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Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial
Authors: Lilian Vliek aff001; Geertjan Overbeek aff002; Bram Orobio de Castro aff003
Authors place of work: Knowledge Centre of Topper Training Foundation, Almere, The Netherlands aff001; Research Priority Area Yield, Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands aff002; Department of Developmental Psychology, Utrecht University, Utrecht, The Netherlands aff003
Published in the journal: PLoS ONE 14(11)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0225504Summary
Most interventions aimed at improving social interactions either target internalising or externalising problem behaviour in children. However, a recent review shows that a transdiagnostic approach might fit better to the diversity of problems within a group and within an individual (comorbidity). We examined the effectiveness of a transdiagnostic intervention, called Topper Training: a cognitive behavioural intervention in the peer group with parents included, that targets both internalising and externalising behaviour problems. A randomised trial with a waiting list control group was conducted, using 132 children with mild to severe psychosocial problems. Children were randomised into 77 intervention and 55 waiting list children (50% boys; age = 8–11 years). GLM repeated measures analyses yielded significant intervention effects directly after the training on parent-reported (but not teacher-reported) emotional symptoms (Cohen’s d = .70), peer relationship problems (d = .41), and impact of these problems (d = .59). Significant effects were also found for child-perceived peer victimisation (d = .62), self-esteem (d = .45) and teacher-reported conduct problems (d = .42). Parent-reported effects on emotional, conduct problems and impact of the problems and child-reported effects on self-esteem were clinically relevant. No significant effects of Topper Training were found for prosocial behaviour and bullying. Within-participant t-tests in the intervention group between post-intervention and follow-up indicated that effects extended over a six-month follow-up period. Depression decreased significantly from post-test to follow-up. In conclusion, children with mild to severe internalising and/or externalising problems can benefit from the transdiagnostic Topper Training intervention.
Keywords:
teachers – Psychological and psychosocial issues – Behavior – Schools – children – emotions – Prosocial behavior – Parenting behavior
Introduction
Children spend a lot of time interacting with other children and this is not an easy job for all of them. Children can show aggressive reactions but also depressive and withdrawn reactions to daily life challenges such as trying to belong to a group, bullying, denial or other social situations [1]. To a certain level, these challenges belong to normal development. From a biopsychosocial perspective [2], the interaction of biological, psychological and social aspects can create vulnerability for children in certain environments to develop problems. When these interaction processes continue, the first symptoms or psychosocial problems can develop. With psychosocial problems we mean emotional (or internalising), conduct (or externalising) and social peer problems, following the definition of Theunissen [3]. The prevalence of psychosocial problems in Dutch 8 - to 12 - year old children is 10% [4]. More specific: 8% of Dutch primary school children shows conduct problems and 12% shows emotional problems (parent report) [5]. Early conduct and emotional problems are found to be important predictors of depression, delinquency, school dropout and psychological disorders later on in life [6]. Reducing these problems at an early age with indicative preventive interventions directed at psychosocial problems may prevent escalation into severe problems that are harder to treat [7] and save society from the associated costs and risks [8].
Many of the interventions directed at social interactions target one kind of problem behaviour: either internalising or externalising problems. In a recent review, Marchette and Weisz [9] argue that there is a mismatch between this focal treatment on single problems and treatment of children in real-world clinical care. Children very frequently have comorbid problems and are thus diagnostically heterogeneous. This notion is in line with findings of Caspi et al. [10]. Their study indicated that psychiatric disorders could best be explained using one general psychopathology factor: the p factor. They argued that this p factor makes it difficult to find strongly effective treatments for individual mental disorders. Thus, working with transdiagnostic approaches may be a better idea. With a transdiagnostic approach we mean an intervention in which a guiding therapeutic strategy is universally applied across the range of presenting conditions (see also [11]). This approach has some advantages above single-diagnosis protocols. First, the single-diagnosis protocols do not provide guidance on how to address co-occurring diagnoses (e.g. [12]. Some studies have indeed shown that these protocols demonstrate poorer outcomes for the primary disorder for the individuals presenting with more than one diagnosis (e.g. [13]). Another advantage is that therapists need only to receive training in one protocol rather than costly and time-intensive training for multiple interventions [14].
In delineating a potentially effective transdiagnostic approach, it is important to delineate key intervention strategies and focus points of the intervention. Earlier studies have identified specific effective intervention strategies that seem to work in decreasing internalising and externalising problems in youth. Cognitive behavioural interventions [15, 16], parent-child training [17] and peer group interventions [18] are generally found to be effective ways of stimulating social interactions. Social competence calls upon a complex set of skills and competencies. Therefore, in the Handbook of Youth Prevention Science [19], we recommended to focus on several factors to include in preventive interventions for psychosocial problems. In sum, these are relational factors (such as involving peers, diminish reinforcement of negative behaviour, give dominant children insight into their actual popularity, train parents and teachers) and child factors (such as practice social skills, train social information processing, emotion regulation, and realistic self-esteem. In addition to focussing on these risk and protective factors, we recommended to focus on the authentic desire of children (their positive intentions) and on their feeling of responsibility for their behaviour (at a developmentally appropriate level). These last focus points are similar to the concept of autonomy in the Self-Determination Theory [20, 21]. The theory is based on the assumption that people have natural tendencies. They want to grow, to master challenges and to integrate new experiences into a coherent sense of self. This does not occur automatically. When people feel satisfied in their basic psychological needs: autonomy, competence and relatedness, they will develop and function effectively and experience wellness. Whether or not these needs are satisfied is depending on the child’s interaction with the environment. Following this theory, internalising and externalising behaviour can be understood in terms of reactions to basic needs being thwarted [20]. This implies that in trying to decrease internalising or externalising behaviour and to increase socially competent behaviour, an intervention should stimulate not only the above-mentioned developmental child and relational factors, but also children’s feelings of autonomy, competence and relatedness.
Topper training
This study examines the effectiveness of Topper Training (“Kanjertraining” in Dutch; [22]) in a mental health care setting. Topper Training is a well-known intervention in the Netherlands [23]. This training is directed at children with internalising as well as externalising behaviour and takes into account the importance of motivation, autonomy, competence and relatedness. It includes cognitive behavioural techniques and is directed at the child and its environment: classmates, school and parents. More specifically, the training is given in three settings: 1) as a universal intervention in primary and secondary schools by teachers; 2) as a curative classroom intervention in disrupted classes by psychologists; and 3) as an indicative preventive intervention in mental health care centres to children and their parents when there is a concern about the social development of the child because of mild to severe psychosocial problems. In all three settings, the intervention is transdiagnostic: targeting mild to severe internalising and externalising behaviour (problems). The program focuses on the attitudes and behaviour of children and parents and in the school settings of educators and the head of the school. Variants of the Topper Training method to create positive group climates are also widely used in sports associations, out-of-school childcare, churches and entire neighbourhoods. In this article, the intervention is studied in the context of a mental health care centre, as an indicated preventive intervention.
The training takes into account the importance of motivation and autonomy by reminding children of their positive intentions and motivation to behave prosocially and by making children aware of their ability to choose their own (autonomous) behaviour. The main method that is used to foster these skills is the use of four caps.
The white cap stands for authentic behaviour on a base of trust in oneself and in the other. Different coloured caps in combination with the white cap cover many ways in which people feel authentic and act based on trust. The black cap in combination with the white cap represents power, leadership, initiative taking and spirit. In the same way, the yellow with white cap represents modesty and being sensitive to others needs and feelings. The combination of red and white cap represents humour (with respect for all parties) and being able to relativise.
All coloured caps have their pitfall. Problematic behaviour (internalising and externalising behaviour) is seen as non-authentic behaviour because, most of the time, it is not the desire of the child to behave without the white cap [22]. The black cap without the white cap stands for aggressive and dominating behaviour; the yellow cap stands for shy, anxious and depressed behaviour; the red cap stands for annoyingly funny, careless and 'accomplice-like' behaviour. A key point is that while children may behave in accordance with the role that belongs to a certain cap, they are not identified or labelled as such. In other words: the cap refers to behaviour, not to a personal trait. Difficult social situations are acted out in role-plays, for example bullying situations that have arisen in the class. The caps can also be used outside the training sessions: children, teachers and parents can ask children “Which cap are you wearing?” so as to make children more conscious of their behaviour. Subsequently, they can ask the child whether he/she would like to put on the white cap. A more detailed description of the theoretical ground and method of Topper Training can be found in [23]. The concept of the white cap is comparable to the view of Self-Determination Theory (SDT) where people have a natural tendency to express and develop themselves. The basic needs in SDT can be linked to the method and theoretical grounds of Topper Training: autonomy (Topper Training says “be yourself, make your own choices”), feeling of competence (by practicing social skills and increasing the feeling of control over one’s life) and relatedness (exercises in interaction with others and trust in others).
Previous research on Topper training
In a quasi-experimental study, the effectiveness of Topper Training was established in a classroom context [23]. Classes (third to sixth grade; age range 8 to 13 years) designated as problematic by their teacher and/or the head of the school were trained by a psychologist. Parents and heads of schools were actively involved and the teachers were coached. The intervention consisted of an average of 15 training hours. Fourteen trained classes (n = 353) were compared to fourteen control classes (n = 343) from the same primary schools. Multilevel analyses revealed medium to large effects on classroom climate: relationship with the teacher, perceived social acceptance by classmates and disruptive behaviour according to the teacher. Cohen’s effect sizes ranged from .66 to 1.55. At the individual level, trained children showed improvements in self-reported prosocial behaviour, depressed mood and self-esteem when compared to the control children. Effect sizes ranged from .20 to .41.
In another quasi-experimental study in a mental healthcare setting [24], 185 trained children were compared to 39 waiting list control children (all between 8 and 11 years old). The training was directed at children with mild to severe psychosocial problems and their parents. After ten 90-minute sessions, the children showed significant decreases in parent-reported internalising and externalising problems, aggression, withdrawn-depressed behaviour, social problems and their problems in general. Marginally significant effects were found for attention problems, anxious-depressed problems and somatic problems. Effect sizes ranged from .26 to .46.
These studies were done under real-world conditions: participants applied for the training as usual and the training was given as usual. An advantage of this approach is that the results are easily transferrable to daily practice. This is crucial because Topper Training is already widely implemented in the Netherlands.
The present study
The quasi-experimental design of both earlier studies did not allow strong conclusions to be drawn on the causal effect of the intervention. To overcome this limitation, the aim of this study was to examine Topper Training effects with a more stringent test: a randomised trial. Earlier studies were based on child, parent or teacher reports. The present study uses multiple informants in one study: parents, teachers and children. Moreover, we added a follow-up measurement after six months. The main question is: Is Topper Training effective for 8 - to 11 year olds with mild to severe problems in social interaction in a mental health care setting, and does this effect remain for half a year?
We conducted the research in a mental healthcare centre in Almere, a medium-sized city in a central region of the Netherlands. The target population in this mental healthcare centre consisted of children with mild to severe problems in social interaction. Our primary hypothesis was: Topper Training can effectively reduce emotional problems and, conduct problems. Moreover, we expected that Topper Training could increase self-worth and prosocial behaviour and could decrease peer problems, depression, bullying and victimisation and could help children to cope more adequately with the challenges or problems they faced. Therefore, we hypothesised that Topper Training would also reduce the impact that problems have on the lives of children. Moreover, we hypothesised that the effects would sustain until 6-months follow-up.
Materials and methods
Design
We used a randomised trial with two conditions (intervention group and waiting list control group), three measurement points (pre, post and six-month follow-up) and three informants (child, teacher, parents). Individual children were randomly assigned to the intervention group or to the waiting list group in a 3 : 2 ratio using a simple randomisation procedure (a throw of the dice, 6 was ‘throw again’). The 3 : 2 allocation ratio was chosen for practical reasons: in September 2010 and 2011 three groups could start and in February 2011 and 2012 only two groups could start with the training (which was the delayed intervention of the waiting list group). To recruit sufficient numbers of participants, children were recruited in two time periods, between February 2010 and August 2010 and the same period one year later. The intervention started half yearly in September 2010, February 2011, September 2011 and February 2012 so that the waiting list group received the intervention six months after the intervention group.
