Possible link between dental diseases and arteriosclerosis in patients on hemodialysis
Autoři:
Taro Misaki aff001; Akiko Fukunaga aff003; Yoshitaka Shimizu aff001; Akira Ishikawa aff004; Kazuhiko Nakano aff005
Působiště autorů:
Division of Nephrology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan
aff001; Department of Nursing, Faculty of Nursing, Seirei Christopher University, Hamamatsu, Shizuoka, Japan
aff002; Division of Dentistry, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan
aff003; Ai Dental Clinic, Hamamatsu, Shizuoka, Japan
aff004; Department of Pediatric Dentistry, Division of Oral Infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
aff005
Vyšlo v časopise:
PLoS ONE 14(12)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0225038
Souhrn
Background
Patients on hemodialysis must undergo this procedure at a hospital three times weekly and might be unable to visit a dentist. In addition, dentists might hesitate to provide oral care because such patients tend to bleed because they are medicated with anticoagulants, are susceptible to bacterial infections, and might have unusual drug reactions. We postulated that patients on hemodialysis have worse oral status than healthy people, which in turn might predispose such patients to systemic complications.
Methods
We compared the status of dental caries and periodontal diseases among 80 patients on hemodialysis and 76 healthy individuals (controls) using the decayed, missing, or filled teeth (DMFT) index, total number of C4 teeth (destruction of the entire tooth crown), and periodontal pocket depth. Clinical data were analyzed after all patients on hemodialysis and controls provided written, informed consent to participate in the study.
Results
Total number of C4 teeth (p = 0.021), missing teeth (MT) index (p = 0.0302), and DMFT index score ≥ 24 (p = 0.017) were significantly higher in patients on hemodialysis than controls. Pulse pressure (p = 0.0042) and the prevalence of a history of heart disease such as angina pectoris and acute myocardial infarction (p = 0.029) were higher in patients on hemodialysis with higher (≥ 24) than lower (< 24) DMFT index scores. Periodontal pocket depth was not significantly different between these two groups.
Conclusion
Worse status of dental caries is possibly associated with arteriosclerosis among patients on hemodialysis.
Klíčová slova:
Blood pressure – Cardiovascular diseases – Caries – Dentition – Chronic kidney disease – Medical dialysis – Parathyroid hormone – Periodontal diseases
Zdroje
1. Misaki T, Naka S, Hatakeyama R, Fukunaga A, Nomura R, Isozaki T, et al. Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions. Scientific reports. 2016;6:36455. Epub 2016/11/05. doi: 10.1038/srep36455 27811984; PubMed Central PMCID: PMC5095553.
2. Dhaun N, Bellamy CO, Cattran DC, Kluth DC. Utility of renal biopsy in the clinical management of renal disease. Kidney international. 2014;85(5):1039–48. Epub 2014/01/10. doi: 10.1038/ki.2013.512 24402095.
3. Montebugnoli L, Servidio D, Miaton RA, Prati C, Tricoci P, Melloni C. Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors. Journal of clinical periodontology. 2004;31(1):25–9. Epub 2004/04/03. doi: 10.1111/j.0303-6979.2004.00432.x 15058371.
4. Montebugnoli L, Servidio D, Miaton RA, Prati C, Tricoci P, Melloni C, et al. Periodontal health improves systemic inflammatory and haemostatic status in subjects with coronary heart disease. Journal of clinical periodontology. 2005;32(2):188–92. Epub 2005/02/05. doi: 10.1111/j.1600-051X.2005.00641.x 15691350.
5. Yue Q, Yin FT, Zhang Q, Yuan C, Ye MY, Wang XL, et al. Carious status and supragingival plaque microbiota in hemodialysis patients. PloS one. 2018;13(10):e0204674. Epub 2018/10/10. doi: 10.1371/journal.pone.0204674 30300382; PubMed Central PMCID: PMC6177147.
6. Chambrone L, Foz AM, Guglielmetti MR, Pannuti CM, Artese HP, Feres M, et al. Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate. Journal of clinical periodontology. 2013;40(5):443–56. Epub 2013/02/26. doi: 10.1111/jcpe.12067 23432795.
7. Ruospo M, Palmer SC, Craig JC, Gentile G, Johnson DW, Ford PJ, et al. Prevalence and severity of oral disease in adults with chronic kidney disease: a systematic review of observational studies. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association—European Renal Association. 2014;29(2):364–75. Epub 2013/10/02. doi: 10.1093/ndt/gft401 24081863.
