Remote ischaemic conditioning and early changes in plasma creatinine as markers of one year kidney graft function—A follow-up of the CONTEXT study
Autoři:
Marie B. Nielsen aff001; Nicoline V. Krogstrup aff001; Mihai Oltean aff004; Gertrude J. Nieuwenhuijs-Moeke aff005; Frank J. M. F. Dor aff006; Henrik Birn aff001; Bente Jespersen aff001
Působiště autorů:
Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark
aff001; Departments of Clinical Medicine, Aarhus University, Aarhus, Denmark
aff002; Department of Renal Medicine, Herlev Hospital, Herlev, Denmark
aff003; The Transplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden
aff004; Department of Anaesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
aff005; Division of HPB & Transplant Surgery, Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
aff006; Imperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College, London, United Kingdom
aff007; Department of Biomedicine, Aarhus University, Aarhus, Denmark
aff008
Vyšlo v časopise:
PLoS ONE 14(12)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0226882
Souhrn
Background
Ischaemia-reperfusion injury in kidney transplantation leads to delayed graft function (DGF), which is associated with reduced long term graft function. Remote ischaemic conditioning (RIC) improved early kidney graft function in a porcine model of donation after brain death and was associated with improved long-term cardiac outcome after myocardial ischaemia. This randomised, double-blinded trial evaluated the effect of RIC on kidney graft outcome in the first year, and examined the predictive value of a new measure of initial kidney graft function, i.e. the estimated time to a 50% reduction in plasma creatinine post-transplantation (tCr50).
Methods
A total of 225 patients undergoing deceased donor kidney transplantation were randomised to RIC or a sham procedure performed prior to kidney reperfusion. Up to four repetitive cycles of five minutes of leg ischaemia and five minutes of reperfusion were given. GFR, plasma creatinine, cystatin C and neutrophil gelatinase associated lipocalin (NGAL) were measured at three and twelve months and estimated GFR was calculated using four different equations. Other secondary outcomes were identified from patient files.
Results
RIC did not affect GFR or other outcomes when compared to the sham procedure at three or twelve months. tCr50 correlated with one year graft function (p<0.0001 for both mGFR and eGFR estimates). In contrast, DGF i.e. “need of dialysis the first week” did not correlate significantly with one year GFR.
Conclusion
RIC during deceased donor kidney transplantation did not improve one year outcome. However, tCr50 may be a relevant marker for studies aiming to improve graft onset.
Trial registration
www.ClinicalTrials.gov Identifier: NCT01395719.
Klíčová slova:
Creatinine – Glomerular filtration rate – Ischemia – Kidneys – Medical dialysis – Renal transplantation – Reperfusion – Transplant rejection
Zdroje
1. Yarlagadda SG, Coca SG, Formica RN Jr, Poggio ED, Parikh CR. Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis. Nephrol Dial Transplant 2009 Mar;24(3):1039–1047. doi: 10.1093/ndt/gfn667 19103734
2. Summers DM, Johnson RJ, Allen J, Fuggle SV, Collett D, Watson CJ, et al. Analysis of factors that affect outcome after transplantation of kidneys donated after cardiac death in the UK: a cohort study. Lancet 2010 Oct 16;376(9749):1303–1311. doi: 10.1016/S0140-6736(10)60827-6 20727576
3. Perico N, Cattaneo D, Sayegh MH, Remuzzi G. Delayed graft function in kidney transplantation. Lancet 2004 Nov 13–19;364(9447):1814–1827. doi: 10.1016/S0140-6736(04)17406-0 15541456
4. Ojo AO, Wolfe RA, Held PJ, Port FK, Schmouder RL. Delayed graft function: risk factors and implications for renal allograft survival. Transplantation 1997 Apr 15;63(7):968–974. doi: 10.1097/00007890-199704150-00011 9112349
5. Miglinas M, Supranaviciene L, Mateikaite K, Skebas K, Kubiliene A. Delayed graft function: risk factors and the effects of early function and graft survival. Transplant Proc 2013 May;45(4):1363–1367. doi: 10.1016/j.transproceed.2013.03.014 23726573
6. Candilio L, Malik A, Hausenloy DJ. Protection of organs other than the heart by remote ischemic conditioning. J Cardiovasc Med (Hagerstown) 2013 Mar;14(3):193–205.