All parents signed a consent form to indicate that they agreed to participate in the study. The study was approved by the Ethics review board of the Faculty of social and behavioural sciences of the University of Amsterdam, The Netherlands. The trial was registered under number 2014-CDE-3827 as “Effectiveness of Topper Training”. This trial is listed on the ISRCTN registry as “Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation” with study ID ISRCTN14967790, see http://www.isrctn.com/ISRCTN14967790. We registered the trial after participant recruitment, because the training was financed as preventive and not part of clinical mental health care at that time. There are no other clinical trials at the moment for this intervention.
Participants
Children were recruited in primary schools and public health institutions in Almere in the Netherlands. Schools and institutions received posters and were informed about the possibility for children to participate in the Topper Training for free. The posters were directed at parents who were concerned about their child because of problems regarding social interaction. Examples of these problems were given, such as victimisation, low self-esteem, socially unskilful behaviour and aggressive behaviour.
Eligible participants were children who were in primary school, were aged between 8 and 11 years, experienced internalising and/or externalising problems in social interactions and were motivated to follow the training programme (as were their parents). These criteria were exactly the same as those used in the daily practice of the training. A total of 140 families were eligible for inclusion in the study (see Fig 1). Of those, 134 families (96.3%) expressed their desire to participate in the study and gave their permission. The 134 children from these families were randomly assigned to the intervention group (n = 79) and waiting list group (n = 55). Two children from the intervention group did not report any problems at the interview stage and therefore chose not to participate in the intervention. At post-intervention (T2), all of the remaining children (77 intervention and 55 waiting list children) were still participating in the study. A sensitivity analysis in Gpower indicates that with power of .95, the sample size allowed for detection of modest effect sizes of d > .31 (effect size f > .157).
Fig. 1. Participant flow chart. n = number of children, T1 = measurement 1, T2 = measurement 2, T3 = Measurement 3, CDI = Child Depression Inventory, CBSK = The Dutch version of the Self-Perception Profile for Children. The waiting list group received the intervention half a year later than the intervention group, see Fig 2. By that time, one child had decided not to participate in the intervention because the previously reported problems were no longer apparent. Five other (waiting list) children dropped out during the intervention: one child dropped out because the parents were in the process of a divorce, two children dropped out because of family problems and two children dropped out of the intervention for other, unknown reasons. All of these six children were included in the second time point before their intervention and dropped out thereafter. At the third measurement point, we were unable to contact two other children in the intervention group and one in the waiting list group.
Fig. 2. Measurement (T1, T2, T3) and intervention occasions starting in 2010 and 2011. Baseline demographic and clinical characteristics of the intervention and waiting list groups are shown in Table 1. Clinical problems that were the most reported were emotional symptoms, self-perceived victimisation and impact of the problems. According to the parents, about 10% of the children were diagnosed as having ADHD or ADD, one child had an anxiety disorder, one child had a disorder in the autistic spectrum and one child had attachment problems. The children with ADHD or ADD were prescribed medication for their condition.
Tab. 1. Baseline demographic and clinical characteristics of intervention and waiting list group. The intervention and control groups did not differ in age (t(130) = 1.540, p = .126) or gender (Chi 2(1) = .779, p = .377). Mean age was 9.38 years (SD = 1.2). The percentage of boys was 50%. Level of education of the parents did not differ between the groups: the distribution of families in low, middle and high educational segments was 7%, 42% and 51% respectively (Chi 2(2) = .338, p = .845). Also, ethnic composition did not differ between the groups (Chi 2(2) = 3.349, p = .187), 78% was Dutch, 5% Western migrant and 17% non-Western migrant.
Attendance
Attendance was high for both groups. The mean attendance for the intervention group over ten group sessions was 9.4 sessions (SD = .7), with 55% of the children attending all ten sessions, 35% attending nine sessions and 10% attending eight or seven sessions. Mean attendance during the intervention period of the waiting list group was 9.5 sessions (SD = .8), with 64% of the children attending all ten sessions, 24% attending nine sessions and 12% attending eight or seven sessions. Five intervention children filled in the post-intervention measurement after nine training sessions instead of ten. This was done because these children would not be able to fill in the questionnaires directly after the last training session. To ensure a post-test measure for these children, we chose to let them fill it in directly after the ninth session.
Procedure
After recruitment, the pre-test measurement took place (T1, around June 2010 and for the second group June 2011), followed by the randomisation procedure. The intervention group then started with the intervention, followed by a post-intervention measurement (T2, December of the same year) directly after the last training session. Half a year later the follow-up measurement (T3 in May) took place. We organised a meeting for each training group to fill in all the questionnaires again. The waiting list group had to wait half a year after the first measurement and then completed the second measurement at the same time point as the intervention group. Thereafter, the waiting list group received the intervention, followed by the post-intervention measurement (T3) directly after the last training session (see Fig 2). All children had an interview that was planned after their pre-test preceding the intervention: after T1 for the intervention group and after T2 for the waiting list group. In the original study protocol, (see S2 File and S3 File), we planned to have two pre-test measurement occasions: in May and August. However, we decided to omit the August measurement. The reason was that for some of the children theses time points were too close to each other (because they registered in June or July). This made the August measurement less functional.
In general, parents filled in questionnaires at home before the intervention and at the mental health care centre after the last session. Teachers received the questionnaires from the parents and sent them back. Children filled in the questionnaires under supervision at the mental health care centre. The control group filled in pretest questionnaires at school under supervision, because the intake was half a year later. Completion of the questionnaires took about 15–20 minutes.
To motivate parents to fill in the questionnaires at three separate points in time, the training was offered for free (upon the precondition that all measurement occasions were completed) and parents received a report with the results for their child. Children, parents and teachers were all knowledgeable as to who was in the intervention condition and who was not: it was not possible to blind participants, parents or teachers.
Intervention
Topper Training was provided by two trained psychologists with 5 and 7 years experience each in giving this training. The intervention consisted of ten 90-minute group sessions given every two weeks. Training groups contained a maximum of 15 children with internalising and/or externalising problems. In S5 File we give a more detailed description of the intervention.
Measures
Strengths and Difficulties Questionnaire (SDQ)
Parents and teachers reported children’s problem behaviour on the SDQ [25, 26] a 25-item measure of problem behaviour and prosocial behaviour. We used the Emotional Symptoms scale (5 items), Conduct Problems scale (5 items), Peer Problems scale (5 items) and Prosocial Behaviour scale (5 items). We did not use the Attention and Hyperactivity scale in this study, because this is not one of the goals of Topper Training. Items were rated on a scale ranging from 0 (not true) to 2 (certainly true). In our sample, Cronbach’s alpha ranged between .69 and .81 for teacher reports and between .50 (mother report on Emotional Symptoms scale) and .71 for parent reports. Concurrent validity in a Dutch sample was established [26].
We used the extended SDQ with an additional impact supplement. This supplement provides an impact score, which is the sum of the scores on the distress and social incapacity items. The Impact score is found to discriminate better between community and clinic samples than symptom scores [27]. Pre-test scores of mother and father were strongly correlated (r between .51 and .79). We decided to take the average parent score by computing the mean score of father and mother. When the score of only one parent was available at a given point in time, we also used the score of that parent at the other time points for that child to ensure correct within-subject comparisons. This was the case for five training children and two control children.
Child Depression Inventory (CDI)
We assessed depressive symptoms through a Dutch translation [28] of the Children’s Depression Inventory (CDI) [29]. In this translation, one item from the original CDI concerning suicidal ideation (“I want to kill myself”) was replaced by two less precarious questions: I (never/sometimes/-often) think “I wish I was dead” and I (always/sometimes not/do not) think that life is worth living. This resulted in a 28-item questionnaire. For each item, children selected one of three statements indicating how they had felt over the past 2 weeks. The CDI has strong predictive, convergent and construct validity (e.g., [30, 31]), and was shown to have adequate internal consistency and test-retest reliability in previous studies [29, 32]. Cronbach’s alpha in the current sample was .85. On the basis of cut-off scores suggested by Kovacs [29], scores below 13 were rated as normal and scores of 16 or higher were rated as clinically depressed.
Self-Perception Profile for Children (SPPC)
We used the self-esteem scale from the Dutch version [33] of the Self-Perception Profile for Children [34]. This scale consists of 6 items. Each item consists of two opposing descriptions, from which children have to choose one and then indicate whether this is somewhat true or totally true for them. Accordingly, each item is scored on a four-point scale, with a higher score reflecting a more positive view of oneself. The Dutch version was found to be reliable (Cronbach’s alpha = .74 and test-retest reliability after four weeks was .74 [33]. The construct and concurrent validity was established in a Dutch sample [35]. Internal consistency in the current sample was .88. Scores below the 10th percentile were rated as clinically low and above the 20th percentile as normal. This translates into different scores for boys and girls: girls scored clinical below 16, boys below 17. Scores of 18 or higher were rated as normal for boys and girls.
Topper questionnaire
We used the Topper questionnaire [36] to measure bullying and self-perceived peer victimisation. Bullying was measured by the question: ‘I bully at school’ and self-perceived peer victimisation was measured by two questions: ‘I am afraid of being bullied’ and ‘I get bullied’, comparable to The Revised Olweus Bully/Victim Questionnaire [37]. For each statement children chose “totally not true,” “not really true,” “a little true” or “totally true” using a four-point Likert scale. Correlations with the other dependent variables of this study were in the expected direction and gave support for the concurrent validity of these questions, see S1 Table.
This questionnaire was filled in at home since supervision was not necessary. All other child questionnaires were completed under the supervision of a test assistant. Clinical relevance was measured by categorising children as ‘bully’ or ‘non-bully’ and ‘victim’ or ‘non—victim’. Children with a score below 3 (“totally not true” and “not really true”) were rated as non-victim or non-bully; children with a score of 3 or higher (“a little true” or “totally true”) were rated as victim or bully. This classification is comparable to the criterion (i.e. more than once or twice) used by Farrington and Ttofi [38] in their meta-analysis. The other scales of the Topper questionnaire were filled in, but we decided not to use them in this study because we already measured these aspects with other measures (CDI and SDQ).
The dependent variables correlated with each other in the expected directions and strength. Pearson correlations varied between r = -.72 (p < .001) and r = .46 (p < .001). For a complete overview of all correlations, see S1 Table.
Data analyses
To test the immediate effects of Topper Training, we used Repeated Measures ANOVA with group (intervention, waiting list) as between group factor and time (T1, T2) as within group factor. A significant group x time interaction effect indicated an intervention effect. Effect sizes (Cohen’s d) were calculated by subtracting the T1-T2 change in the waitlist group from the T1-T2 change in the intervention group. And diving this by the pooled standard deviation of the T1-T2 difference scores (see [39]). Based on these difference scores we computed the confidence interval for Cohen’s d. To determine the clinical relevance of these results, we computed the proportion of children in each group that moved from the clinical to the normal range, based on the normative data of the instruments.
We used the three time points for the waiting list group to test for additional evidence of an intervention effect. The slope between T2 and T3 (the intervention period) was compared with the slope between T1 and T2 (waiting list period). The significance of the difference was tested with a quadratic interaction effect in a repeated measures analysis, while only including the waiting list group. A significant interaction in combination with inspection of the graphs for the direction of the interaction was used as an additional test for the intervention effect. To examine the extent to which immediate post-test change was maintained at the six-month follow-up in the intervention group, Paired-Samples t-tests were used on immediate post-test and follow-up scores.
We checked assumptions before conducting the repeated measures ANOVA. Most variables had a normal distribution. Some did not have a normal distribution, as was expected (e.g. depression). With a sample size of more than 30, this does not give a bias in the analyses (central limit theorem). Sphericity is only applicable when comparing three time points; in this study we only compare two time points in the analyses. Scores are independent since the control and training groups did not have any contact and could not influence each other’s answers on the questionnaires.
