Comparison of plasma fatty acid binding protein 4 concentration in venous and capillary blood

English version

Autoři: Shigeharu Numao ^aff001; Yoshinori Nagasawa ^aff002; Naomi Goromaru ^aff003; Shunichi Tamaki ^aff003
Působiště autorů: Department of Sports and Life Sciences, National Institute of Fitness and Sports in Kanoya, Kagoshima, Japan ^aff001; Department of Health and Sports Sciences, Kyoto Pharmaceutical University, Kyoto, Japan ^aff002; Yamashina Takeda Racto Clinic, Kyoto, Japan ^aff003
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226374

Souhrn

Circulating fatty acid binding protein 4 (FABP4) is associated with various diseases and simple and less invasive techniques for assessment of FABP4 concentration are required in clinical research setting. The purpose of the present study was to assess the correlation of plasma FABP4 concentration between venous and capillary blood in healthy young adults. Twenty-eight healthy young adults aged from 20 to 26 years (mean age, 22.2 ± 1.4 years, 14 males and 14 females) were included. Paired resting blood samples were taken from the cubital vein (venous) and fingertip (capillary) blood. Plasma FABP4 concentration in both blood was analyzed by enzyme-linked Immunosorbent assay. Plasma FABP4 concentration did not differ significantly between venous and capillary blood (−0.11± 0.75 ng/mL, p = 0.447, 95%CI: -0.402–0.182). Pearson’s correlation coefficient for plasma FABP4 concentration between venous and capillary blood samples suggests strong correlation (r = 0.961, p < 0.001). The Bland & Altman plot showed a non-significant bias (−0.11 ± 0.75 ng/mL, p = 0.684) and the 95% limits of agreement ranged from −1.59 to 1.37 ng/mL. FABP4 concentration in both venous and capillary blood was significantly higher in females than in males (venous blood: p = 0.041; capillary blood: p = 0.049). These results suggest that capillary blood sampling can detect gender difference and is useful for the assessment of FABP4 concentration.

Klíčová slova:

Adipocytes – Blood – Blood plasma – Capillaries – Enzyme-linked immunoassays – Fats – Fatty acids – Young adults

Zdroje

1. Furuhashi M, Saitoh S, Shimamoto K, Miura T. Fatty acid-binding protein 4 (FABP4): Pathophysiological insights and potent clinical biomarker of metabolic and cardiovascular diseases. Clin Med Insights Cardiol. 2015; 8: 23–33. https://doi.org/10.4137/CMC.S17067 25674026

2. Spiegelman BM, Frank M, Green H. Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J Biol Chem. 1983; 258: 10083–10089. 6411703

3. Hunt CR, Ro JH, Dobson DE, Min HY, Spiegelman BM. Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes. Proc Natl Acad Sci USA. 1986; 83: 3786–3790. doi: 10.1073/pnas.83.11.3786 3520554

4. Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL et al. Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. Biochemistry. 1989; 28: 8683–8690. doi: 10.1021/bi00448a003 2481498

5. Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A et al. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab. 2013; 17: 768–778. https://doi.org/10.1016/j.cmet.2013.04.012 23663740

6. Mita T, Furuhashi M, Hiramitsu S, Ishii J, Hoshina K, Ishimura S et al. FABP4 is secreted from adipocytes by adenyl cyclase-PKA- and guanylyl cyclase-PKG-dependent lipolytic mechanisms. Obesity (Silver Spring). 2015; 23: 359–367. https://doi.org/10.1002/oby.20954 25521833

7. Furuhashi M, Yuda S, Muranaka A, Kawamukai M, Matsumoto M, Tanaka M et al. Circulating Fatty Acid-Binding Protein 4 Concentration Predicts the Progression of Carotid Atherosclerosis in a General Population Without Medication. Circ J. 2018; 82: 1121–1129. https://doi.org/10.1253/circj.CJ-17-1295 29445067

8. Yeung DC, Xu A, Cheung CW, Wat NM, Yau MH, Fong CH et al. Serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 2007; 27: 1796–1802. https://doi.org/10.1161/ATVBAHA.107.146274 17510463

9. Xu A, Wang Y, Xu JY, Stejskal D, Tam S, Zhang J et al. Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin Chem. 2006; 52: 405–413. https://doi.org/10.1373/clinchem.2005.062463 16423904

10. Haluzik MM, Anderlová K, Dolezalová R, Adamíková A, Haluzíková D, Housová J et al. Serum adipocyte fatty acid binding protein levels in patients with type 2 diabetes mellitus and obesity: the influence of fenofibrate treatment. Physiol Res. 2009; 58: 93–99. 18198986

11. Ota H, Furuhashi M, Ishimura S, Koyama M, Okazaki Y, Mita T et al. Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation. Am J Hypertens. 2012; 25: 1124–1130. https://doi.org/10.1038/ajh.2012.88 22717543

12. Furuhashi M, Omori A, Matsumoto M, Kataoka Y, Tanaka M, Moniwa N et al. Independent Link Between Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and FABP4 in a General Population Without Medication. Am J Cardiol. 2016; 118: 198–203. https://doi.org/10.1016/j.amjcard.2016.04.037 27241838

