Towards elimination of measles and rubella in Italy: Progress and challenges
Autoři:
Giovanna Adamo aff001; Valentina Baccolini aff001; Azzurra Massimi aff001; Domenico Barbato aff001; Rosario Cocchiara aff001; Carolina Di Paolo aff001; Annamaria Mele aff001; Sara Cianfanelli aff001; Aurora Angelozzi aff001; Fulvio Castellani aff001; Carla Salerno aff001; Claudia Isonne aff001; Antonino Bella aff003; Antonietta Filia aff003; Martina del Manso aff003; Melissa Baggieri aff004; Loredana Nicoletti aff004; Fabio Magurano aff004; Stefania Iannazzo aff005; Carolina Marzuillo aff001; Paolo Villari aff001
Působiště autorů:
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
aff001; National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
aff002; Department of Infectious Diseases, National Institute of Health, Rome, Italy
aff003; National Reference Laboratory for Measles and Rubella, National Institute of Health, Rome, Italy
aff004; Infectious Diseases and International Prophylaxis Office, Ministry of Health, Rome, Italy
aff005
Vyšlo v časopise:
PLoS ONE 14(12)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0226513
Souhrn
Introduction
In the WHO European Region, endemic transmission of measles and rubella had been interrupted by 37 and 42 of the 53 member states (MSs), respectively, by 2018. Sixteen MSs are still endemic for measles, 11 for rubella and nine for both diseases, the latter including Italy. Elimination is documented by each country’s National Verification Committee (NVC) through an annual status update (ASU).
Objective
By analysing data used to produce the ASUs, we aimed to describe the advances made by Italy towards elimination of measles and rubella. Moreover, we propose a set of major interventions that could facilitate the elimination process.
Methods
A total of 28 indicators were identified within the six core sections of the ASU form and these were evaluated for the period 2013–2018. These indicators relate to the incidence of measles/rubella; epidemiological investigation of cases; investigation of outbreaks; performance of the surveillance system; population immunity levels; and implementation of supplemental immunization activities (SIAs).
Results
From 2013 to 2018, epidemiological and laboratory analyses of measles cases in Italy improved substantially, allowing timely investigation in 2017 and 2018 of most outbreak and sporadic cases and identification of the majority of genotypic variants. Moreover, since 2017, vaccination coverage has increased significantly. Despite these improvements, several areas of concern emerged, prompting the following recommendations: i) improve outbreak monitoring; ii) strengthen the MoRoNet network; iii) increase the number of SIAs; iv) reinforce vaccination services; v) maintain regional monitoring; vi) design effective communication strategies; vii) foster the role of general practitioners and family paediatricians.
Conclusions
The review of national ASUs is a crucial step to provide the NVC with useful insights into the elimination process and to guide the development of targeted interventions. Against this background, the seven recommendations proposed by the NVC have been shared with the Italian Ministry of Health and the Technical Advisory Group on measles and rubella elimination and have been incorporated into the new Italian Elimination Plan 2019–2023 as a technical aid to facilitate the achievement of disease elimination goals.
Klíčová slova:
Government laboratories – Italian people – Italy – Measles – Measles virus – Rubella – Vaccination and immunization – Vaccines
Zdroje
1. WHO Regional Office for Europe. 8th meeting of the European Regional Verification Commission for Measles and Rubella Elimination (RVC). Copenhagen: WHO Regional Office for Europe; 2019. Available from: http://www.euro.who.int/en/health-topics/communicable-diseases/measles-and-rubella/publications/2018/7th-meeting-of-the-european-regional-verification-commission-for-measles-and-rubella-elimination-rvc.-report
2. WHO Regional Office for Europe. Eliminating measles and rubella—Framework for the verification process in the WHO European Region. Copenhagen: WHO Regional Office for Europe; 2014. Available from: http://www.euro.who.int/__data/assets/pdf_file/0009/247356/Eliminating-measles-and-rubella-Framework-for-the-verification-process-in-the-WHO-European-Region.pdf
3. WHO Regional Office for Europe. A report on the epidemiology of selected vaccine-preventable diseases in the European Region. WHO EpiBrief 2018; 1:1–16. http://www.euro.who.int/__data/assets/pdf_file/0009/370656/epibrief-1-2018-eng.pdf
4. Adamo G, Sturabotti G, De Soccio P, Prencipe GP, Sciarra I, Baccolini V, et al. [The elimination of measles and rubella in Italy]. Ig Sanità Pubbl. 2017;73(5):429–442. 29433130
5. Adamo G, Sturabotti G, D'Andrea E, Baccolini V, Romano F, Innazzo S, et al. The end of measles and congenital rubella: an achievable dream? Ann Ig. 2017; 29(1):1–26. doi: 10.7416/ai.2017.2128 28067934
6. Adamo G, Sturabotti G, Baccolini V, de Soccio P, Prencipe GP, Bella A, et al. Regional reports for the subnational monitoring of measles elimination in Italy and the identification of local barriers to the attainment of the elimination goal. PLoS One. 2018 Oct 24;13(10):e0205147. doi: 10.1371/journal.pone.0205147 30356247
7. WHO Regional Office for Europe. Guidelines for measles and rubella outbreak investigation and response in the WHO European Region. Copenhagen: WHO Regional Office for Europe; 2013. Available from: http://www.euro.who.int/__data/assets/pdf_file/0003/217164/OutbreakGuidelines-updated.pdf?ua=1
8. Mo.Ro.Net–liberi dal morbillo e dalla rosolia [Mo.Ro.Net.–free from measles and rubella]. Italian. Available from: http://moronetlab.it/
9. Magurano F, Baggieri M, Mazzili F, Bucci P, Marchi A, Nicoletti L, et al. Measles in Italy: Viral strains and crossing borders. Int. J Infect Dis. 2019; 79:199–201.