Results
Baseline differences between intervention and waiting list groups
At baseline, the groups only differed on self-perceived peer victimisation (t (121) = 1.984, p = .05). The intervention group scored higher at baseline (M = 2.3, SD = 1.0) than the waiting list group (M = 2.0, SD = 0.9). We corrected for these pre-test differences by entering the pre-intervention score as a covariate in an ANCOVA on the intervention effect. Mean scores did not differ between the intervention and control group for any other variable, including bullying, depression, self-esteem or the parent and teacher SDQ scales (all p’s > .05).
Immediate effects
Table 2 provides descriptive statistics for the intervention and waiting list groups at pre-intervention (T1), post-intervention (T2) and half a year later (T3). We plotted these mean scores in Figs 3–9 and in S1 and S2 Figs, calling the intervention group ‘Immediate Topper’ and the waiting list group ‘Waiting list Topper’. Table 3 provides the results from repeated measures analyses. The table shows Cohen’s d and its confidence intervals and the interactions between intervention group and time: the intervention effects. This interaction effect, indicating more positive change in the intervention group compared to the waiting list group, was significant for self-perceived peer victimisation F(1,119) = 6.66, p = .011, d = .62, self-worth F(1, 130) = 6.51, p = .012, d = .45, parent-reported (but not teacher-reported) emotional symptoms F(1,127) = 15.12, p = 1,62 * 10−4, d = .70, peer relationship problems F(1,127) = 5.14, p = .025, d = .41, and the impact of these problems F(1, 127) = 8.59, p = .004, d = .59) and teacher-reported (but not parent-reported) conduct problems F(1,118) = 4.95, p = .028, d = .42. No significant effects were found on self-reported bullying, depression or prosocial behaviour. No adverse effects were found: in all cases where no effects were found, the intervention group improved as much as the waiting list group did.
Fig. 3. Significant effect of Topper Training on parent-reported (but not teacher-reported) emotional symptoms. N.B. The Figure plots a decrease of emotional symptoms during Topper Training period: between T1 and T2 for Immediate training group and between T2 and T3 for Waiting list group. Fig. 4. Significant effect of Topper Training on teacher-reported (but not parent-reported) conduct problems. Fig. 5. Significant effect of Topper Training on parent-reported (but not teacher-reported) peer relationship problems. Fig. 6. No significant effect of Topper Training on prosocial behaviour. Fig. 7. Significant effect of Topper Training on self-perceived peer victimisation. Fig. 8. Significant effect of Topper Training on self-worth. Fig. 9. Significant effect of Topper Training on depression six months after the intervention. N.B. Depression significantly decreased between T2 and T3 for the Immediate Topper group. This could not be compared to a waiting list group, since the waiting list group received the training during this period. Tab. 2. Means and standard deviations (between brackets) for the intervention and waiting list group at T1, T2, and T3 (with clinical cut-offs of each subscale between brackets). Tab. 3. Intervention effects: Time by condition interactions in repeated measures ANOVA’s. Additional within-group analyses of effects in the delayed intervention group
Additional analyses were conducted to test for the effects of Topper Training in the waiting list (i.e. delayed intervention) group. In these analyses changes in the outcome variables during the waiting list period were compared with changes in the same group during the intervention period using repeated measures ANOVA’s with the three time points and a quadratic contrast. Significant quadratic effects (indicating more improvement during the intervention period than during the waiting list period) were found for Self-perceived peer victimisation: F(1,42) = 4.23, p = .046, parent-reported Emotional symptoms: F(1,44) = 5.73, p = .021, and Impact of the problems: F(1,44) = 6.85, p = .011. No quadratic (intervention) effects were found for teachers: improvements experienced during the waiting list period were comparable with improvements during intervention, resulting only in significant linear effects.
Maintenance of effects
Due to the delayed intervention design, no half-year follow-up data were available for the control group. We therefore tested whether outcomes were stable or improved from immediate post-intervention to the six-month follow-up for the intervention group separately. Within-participants t-tests indicated that scores did not change between immediate post-test and six-month follow-up for all scales on which immediate effects were found (see also Figs 3–8, S1 Fig and S2 Fig). While no immediate effect was found for depression (the waiting list group improved as much as the intervention group) the scores at follow-up were significantly lower than the scores at post-intervention, which may tentatively suggest that Topper Training reduces depression in the long run.
Clinical relevance
Besides comparing average scores of the whole sample, it is interesting to test the effect of Topper Training specifically for children who scored in the clinical range. Clinical relevance of the results (i.e. the extent to which children scoring in the clinical range at pre-test showed movement to the normal range at post-test) is shown in Table 4. For most of the problem domains, the proportion of children scoring in the clinical range at baseline that moved to the normal distribution at post-test in the intervention group was substantial (30% to 70% across different measurements). Parent - and child-reported proportions of improvement were significantly higher in the intervention group than in the waiting list group for emotional and conduct problems, impact and self-esteem. Teacher-reported proportions were more similar in the intervention and waiting list groups, resulting in no statistical differences.
Tab. 4. Clinical relevance of results: Percentage of children who moved from clinical to normal range. Discussion
In this study we evaluated the effects of the indicated preventive transdiagnostical intervention Topper Training in 8 - to 11 year olds with mild to severe problems in social interaction in a mental health care setting. We hypothesised main effects on conduct as well as emotional problems. In line with this hypothesis, we found significant effects on parent reported emotional problems and on teacher reported conduct problems. We discuss possible explanations for the difference between parental and teacher report later on. Is it recommendable to give Topper Training to children with clinical emotional or conduct problems? Although only a subsample of the children could be included for this analysis, we found significant effects in our ‘clinical relevance analysis’. Almost half of the parents (47%) of children with clinical emotional problems reported that those problems were reduced to a normal range after the training, compared to 16% in the waiting list group. This is in line with our previous study in a mental health care setting [24], were parents reported a large effect for children with clinical internalising problems (d = .87).
Although parents did not report an effect on conduct problems in the whole sample, we found that 64% of the children with clinical conduct problems scored in the normal range at posttest (13% in waiting list group). This is in line with our previous study [24] that shows significant effects on parental reported clinical externalising problems and aggression. The overall effect on teacher reported conduct problems was in line with effects of Topper Training in a classroom context [23], where the teacher reported a large effect on disruptive behaviour at the classroom level.
Regarding the secondary outcomes, parents perceived a decline in peer problems (in line with our earlier findings [24]) and impact of those problems on the lives of the children, but no decrease in prosocial behaviour (in contrary to our previous study in a classroom context [23]). Additionally, half of the parents reported that the impact of the problems reduced from very high to normal (compared to 13%). Children experienced significant less peer victimisation and an increased self-worth after training (in line with effects in a classroom context [23], but no decrease on bullying (we did not measure this before). The training created a healthy self-worth for 69% of the children with clinical low self-worth (compared to 17%). All benefits of the training sustained up to half a year.
The effects of Topper Training on depression need a closer look. It appears that in the waiting list condition, children become less depressed over time without intervention. During the intervention, Topper Training does not seem to have an additional effect on depression. However, six months after the training, depression had declined even more in the training group. This suggests a sleeper effect. In the current design, we cannot make causal inferences on this, but it might indicate that Topper Training gives children tools to deal in a different way with social situations and that this gives them control over their lives and hence on the long run reduces depressed feelings. This would be in line with the mentioned ideas of Self-Determination Theory: stimulating autonomy, competence and relatedness (which Topper Training does) will contribute to well-being and hence reduce depressed mood.
Taken together, the results provide additional support for the effectiveness of Topper Training in 8 - to 11-year-old children with mild to severe psychosocial problems, under real-world conditions. The effects are substantial and are in line with previous research on Topper Training in a mental healthcare setting and in a classroom setting [23, 24]. The discrepancies between parent - and teacher-reported effects are salient in this study. A surprising finding was that parents in the current study did not report significant improvements in their child’s conduct problems, while this was reported by the teachers, and while parent-reported conduct problems of the child were found to decrease in our earlier studies in a mental healthcare setting [24] and in a classroom context [23]. When we take a closer look at the data, it appears that the children in our sample had on average low conduct problems, showing a bottom-effect. Only about 15–18% of the children showed clinical conduct problems at pre-test according to parents. Topper Training was clearly effective for those children: about two-thirds of the children with clinical-level conduct problems at pre-test moved to the normal range at post-test (compared to 13% in the waiting list group). The fact that the improvement in conduct problems was clinically relevant but not statistically significant may be a consequence of the heterogeneity of the sample. To test whether Topper Training is effective for children with behavioural problems, a fully clinical sample would perhaps be more suited.
In contrast to parents, teachers did not seem to experience any effect of Topper Training on emotional symptoms, peer relationship problems and impact. Inspection of the data reveals that teachers experienced improvements in emotional and peer problems in control group children while they were waiting for the intervention. This might indicate that teachers may have been especially attentive to the children who were placed on a waiting list. This extra attention might have had a positive influence on the children, in that they may have felt more noticed and understood by the teacher, which in itself can lead to a reduction in emotional symptoms. Another explanation for the discrepancy between parent - and teacher-reports could be that teachers may be more sensitive to perceiving (changes in) conduct problems in a classroom context than to changes in emotional problems that are not readily observable. Yet another explanation might be that the new child social-emotional skills that have an effect on emotional symptoms and peer interaction are only practiced in the home context and have not yet been generalised into the school setting. This may take more time. Decreases in peer problems perceived by the teacher give support for this notion: six-month follow up scores of the teachers were comparable to post-test scores of the parents.
At first sight, another surprising finding was that Topper Training effectively reduced peer victimisation while the program did not affect levels of self-reported bullying. Perhaps this pattern of findings can be explained by the fact that there was very little self-reported bullying among the children in the current sample at baseline, so improvements could hardly be made. Future studies, with other criteria for inclusion, may test whether Topper Training reduces bullying by children who are selected for bullying behaviour. In addition, contrary to expectations, we did not find any significant effects on prosocial behaviour. Topper Training seems to have more effect on reducing problems than it does on stimulating positive behaviour. An explanation may be that children in this sample scored in the normal range at pretest on prosocial behaviour, on average (which in the SDQ means: being helpful and kind, sharing), which may have resulted in a ceiling effect.
For comparability with other studies, we used a significance level of p < .05, to identify results as either ‘significant’ or not. Our ‘significant’ p-values range from .011 to .046. Taking into account the applied nature of our study, these are fruitful results. However, if we translate those p-values to Bayes Factors (B), representing the amount of evidence supporting alternative hypothesis against the null hypothesis (see [40]), we see that most of our data cannot be considered “strong” evidence (Johnson [41] suggests to test at p < .005 (corresponding to a strong evidence criterion, or Bayes Factor of B > 14). Following that criterion, the effects on parent-reported emotional problems (p = 1,62 * 10−4 which corresponds to B = 260) and impact of the problems (p = .004: B = 17) give strong evidence for the difference in development between trained children and waitlist children. Thus, with this more stringent criterium we conclude that it is very likely that children receiving Topper Training show reductions in emotional problems and impact of the problems according to parents.
Limitations and strengths
The present study provides a stringent test of the effectiveness of Topper Training, but it is still characterised by some limitations. One limitation of this study is that while we used multi-informant assessments, none of the informants were blind to condition. This might have influenced their responses. Another limitation is that the follow-up data for children who received the intervention directly could not be compared to a control group that did not undergo an intervention. A third limitation is that only a subset of our sample scored in the clinical range at pre-test: this made the sample size for calculating clinical relevance relatively small. While the clinical relevance of the current results is certainly promising, we need to test the effectiveness in a more clinical sample to generalise the results to a more clinical population. A fourth limitation of this study is that although we were generally able to use reliable and valid measures, bullying and peer victimisation were measured by only one and two questions, respectively. However, the Olweus Bully/Victim questionnaire [37] is used in many studies, and it too relies on two main questions (comparable to the ones we used in our study). Finally, to make our results more comparable to those obtained when using Olweus’ complete questionnaire, it would have been better if we had used similar response options to those used in previous studies, such as ‘not at all’, ‘only once or twice’, ‘two or three times a month’, ‘about once a week’, and ‘several times a week’. We did not do this because the questionnaire being used was part of the normal intervention intake procedure, with standard answering categories for all questions.