8. Borawski J, Wilczynska-Borawska M, Stokowska W, Mysliwiec M. The periodontal status of pre-dialysis chronic kidney disease and maintenance dialysis patients. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association—European Renal Association. 2007;22(2):457–64. Epub 2006/11/25. doi: 10.1093/ndt/gfl676 17124280.
9. Covic A, Vervloet M, Massy ZA, Torres PU, Goldsmith D, Brandenburg V, et al. Bone and mineral disorders in chronic kidney disease: implications for cardiovascular health and ageing in the general population. The lancet Diabetes & endocrinology. 2018;6(4):319–31. Epub 2017/10/21. doi: 10.1016/S2213-8587(17)30310-8 29050900.
10. Tonelli M, Wiebe N, Culleton B, House A, Rabbat C, Fok M, et al. Chronic kidney disease and mortality risk: a systematic review. Journal of the American Society of Nephrology: JASN. 2006;17(7):2034–47. Epub 2006/06/02. doi: 10.1681/ASN.2005101085 16738019.
11. Blinkhorn AS, Davies RM. Caries prevention. A continued need worldwide. Int Dent J. 1996;46(3):119–25. Epub 1996/06/01. 8886863.
12. Bossola M, Tazza L. Xerostomia in patients on chronic hemodialysis. Nature reviews Nephrology. 2012;8(3):176–82. Epub 2012/01/18. doi: 10.1038/nrneph.2011.218 22249779.
13. Palmer SC, Ruospo M, Wong G, Craig JC, Petruzzi M, De Benedittis M, et al. Dental Health and Mortality in People With End-Stage Kidney Disease Treated With Hemodialysis: A Multinational Cohort Study. American journal of kidney diseases: the official journal of the National Kidney Foundation. 2015;66(4):666–76. Epub 2015/06/30. doi: 10.1053/j.ajkd.2015.04.051 26120038.
14. Survey on actual conditions of dental diseases. Reports of the ministry of Health, Labour and Welfare of Japan. 2016:p13.
15. Kanda E, Kato A, Masakane I, Kanno Y. A new nutritional risk index for predicting mortality in hemodialysis patients: Nationwide cohort study. PloS one. 2019;14(3):e0214524. Epub 2019/03/29. doi: 10.1371/journal.pone.0214524 30921398; PubMed Central PMCID: PMC6438476.
16. Chertow GM, Liu J, Monda KL, Gilbertson DT, Brookhart MA, Beaubrun AC, et al. Epoetin Alfa and Outcomes in Dialysis amid Regulatory and Payment Reform. Journal of the American Society of Nephrology: JASN. 2016;27(10):3129–38. Epub 2016/02/27. doi: 10.1681/ASN.2015111232 26917691; PubMed Central PMCID: PMC5042674.
17. Wakasugi M, Kazama JJ, Narita I. Mortality trends among Japanese dialysis patients, 1988–2013: a joinpoint regression analysis. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association—European Renal Association. 2016;31(9):1501–7. Epub 2016/07/13. doi: 10.1093/ndt/gfw249 27402812.
18. Masakane I, Nakai S, Ogata S, Kimata N, Hanafusa N, Hamano T, et al. An Overview of Regular Dialysis Treatment in Japan (As of 31 December 2013). Therapeutic apheresis and dialysis: official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2015;19(6):540–74. Epub 2016/01/16. doi: 10.1111/1744-9987.12378 26768810.
19. Chae CU, Pfeffer MA, Glynn RJ, Mitchell GF, Taylor JO, Hennekens CH. Increased pulse pressure and risk of heart failure in the elderly. Jama. 1999;281(7):634–9. Epub 1999/02/24. doi: 10.1001/jama.281.7.634 10029125.
20. Blacher J, Staessen JA, Girerd X, Gasowski J, Thijs L, Liu L, et al. Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients. Archives of internal medicine. 2000;160(8):1085–9. Epub 2000/05/02. doi: 10.1001/archinte.160.8.1085 10789600.
21. Nakano K, Inaba H, Nomura R, Nemoto H, Takeda M, Yoshioka H, et al. Detection of cariogenic Streptococcus mutans in extirpated heart valve and atheromatous plaque specimens. Journal of clinical microbiology. 2006;44(9):3313–7. Epub 2006/09/07. doi: 10.1128/JCM.00377-06 16954266; PubMed Central PMCID: PMC1594668.
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PLOS One
2019 Číslo 12
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