Effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) on dental hypersensitivity: A randomized controlled clinical trial
Autoři:
Mariangela Ivette Guanipa Ortiz aff001; Cristiane de Melo Alencar aff001; Brennda Lucy Freitas De Paula aff001; Eliane Bemerguy Alves aff001; Jesuína Lamartine Nogueira Araújo aff001; Cecy Martins Silva aff001
Působiště autorů:
School of Dentistry, Federal University of Pará, Belém, Pará, Brazil
aff001
Vyšlo v časopise:
PLoS ONE 14(12)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0225501
Souhrn
Objective
This randomized controlled clinical trial aimed to evaluate the effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) in the treatment of dentin hypersensitivity (DH), and the impact of this on the health-related quality of life (HRQL).
Methods
Eighty teeth with DH were randomized into four groups and received three treatment sessions: PLACEBO = placebo + LASER application mimicking; CPP-ACPF = CPP-ACPF + LASER application mimicking; PBM = placebo + LASER active application; CPP-ACPF+PBM = CPP-ACPF + LASER active application. Tactile (exploratory probe) and evaporative (triple syringe) stimuli were used to measure DH and were recorded with the aid of a visual analogue scale (VAS) after the 1st, 2nd and 3rd treatment sessions and one-month follow-up. The HRQL was recorded in the DH experience questionnaire (DHEQ).
Results
The intragroup comparison showed a significant reduction in DH (p < 0.05) with both stimuli after one-month follow-up. The intergroup comparison with the evaporative stimulus showed that CPP-ACPF+PBM significantly reduced DH when compared to the rest of treatments, after one-month follow-up. CPP-ACPF+PBM group statistically differed from the other treatment groups in the DHEQ evaluation after one-month follow-up.
Conclusion
After one-month follow-up, the association of CPP-ACPF with PBM was effective in the reduction of DH and promoted a positive impact on the HRQL of the participants of this study.
Klíčová slova:
Casein – Dentin – Fluorides – Lasers – Pain sensation – Randomized controlled trials – Teeth – Hypersensitivity
Zdroje
1. West NX, Lussi A, Seong J, Hellwig E. Dentin hypersensitivity: pain mechanisms and etiology of exposed cervical dentin. Clin Oral Investig. 2013;17(1):S9–19.
2. Machuca C, Vettore M V, Krasuska M, Baker SR, Robinson PG. Using classification and regression tree modelling to investigate response shift patterns in dentine hypersensitivity. BMC Med Res Methodol. 2017;17(1):120. doi: 10.1186/s12874-017-0396-3 28806921
3. Canadian Advisory Board on Dentin Hypersensitivity. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. J Can Dent Assoc. 2003;69(4):221–226. 12662460
4. Bergamini MR, Bernardi MM, Sufredini IB, Ciaramicoli MT, Kodama RM, Kabadayan F, et al. Dentin hypersensitivity induces anxiety and increases corticosterone serum levels in rats. Life Sci. 2014;98(2):96–102. doi: 10.1016/j.lfs.2014.01.004 24456713
5. Schmidlin PR, Sahrmann P. Current management of dentin hypersensitivity. Clin Oral Investig. 2013;17(1):S55–59. doi: 10.1007/s00784-012-0912-0 22350036
6. Mantzourani M, Sharma D. Dentine sensitivity: past, present, and future. J Dent. 2013;41(4):S3–17. doi: 10.1016/S0300-5712(13)70002-2
7. Mahajan G, Kaur H, Gautam A. Prevalence of buccal cervical dentine hypersensitivity and related risk factors a cross-sectional study. Int Dent Med J Adv Res. 2017;3:1–5. doi: 10.15713/ins.idmjar.64