An important strength of this study is the random assignment of the children to either the intervention or waiting list group, which makes causal inference strong. In addition, the training was given under real-world conditions with routine provision of a training that is already widely implemented in this way. This makes the results significant in practical terms: this intervention in other mental healthcare centres by trained psychologists is likely to be effective. Results of an earlier study in these centres were found to be in line with the present findings [24]. Another strength of the study is the heterogeneity of the sample. This intervention is not only directed at and effective for children with either internalising or externalising problems, but rather is directed at the whole spectrum of psychosocial problems, taking into account one underlying general psychopathology factor: the p factor, as suggested by Caspi et al. [10].
Conclusion and future research
Overall, these findings indicate that cognitive behavioural techniques taught in a peer group with an additional parent training and a focus on autonomy, competence and relatedness can be effective for children aged 8 to 11 years with psychosocial problems. Since Topper Training is widely implemented in the Netherlands and this study was done under real-world conditions, these results are promising in terms of the daily practice of this intervention for children with psychosocial problems. These effects were measured after 10 sessions, taking about five months in total. The intervention does not demand costly diagnostic tests, but can be followed without referral. This makes the intervention feasible.
As an additional step towards examining the effective elements of interventions for children with psychosocial problems, future research might examine the effectiveness of separate elements of the training. Moreover, a larger sample would enable us to examine the effectiveness of Topper Training in subsamples based on gender, age and severity of problems which would yield more information on the question for whom the intervention is more (or less) effective.
Supporting information
S1 Fig [tif]
Significant effect of Topper Training on parent-reported (but not teacher-reported) impact of the problems.S2 Fig [tif]
No significant effect on self-reported bullying.S1 File [doc]
Abstract in Dutch.S2 File [doc]
Trial study protocol in Dutch.S3 File [doc]
Trial study protocol in English.S4 File [doc]
CONSORT checklist.S5 File [doc]
Description of the intervention Topper Training.S1 Table [doc]
Correlations of all outcome measures.
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- Development of a multi-locus typing scheme for an Enterobacteriaceae linear plasmid that mediates inter-species transfer of flagella
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- The trajectory of patterns of light and sedentary physical activity among females, ages 14-23
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- Measuring the complexity of directed graphs: A polynomial-based approach
- Estimation of maize evapotraspiration under drought stress - A case study of Huaibei Plain, China
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- Developmental conservation of microRNA gene localization at the nuclear periphery
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- Bacterial communities in the rhizosphere, phyllosphere and endosphere of tomato plants
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- Does aneurysm side influence the infarction side and patients´ outcome after subarachnoid hemorrhage?
- Raising the bar: Recovery ambition for species at risk in Canada and the US
- Management of locally advanced non-small cell lung cancer in the modern era: A national Italian survey on diagnosis, treatment and multidisciplinary approach
- Foraging strategies are maintained despite workforce reduction: A multidisciplinary survey on the pollen collected by a social pollinator
- Incidence of colorectal cancer in Eritrea: Data from the National Health Laboratory, 2011-2017
- Integrated analysis of miRNA landscape and cellular networking pathways in stage-specific prostate cancer
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- Variation in the LRR region of Pi54 protein alters its interaction with the AvrPi54 protein revealed by in silico analysis
- Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells
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- The association between sleep problems and academic performance in primary school-aged children: Findings from a Norwegian longitudinal population-based study
- Estimating the national cost burden of in-hospital needlestick injuries among healthcare workers in Japan
- Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data
- Dispersion of Legionella bacteria in atmosphere: A practical source location estimation method
- Integrative proteomic and phosphoproteomic profiling of prostate cell lines
- Treatment paths for localised prostate cancer in Italy: The results of a multidisciplinary, observational, prospective study (Pros-IT CNR)
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- Barriers to implementation of emergency obstetric and neonatal care in rural Pakistan
- Testosterone supplementation improves insulin responsiveness in HFD fed male T2DM mice and potentiates insulin signaling in the skeletal muscle and C2C12 myocyte cell line
- Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma
- Factors influencing bird-building collisions in the downtown area of a major North American city
- Collembola laterally move biochar particles
- Decreased retinal thickness in patients with Alzheimer’s disease is correlated with disease severity
- Moving system with action sport cameras: 3D kinematics of the walking and running in a large volume
- Factors influencing subclinical atherosclerosis in patients with biopsy-proven nonalcoholic fatty liver disease
- Boundary violations and adolescent drinking: Observational evidence that symbolic boundaries moderate social influence
- Inadequate conflict of interest policies at most French teaching hospitals: A survey and website analysis
- A new resolution function to evaluate tree shape statistics
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- Lifetime prevalence of intimate partner violence against women in an urban Brazilian city: A cross-sectional survey
- The factors associated with being left-behind children in China: Multilevel analysis with nationally representative data
- High heat tolerance in plants from the Andean highlands: Implications for paramos in a warmer world
- Quantifying pediatric patient need for second- and third-line HIV treatment: A tool for decision-making in resource-limited settings
- Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors
- Iodine status of non-pregnant women and availability of food vehicles for fortification with iodine in a remote community in Gulf province, Papua New Guinea
- Fibre and extracellular matrix contributions to passive forces in human skeletal muscles: An experimental based constitutive law for numerical modelling of the passive element in the classical Hill-type three element model
- The status of imported Barremian-Bedoulian flint in north-eastern Iberia during the Middle Neolithic. Insights from the variscite mines of Gavà (Barcelona)
- Psychology of personal data donation
- Radiocarbon dating and cultural dynamics across Mongolia’s early pastoral transition
- MARGO (Massively Automated Real-time GUI for Object-tracking), a platform for high-throughput ethology
- Visual detection of time-varying signals: Opposing biases and their timescales
- Results from a World Health Organization pilot of the Basic Emergency Care Course in Sub Saharan Africa
- Scientists’ opinions and attitudes towards citizens’ understanding of science and their role in public engagement activities
- Dacentrurine stegosaurs (Dinosauria): A new specimen of Miragaia longicollum from the Late Jurassic of Portugal resolves taxonomical validity and shows the occurrence of the clade in North America
- Integrated pan-cancer gene expression and drug sensitivity analysis reveals SLFN11 mRNA as a solid tumor biomarker predictive of sensitivity to DNA-damaging chemotherapy
- Does membrane feeding compromise the quality of Aedes aegypti mosquitoes?
- Morphology, phylogeny, and taxonomy of two species of colonial volvocine green algae from Lake Victoria, Tanzania
- Metabolomics profiles associated with HbA1c levels in patients with type 2 diabetes
- Exploring local realities: Perceptions and experiences of healthcare workers on the management and control of drug-resistant tuberculosis in Addis Ababa, Ethiopia
- Sex differences in the treatment and outcome of emergency general surgery
- Comorbidities and costs in HIV patients: A retrospective claims database analysis in Germany
- Barriers to integration of bioinformatics into undergraduate life sciences education: A national study of US life sciences faculty uncover significant barriers to integrating bioinformatics into undergraduate instruction
- Local unemployment changes the springboard effect of low pay: Evidence from England
- A comparison of body composition assessment methods in climbers: Which is better?
- Comparison of an in-house ‘home-brew’ and commercial ViroSeq integrase genotyping assays on HIV-1 subtype C samples
- Elucidating genetic variability and population structure in Venturia inaequalis associated with apple scab diseaseusing SSR markers
- Clustering via hypergraph modularity
- Indomethacin enhances anti-tumor efficacy of a MUC1 peptide vaccine against breast cancer in MUC1 transgenic mice
- Multistage fuzzy comprehensive evaluation of landslide hazards based on a cloud model
- Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A
- Pharmacological signatures of the reduced incidence and the progression of cognitive decline in ageing populations suggest the protective role of beneficial polypharmacy
- Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”
- Complex interaction networks of cytokines after transarterial chemotherapy in patients with hepatocellular carcinoma
- Gender essentialism in transgender and cisgender children
- Insertional mutagenesis in the zoonotic pathogen Chlamydia caviae
- Being there: A scoping review of grief support training in medical education
- Does the psychological profile influence the position of promising young futsal players?
- Effect of self-rated health status on functioning difficulties among older adults in Ghana: Coarsened exact matching method of analysis of the World Health Organization’s study on global AGEing and adult health, Wave 2
- Olfactory screening of Parkinson’s Disease patients and healthy subjects in China and Germany: A study of cross-cultural adaptation of the Sniffin’ Sticks 12-identification test
- Molecular evolution of cytochrome C oxidase-I protein of insects living in Saudi Arabia
- Correlates of leisure-time sedentary behavior among 181,793 adolescents aged 12-15 years from 66 low- and middle-income countries
- Cost-effectiveness analysis of Mucosal Leishmaniasis diagnosis with PCR-based vs parasitological tests in Colombia
- Spatiotemporal analysis of historical records (2001–2012) on dengue fever in Vietnam and development of a statistical model for forecasting risk
- Resilience assessment of Puerto Rico’s coral reefs to inform reef management
- Effect of community based health education on knowledge and attitude towards iron and folic acid supplementation among pregnant women in Kiambu County, Kenya: A quasi experimental study
- Implementation and effectiveness of non-specialist mediated interventions for children with Autism Spectrum Disorder: A systematic review and meta-analysis
- A tailored cognitive behavioral program for juvenile justice-referred females at risk of substance use and delinquency: A pilot quasi-experimental trial
- Impact of adjusted kidney volume measured in the bench surgery on one-year renal function in kidney transplantation
- Machine learning algorithm validation with a limited sample size
- The magnitude of suicidal ideation, attempts and associated factors of HIV positive youth attending ART follow ups at St. Paul’s hospital Millennium Medical College and St. Peter’s specialized hospital, Addis Ababa, Ethiopia, 2018
- The nonlinear effect of financial and fiscal policies on poverty alleviation in China—An empirical analysis of Chinese 382 impoverished counties with PSTR models
- Impacts of risk and competition on the profitability of banks: Empirical evidence from Pakistan
- Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing
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- Live observation of the oviposition process in Daphnia magna
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- Nodosilinea signiensis sp. nov. (Leptolyngbyaceae, Synechococcales), a new terrestrial cyanobacterium isolated from mats collected on Signy Island, South Orkney Islands, Antarctica
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- Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells
- Amazon climatic factors driving terpene composition of Iryanthera polyneura Ducke in terra-firme forest: A statistical approach
- Differences in clinical features of cluster headache between drinkers and nondrinkers in Japan
- Distribution of macular ganglion cell layer thickness in foveal hypoplasia: A new diagnostic criterion for ocular albinism
- Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer
- Effect of mechanochemical activation of natural phosphorite structure as well as phosphorus solubility
- Automated content analysis across six languages
- A deep learning reconstruction framework for X-ray computed tomography with incomplete data
- Integrating interconception care in preventive child health care services: The Healthy Pregnancy 4 All program
- The prognostic significance of tumor-infiltrating lymphocytes assessment with hematoxylin and eosin sections in resected primary lung adenocarcinoma
- Effectiveness of novel fabrics to resist punctures and lacerations from white shark (Carcharodon carcharias): Implications to reduce injuries from shark bites
- Bacillus Calmette-Guérin (BCG) therapy lowers the incidence of Alzheimer’s disease in bladder cancer patients
- Serial block-face scanning electron microscopy reveals neuronal-epithelial cell fusion in the mouse cornea
- Salt or fish (or salted fish)? The Bronze Age specialised sites along the Tyrrhenian coast of Central Italy: New insights from Caprolace settlement
- Pragmatic language dysfunction in systemic lupus erythematosus patients: Results from a single center Italian study
- Association between cerebral atrophy and osteoporotic vertebral compression fractures
- Latitudinal gradient of cyanobacterial diversity in tidal flats
- Gene expression based survival prediction for cancer patients—A topic modeling approach
- Understanding allergic multimorbidity within the non-eosinophilic interactome
- The association between psychological distress and angina pectoris: A population-based study
- Comparative analysis on Facebook post interaction using DNN, ELM and LSTM
- Cerebellum-mediated trainability of eye and head movements for dynamic gazing
- Psychological and physiological effects of applying self-control to the mobile phone
- Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy
- Genome-wide SNP analyses reveal population structure of Portunus pelagicus along Vietnam coastline
- Modulating transcription through development of semi-synthetic yeast core promoters
- Left-handed metamaterial bandpass filter for GPS, Earth Exploration-Satellite and WiMAX frequency sensing applications
- Cost-effectiveness analysis of PSA-based mass screening: Evidence from a randomised controlled trial combined with register data
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- Validation of the group tasks uncertainty model (MITAG) in a German sample
- Parent psychological wellbeing in a single-family room versus an open bay neonatal intensive care unit
- Optimizing the procedure of grain nutrient predictions in barley via hyperspectral imaging
- In-situ time resolved spectrographic measurement using an additively manufactured metallic micro-fluidic analysis platform
- Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity
- Characterization of the placental transcriptome through mid to late gestation in the mare
- Indirect violence exposure and mental health symptoms among an urban public-school population: Prevalence and correlates
- Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method
- Predictors of never having a mammogram among Chinese, Vietnamese, and Korean immigrant women in the U.S.