7. Heusch G, Botker HE, Przyklenk K, Redington A, Yellon D. Remote ischemic conditioning. J Am Coll Cardiol 2015 Jan 20;65(2):177–195. doi: 10.1016/j.jacc.2014.10.031 25593060
8. Soendergaard P, Krogstrup NV, Secher NG, Ravlo K, Keller AK, Toennesen E, et al. Improved GFR and renal plasma perfusion following remote ischaemic conditioning in a porcine kidney transplantation model. Transpl Int 2012 Sep;25(9):1002–1012. doi: 10.1111/j.1432-2277.2012.01522.x 22775333
9. Sloth AD, Schmidt MR, Munk K, Kharbanda RK, Redington AN, Schmidt M, et al. Improved long-term clinical outcomes in patients with ST-elevation myocardial infarction undergoing remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention. Eur Heart J 2014 Jan;35(3):168–175. doi: 10.1093/eurheartj/eht369 24031025
10. Krogstrup NV, Oltean M, Bibby BM, Nieuwenhuijs-Moeke GJ, Dor FJ, Birn H, et al. Remote ischaemic conditioning on recipients of deceased renal transplants, effect on immediate and extended kidney graft function: a multicentre, randomised controlled trial protocol (CONTEXT). BMJ Open 2015 Aug 20;5(8):e007941-2015-007941.
11. Yarlagadda SG, Coca SG, Garg AX, Doshi M, Poggio E, Marcus RJ, et al. Marked variation in the definition and diagnosis of delayed graft function: a systematic review. Nephrol Dial Transplant 2008 Sep;23(9):2995–3003. doi: 10.1093/ndt/gfn158 18408075
12. Krogstrup NV, Bibby BM, Aulbjerg C, Jespersen B, Birn H. A new method of modelling early plasma creatinine changes predicts 1-year graft function after kidney transplantation. Scand J Clin Lab Invest 2016 Jul;76(4):319–323. doi: 10.3109/00365513.2016.1161233 27171580
13. Krogstrup NV, Oltean M, Nieuwenhuijs-Moeke GJ, Dor FJ, Moldrup U, Krag SP, et al. Remote Ischemic Conditioning on Recipients of Deceased Renal Transplants Does Not Improve Early Graft Function: A Multicenter Randomized, Controlled Clinical Trial. Am J Transplant 2017 Apr;17(4):1042–1049. doi: 10.1111/ajt.14075 27696662
14. Ramirez-Sandoval JC, Herrington W, Morales-Buenrostro LE. Neutrophil gelatinase-associated lipocalin in kidney transplantation: A review. Transplant Rev (Orlando) 2015 Jul;29(3):139–144.
15. Nielsen MB, Krogstrup NV, Nieuwenhuijs-Moeke GJ, Oltean M, Dor FJMF, Jespersen B, et al. P-NGAL Day 1 predicts early but not one year graft function following deceased donor kidney transplantation—The CONTEXT study. PLoS One 2019 Feb 28;14(2):e0212676. doi: 10.1371/journal.pone.0212676 30817778
16. Medeiros FS, Sapienza MT, Prado ES, Agena F, Shimizu MH, Lemos FB, et al. Validation of plasma clearance of 51Cr-EDTA in adult renal transplant recipients: comparison with inulin renal clearance. Transpl Int 2009 Mar;22(3):323–331. doi: 10.1111/j.1432-2277.2008.00799.x 19055616
17. Levey AS, Greene T, Kusek JW, Beck GJ. A simplified equation to predict glomerular filtration rate from serum creatinine. Am Soc Nephrol 2000;11(155A).
18. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009 May 5;150(9):604–612. doi: 10.7326/0003-4819-150-9-200905050-00006 19414839
19. Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 2012 Jul 5;367(1):20–29. doi: 10.1056/NEJMoa1114248 22762315
20. Heinen A, Behmenburg F, Aytulun A, Dierkes M, Zerbin L, Kaisers W, et al. The release of cardioprotective humoral factors after remote ischemic preconditioning in humans is age- and sex-dependent. J Transl Med 2018 Apr 27;16(1):112-018-1480-0.
21. MacAllister R, Clayton T, Knight R, Robertson S, Nicholas J, Motwani M, et al. REmote preconditioning for Protection Against Ischaemia–Reperfusion in renal transplantation (REPAIR): a multicentre, multinational, double-blind, factorial designed randomised controlled trial. 2015 May(No. 2.3.).
22. Wu J, Feng X, Huang H, Shou Z, Zhang X, Wang R, et al. Remote ischemic conditioning enhanced the early recovery of renal function in recipients after kidney transplantation: a randomized controlled trial. J Surg Res 2014 May 1;188(1):303–308. doi: 10.1016/j.jss.2013.06.058 24556231
23. Nicholson ML, Pattenden CJ, Barlow AD, Hunter JP, Lee G, Hosgood SA. A Double Blind Randomized Clinical Trial of Remote Ischemic Conditioning in Live Donor Renal Transplantation. Medicine (Baltimore) 2015 Aug;94(31):e1316.
24. Chen Y, Zheng H, Wang X, Zhou Z, Luo A, Tian Y. Remote ischemic preconditioning fails to improve early renal function of patients undergoing living-donor renal transplantation: a randomized controlled trial. Transplantation 2013 Jan 27;95(2):e4–6. doi: 10.1097/TP.0b013e3182782f3a 23325011
25. van den Akker EK, Hesselink DA, Manintveld OC, Lafranca JA, de Bruin RW, Weimar W, et al. Ischemic postconditioning in human DCD kidney transplantation is feasible and appears safe. Transpl Int 2014 Feb;27(2):226–234. doi: 10.1111/tri.12242 24236960
26. Saat TC, van den Akker EK, IJzermans JN, Dor FJ, de Bruin RW. Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation? J Transl Med 2016 Jan 20;14:20-016-0767-2.
27. Bunte S, Behmenburg F, Eckelskemper F, Mohr F, Stroethoff M, Raupach A, et al. Cardioprotection by Humoral Factors Released After Remote Ischemic Preconditioning Depends on Anesthetic Regimen. Crit Care Med 2019 Jan 2.
28. Dagenais F, Cartier R, Hollmann C, Buluran J. Calcium-channel blockers preserve coronary endothelial reactivity after ischemia-reperfusion. Ann Thorac Surg 1997 Apr;63(4):1050–1056. doi: 10.1016/s0003-4975(96)01278-7 9124904
29. Lemoine S, Pillot B, Rognant N, Augeul L, Rayberin M, Varennes A, et al. Postconditioning with cyclosporine a reduces early renal dysfunction by inhibiting mitochondrial permeability transition. Transplantation 2015 Apr;99(4):717–723. doi: 10.1097/TP.0000000000000530 25793558
30. Tuuminen R, Holmstrom E, Raissadati A, Saharinen P, Rouvinen E, Krebs R, et al. Simvastatin pretreatment reduces caspase-9 and RIPK1 protein activity in rat cardiac allograft ischemia-reperfusion. Transpl Immunol 2016 Jul;37:40–45. doi: 10.1016/j.trim.2016.05.001 27155462
31. Morariu AM, Schuurs TA, Leuvenink HG, van Oeveren W, Rakhorst G, Ploeg RJ. Early events in kidney donation: progression of endothelial activation, oxidative stress and tubular injury after brain death. Am J Transplant 2008 May;8(5):933–941. doi: 10.1111/j.1600-6143.2008.02166.x 18318776
32. Kierulf-Lassen C, Nieuwenhuijs-Moeke GJ, Krogstrup NV, Oltean M, Jespersen B, Dor FJ. Molecular Mechanisms of Renal Ischemic Conditioning Strategies. Eur Surg Res 2015 Sep 2;55(3):151–183. doi: 10.1159/000437352 26330099
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