Interocular asymmetry of the superonasal retinal nerve fibre layer thickness and blood vessel diameter in healthy subjects
Autoři:
Angelica Ly aff001; Jennifer Banh aff002; Patricia Luu aff002; Jessie Huang aff001; Michael Yapp aff001; Barbara Zangerl aff001
Působiště autorů:
Centre for Eye Health, Sydney, New South Wales, Australia
aff001; School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
aff002
Vyšlo v časopise:
PLoS ONE 14(12)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0226728
Souhrn
Background
Optical coherence tomography is commonly used to measure the retinal nerve fibre layer thickness in both normal and diseased eyes; however, variation among normal eyes is common and may limit the usefulness of the results. The aim of this study was to explore the interocular asymmetries in retinal nerve fibre layer thickness in a group of normal eyes and to investigate the influence of blood vessel diameter on local retinal nerve fibre layer thickness.
Methods
In this prospective study, retinal nerve fibre layer thickness and blood vessel diameter across 100 healthy participants were measured using two optical coherence tomography instruments. Individuals were categorised into two groups based on the presence or absence of interocular retinal nerve fibre layer thickness asymmetry beyond the 75th percentile of all participants.
Results
The superonasal sectoral retinal nerve fibre layer thickness was significantly greater in the left eye compared to the right, across all three sectors. Mean blood vessel diameter showed a corresponding difference in thickness at one of the superonasal sectors. Linear regression showed a positive and moderate correlation between blood vessel diameter and focal retinal nerve fibre layer thickness. This trend persisted across both arteries and veins, but veins showed larger variability between left and right eye in participants with marked superonasal retinal nerve fibre layer asymmetry.
Conclusion
Retinal nerve fibre layer thickness and blood vessel diameter vary significantly between eyes even in healthy individuals. These asymmetries in a normal population should be taken into consideration when interpreting the retinal nerve fibre layer thickness measurements from optical coherence tomography to assist in distinguishing normal variations from disease.
Klíčová slova:
Arteries – Blood vessels – Eye diseases – Eyes – Nerve fibers – Optic nerve – Optic neuropathy – Veins
Zdroje
1. Field MG, Alasil T, Baniasadi N, Que C, Simavli H, Sobeih D, et al. Facilitating Glaucoma Diagnosis With Intereye Retinal Nerve Fiber Layer Asymmetry Using Spectral-Domain Optical Coherence Tomography. Journal of Glaucoma. 2016;25: 167–76. doi: 10.1097/IJG.0000000000000080 24921896
2. Sullivan-Mee M, Ruegg CC, Pensyl D, Halverson K, Qualls C. Diagnostic precision of retinal nerve fiber layer and macular thickness asymmetry parameters for identifying early primary open-angle glaucoma. Am J Ophthalmol. 2013;156: 567–77 e1. doi: 10.1016/j.ajo.2013.04.037 23810475
3. Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA. 2014;311: 1901–11. doi: 10.1001/jama.2014.3192 24825645
4. Hwang YH, Song M, Kim YY, Yeom DJ, Lee JH. Interocular symmetry of retinal nerve fibre layer thickness in healthy eyes: a spectral-domain optical coherence tomographic study. Clin Exp Optom. 2014;97: 550–4. doi: 10.1111/cxo.12218 25331078
5. Hood DC, Fortune B, Arthur SN, Xing D, Salant JA, Ritch R, et al. Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography. J Glaucoma. 2008;17: 519–28. doi: 10.1097/IJG.0b013e3181629a02 18854727