- The impact of hepatic steatosis on portal hypertension
- How do and could clinical guidelines support patient-centred care for women: Content analysis of guidelines
- Study of the epidemiological behavior of malaria in the Darien Region, Panama. 2015–2017
- School-based obesity prevention for busy low-income families—Organisational and personal barriers and facilitators to implementation
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- Methods for the identification of farm escapees in feral mink (Neovison vison) populations
- Transcriptional analysis of amino acid, metal ion, vitamin and carbohydrate uptake in butanol-producing Clostridium beijerinckii NRRL B-598
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- Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model
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- Predicting atrial fibrillation in primary care using machine learning
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- An assessment of khat consumption habit and its linkage to household economies and work culture: The case of Harar city
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- Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients
- A qualitative research synthesis of contextual factors contributing to female overweight and obesity over the life course in sub-Saharan Africa
- Insight into the relationship between aryl-hydrocarbon receptor and β-catenin in human colon cancer cells
- Hidden noise in immunologic parameters might explain rapid progression in early-onset periodontitis
- The role of stigma in the acceptance and disclosure of HIV among recently diagnosed men who have sex with men in Australia: A qualitative study
- Detection of Schistosoma japonicum and Oncomelania hupensis quadrasi environmental DNA and its potential utility to schistosomiasis japonica surveillance in the Philippines
- Does age influence the quality of life in children with atopic dermatitis?
- Questioning the lasting effect of galvanic vestibular stimulation on postural control
- Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment
- Characterization of 20 complete plastomes from the tribe Laureae (Lauraceae) and distribution of small inversions
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- Nonalcoholic fatty liver disease is an early predictor of metabolic diseases in a metabolically healthy population
- Occurrence and multilocus genotyping of Giardia duodenalis from post-weaned dairy calves in Sichuan province, China
- Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells
- Gender disparities in scientific production: A nationwide assessment among physicians in Peru
- Effect of F1 and F2 generations on genetic variability and working steps of doubled haploid production in maize
- Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data
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- A handy method to remove bacterial contamination from fungal cultures
- The self-care profiles and its determinants among adults with hypertension in primary health care clinics in Selangor, Malaysia
- The mutational landscape of quinolone resistance in Escherichia coli
- Exploring the influence of self-perceptions on the relationship between motor competence and identity in adolescents
- Study on the damage characteristics of gas-bearing shale under different unloading stress paths
- EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
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- Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening
- Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia
- Health impact of hepatic-venous-occlusive disease in a small town in Ethiopia—Case study from Tahtay koraro district in Tigray region, 2017
- Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
- Development of a quantitative PCR assay for the detection and enumeration of a potentially ciguatoxin-producing dinoflagellate, Gambierdiscus lapillus (Gonyaulacales, Dinophyceae)
- Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)
- Seasonal oyster harvesting recorded in a Late Archaic period shell ring
- Population preferences for breast cancer screening policies: Discrete choice experiment in Belarus
- Respiratory health and inflammatory markers - Exposure to respirable dust and quartz and chemical binders in Swedish iron foundries
- Trends and predictors of mother-to-child transmission of HIV in an era of protocol changes: Findings from two large health facilities in North East Nigeria
- Elevated Ki-67 (MIB-1) expression as an independent predictor for unfavorable pathologic outcomes and biochemical recurrence after radical prostatectomy in patients with localized prostate cancer: A propensity score matched study
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- Carvedilol improves glucose tolerance and insulin sensitivity in treatment of adrenergic overdrive in high fat diet-induced obesity in mice
- Institutional differences in USMLE Step 1 and 2 CK performance: Cross-sectional study of 89 US allopathic medical schools
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- Appropriate management of acute gastroenteritis in Australian children: A population-based study
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- ADAPTS: Automated deconvolution augmentation of profiles for tissue specific cells
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- Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains
- Genome-wide identification and characterization, phylogenetic comparison and expression profiles of SPL transcription factor family in B. juncea (Cruciferae)
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- Elevated interleukin-25 and its association to Th2 cytokines in systemic lupus erythematosus with lupus nephritis
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- Involvement of extracellular vesicles in the macrophage-tumor cell communication in head and neck squamous cell carcinoma
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- Concurrent validity and discriminative ability of Dutch performance-based motor tests in 5 to 6 years old children
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- Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia
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- The impact of “male clinics” on health-seeking behaviors of adult men in rural Kenya
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- Utility of the new cobas HCV test for viral load monitoring during direct-acting antiviral therapy
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- Streptococcal phosphotransferase system imports unsaturated hyaluronan disaccharide derived from host extracellular matrices
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- Effects of an incremental theory of personality intervention on the reciprocity between bullying and cyberbullying victimization and perpetration in adolescents
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- Reproducibility, stability, and accuracy of microbial profiles by fecal sample collection method in three distinct populations
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- A global overview of cassava genetic diversity
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- Evaluation of comprehensive improvement for mild and moderate soil salinization in arid zone
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- Magnitude and associated factors of postpartum depression among women in Nekemte town, East Wollega zone, west Ethiopia, 2019: A community-based study
- Comparison of continuous wave and cold lateral condensation filling techniques in 3D printed simulated C-shape canals instrumented with Reciproc Blue or Hyflex EDM
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- The household economic costs associated with depression symptoms: A cross-sectional household study conducted in the North West province of South Africa
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- Characterization of two thermophilic cellulases from Talaromyces leycettanus JCM12802 and their synergistic action on cellulose hydrolysis
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- Improving the antimicrobial efficacy against resistant Staphylococcus aureus by a combined use of conjugated oligoelectrolytes
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- Effects of virtual reality rehabilitation training on gait and balance in patients with Parkinson's disease: A systematic review
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- Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China
- One-year follow-up of changes in refraction and aberrations induced by corneal incision
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- An assessment of the Dutch experience with health insurers acting as healthcare advisors
- Perception of potential harm and benefits of HIV vaccine trial participation: A qualitative study from urban Tanzania
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- Deep brain stimulation restores the glutamatergic and GABAergic synaptic transmission and plasticity to normal levels in kindled rats
- Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals
- Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model
- Long-term retention on antiretroviral therapy among infants, children, adolescents and adults in Malawi: A cohort study
- Histochemical quantification of collagen content in articular cartilage
- Optogenetically transduced human ES cell-derived neural progenitors and their neuronal progenies: Phenotypic characterization and responses to optical stimulation
- Ion torrent high throughput mitochondrial genome sequencing (HTMGS)
- Outpatient antibiotic prescription rate and pattern in the private sector in India: Evidence from medical audit data
- Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination
- Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon
- Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures
- CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say
- Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches
- Proton pump inhibitor use increases the risk of peritonitis in peritoneal dialysis patients
- Comparative distribution of extended-spectrum beta-lactamase–producing Escherichia coli from urine infections and environmental waters
- Sex differences in thigh muscle volumes, sprint performance and mechanical properties in national-level sprinters
- Maternal serum and cord blood leptin concentrations at delivery
- Winter nitrification in ice-covered lakes
- Intolerance of uncertainty fuels depressive symptoms through rumination: Cross-sectional and longitudinal studies
- Monitoring exercise-induced muscle damage indicators and myoelectric activity during two weeks of knee extensor exercise training in young and old men
- Can adoption of pollution prevention techniques reduce pollution substitution?
- The association between self-efficacy and self-management behaviors among Chinese patients with type 2 diabetes
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- Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study
- Evaluation of forearm vascular resistance during orthostatic stress: Velocity is proportional to flow and size doesn’t matter
- Proton pencil minibeam irradiation of an in-vivo mouse ear model spares healthy tissue dependent on beam size
- Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring
- Aspartate aminotransferase-to-platelet ratio index (APRI): A potential marker for diagnosis in patients at risk of severe malaria caused by Plasmodium vivax
- Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology
- Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal
- Clinical characteristics of neonatal fulminant necrotizing enterocolitis in a tertiary Children's hospital in the last 10 years
- Effects of neuromuscular electrical stimulation training on muscle size in collegiate track and field athletes
- Adaptive fuzzy flow rate control considering multifractal traffic modeling and 5G communications
- Evaluation of four commercial tests for detecting ceftiofur in waste milk bulk tank samples
- A smart tele-cytology point-of-care platform for oral cancer screening
- Vasopressin SNP pain factors and stress in sickle cell disease
- Carbonate production of Micronesian reefs suppressed by thermal anomalies and Acanthaster as sea-level rises
- Microbial metabolisms in an abyssal ferromanganese crust from the Takuyo-Daigo Seamount as revealed by metagenomics
- Incidence of chronic kidney disease hospitalisations and mortality in Espírito Santo between 1996 to 2017
- The impact of short-term machine perfusion on the risk of cancer recurrence after rat liver transplantation with donors after circulatory death
- Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS)
- Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012
- The effects of prolonged single night session of videogaming on sleep and declarative memory
- Diversity, distribution and dynamics of large trees across an old-growth lowland tropical rain forest landscape
- Mapping developmental QTL for plant height in soybean [Glycine max (L.) Merr.] using a four-way recombinant inbred line population
- Vaginal ring acceptability and related preferences among women in low- and middle-income countries: A systematic review and narrative synthesis
- UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal
- Positive selection and precipitation effects on the mitochondrial NADH dehydrogenase subunit 6 gene in brown hares (Lepus europaeus) under a phylogeographic perspective
- Evaluation of Minimum Inhibitory Concentrations for 154 Mycoplasma synoviae isolates from Italy collected during 2012-2017
- Enhancement of antibiotics antimicrobial activity due to the silver nanoparticles impact on the cell membrane
- Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
- Correction: Effect of corruption on perceived difficulties in healthcare access in sub-Saharan Africa
- Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters
- Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects
- Integrated value-chain and risk assessment of Pig-Related Zoonoses in Ghana
- Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy
- Cassava yield traits predicted by genomic selection methods
- Verification of hub genes in the expression profile of aortic dissection
- Pig farmers’ willingness to pay for management strategies to reduce aggression between pigs
- Metabolomic response of Euglena gracilis and its bleached mutant strain to light
- Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis
- Newly educated care managers’ experiences of providing care for persons with stress-related mental disorders in the clinical primary care context
- Real-time telemetry monitoring of oxygen in the central complex of freely-walking Gromphadorhina portentosa
- Qualification programmes for immigrant health professionals: A systematic review
- An analytical model to minimize the latency in healthcare internet-of-things in fog computing environment
- Grain filling of early-season rice cultivars grown under mechanical transplanting
- Intercalation of small molecules into DNA in chromatin is primarily controlled by superhelical constraint
- Correlative evidence for co-regulation of phosphorus and carbon exchanges with symbiotic fungus in the arbuscular mycorrhizal Medicago truncatula
- How to design a dose-finding study on combined agents: Choice of design and development of R functions
- Altered expression of Notch1 in Alzheimer's disease
- The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women
- Trunk velocity-dependent Light Touch reduces postural sway during standing
- Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: An investigation in 78 cases using STARD guidelines
- Trade-offs in motivating volunteer effort: Experimental evidence on voluntary contributions to science
- Does caching strategy vary with microclimate in endangered Mt. Graham red squirrels?