13. von Eynatten M, Breitling LP, Roos M, Baumann M, Rothenbacher D, Brenner H. Circulating adipocyte fatty acid-binding protein levels and cardiovascular morbidity and mortality in patients with coronary heart disease: a 10-year prospective study. Arterioscler Thromb Vasc Biol. 2012; 32: 2327–2335. https://doi.org/10.1161/ATVBAHA.112.248609 22679309

14. Chow WS, Tso AW, Xu A, Yuen MM, Fong CH, Lam TH et al. Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: a 12-year prospective study. J Am Heart Assoc. 2013; 2: e004176. https://doi.org/10.1161/JAHA.112.004176 23525430

15. Guaita-Esteruelas S, Saavedra-García P, Bosquet A, Borràs J, Girona J, Amiliano K et al. Adipose-Derived Fatty Acid-Binding Proteins Plasma Concentrations Are Increased in Breast Cancer Patients. Oncologist. 2017; 22: 1309–1315. https://doi.org/10.1634/theoncologist.2016-0483 28701570

16. Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES et al. Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Sci Transl Med.2015; 7:319ra205. https://doi.org/10.1126/scitranslmed.aac6336 26702093

17. Simmonds MJ, Baskurt OK, Meiselman HJ, Marshall-Gradisnik SM. A comparison of capillary and venous blood sampling methods for the use in haemorheology studies. Clin Hemorheol Microcirc. 2011; 47: 111–119. https://doi.org/10.3233/CH-2010-1372 21339631

18. Sitoe N, Luecke E, Tembe N, Matavele R, Cumbane V, Macassa E et al. Absolute and percent CD4+T-cell enumeration by flow cytometry using capillary blood. J Immunol Methods. 2011; 372: 1–6. https://doi.org/10.1016/j.jim.2011.07.008 21787779

19. Colagiuri S, Sandbaek A, Carstensen B, Christensen J, Glumer C, Lauritzen T et al. Comparability of venous and capillary glucose measurements in blood. Diabet Med. 2003; 20: 953–956. doi: 10.1046/j.1464-5491.2003.01048.x 14632723

20. Eriksson M, Sartono E, Martins CL, Balé C, Garly ML, Whittle H et al. A comparison of ex vivo cytokine production in venous and capillary blood. Clin Exp Immunol. 2007; 150: 469–476. https://doi.org/10.1111/j.1365-2249.2007.03515.x 17924971

21. Kuwa K, Nakayama T, Hoshino T, Tominaga M. Relationships of glucose concentrations in capillary whole blood, venous whole blood and venous plasma. Clin Chim Acta. 2001; 307: 187–192. https://doi.org/10.1111/j.1365-2249.2007.03515.x 11369356

22. Bland JM, Altman DG. Comparing methods of measurement: why plotting difference against standard method is misleading. Lancet. 1995; 346: 1085–1087. doi: 10.1016/s0140-6736(95)91748-9 7564793

23. Ishimura S, Furuhashi M, Watanabe Y, Hoshina K, Fuseya T, Mita T et al. Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population. PLoS One. 2013; 8: e81318. https://doi.org/10.1371/journal.pone.0081318 24278421

24. Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011; 43: 1334–1359. https://doi.org/10.1249/MSS.0b013e318213fefb 21694556

25. Krskova K, Eckertova M, Kukan M, Kuba D, Kebis A, Olszanecki R et al. Aerobic training lasting for 10 weeks elevates the adipose tissue FABP4, Gialpha, and adiponectin expression associated by a reduced protein oxidation. Endocr Regul. 2012; 46: 137–146. doi: 10.4149/endo_2012_03_137 22808905

26. Safarzade A, Talebi-Garakani E. Short term resistance training enhanced plasma apoA-I and FABP4 levels in Streptozotocin-induced diabetic rats. J Diabetes Metab Disord. 2014; 13: 41. https://doi.org/10.1186/2251-6581-13-41 24593955

27. Fischer H, Gustafsson T, Sundberg CJ, Norrbom J, Ekman M, Johansson O et al. Fatty acid binding protein 4 in human skeletal muscle. Biochem Biophys Res Commun. 2006; 346: 125–130. https://doi.org/10.1016/j.bbrc.2006.05.083 16750515

28. Iso T, Sunaga H, Matsui H, Kasama S, Oshima N, Haruyama H et al. Serum levels of fatty acid binding protein 4 and fat metabolic markers in relation to catecholamines following exercise. Clin Biochem. 2017; 50: 896–902. https://doi.org/10.1016/j.clinbiochem.2017.05.021 28583436

29. Kempe K, Price D, Ellison J, Marhoul J, Morrow L, Win K et al. Capillary and venous blood glucose concentrations measured during intravenous insulin and glucose infusion: a comparison of steady and dynamic states. Diabetes Technol Ther. 2009; 11: 669–674. https://doi.org/10.1089/dia.2009.0023 19821760

Comparison of plasma fatty acid binding protein 4 concentration in venous and capillary blood

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