8. Coleman TA, Grippo JO, Kinderknecht KE. Cervical dentin hypersensitivity. Part II: Associations with abfractive lesions. Quintessence Int. 2000;31(7):466–473. 11203968
9. Sgolastra F, Petrucci A, Severino M, Gatto R, Monaco A. Lasers for the treatment of dentin hypersensitivity: a meta-analysis. J Dent Res. 2013;92(6):492–499. doi: 10.1177/0022034513487212 23609160
10. West NX, Seong J, Davies M. Management of dentine hypersensitivity: efficacy of professionally and self-administered agents. J Clin Periodontol. 2015;42(1):S256–302. doi: 10.1111/jcpe.12336 25495777
11. Soares R, De Ataide IDN, Fernandes M, Lambor R. Assessment of enamel remineralisation after treatment with four different remineralising agents: A Scanning Electron Microscopy (SEM) Study. J Clin diagnostic Res. 2017;11(4):ZC136–ZC141. doi: 10.7860/JCDR/2017/23594.9758 28571281
12. Huq NL, Myroforidis H, Cross KJ, Stanton DP, Veith PD, Ward BR, et al. The interactions of CPP-ACP with saliva. Int J Mol Sci. 2016;17(6):E915. doi: 10.3390/ijms17060915 27294918
13. Pandeshwar P, Mahesh DR, Reshma D, Shastry SP, Kaul R, Srinivasreddy MB. Photobiomodulation in oral medicine: a review. J Investig Clin Dent. 2016;7(2):114–126. doi: 10.1111/jicd.12148 25720555
14. Umberto R, Claudia R, Gaspare P, Gianluca T, Alessandro del V. Treatment of dentine hypersensitivity by diode laser: a clinical study. Int J Dent. 2012;2012:858–950. doi: 10.1155/2012/858950 22792109
15. Gojkov-Vukelic M, Hadzic S, Zukanovic A, Pasic E, Pavlic V. Application of diode laser in the treatment of dentine hypersensitivity. Med Arch. 2016;70(6):466–469. doi: 10.5455/medarh.2016.70.466-469 28210023
16. Wang L, Magalhães AC, Francisconi-Dos-Rios LF, Calabria MP, Araújo D, Buzalaf M, et al. Treatment of dentin hypersensitivity using nano-hydroxyapatite pastes: a randomized three-month clinical trial. Oper Dent. 2016;41(4):E93–E101. doi: 10.2341/15-145-C 26919080
17. Splieth CH, Tachou A. Epidemiology of dentin hypersensitivity. Clin Oral Investig. 2013;17(l)1:S3–8. doi: 10.1007/s00784-012-0889-8 23224064
18. Douglas-De-Oliveira DW, Vitor GP, Silveira JO, Martins CC, Costa FO, Cota LOM. Effect of dentin hypersensitivity treatment on oral health related quality of life—A systematic review and meta-analysis. J Dent. 2017;71:1–8. doi: 10.1016/j.jdent.2017.12.007 29262305
19. Turner L, Shamseer L, Altman DG, Weeks L, Peters J, Kober T, et al. Consolidated standards of reporting trials (CONSORT) and the completeness of reporting of randomized controlled trials (RCTs) published in medical journals. Cochrane Database Syst Rev. 2012;14(11):MR000030. doi: 10.1002/14651858.MR000030.pub2 23152285
20. Calvert M, Brundage M, Jacobsen PB, Schünemann HJ, Efficace F. The CONSORT patient-reported outcome (PRO) extension: implications for clinical trials and practice. Health Qual Life Outcomes. 2013;11:184. doi: 10.1186/1477-7525-11-184 24168680
21. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191–2194. doi: 10.1001/jama.2013.281053 24141714
22. Smith BG, Knight JK. An index for measuring the wear of teeth. Br Dent J. 1984;156(12):435–438. doi: 10.1038/sj.bdj.4805394 6590081
23. Miller PD. A classification of marginal tissue recession. Int J Periodontics Restorative Dent. 1985;5(2):8–13. 3858267
24. Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. J Clin Periodontol. 1997;24(11):808–813. doi: 10.1111/j.1600-051x.1997.tb01194.x 9402502