- Assessment of energy expenditure during high intensity cycling and running using a heart rate and activity monitor in young active adults
- Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)
- Implementation of a screening, brief intervention and referral to treatment programme for risky substance use in South African emergency centres: A mixed methods evaluation study
- Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study
- The calcium sensor OsCBL1 modulates nitrate signaling to regulate seedling growth in rice
- Acceptability of and treatment preferences for recurrent bacterial vaginosis—Topical lactic acid gel or oral metronidazole antibiotic: Qualitative findings from the VITA trial
- Mathematical determination of the HIV-1 matrix shell structure and its impact on the biology of HIV-1
- Contingent negative variation during a modified cueing task in simulated driving
- CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition
- Effect of feeding patterns on growth and nutritional status of children aged 0-24 months: A Chinese cohort study
- A fecal sequel: Testing the limits of a genetic assay for bat species identification
- Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study
- Short and long-term clinical effectiveness and cost-effectiveness of a late-phase community-based balance and gait exercise program following hip fracture. The EVA-Hip Randomised Controlled Trial
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- Brazilian norms for the Bank of Standardized Stimuli (BOSS)
- Distinct varieties of aesthetic chills in response to multimedia
- Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses’ Health Study
- Correction: Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
- New formulation of the Gompertz equation to describe the kinetics of untreated tumors
- Development of visual perception of others’ actions: Children’s judgment of lifted weight
- Retrospective comparative analysis of intraocular lens calculation formulas after hyperopic refractive surgery
- Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution
- Development and validation of exhaled breath condensate microRNAs to identify and endotype asthma in children
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- Risk factors affecting dairy cattle protective grouping behavior, commonly known as bunching, against Stomoxys calcitrans (L.) on California dairies
- Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing
- Characterisation and microbial community analysis of lipid utilising microorganisms for biogas formation
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- Exploring optimization strategies for improving explicit water models: Rigid n-point model and polarizable model based on Drude oscillator
- Artificial insemination with fresh, liquid stored and frozen thawed semen in dromedary camels
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- Numerical study on the start and unstart phenomena in a scramjet inlet-isolator model
- Effects of dietary supplementation with apple peel powder on the growth, blood and liver parameters, and transcriptome of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
- Urban growth simulation in different scenarios using the SLEUTH model: A case study of Hefei, East China
- Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
- Factors associated with medication adherence among people with diabetes mellitus in poor urban areas of Cambodia: A cross-sectional study
- Mammary microbiome of lactating organic dairy cows varies by time, tissue site, and infection status
- Force field generalization and the internal representation of motor learning
- Polyphenism of visual and chemical secondary sexually-selected wing traits in the butterfly Bicyclus anynana: How different is the intermediate phenotype?
- Minimal genetic differentiation of the malaria vector Nyssorhynchus darlingi associated with forest cover level in Amazonian Brazil
- The impact of leisure activities on older adults’ cognitive function, physical function, and mental health
- scafSLICR: A MATLAB-based slicing algorithm to enable 3D-printing of tissue engineering scaffolds with heterogeneous porous microarchitecture
- Association of serum leptin and adiponectin concentrations with echocardiographic parameters and pathophysiological states in patients with cardiovascular disease receiving cardiovascular surgery
- Operation of cognitive memory inhibition in adults with Down syndrome: Effects of maintenance load and material
- Influences on surgical antimicrobial prophylaxis decision making by surgical craft groups, anaesthetists, pharmacists and nurses in public and private hospitals
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- Expression of Concern: The Role of the RACK1 Ortholog Cpc2p in Modulating Pheromone-Induced Cell Cycle Arrest in Fission Yeast
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- Investigating cooperation with robotic peers
- Synthesis, purification and crystallization of a putative critical bulge of HAR1 RNA
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- Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
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- Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis
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- Improvements in the learnability of smartphone haptic interfaces for visually impaired users
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- Cyclic loading test study on a new cast-in-situ insulated sandwich concrete wall
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- Prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients
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- Real-world evidence of the effectiveness of ombitasvir-paritaprevir/r ± dasabuvir ± ribavirin in patients monoinfected with chronic hepatitis C or coinfected with human immunodeficiency virus-1 in Spain
- Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
- Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice
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- Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation
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- Reorganization of spatial configurations in visual working memory: A matter of set size?
- Unravelling travellers’ route choice behaviour at full-scale urban network by focusing on representative OD pairs in computer experiments
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- Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis
- Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population
- Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians
- Increasing knowledge of HIV status in a country with high HIV testing coverage: Results from the Botswana Combination Prevention Project
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- Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis
- Identifying candidate diagnostic markers for early stage of non-small cell lung cancer
- Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
- Correction: KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway
- Unique developmental trajectories of risk behaviors in adolescence and associated outcomes in young adulthood
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- Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants
- Foxtail millet (Setaria italica (L.) P. Beauv) CIPKs are responsive to ABA and abiotic stresses
- Autonomous drone hunter operating by deep learning and all-onboard computations in GPS-denied environments
- Heterogeneity Diffusion Imaging of gliomas: Initial experience and validation
- Frequency cluster formation and slow oscillations in neural populations with plasticity
- DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy
- Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
- Analytical solution to swing equations in power grids
- Pathways to conspiracy: The social and linguistic precursors of involvement in Reddit’s conspiracy theory forum
- Spatiotemporally random and diverse grid cell spike patterns contribute to the transformation of grid cell to place cell in a neural network model
- Empathic concern and personal distress depend on situational but not dispositional factors
- Who is more susceptible to job stressors and resources? Sensory-processing sensitivity as a personal resource and vulnerability factor
- Cost-effectiveness of integrating postpartum antiretroviral therapy and infant care into maternal & child health services in South Africa
- A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
- One step at a time: Physical activity is linked to positive interpretations of ambiguity
- Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells
- Evaluation of various methods of selection of B. subtilis strains capable of secreting surface-active compounds
- Association between US Pharmacopeia (USP) monograph standards, generic entry and prescription drug costs
- Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects
- On sorption hysteresis in wood: Separating hysteresis in cell wall water and capillary water in the full moisture range
- Inbreeding, Allee effects and stochasticity might be sufficient to account for Neanderthal extinction
- Reliability and construct validity of the stepping-forward affordance perception test for fall risk assessment in community-dwelling older adults
- Socioeconomic determinants of nutritional status among ‘Baiga’ tribal children In Balaghat district of Madhya Pradesh: A qualitative study
- Study on characteristics of fire plume in building facade window under lateral blow
- ‘When you talk to someone in a bad way or always put her under pressure, it is actually worse than beating her’: Conceptions and experiences of emotional intimate partner violence in Rwanda and South Africa
- Effects of 6-mercaptopurine in pressure overload induced right heart failure
- The association between haemoglobin levels in the first 20 weeks of pregnancy and pregnancy outcomes
- Implementation and evaluation of an antimicrobial stewardship programme in companion animal clinics: A stepped-wedge design intervention study
- Factors associated with persistently high-cost health care utilization for musculoskeletal pain
- Nitrogen and chlorophyll status determination in durum wheat as influenced by fertilization and soil management: Preliminary results
- Effect of repeated in vivo microCT imaging on the properties of the mouse tibia
- Coupling environment and physiology to predict effects of climate change on the taxonomic and functional diversity of fish assemblages in the Murray-Darling Basin, Australia
- Hematology and plasma biochemistries in the Blanding’s turtle (Emydoidea blandingii) in Lake County, Illinois
- CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae
- Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors
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- Why men with a low-risk prostate cancer select and stay on active surveillance: A qualitative study
- Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis
- Combined treatment (image-guided thrombectomy and endovascular therapy with open femoral access) for acute lower limb ischemia: Clinical efficacy and outcomes
- Low-latency single channel real-time neural spike sorting system based on template matching
- Quantifying the scale effect in geospatial big data using semi-variograms
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- Spatial and temporal variations in female size at maturity of a Southern Rock Lobster (Jasus edwardsii) population: A likely response to climate change
- Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
- Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies
- Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity
- Magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, Southwest, Ethiopia, 2018: A cross -sectional study
- Effectiveness of telerehabilitation in the management of adults with stroke: A systematic review
- Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys
- Correction: Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin
- Retraction: Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization
- Evaluation of neutral oral contrast agents for assessment of the small bowel at abdominal staging CT
- Blood type and breed-associated differences in cell marker expression on equine bone marrow-derived mesenchymal stem cells including major histocompatibility complex class II antigen expression
- Induced abortion and future use of IVF treatment; A nationwide register study
- Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan
- Measurement of finger joint angle using stretchable carbon nanotube strain sensor
- Determinants of mortality among patients with drug-resistant tuberculosis in northern Nigeria
- Drugs modulating stochastic gene expression affect the erythroid differentiation process
- Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study
- Prognostic value of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma treated with transarterial chemotherapy: A systematic review and meta-analysis
- Avermectin induces the oxidative stress, genotoxicity, and immunological responses in the Chinese Mitten Crab, Eriocheir sinensis
- Antibiotic use in mandarin production (Citrus reticulata Blanco) in major mandarin-producing areas in Thailand: A survey assessment
- Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits
- Correction: Good and Bad in the Hands of Politicians: Spontaneous Gestures during Positive and Negative Speech
- Adolescents with worse levels of oral health literacy have more cavitated carious lesions
- Effective methods for the inactivation of Francisella tularensis
- Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients
- Correlation between internal pudendal artery stenosis and erectile dysfunction in patients with suspected coronary artery disease
- Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation
- Population productivity of shovelnose rays: Inferring the potential for recovery
- Correction: Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era
- Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis
- Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression
- Changes in weight and body composition across five years at university: A prospective observational study
- Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning
- Effects of insulin signaling on mouse taste cell proliferation
- Patient-level cost of home- and facility-based child pneumonia treatment in Suba Sub County, Kenya
- TAP: A static analysis model for PHP vulnerabilities based on token and deep learning technology
- Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil
- Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: Results of a cluster randomized controlled trial
- Changes over time in creatinine clearance and comparison of emergent adverse events for HIV-positive adults receiving standard doses (300 mg/day) of lamivudine-containing antiretroviral therapy with baseline creatinine clearance of 30–49 vs ≥50 mL/min
- Population dynamics of foxes during restricted-area culling in Britain: Advancing understanding through state-space modelling of culling records
- Impacts of experimental advisory exit speed sign on traffic speeds for freeway exit ramp
- In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium
- Monitoring quality indicators for the Xpert MTB/RIF molecular assay in Ethiopia
- Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
- Correction: Using remote sensing to detect whale strandings in remote areas: The case of sei whales mass mortality in Chilean Patagonia
- Comparison of the inoculum size effects of antibiotics on IMP-6 β-lactamase-producing Enterobacteriaceae co-harboring plasmid-mediated quinolone resistance genes
- Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma
- Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720
- Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
- Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels
- Comparison of two experimental ARDS models in pigs using electrical impedance tomography
- Are primary school children attending full-day school still engaged in sports clubs?
