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The relation between local and distal muscle fat infiltration in chronic whiplash using magnetic resonance imaging


Autoři: Anette Karlsson aff001;  Anneli Peolsson aff002;  James Elliott aff004;  Thobias Romu aff001;  Helena Ljunggren aff003;  Magnus Borga aff001;  Olof Dahlqvist Leinhard aff002
Působiště autorů: Department of Biomedical Engineering, Linköping University, Linköping, Sweden aff001;  Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden aff002;  Department of Medical and Health Sciences, Physiotherapy, Linköping University, Linköping, Sweden aff003;  Faculty of Health Sciences, The University of Sydney, Northern Sydney Local Health District, The Kolling Institute, St Leonards, NSW, Australia aff004;  Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America aff005;  Department of Medical and Health Sciences, Linkoping University, Linköping, Sweden aff006
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226037

Souhrn

The objective of this study was to investigate the relationship between fat infiltration in the cervical multifidi and fat infiltration measured in the lower extremities to move further into understanding the complex signs and symptoms arising from a whiplash trauma. Thirty-one individuals with chronic whiplash associated disorders, stratified into a mild/moderate group and a severe group, together with 31 age- and gender matched controls were enrolled in this study. Magnetic resonance imaging was used to acquire a 3D volume of the neck and of the whole-body. Cervical multifidi was used to represent muscles local to the whiplash trauma and all muscles below the hip joint, the lower extremities, were representing widespread muscles distal to the site of the trauma. The fat infiltration was determined by fat fraction in the segmented images. There was a linear correlation between local and distal muscle fat infiltration (p<0.001, r2 = 0.28). The correlation remained significant when adjusting for age and WAD group (p = 0.009) as well as when correcting for age, WAD group and BMI (p = 0.002). There was a correlation between local and distal muscle fat infiltration within the severe WAD group (p = 0.0016, r2 = 0.69) and in the healthy group (p = 0.022, r2 = 0.17) but not in the mild/moderate group (p = 0.29, r2 = 0.06). No significant differences (p = 0.11) in the lower extremities’ MFI between the different groups were found. The absence of differences between the groups in terms of lower extremities’ muscle fat infiltration indicates that, in this particular population, the whiplash trauma has a local effect on muscle fat infiltration rather than a generalized.

Klíčová slova:

Fats – Imaging techniques – Magnetic resonance imaging – Muscle analysis – Musculoskeletal injury – Myalgia – Spinal cord injury – Traumatic injury


Zdroje

1. Carroll LJ, Holm LW, Hogg-Johnson S, Cote P, Cassidy JD, Haldeman S, et al. Course and prognostic factors for neck pain in whiplash-associated disorders (WAD): results of the Bone and Joint Decade 2000–2010 Task Force on Neck Pain and Its Associated Disorders. Spine. 2008;33(4 Suppl):S83–92. doi: 10.1097/BRS.0b013e3181643eb8 18204405

2. Leth-Petersen S, Rotger GP. Long-term labour-market performance of whiplash claimants. Journal of health economics. 2009;28(5):996–1011. doi: 10.1016/j.jhealeco.2009.06.013 19683817

3. Rebbeck T, Sindhusake D, Cameron ID, Rubin G, Feyer AM, Walsh J, et al. A prospective cohort study of health outcomes following whiplash associated disorders in an Australian population. Injury prevention: journal of the International Society for Child and Adolescent Injury Prevention. 2006;12(2):93–8.

4. Spitzer WO, Skovron ML, Salmi LR, Cassidy JD, Duranceau J, Suissa S, et al. Scientific monograph of the Quebec Task Force on Whiplash-Associated Disorders: redefining "whiplash" and its management. Spine. 1995;20(8 Suppl):1S–73S. 7604354

5. Elliott J, Jull G, Noteboom JT, Darnell R, Galloway G, Gibbon WW. Fatty infiltration in the cervical extensor muscles in persistent whiplash-associated disorders: a magnetic resonance imaging analysis. Spine. 2006;31(22):E847–55. doi: 10.1097/01.brs.0000240841.07050.34 17047533

6. Elliott J, Sterling M, Noteboom JT, Darnell R, Galloway G, Jull G. Fatty infiltrate in the cervical extensor muscles is not a feature of chronic, insidious-onset neck pain. Clinical radiology. 2008;63(6):681–7. doi: 10.1016/j.crad.2007.11.011 18455560

7. Karlsson A, Leinhard OD, Aslund U, West J, Romu T, Smedby O, et al. An Investigation of Fat Infiltration of the Multifidus Muscle in Patients With Severe Neck Symptoms Associated With Chronic Whiplash-Associated Disorder. The Journal of orthopaedic and sports physical therapy. 2016;46(10):886–93. doi: 10.2519/jospt.2016.6553 27590177

8. Anderson JS, Hsu AW, Vasavada AN. Morphology, architecture, and biomechanics of human cervical multifidus. Spine (Phila Pa 1976). 2005;30(4):E86–91.