25. Boiko OV, Baker SR, Gibson BJ, Locker D, Sufi F, Barlow AP, et al. Construction and validation of the quality of life measure for dentine hypersensitivity (DHEQ). J Clin Periodontol. 2010;37(11):973–980. doi: 10.1111/j.1600-051X.2010.01618.x 20860720
26. Douglas-De-Oliveira DW, Lages FS, Paiva SM, Cromley JG, Robinson PG, Cota LOM. Cross-cultural adaptation of the Brazilian version of the Dentine Hypersensitivity Experience Questionnaire (DHEQ-15). Braz Oral Res. 2018;32:e37. doi: 10.1590/1807-3107bor-2018.vol32.0037 29723336
27. Lopes AO, de Paula Eduardo C, Aranha ACC. Evaluation of different treatment protocols for dentin hypersensitivity: an 18-month randomized clinical trial. Lasers Med Sci. 2017;32(5):1023–1030. doi: 10.1007/s10103-017-2203-0 28391435
28. Cunha-Cruz J, Wataha JC, Heaton LJ, Rothen M, Sobieraj M, Scott J, Berg J, Northwest Practice-based Research Collaborative in Evidence based Dentistry. The prevalence of dentin hypersensitivity in general dental practices in the northwest United States. J Am Dent Assoc. 2013;144(3):288–296. doi: 10.14219/jada.archive.2013.0116 23449905
29. Yoshizaki KT, Francisconi-Dos-Rios LF, Sobral MP, Aranha AC, Mendes FM, Scaramucci T. Clinical features and factors associated with non-carious cervical lesions and dentin hypersensitivity. J Oral Rehabil. 2017;44(2):112–118. doi: 10.1111/joor.12469 27973740
30. Alcântara PM, Barroso NFF, Botelho AM, Douglas-de-Oliveira DW, Gonçalves PF, Flecha OD. Associated factors to cervical dentin hypersensitivity in adults: a transversal study. BMC Oral Health. 2018;18(1):155. doi: 10.1186/s12903-018-0616-1 30176855
31. West N, Seong J, Davies M. Dentine hypersensitivity. Monogr Oral Sci. 2014;25:108–22. doi: 10.1159/000360749 24993261
32. Kennedy-Martin T, Curtis S, Faries D, Robinson S, Johnston J. A literature review on the representativeness of randomized controlled trial samples and implications for the external validity of trial results. Trials. 2015;16:495. doi: 10.1186/s13063-015-1023-4 26530985
33. Mehta D, Gowda V, Finger WJ, Sasaki K. Randomized, placebo-controlled study of the efficacy of a calcium phosphate containing paste on dentin hypersensitivity. Dent Mater Off Publ Acad Dent Mater. 2015;31(11):1298–1303. doi: 10.1016/j.dental.2015.08.162 26361810
34. Moosavi H, Maleknejad F, Sharifi M, Ahrari F. A randomized clinical trial of the effect of low-level laser therapy before composite placement on postoperative sensitivity in class V restorations. Lasers Med Sci. 2015;30(4):1245–1249. doi: 10.1007/s10103-014-1565-9 24811085
35. Hall C, Mason S, Cooke J. Exploratory randomised controlled clinical study to evaluate the comparative efficacy of two occluding toothpastes—a 5% calcium sodium phosphosilicate toothpaste and an 8% arginine/calcium carbonate toothpaste—for the longer-term relief of dentine hypersensitivity. J Dent. 2017;60:36–43. doi: 10.1016/j.jdent.2017.02.009 28219674
36. Addy M, West NX, Barlow A, Smith S. Dentine hypersensitivity: is there both stimulus and placebo responses in clinical trials?. Int J Dent Hyg. 2007;5(1):53–59. doi: 10.1111/j.1601-5037.2007.00228.x 17250579
37. Wierichs RJ, Stausberg S, Lausch J, Meyer-Lueckel H, Esteves-Oliveira M. Caries-preventive effect of NaF, NaF plus TCP, NaF plus CPP-ACP, and SDF varnishes on sound dentin and artificial dentin caries in vitro. Caries Res. 2018;52(3):199–211. doi: 10.1159/000484483 29339648