- Stroke risks in women with dysmenorrhea by age and stroke subtype
- Changes in patterns of mortality rates and years of life lost due to firearms in the United States, 1999 to 2016: A joinpoint analysis
- In vitro modeling of Batrachochytrium dendrobatidis infection of the amphibian skin
- Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients
- Correction: Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods
- Characterisation of early metazoan secretion through associated signal peptidase complex subunits, prohormone convertases and carboxypeptidases of the marine sponge (Amphimedon queenslandica)
- Time trends between 2002 and 2017 in correlates of self-reported sitting time in European adults
- Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis
- Changes in HbA1c during the first six years after the diagnosis of Type 2 diabetes mellitus predict long-term microvascular outcomes
- Correction: Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
- Correction: Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Establishing an infrastructure for collaboration in primate cognition research
- Correction: The impact of public health insurance on health care utilisation, financial protection and health status in low- and middle-income countries: A systematic review
- Health provider and service-user experiences of sensory modulation rooms in an acute inpatient psychiatry setting
- Comparison of potential drug-drug interactions with metabolic syndrome medications detected by two databases
- The Polish version of the Cultural Intelligence Scale: Assessment of its reliability and validity among healthcare professionals and medical faculty students
- Selection of optimal reference genes for qRT-PCR analysis of shoot development and graviresponse in prostrate and erect chrysanthemums
- Metastasis risk prediction model in osteosarcoma using metabolic imaging phenotypes: A multivariable radiomics model
- Defining hospital community benefit activities using Delphi technique: A comparison between China and the United States
- Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
- A robust multi-objective optimization framework to capture both cellular and intercellular properties in cardiac cellular model tuning: Analyzing different regions of membrane resistance profile in parameter fitting
- Sea star wasting disease demography and etiology in the brooding sea star Leptasterias spp.
- Diagnostic plasma miRNA-profiles for ovarian cancer in patients with pelvic mass
- Genetic diversity and drug resistance of HIV-1 among infected pregnant women newly diagnosed in Luanda, Angola
- I’ve been robbed! – Can changes in floral traits discourage bee pollination?
- Visualising statistical models using dynamic nomograms
- Assessing the capacity of Malawi’s district and central hospitals to manage traumatic diaphyseal femoral fractures in adults
- Diagnostic performance of basal cortisol level at 0900-1300h in adrenal insufficiency
- The Mastery Rubric for Bioinformatics: A tool to support design and evaluation of career-spanning education and training
- Microdissection and whole chromosome painting confirm karyotype transformation in cryptic species of the Lariophagus distinguendus (Förster, 1841) complex (Hymenoptera: Pteromalidae)
- Quality of Kangaroo Mother Care services in Ethiopia: Implications for policy and practice
- Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid cancer
- iTRAQ-based high-throughput proteomics analysis reveals alterations of plasma proteins in patients infected with human bocavirus
- The detection of a non-anemophilous plant species using airborne eDNA
- Perception and control of low cable operation forces in voluntary closing body-powered upper-limb prostheses
- Neoadjuvant chemotherapy plus surgery versus concurrent chemoradiotherapy in stage IB2-IIB cervical cancer: A systematic review and meta-analysis
- Randomized methods to characterize large-scale vortical flow networks
- Disentangling the coexistence strategies of mud-daubing wasp species through trophic analysis in oases of Baja California peninsula
- Front-of-pack nutritional labels: Understanding by low- and middle-income Mexican consumers
- Distress in patients with end-stage renal disease: Staff perceptions of barriers to the identification of mild-moderate distress and the provision of emotional support
- Pathways to antibiotics in Bangladesh: A qualitative study investigating how and when households access medicine including antibiotics for humans or animals when they are ill
- DOC export is exceeded by C fixation in May Creek: A late-successional watershed of the Copper River Basin, Alaska
- Behavioral observation of prosocial behavior and social initiative is related to preschoolers’ psychopathological symptoms
- Evaluating the impact of citations of articles based on knowledge flow patterns hidden in the citations
- Correction: Economic sanctions and academia: Overlooked impact and long-term consequences
- Correction: A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization
- Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
- Price dispersion of generic medications
- Sex differences in body composition but not neuromuscular function following long-term, doxycycline-induced reduction in circulating levels of myostatin in mice
- The emotion regulation effect of cognitive control is related to depressive state through the mediation of rumination: An ERP study
- Comparison of SMS-EPI and 3D-EPI at 7T in an fMRI localizer study with matched spatiotemporal resolution and homogenized excitation profiles
- Left ventricular mass normalization for body size in children based on an allometrically adjusted ratio is as accurate as normalization based on the centile curves method
- Correction: Combining biophysical parameters, spectral indices and multivariate hyperspectral models for estimating yield and water productivity of spring wheat across different agronomic practices
- Correction: Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- 'Small small quarrels bring about happiness or love in the relationships’: Exploring community perceptions and gendered norms contributing to male perpetrated intimate partner violence in the Central Region of Ghana
- The performance of practitioners conducting facial comparisons on images of children across age
- Increased amounts and stability of telomeric repeat-containing RNA (TERRA) following DNA damage induced by etoposide
- Patients with limitation or withdrawal of life supporting care admitted in a medico-surgical intermediate care unit: Prevalence, description and outcome over a six-month period
- Correction: Diverse radiofrequency sensitivity and radiofrequency effects of mobile or cordless phone near fields exposure in Drosophila melanogaster
- Predicting the performance of TV series through textual and network analysis: The case of Big Bang Theory
- Risk of temperature, humidity and concentrations of air pollutants on the hospitalization of AECOPD
- Mixed methods grant applications in the health sciences: An analysis of reviewer comments
- Renal abnormalities among children with sickle cell conditions in highly resource-limited setting in Ghana
- Size matters: How reaching and vergence movements are influenced by the familiar size of stereoscopically presented objects
- Willingness to receive institutional and community-based eldercare among the rural elderly in China
- An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences
- Beyond executive functions, creativity skills benefit academic outcomes: Insights from Montessori education
- A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions
- Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease
- Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma
- The fight against polio through the NO-DO newsreels during the Francoism period in Spain
- Ocean sound levels in the northeast Pacific recorded from an autonomous underwater glider
- Cost-consequence analysis of influenza vaccination among the staff of a large teaching hospital in Rome, Italy: A pilot study
- The relationship among the progression of inflammation in umbilical cord, fetal inflammatory response, early-onset neonatal sepsis, and chorioamnionitis
- How medical professional students view older people with dementia: Implications for education and practice
- An enhanced nonparametric EWMA sign control chart using sequential mechanism
- Land use change, carbon stocks and tree species diversity in green spaces of a secondary city in Myanmar, Pyin Oo Lwin
- Is there a difference in women’s experiences of care with medication vs. manual vacuum aspiration abortions? Determinants of person-centered care for abortion services
- Maternal complications in pregnancy and childbirth for women with epilepsy: Time trends in a nationwide cohort
- Adsorption of oxytetracycline on kaolinite
- Interdisciplinary stratified care for low back pain: A qualitative study on the acceptability, potential facilitators and barriers to implementation
- The role of resource transfer in positive, non-additive litter decomposition
- The impact of language on the interpretation of resuscitation clinical care plans by doctors. A mixed methods study
- Quantum dots reveal heterogeneous membrane diffusivity and dynamic surface density polarization of dopamine transporter
- Genomic analysis of Shiga toxin-producing Escherichia coli from patients and asymptomatic food handlers in Japan
- The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress
- Anatomical, taxonomic, and phylogenetic reappraisal of a poorly known ghost knifefish, Tembeassu marauna (Ostariophysi: Gymnotiformes), using X-ray microcomputed tomography
- Matrix-assisted laser desorption/ionization time of flight mass spectrometry identification of Vibrio (Listonella) anguillarum isolated from sea bass and sea bream
- Recommendations of older adults on how to use the PROM ‘TOPICS-MDS’ in healthcare conversations: A Delphi study
- The winner takes it all—Competitiveness of single nodes in globalized supply networks
- Hamsters in the city: A study on the behaviour of a population of common hamsters (Cricetus cricetus) in urban environment
- Correction: Liquid biopsies for omics-based analysis in sentinel mussels
- Size matters! Association between journal size and longitudinal variability of the Journal Impact Factor
- Drug resistance and epidemiology characteristics of multidrug-resistant tuberculosis patients in 17 provinces of China
- A model-based framework for chronic hepatitis C prevalence estimation
- Adding rewards to regulation: The impacts of watershed conservation on land cover and household wellbeing in Moyobamba, Peru
- Clinical determinants of social media use in individuals with schizophrenia
- Arsenic and nutrient absorption characteristics and antioxidant response in different leaves of two ryegrass (Lolium perenne) species under arsenic stress
- An evolution of socioeconomic related inequality in teenage pregnancy and childbearing in Malawi
- A single plasmid based CRISPR interference in Synechocystis 6803 – A proof of concept
- Structural vulnerability to narcotics-driven firearm violence: An ethnographic and epidemiological study of Philadelphia’s Puerto Rican inner-city
- Temporal trends in intracerebral hemorrhage: Evidence from the Austrian Stroke Unit Registry
- Prevalence and risk factors for multi-drug resistant Escherichia coli among poultry workers in the Federal Capital Territory, Abuja, Nigeria
- Prediction of disease-related metabolites using bi-random walks
- Clinical use, efficacy, and durability of maraviroc for antiretroviral therapy in routine care: A European survey
- Biomarker discovery in inflammatory bowel diseases using network-based feature selection
- The Cinderella Complex: Word embeddings reveal gender stereotypes in movies and books
- Exoproteome profiling of Trypanosoma cruzi during amastigogenesis early stages
- Reproducible phenotype alteration due to prolonged cooling of the pupae of Polyommatus icarus butterflies
- Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats
- Pharmacy-based predictors of non-adherence, non-persistence and reinitiation of antihypertensive drugs among patients on oral diabetes drugs in the Netherlands
- Systematic review of the accuracy of plasma preparation tubes for HIV viral load testing
- Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex
- “Anybody can make kids; it takes a real man to look after your kids”: Aboriginal men’s discourse on parenting
- Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions
- Maternal interpregnancy weight change and premature birth: Findings from an English population-based cohort study
- Correction: Identifying performance benchmarks and determinants for reproductive performance and calf survival using a longitudinal field study of cow-calf herds in western Canada
- Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease
- Treatment of Urethral Pain Syndrome (UPS) in Sweden
- Migration and political polarization in the U.S.: An analysis of the county-level migration network
- Epidemiology and complications of late-onset sepsis: an Italian area-based study
- The relationship between women’s experience of intimate partner violence and other socio-demographic factors, and under-5 children’s health in South Africa
- Association between trunk and gluteus muscle size and long jump performance
- Multimorbidity and complex multimorbidity in Brazilian rural workers
- Correction: Interspecific Phylogenic Relationships within Genus Melilotus Based on Nuclear and Chloroplast DNA
- Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions
- Wolf diet and prey selection in the South-Eastern Carpathian Mountains, Romania
- In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms
- Sample size issues in multilevel logistic regression models
- Seed germination ecology of Ageratum houstonianum: A major invasive weed in Nepal
- Experiences of lifestyle change among women with gestational diabetes mellitus (GDM): A behavioural diagnosis using the COM-B model in a low-income setting
- Pharmacologic management of HCV treatment in patients with HCV monoinfection vs. HIV/HCV coinfection: Does coinfection really matter?