9. Pedler A, McMahon K, Galloway G, Durbridge G, Sterling M. Intramuscular fat is present in cervical multifidus but not soleus in patients with chronic whiplash associated disorders. PloS one. 2018;13(5):e0197438. doi: 10.1371/journal.pone.0197438 29795590

10. Elliott J, Pedler A, Kenardy J, Galloway G, Jull G, Sterling M. The temporal development of fatty infiltrates in the neck muscles following whiplash injury: an association with pain and posttraumatic stress. PloS one. 2011;6(6):e21194. doi: 10.1371/journal.pone.0021194 21698170

11. Elliott JM, Courtney DM, Rademaker A, Pinto D, Sterling MM, Parrish TB. The Rapid and Progressive Degeneration of the Cervical Multifidus in Whiplash: An MRI Study of Fatty Infiltration. Spine. 2015;40(12):E694–700. doi: 10.1097/BRS.0000000000000891 25785961

12. Linnstaedt SD, Riker KD, Walker MG, Nyland JE, Zimny E, Lewandowski C, et al. MicroRNA 320a Predicts Chronic Axial and Widespread Pain Development Following Motor Vehicle Collision in a Stress-Dependent Manner. The Journal of orthopaedic and sports physical therapy. 2016;46(10):911–9. doi: 10.2519/jospt.2016.6944 27690835

13. Linnstaedt SD, Walker MG, Parker JS, Yeh E, Sons RL, Zimny E, et al. MicroRNA circulating in the early aftermath of motor vehicle collision predict persistent pain development and suggest a role for microRNA in sex-specific pain differences. Mol Pain. 2015;11:66. doi: 10.1186/s12990-015-0069-3 26498117

14. McLean SA. The potential contribution of stress systems to the transition to chronic whiplash-associated disorders. Spine. 2011;36(25 Suppl):S226–32. doi: 10.1097/BRS.0b013e3182387fb4 22020617

15. Elliott JM, Dewald JP, Hornby TG, Walton DM, Parrish TB. Mechanisms underlying chronic whiplash: contributions from an incomplete spinal cord injury? Pain Med. 2014;15(11):1938–44. doi: 10.1111/pme.12518 25139822

16. Guez M, Hildingsson C, Rosengren L, Karlsson K, Toolanen G. Nervous tissue damage markers in cerebrospinal fluid after cervical spine injuries and whiplash trauma. J Neurotrauma. 2003;20(9):853–8. doi: 10.1089/089771503322385782 14577863

17. Smith AC, Parrish TB, Hoggarth MA, McPherson JG, Tysseling VM, Wasielewski M, et al. Potential associations between chronic whiplash and incomplete spinal cord injury. Spinal Cord Ser Cases. 2015;1.

18. Elliott JM, Pedler AR, Cowin G, Sterling M, McMahon K. Spinal cord metabolism and muscle water diffusion in whiplash. Spinal Cord. 2012;50(6):474–6. doi: 10.1038/sc.2011.17 21383759

19. Clark BC. In vivo alterations in skeletal muscle form and function after disuse atrophy. Med Sci Sports Exerc. 2009;41(10):1869–75. doi: 10.1249/MSS.0b013e3181a645a6 19727027

20. Manini TM, Clark BC, Nalls MA, Goodpaster BH, Ploutz-Snyder LL, Harris TB. Reduced physical activity increases intermuscular adipose tissue in healthy young adults. Am J Clin Nutr. 2007;85(2):377–84. doi: 10.1093/ajcn/85.2.377 17284732

21. Passatore M, Roatta S. Influence of sympathetic nervous system on sensorimotor function: whiplash associated disorders (WAD) as a model. European journal of applied physiology. 2006;98(5):423–49. doi: 10.1007/s00421-006-0312-8 17036216

22. Vernon H, Mior S. The Neck Disability Index: a study of reliability and validity. Journal of manipulative and physiological therapeutics. 1991;14(7):409–15. 1834753

23. Ludvigsson ML, Peterson G, O'Leary S, Dedering A, Peolsson A. The Effect of Neck-specific Exercise With, or Without a Behavioral Approach, on Pain, Disability, and Self-Efficacy in Chronic Whiplash-associated Disorders: A Randomized Clinical Trial. The Clinical journal of pain. 2015;31(4):294–303. doi: 10.1097/AJP.0000000000000123 24918474

24. Peolsson A, Landen Ludvigsson M, Overmeer T, Dedering A, Bernfort L, Johansson G, et al. Effects of neck-specific exercise with or without a behavioural approach in addition to prescribed physical activity for individuals with chronic whiplash-associated disorders: a prospective randomised study. BMC musculoskeletal disorders. 2013;14:311. doi: 10.1186/1471-2474-14-311 24171699

25. Harms-Ringdahl K, Carlsson AM, Ekholm J, Raustorp A, Svensson T, Toresson HG. Pain assessment with different intensity scales in response to loading of joint structures. Pain. 1986;27(3):401–11. doi: 10.1016/0304-3959(86)90163-6 3808744

26. Romu T, Dahlstrom N, Leinhard OD, Borga M. Robust water fat separated dual-echo MRI by phase-sensitive reconstruction. Magn Reson Med. 2017;78(3):1208–16. doi: 10.1002/mrm.26488 27775180

27. Romu T, Borga M, Dahlqvist Leinhard O. MANA—Multi scale adaptive normalized averaging. Proceedings—International Symposium on Biomedical Imaging (ISBI). 2011;art.no. 5872424:361–4.