10. Italian Ministry of Health (MoH). Il Decreto vaccini è legge, tutte le novità. [The vaccination decree is now law, all the novelties introduced]. Rome: MoH; 2017. Italian. Available from: http://www.salute.gov.it/portale/news/p3_2_1_1_1.jsp?lingua=italiano&menu=notizie&p=dalministero&id=3027
11. Bozzola E, Spina G, Russo R, Bozzola M, Corsello G, Villani A. Mandatory vaccinations in European countries, undocumented information, false news and the impact on vaccination uptake: the position of the Italian pediatric society. Ital J Pediatr. 2018 Jun 14;44(1):67. doi: 10.1186/s13052-018-0504-y 29898770
12. Italian Ministry of Health (MoH). [Piano Nazionale Prevenzione Vaccinale. PNPV 2017–2019]. Rome: MoH; 2018. Available from: http://www.salute.gov.it/imgs/C_17_pubblicazioni_2571_allegato.pdf
13. Legge 11 dicembre 2016, n. 232. Bilancio di previsione dello Stato per l'anno finanziario 2017 e bilancio pluriennale per il triennio 2017–2019. (16G00242). G.U. Serie Generale, n. 297 del 21 dicembre 2016.
14. Grant GB, Reef SE, Patel M, Knapp JK, Dabbagh A. Progress in Rubella and Congenital Rubella Syndrome Control and Elimination—Worldwide, 2000–2016. MMWR Morb Mortal Wkly Rep. 2017 Nov 17;66(45):1256–1260. doi: 10.15585/mmwr.mm6645a4 29145358
15. Italian Ministry of Health (MoH). [Circolare “Aggiornamento del sistema di sorveglianza integrata del morbillo e della rosolia, per il rafforzamento degli obiettivi di eliminazione”, prot. 33189 del 12 novembre 2018]. Rome: MoH; 2018. Available from: http://www.trovanorme.salute.gov.it/norme/renderNormsanPdf?anno=2018&codLeg=66521&parte=1%20&serie=null
16. Filia A, Bella A, Rota MC, Tavilla A, Magurano F, Baggieri M, et al. Analysis of national measles surveillance data in Italy from October 2010 to December 2011 and priorities for reaching the 2015 measles elimination goal. Euro Surveill. 2013;18:1–7.
17. Filia A, Bella A, Del Manso M, Baggieri M, Magurano F, Rota MC. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 − what is making elimination so difficult? Euro Surveill. 2017;22:1–5.
18. Filia A, Bella A, Cadeddu G, Milia MR, Del Manso M, Rota MC, et al. Extensive Nosocomial Transmission of Measles Originating in Cruise Ship Passenger, Sardinia, Italy, 2014. Emerg Infect Dis. 2015;21(8):1444–6. doi: 10.3201/eid2108.141105 26196266
19. Gualano MR, Bert F, Voglino G, Buttinelli E, D'Errico MM, De Waure C, et al. Attitudes towards compulsory vaccination in Italy: Results from the NAVIDAD multicentre study. Vaccine. 2018;23:3368–3374.
20. Massimi A, Rosso A, Marzuillo C, Prencipe GP, de Soccio P, Adamo G, et al. Childhood vaccinations: A pilot study on knowledge, attitudes and vaccine hesitancy in pregnant women. Epidemiology Biostatistics and Public Health. 2017;4:e12625.1–e12625.5.