6. Hood DC, Salant JA, Arthur SN, Ritch R, Liebmann JM. The location of the inferior and superior temporal blood vessels and interindividual variability of the retinal nerve fiber layer thickness. J Glaucoma. 2010;19: 158–66. doi: 10.1097/IJG.0b013e3181af31ec 19661824
7. Flitcroft DI, He M, Jonas JB, Jong M, Naidoo K, Ohno-Matsui K, et al. IMI—Defining and Classifying Myopia: A Proposed Set of Standards for Clinical and Epidemiologic Studies. Invest Ophthalmol Vis Sci. 2019;60: M20–m30. doi: 10.1167/iovs.18-25957 30817826
8. Pawar N, Maheshwari D, Ravindran M, Ramakrishnan R. Interocular symmetry of retinal nerve fiber layer and optic nerve head parameters measured by Cirrus high-definition optical coherence tomography in a normal pediatric population. Indian J Ophthalmol. 2017;65: 955–62. doi: 10.4103/ijo.IJO_71_17 29044060
9. Budenz DL. Symmetry between the right and left eyes of the normal retinal nerve fiber layer measured with optical coherence tomography (an AOS thesis). Trans Am Ophthalmol Soc. 2008;106: 252–75. 19277241
10. Mwanza JC, Durbin MK, Budenz DL. Interocular symmetry in peripapillary retinal nerve fiber layer thickness measured with the Cirrus HD-OCT in healthy eyes. Am J Ophthalmol. 2011;151: 514–21.e1. doi: 10.1016/j.ajo.2010.09.015 21236402
11. Jonas JB, Naumann GO. Parapapillary retinal vessel diameter in normal and glaucoma eyes. II. Correlations. Invest Ophthalmol Vis Sci. 1989;30: 1604–11. 2745001
12. Pereira I, Weber S, Holzer S, Fischer G, Vass C, Resch H. Compensation for retinal vessel density reduces the variation of circumpapillary RNFL in healthy subjects. PLoS One. 2015;10: e0120378. doi: 10.1371/journal.pone.0120378 25786232
13. Pereira I, Weber S, Holzer S, Resch H, Kiss B, Fischer G, et al. Correlation between retinal vessel density profile and circumpapillary RNFL thickness measured with Fourier-domain optical coherence tomography. Br J Ophthalmol. 2014;98: 538–43. doi: 10.1136/bjophthalmol-2013-303910 24390166
14. Park JJ, Oh DR, Hong SP, Lee KW. Asymmetry analysis of the retinal nerve fiber layer thickness in normal eyes using optical coherence tomography. Korean J Ophthalmol. 2005;19: 281–7. doi: 10.3341/kjo.2005.19.4.281 16491818
15. Hall JK, Andrews AP, Walker R, Piltz-Seymour JR. Association of retinal vessel caliber and visual field defects in glaucoma. Am J Ophthalmol. 2001;132: 855–9. doi: 10.1016/s0002-9394(01)01200-4 11730648
16. Langenegger SJ, Funk J, Toteberg-Harms M. Reproducibility of retinal nerve fiber layer thickness measurements using the eye tracker and the retest function of Spectralis SD-OCT in glaucomatous and healthy control eyes. Invest Ophthalmol Vis Sci. 2011;52: 3338–44. doi: 10.1167/iovs.10-6611 21330656
Článek vyšel v časopise
PLOS One
2019 Číslo 12
- S diagnostikou Parkinsonovy nemoci může nově pomoci AI nástroj pro hodnocení mrkacího reflexu
- Je libo čepici místo mozkového implantátu?
- Pomůže v budoucnu s triáží na pohotovostech umělá inteligence?
- AI může chirurgům poskytnout cenná data i zpětnou vazbu v reálném čase
- Nová metoda odlišení nádorové tkáně může zpřesnit resekci glioblastomů
Nejčtenější v tomto čísle
- Methylsulfonylmethane increases osteogenesis and regulates the mineralization of the matrix by transglutaminase 2 in SHED cells
- Oregano powder reduces Streptococcus and increases SCFA concentration in a mixed bacterial culture assay
- The characteristic of patulous eustachian tube patients diagnosed by the JOS diagnostic criteria
- Parametric CAD modeling for open source scientific hardware: Comparing OpenSCAD and FreeCAD Python scripts
Zvyšte si kvalifikaci online z pohodlí domova
Všechny kurzy