28. Malmberg F, Lindblad J, Nyström I, editors. Sub-Pixel Segmentation with the Image Foresting Transform. 13th International Workshop on Combinatorial Image Analysis (IWCIA'09); 2009; Playa del Carmen, Mexico.

29. Karlsson A, Rosander J, Romu T, Tallberg J, Gronqvist A, Borga M, et al. Automatic and quantitative assessment of regional muscle volume by multi-atlas segmentation using whole-body water-fat MRI. J Magn Reson Imaging. 2015;41(6):1558–69. doi: 10.1002/jmri.24726 25111561

30. West J, Romu T, Thorell S, Lindblom H, Berin E, Holm AS, et al. Precision of MRI-based body composition measurements of postmenopausal women. PloS one. 2018;13(2):e0192495. doi: 10.1371/journal.pone.0192495 29415060

31. Thomas MS, Newman D, Leinhard OD, Kasmai B, Greenwood R, Malcolm PN, et al. Test-retest reliability of automated whole body and compartmental muscle volume measurements on a wide bore 3T MR system. Eur Radiol. 2014;24(9):2279–91. doi: 10.1007/s00330-014-3226-6 24871333

32. Elliott JMP T.B.; Walton D.M.; Vassallo A.J.; Fundaun J.; Wasielewski M.; Courtney D.M. Does Overall Cervical Spine Pathology REalte to the Clinical Heterogeneity of Chronic Whiplash?. American Journal of Emergency Medicince 2019.

33. Gerdle B, Forsgren MF, Bengtsson A, Leinhard OD, Soren B, Karlsson A, et al. Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients—a 31P-MRS study. European journal of pain. 2013;17(8):1205–15. doi: 10.1002/j.1532-2149.2013.00284.x 23364928

34. Cohen-Adad J, El Mendili MM, Lehericy S, Pradat PF, Blancho S, Rossignol S, et al. Demyelination and degeneration in the injured human spinal cord detected with diffusion and magnetization transfer MRI. Neuroimage. 2011;55(3):1024–33. doi: 10.1016/j.neuroimage.2010.11.089 21232610

35. De Leener B, Levy S, Dupont SM, Fonov VS, Stikov N, Louis Collins D, et al. SCT: Spinal Cord Toolbox, an open-source software for processing spinal cord MRI data. Neuroimage. 2017;145(Pt A):24–43. doi: 10.1016/j.neuroimage.2016.10.009 27720818

36. Martin AR, De Leener B, Cohen-Adad J, Aleksanderek I, Cadotte DW, Kalsi-Ryan S, et al. 163 Microstructural MRI Quantifies Tract-Specific Injury and Correlates With Global Disability and Focal Neurological Deficits in Degenerative Cervical Myelopathy. Neurosurgery. 2016;63 Suppl 1:165.

37. Smith AC, Weber KA 2nd, O'Dell DR, Parrish TB, Wasielewski M, Elliott JM. Lateral corticospinal tract damage correlates with motor output in incomplete spinal cord injury. Archives of physical medicine and rehabilitation. 2017.

38. Smith AC, Weber KA, Parrish TB, Hornby TG, Tysseling VM, McPherson JG, et al. Ambulatory function in motor incomplete spinal cord injury: a magnetic resonance imaging study of spinal cord edema and lower extremity muscle morphometry. Spinal Cord. 2017;55(7):672–8. doi: 10.1038/sc.2017.18 28244504

39. Crawford RJ, Cornwall J, Abbott R, Elliott JM. Manually defining regions of interest when quantifying paravertebral muscles fatty infiltration from axial magnetic resonance imaging: a proposed method for the lumbar spine with anatomical cross-reference. BMC musculoskeletal disorders. 2017;18(1):25. doi: 10.1186/s12891-016-1378-z 28103921

40. Elliott JM, Cornwall J, Kennedy E, Abbott R, Crawford RJ. Towards defining muscular regions of interest from axial magnetic resonance imaging with anatomical cross-reference: part II—cervical spine musculature. BMC Musculoskelet Disord. 2018;19(1):171. doi: 10.1186/s12891-018-2074-y 29807530

41. Weber KA, Smith AC, Wasielewski M, Eghtesad K, Upadhyayula PA, Wintermark M, et al. Deep Learning Convolutional Neural Networks for the Automatic Quantification of Muscle Fat Infiltration Following Whiplash Injury. Sci Rep. 2019;9(1):7973. doi: 10.1038/s41598-019-44416-8 31138878

42. West J, Dahlqvist Leinhard O, Romu T, Collins R, Garratt S, Bell JD, et al. Feasibility of MR-Based Body Composition Analysis in Large Scale Population Studies. PloS one. 2016;11(9):e0163332. doi: 10.1371/journal.pone.0163332 27662190


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