrax
- Analysis of cholesterol in mouse brain by HPLC with UV detection
- Sugar, amino acid and inorganic ion profiling of the honeydew from different hemipteran species feeding on Abies alba and Picea abies
- Exploring prior diseases associated with incident late-onset Alzheimer’s disease dementia
- Hypertension prevalence in patients attending tertiary pain management services, a registry-based Australian cohort study
- SRL pathogenicity island contributes to the metabolism of D-aspartate via an aspartate racemase in Shigella flexneri YSH6000
- Correction: Comprehensive genome-wide analysis of the pear (Pyrus bretschneideri) laccase gene (PbLAC) family and functional identification of PbLAC1 involved in lignin biosynthesis
- Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model
- Water consumption and prevalence of irritable bowel syndrome among adults
- Mixed evidence for the relationship between periodontitis and Alzheimer’s disease: A bidirectional Mendelian randomization study
- Correction: Health conditions associated with overweight in climacteric women
- Correction: Determining Glomerular Filtration Rate in Homozygous Sickle Cell Disease: Utility of Serum Creatinine Based Estimating Equations
- Modelling the number of antenatal care visits in Bangladesh to determine the risk factors for reduced antenatal care attendance
- Correction: Cumulative viral load as a predictor of CD4+ T-cell response to antiretroviral therapy using Bayesian statistical models
- Dominant negative effects by inactive Spa47 mutants inhibit T3SS function and Shigella virulence
- ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain
- Diel patterns in swimming behavior of a vertically migrating deepwater shark, the bluntnose sixgill (Hexanchus griseus)
- Life history of northern Gulf of Mexico Warsaw grouper Hyporthodus nigritus inferred from otolith radiocarbon analysis
- Physiology education for intensive care medicine residents: A 15-minute interactive peer-led flipped classroom session
- Strengthening capacity for natural sciences research: A qualitative assessment to identify good practices, capacity gaps and investment priorities in African research institutions
- Systematic scoping review of the concept of ‘genetic identity’ and its relevance for germline modification
- Height of overburden fracture based on key strata theory in longwall face
- Laboratory strains of Bacillus anthracis lose their ability to rapidly grow and sporulate compared to wildlife outbreak strains
- Improvement of classification performance of Parkinson’s disease using shape features for machine learning on dopamine transporter single photon emission computed tomography
- Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey
- Correction: A handy method to remove bacterial contamination from fungal cultures
- Correction: Effect of statin on life prognosis in Japanese patients undergoing hemodialysis
- Retraction: Outer Membrane Protein A (OmpA) of Shigella flexneri 2a Induces TLR2-Mediated Activation of B Cells: Involvement of Protein Tyrosine Kinase, ERK and NF-κB
- Retraction: Biofabrication of streptomycin-conjugated calcium phosphate nanoparticles using red ginseng extract and investigation of their antibacterial potential
- Receiver operating characteristic curve analysis of clinical signs for screening of convergence insufficiency in young adults
- Correction: Drivers of deforestation in the basin of the Usumacinta River: Inference on process from pattern analysis using generalised additive models
- Efficacy of fertilizing method for different potash sources in cotton (Gossypium hirsutum L.) nutrition under arid climatic conditions
- Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome
- Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome
- Retraction: MiR-30a-5p Antisense Oligonucleotide Suppresses Glioma Cell Growth by Targeting SEPT7
- Correction: Dynamics of plasma micronutrient concentrations and their correlation with serum proteins and thyroid hormones in patients with paracoccidioidomycosis
- Impact of lower limb osteoarthritis on health-related quality of life: A cross-sectional study to estimate the expressed loss of utility in the Spanish population
- Correction: Prevalence of damaged and missing teeth among women in the southern plains of Nepal: Findings of a simplified assessment tool
- Correction: Tissue-Specific Expressed Antibody Variable Gene Repertoires
- Retraction: Immunoglobulin G Expression in Lung Cancer and Its Effects on Metastasis
- Correction: Causal knowledge promotes behavioral self-regulation: An example using climate change dynamics
- Retraction: Use of Granulocyte Colony-Stimulating Factor for the Treatment of Thin Endometrium in Experimental Rats
- Correction: Dynamic mechanical and nanofibrous topological combinatory cues designed for periodontal ligament engineering
- Correction: Evaluating the foundations that help avert antimicrobial resistance: Performance of essential water sanitation and hygiene functions in hospitals and requirements for action in Kenya
- From seed to flour: Sowing sustainability in the use of cantaloupe melon residue (Cucumis melo L. var. reticulatus)
- Core Scientific Dataset Model: A lightweight and portable model and file format for multi-dimensional scientific data
- Accounting for measurement error to assess the effect of air pollution on omic signals
- Leucine zipper transcription factor-like 1 binds adaptor protein complex-1 and 2 and participates in trafficking of transferrin receptor 1
- Barriers for tuberculosis case finding in Southwest Ethiopia: A qualitative study
- Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia
- A lower psoas muscle volume was associated with a higher rate of recurrence in male clear cell renal cell carcinoma
- Two angles of overqualification-the deviant behavior and creative performance: The role of career and survival job
- Cost-utility analysis of de-escalating biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis
- Efficient estimation of stereo thresholds: What slope should be assumed for the psychometric function?
- Learning efficient haptic shape exploration with a rigid tactile sensor array
- Effects of dietary supplementation with a microalga (Schizochytrium sp.) on the hemato-immunological, and intestinal histological parameters and gut microbiota of Nile tilapia in net cages
- Regional versus local wind speed and direction at a narrow beach with a high and steep foredune
- Fragmented QRS complex in patients with systemic lupus erythematosus at the time of diagnosis and its relationship with disease activity
- Severe thiamine deficiency in eastern Baltic cod (Gadus morhua)
- Transfer entropy as a variable selection methodology of cryptocurrencies in the framework of a high dimensional predictive model
- Psychometric validation of Czech version of the Sport Motivation Scale
- Correction: Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
- Recognition of personality disorder and anxiety disorder comorbidity in patients treated for depression in secondary psychiatric care
- Correction: Strategies for achieving high sequencing accuracy for low diversity samples and avoiding sample bleeding using illumina platform
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