Longitudinal changes in plasma hemopexin and alpha-1-microglobulin concentrations in women with and without clinical risk factors for pre-eclampsia

English version

Autoři: Katja Murtoniemi ^aff001; Grigorios Kalapotharakos ^aff003; Tero Vahlberg ^aff004; Katri Räikkonen ^aff005; Eero Kajantie ^aff006; Esa Hämäläinen ^aff010; Bo Åkerström ^aff011; Pia M. Villa ^aff012; Stefan R. Hansson ^aff003; Hannele Laivuori ^aff001
Působiště autorů: Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, University of Helsinki, Finland ^aff001; Department of Obstetrics and Gynaecology, University of Turku and Turku University Hospital, Turku, Finland ^aff002; Skåne University Hospital, Department of Clinical Sciences Lund, Department of Obstetrics and Gynecology, Lund University, Lund, Sweden ^aff003; Department of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, Turku, Finland ^aff004; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland ^aff005; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland ^aff006; National Institute for Health and Welfare, Helsinki, Finland ^aff007; Children`s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland ^aff008; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway ^aff009; Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland ^aff010; Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden ^aff011; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland ^aff012; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland ^aff013; Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland ^aff014
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226520

Souhrn

Recent studies have shown increased concentration of fetal hemoglobin (HbF) in pre-eclamptic women. Plasma hemopexin (Hpx) and alpha-1-microglobulin (A1M) are hemoglobin scavenger proteins that protect against toxic effects of free heme released in the hemoglobin degradation process. We used an enzyme-linked immunosorbent assay to analyze maternal plasma Hpx and A1M concentrations at 12–14, 18–20 and 26–28 weeks of gestation in three groups: 1) 51 women with a low risk for pre-eclampsia (LRW), 2) 49 women with a high risk for pre-eclampsia (PE) who did not develop PE (HRW) and 3) 42 women with a high risk for PE who developed PE (HRPE). The study had three aims: 1) to investigate whether longitudinal differences exist between study groups, 2) to examine if Hpx and A1M concentrations develop differently in pre-eclamptic women with small for gestational age (SGA) fetuses vs. pre-eclamptic women with appropriate for gestational age fetuses, and 3) to examine if longitudinal Hpx and A1M profiles differ by PE subtype (early-onset vs. late-onset and severe vs. non-severe PE). Repeated measures analysis of variance was used to analyze differences in Hpx and A1M concentrations between the groups. We found that the differences in longitudinal plasma Hpx and A1M concentrations in HRW compared to HRPE and to LRW may be associated with reduced risk of PE regardless of clinical risk factors. In women who developed PE, a high A1M concentration from midgestation to late second trimester was associated with SGA. There were no differences in longitudinal Hpx and A1M concentrations from first to late second trimester in high-risk women who developed early-onset or. late-onset PE or in women who developed severe or. non-severe PE.

Klíčová slova:

Body Mass Index – Hypertensive disorders in pregnancy – Management of high-risk pregnancies – Oxidative stress – Preeclampsia – Pregnancy

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Longitudinal changes in plasma hemopexin and alpha-1-microglobulin concentrations in women with and without clinical risk factors for pre-eclampsia

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