38. Reynolds EC, Cai F, Cochrane NJ, Shen P, Walker GD, Morgan MV, et al. Fluoride and casein phosphopeptide-amorphous calcium phosphate. J Dent Res. 2008;87(4):344–348. doi: 10.1177/154405910808700420 18362316
39. Berkathullah M, Farook MS, Mahmoud O. The effectiveness of remineralizing agents on dentinal permeability. Biomed Res Int. 2018;2018:4072815. doi: 10.1155/2018/4072815 30276206
40. Praveen R, Thakur S, Kirthiga M, Narmatha M. Comparative evaluation of a low-level laser and topical desensitizing agent for treating dentinal hypersensitivity: A randomized controlled trial. J Conserv Dent. 2018;21(5):495–499. doi: 10.4103/JCD.JCD_197_18 30294109
41. Arany PR, Cho A, Hunt TD, Sidhu G, Shin K, Hahm E, et al. Photoactivation of endogenous latent transforming growth factor–β1 directs dental stem cell differentiation for regeneration. Sci Transl Med. 2014;6(238):238ra69. doi: 10.1126/scitranslmed.3008234 24871130
42. Cochrane NJ, Reynolds EC. Calcium phosphopeptides—mechanisms of action and evidence for clinical efficacy. Adv Dent Res. 2012;24(2):41–47. doi: 10.1177/0022034512454294 22899678
43. Chokshi K, Chokshi A, Konde S, Shetty SR, Chandra KN, Jana S, et al. An in vitro Comparative Evaluation of Three Remineralizing Agents using Confocal Microscopy. J Clin Diagn Res. 2016;10(6):ZC39–ZC42. doi: 10.7860/JCDR/2016/18191.7984 27504408
44. Rahiotis C, Vougiouklakis G. Effect of a CPP-ACP agent on the demineralization and remineralization of dentine in vitro. J Dent. 2007;35(8):695–698. doi: 10.1016/j.jdent.2007.05.008 17614188
45. Fernando JR, Shen P, Sim CPC, Chen YY, Walker GD, Yuan Y, et al. Self-assembly of dental surface nanofilaments and remineralisation by SnF2 and CPP-ACP nanocomplexes. Sci Rep. 2019;9(1):1285. doi: 10.1038/s41598-018-37580-w 30718577
46. Kijsamanmith K, Banomyong D, Burrow MF, Kanchanasantikul P, Wipawiwat S, Srikam S, et al. Effect of Conventional and Acid-modified Casein Phosphopeptide-Amorphous Calcium Phosphate Crèmes on Dentin Permeability Before and After Acid Challenge. Oper Dent. 2019;5 [Epub ahead of print]. doi: 10.2341/17-382-L 30951440
47. Bou Chebel F, Zogheib CM, Baba NZ, Corbani KA. Clinical comparative evaluation of Nd: YAG laser and a new varnish containing casein phosphopeptides-amorphous calcium phosphate for the treatment of dentin hypersensitivity: A prospective study. J Prosthodont Off J Am Coll Prosthodont. 2018;27(9):860–867. doi: 10.1111/jopr.12984 30281183
48. Faraoni JJ, Torres Toro CV, de Matos LLM, Palma-Dibb RG. Efficacy of different strategies to treat root dentin eroded by liquid or gaseous hydrochloric acid associated with brushing abrasion. Arch Oral Biol. 2018;89:65–69. doi: 10.1016/j.archoralbio.2018.02.005 29475189
49. Gillam DG. A New Perspective on Dentine Hypersensitivity–Guidelines for General Dental Practice. Dent Update. 2017;44(1):33–6, 39–42. doi: 10.12968/denu.2017.44.1.33 29172308
50. Veitz-Keenan A, Barna JA, Strober B, Matthews AG, Collie D, Vena D, et al. Treatments for hypersensitive noncarious cervical lesions: A Practitioners Engaged in Applied Research and Learning (PEARL) Network randomized clinical effectiveness study. J Am Dent Assoc. 2013;144(5):495–506. doi: 10.14219/jada.archive.2013.0152 23633698
51. Grippo JO, Simring M, Coleman TA. Abfraction, abrasion, biocorrosion, and the enigma of noncarious cervical lesions: a 20-year perspective. J Esthet Restor Dent. 2012;24(1):10–23. doi: 10.1111/j.1708-8240.2011.00487.x 22296690
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