21. Rosso A, Massimi A, De Vito C, Adamo G, Baccolini V, Marzuillo C, et al. Knowledge and attitudes on pediatric vaccinations and intention to vaccinate in a sample of pregnant women from the City of Rome. Vaccine. 2019 Mar 28;37(14):1954–1963. doi: 10.1016/j.vaccine.2019.02.049 30827733
22. Rosso A, De Vito C, Marzuillo C, Massimi A, DAndrea E, Villari P. The negative effect of financial constraints on planning prevention activities: Some evidence from the Italian experience. Eur J Public Health. 2015;25:1117–9. doi: 10.1093/eurpub/ckv087 25958239
23. Rosso A, Marzuillo C, Massimi A, De Vito C, de Belvis AG, La Torre G, et al. Policy and planning of prevention in Italy: Results from an appraisal of prevention plans developed by Regions for the period 2010–2012. Health Policy. 2015 Jun;119(6):760–9. doi: 10.1016/j.healthpol.2015.03.012 25887486
24. Unim B, De Vito C, Massimi A, D’Andrea E, Rosso A, Villari P, et al. The need to improve implementation and use of lifestyle surveillance systems for planning prevention activities: An analysis of the Italian Regions. Public Health. 2016;130:51–8. doi: 10.1016/j.puhe.2015.08.009 26427315
25. De Vito C, Di Marco M, Marzuillo C, Matarazzo A, Massimi A, Villari P. Does economic crisis affect prevention services? An Italian region as a case study. Epidemiol Biostat Public Heal. 2014;11:1–7.
26. De Vito C, Massimi A, Di Thiene D, Rosso A, D’Andrea E, Vacchio MR, et al. Low level of attention to health inequalities in prevention planning activities of the Italian Regions. Int J Equity Health. 2016;15:1–9. doi: 10.1186/s12939-015-0290-8
27. Adamo G, Baccolini V, Marzuillo C, Sturabotti G, Villari P. Slow progress in measles and rubella elimination in Italy. Epidemiol Biostat Public Health. 2016;13:2015–6.
28. Ammon A, Prats Monné X. Vaccines, trust and European public health. Euro Surveill. 2018;23(17):18–00210.
29. Pianigiani G. Vaccine Law Returns to Force in Italy, Barring 300 Children From Kindergarten. New York Times [newspaper on the Internet]. 2019 Mar 12. Available from: https://www.nytimes.com/2019/03/12/world/europe/italy-vaccine.html
30. Napolitano F, D'Alessandro A, Angelillo IF. Investigating Italian parents'vaccine hesitancy: A cross-sectional survey. Hum Vaccin Immunother. 2018 Jul 3;14(7):1558–1565. doi: 10.1080/21645515.2018.1463943 29641945
31. Bianco A, Mascaro V, Zucco R, Pavia M. Parent perspectives on childhood vaccination: How to deal with vaccine hesitancy and refusal? Vaccine. 2019 Feb 8;37(7):984–990. doi: 10.1016/j.vaccine.2018.12.062 30655175
32. Tafuri S, Gallone MS, Cappelli MG, Martinelli D, Prato R, Germinario C. Addressing the anti-vaccination movement and the role of HCWs. Vaccine. 2014;32(38):4860–5. doi: 10.1016/j.vaccine.2013.11.006 24262311
33. Siliquini R, Saulle R, Rabacchi G, Bert F, Massimi A, Bulzomì V, et al. Validation of a web-based questionnaire for pregnant women to assess utilization of internet: survey among an Italian sample. Ann Ig. 2012 Sep-Oct;24(5):397–405. 23193896
34. Aquino F, Donzelli G, De Franco E, Privitera G, Lopalco PL, Carducci A. The web and public confidence in MMR vaccination in Italy. Vaccine. 2017 Aug 16;35(35 Pt B):4494–4498.
35. Stahl JP, Cohen R, Denis F, Gaudelus J, Martinot A, Lery T, et al. The impact of the web and social networks on vaccination. New challenges and opportunities offered to fight against vaccine hesitancy. Med Mal Infect. 2016;46(3):117–22. doi: 10.1016/j.medmal.2016.02.002 26987960
36. Kata A. Anti-vaccine activists, Web 2.0, and the postmodern paradigm–An overview of tactics and tropes used online by the anti-vaccination movement. Vaccine. 2012; 30(25): p. 3778–89. doi: 10.1016/j.vaccine.2011.11.112 22172504
37. Giambi C, Fabiani M, D'Ancona F, Ferrara L, Fiacchini D, Gallo T, et al. Parental vaccine hesitancy in Italy—Results from a national survey. Vaccine. 2018 Feb 1;36(6):779–787. doi: 10.1016/j.vaccine.2017.12.074 29325822
38. Yaqub O, Castle-Clarke S, Sevdalis N, Chataway J. Attitudes to vaccination: a critical review. Soc Sci Med. 2014;112:1–11. doi: 10.1016/j.socscimed.2014.04.018 24788111
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