- The association between cigarette smoking and serum thyroid stimulating hormone, thyroid peroxidase antibodies and thyroglobulin antibodies levels in Chinese residents: A cross-sectional study in 10 cities
- Mouse movement measures enhance the stop-signal task in adult ADHD assessment
- Ecosystem functioning in urban grasslands: The role of biodiversity, plant invasions and urbanization
- Correction: KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
- Does craniofacial morphology affect third molars impaction? Results from a population-based study in northeastern Germany
- Hyperconnectivity during screen-based stories listening is associated with lower narrative comprehension in preschool children exposed to screens vs dialogic reading: An EEG study
- Weight loss is associated with improved quality of life among rural women completers of a web-based lifestyle intervention
- Long-term high-grain diet altered the ruminal pH, fermentation, and composition and functions of the rumen bacterial community, leading to enhanced lactic acid production in Japanese Black beef cattle during fattening
- Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile
- Golgi reassembly and stacking protein 65 downregulation is required for the anti-cancer effect of dihydromyricetin on human ovarian cancer cells
- SSR marker development in Clerodendrum trichotomum using transcriptome sequencing
- Risk factors for the carriage of Streptococcus infantarius subspecies infantarius isolated from African fermented dairy products
- Development of an intervention tool for precision oral self-care: Personalized and evidence-based practice for patients with periodontal disease
- Personal values in adolescence and psychological distress in adults: A cross-sectional study based on a retrospective recall
- Overactive bladder and bladder pain syndrome/interstitial cystitis in primary Sjögren’s syndrome patients: A nationwide population-based study
- Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: A retrospective review from a single center
- Hip stress distribution - Predictor of dislocation in hip arthroplasties. A retrospective study of 149 arthroplasties
- Mortality, morbidity, and cardiac surgery in Injection Drug Use (IDU)-associated versus non-IDU infective endocarditis: The need to expand substance use disorder treatment and harm reduction services
- Pup mortality in New Zealand sea lions (Phocarctos hookeri) at Enderby Island, Auckland Islands, 2013-18
- In vitro endothelial cell migration from limbal edge-modified Quarter-DMEK grafts
- Liquid Chromatography/Mass Spectrometry based serum metabolomics study on recurrent abortion women with antiphospholipid syndrome
- Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors
- Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty
- Reliability of the Swedish version of the Evidence-Based Practice Attitude Scale assessing physiotherapist’s attitudes to implementation of evidence-based practice
- Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS
- Complete Chloroplast Genomes of Vachellia nilotica and Senegalia senegal: Comparative Genomics and Phylogenomic Placement in a New Generic System
- Retraction: Over-Expression of Superoxide Dismutase Ameliorates Cr(VI) Induced Adverse Effects via Modulating Cellular Immune System of Drosophila melanogaster
- Effect of pre-season training phase on anthropometric, hormonal and fitness parameters in young soccer players
- Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis
- Outcome of patients with heart failure after transcatheter aortic valve implantation
- Fatty acid profile of Romanian’s common bean (Phaseolus vulgaris L.) lipid fractions and their complexation ability by β-cyclodextrin
- Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding
- Treatment of corneal endothelial damage in a rabbit model with a bioengineered graft using human decellularized corneal lamina and cultured human corneal endothelium
- Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis
- Correction: Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
- Correction: Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
- Retraction: Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage
- Correction: Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
- Correction: The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study
- Correction: Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
- Discovering novel disease comorbidities using electronic medical records
- Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome
- Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics
- Social information use in adolescents: The impact of adults, peers and household composition
- Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members
- Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial
- Comparative studies of two generations of NanoString nCounter System
- General practitioners’ perceptions of delayed antibiotic prescription for respiratory tract infections: A phenomenographic study
- Can altered magnetic field affect the foraging behaviour of ants?
- Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011–2018
- A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma
- A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE
- Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma
- Seasonal alternation of the ontogenetic development of the moon jellyfish Aurelia coerulea in Maizuru Bay, Japan
- Reliability of measurement of active trunk movement in wheelchair basketball players
- Chinese SLE Treatment and Research group (CSTAR) registry: Clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus
- Does source credibility matter for point-of-decision prompts? A quasi-experimental field study to increase stair use
- Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study
- Quality and utilization patterns of maternity waiting homes at referral facilities in rural Zambia: A mixed-methods multiple case analysis of intervention and standard of care sites
- Determining an optimal pool size for testing beef herds for Johne’s disease in Australia
- Correction: Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
- APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix
- Testing Species Assignments in Extant Terebratulide Brachiopods: A Three-dimensional Geometric Morphometric Analysis of Long-Looped Brachidia
- A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
- Improved chemotherapy modeling with RAG-based immune deficient mice
- Effect of tracheal antimicrobial peptide on the development of Mannheimia haemolytica pneumonia in cattle
- The internal realities of individuals with type 2 diabetes – a functional framework of self-management practices via Grounded Theory approach
- Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia
- eIF4E and 4EBP1 are prognostic markers of head and neck squamous cell carcinoma recurrence after definitive surgery and adjuvant radiotherapy
- Smoking and other determinants of bone turnover
- Oxygen delivery, oxygen consumption and decreased kidney function after cardiopulmonary bypass
- School engagement of children in early grades: Psychometric, and gender comparisons
- Correction: A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
- Perceived attractiveness of Czech faces across 10 cultures: Associations with sexual shape dimorphism, averageness, fluctuating asymmetry, and eye color
- Discovery of stable and prognostic CT-based radiomic features independent of contrast administration and dimensionality in oesophageal cancer
- Correction: Population-based dementia prediction model using Korean public health examination data: A cohort study
- Location, location, location: Close ties among older continuing care retirement community residents
- Correction: ISED: Constructing a high-resolution elevation road dataset from massive, low-quality in-situ observations derived from geosocial fitness tracking data
- Correction: Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies
- Monitoring fine root growth to identify optimal fertilization timing in a forest plantation: A case study in Northeast Vietnam
- Metabolic costs of spontaneous swimming in Sprattus sprattus L., at different water temperatures
- Enterovirus 71 vaccine acceptance among parents of children < 5 years old and their knowledge of hand, foot and mouth disease, Chongqing, China, 2017
- Correction: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing
- Genetic diversity and antiretroviral resistance-associated mutation profile of treated and naive HIV-1 infected patients from the Northwest and Southwest regions of Cameroon
- Maximum parsimony interpretation of chromatin capture experiments
- Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
- Incidence and characteristics of ventricular tachycardia in patients after percutaneous coronary revascularization of chronic total occlusions
- Estimating measures of latent variables from m-alternative forced choice responses
- Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates
- First evidence of hepatitis E virus infection in a small mammal (yellow-necked mouse) from Croatia
- The inhibitory effects of polypyrrole on the biofilm formation of Streptococcus mutans
- Self-reported adverse drug effects and associated factors among H. pylori infected patients on standard triple therapy: Prospective follow up study
- Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain
- Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
- Remote heart rate monitoring - Assessment of the Facereader rPPg by Noldus
- Seroprevalence of rubella virus antibodies among pregnant women in the Center and South-West regions of Cameroon
- Effectiveness of steam sterilization of reusable medical devices in primary and secondary care public hospitals in Nepal and factors associated with ineffective sterilization: A nation-wide cross-sectional study
- Relevance of HTLV-1 proviral load in asymptomatic and symptomatic patients living in endemic and non-endemic areas of Argentina
- Ritualized aggressive behavior reveals distinct social structures in native and introduced range tawny crazy ants
- The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury
- Screening and characterization of long noncoding RNAs involved in the albinism of Ananas comosus var. bracteatus leaves
- Visual attention to emotional faces in adolescents with social anxiety disorder receiving cognitive behavioral therapy
- A Q fever outbreak associated to courier transport of pets
- Antibodies against measles and rubella virus among different age groups in Thailand: A population-based serological survey
- Molecular diet analysis of Anguilliformes leptocephalus larvae collected in the western North Pacific
- Correction: The relationship between context, structure, and processes with outcomes of 6 regional diabetes networks in Europe
- Correction: The C-reactive protein/albumin ratio as an independent predictor of mortality in patients with severe sepsis or septic shock treated with early goal-directed therapy
- Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection
- Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data
- The implementation of HTA in medicine pricing and reimbursement policies in Indonesia: Insights from multiple stakeholders
- International experiences during United States ophthalmology residency training: Current structure of international experiences and perspectives of faculty mentors at United States training institutions
- Questionable utility of digoxin in left-ventricular assist device recipients: A multicenter, retrospective analysis
- Genotyping and outcomes of presumptive second line ART failure cases switched to third line or maintained on second line ART in Mumbai, India
- A mathematical model of honey bee colony dynamics to predict the effect of pollen on colony failure
- Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner
- An odorant receptor from Anopheles gambiae that demonstrates enantioselectivity to the plant volatile, linalool
- Factors associated with full immunization of children 12–23 months of age in Ethiopia: A multilevel analysis using 2016 Ethiopia Demographic and Health Survey
- Additional evidence that the rat renal interstitium contracts in vivo
- Factors affecting acceptance of at-birth point of care HIV testing among providers and parents in Kenya: A qualitative study
- Removal efficiency of central vacuum system and protective masks to suspended particles from dental treatment
- Psychological well-being and distress in patients with generalized anxiety disorder: The roles of positive and negative functioning
- Conventional rotator cuff versus all-suture anchors—A biomechanical study focusing on the insertion angle in an unlimited cyclic model
- Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD
- An evaluation of genetic causes and environmental risks for bilateral optic atrophy
- Comparative vector competence of the Afrotropical soft tick Ornithodoros moubata and Palearctic species, O. erraticus and O. verrucosus, for African swine fever virus strains circulating in Eurasia
- Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs
- Carbogen gas-challenge BOLD fMRI in assessment of liver hypoxia after portal microcapsules implantation
- Socioeconomic determinants of cancer screening utilisation in Latin America: A systematic review
- Development of an easy-to-use questionnaire assessing critical care nursing competence in Japan: A cross-sectional study
- Towards successful business process improvement – An extension of change acceleration process model
- Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
- Correction: Phylogenetic analysis of hepatitis C virus among HIV/ HCV co-infected patients in Nigeria
- Correction: Relationship between self-disclosure to first acquaintances and subjective well-being in people with schizophrenia spectrum disorders living in the community
- Impact of ATM rs1801516 on late skin reactions of radiotherapy for breast cancer: Evidences from a cohort study and a trial sequential meta-analysis
- Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport
- Soil organic matter rather than ectomycorrhizal diversity is related to urban tree health
- Clinical risk assessment in early pregnancy for preeclampsia in nulliparous women: A population based cohort study
- The relation between circulating levels of vitamin D and parathyroid hormone in children and adolescents with overweight or obesity: Quest for a threshold
- Behavioural evidence for segments as subordinate units in Chinese spoken word production: The form-preparation paradigm revisited
- Correction: Measuring the impact of an interdisciplinary learning project on nursing, architecture and landscape design students’ empathy
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- Improved oxygenation following methylprednisolone therapy and survival in paediatric acute respiratory distress syndrome
- Normative values for relative schoolbag weight in primary school children aged 6-14 from Czech Republic: A pilot study
- Correction: Intensive longitudinal modelling predicts diurnal activity of salivary alpha-amylase
- Correction: SNV discovery and functional candidate gene identification for milk composition based on whole genome resequencing of Holstein bulls with extremely high and low breeding values
- Monoclonal antibody anti-PBP2a protects mice against MRSA (methicillin-resistant Staphylococcus aureus) infections
- Diurnal variations of amplitude of accommodation in different age groups
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- Influence of season and social context on male giant panda (Ailuropoda melanoleuca) vocal behaviour
- Development of an intravaginal ring for the topical delivery of Aurora kinase A inhibitor, MLN8237
- Differential phosphorylation determines the repressor and activator potencies of GLI1 proteins and their efficiency in modulating the HPV life cycle
- Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women
- Depression increases the risk of rotator cuff tear and rotator cuff repair surgery: A nationwide population-based study
- Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes
- Correction: Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T
- Persistent post-discharge opioid prescribing after traumatic brain injury requiring intensive care unit admission: A cross-sectional study with longitudinal outcome
- Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP
- Aerobic exercise increases post-exercise exogenous protein oxidation in healthy young males
- Selection for tandem stop codons in ciliate species with reassigned stop codons
- Research ethics in inter- and multi-disciplinary teams: Differences in disciplinary interpretations
- Correction: Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
- Correction: People making deontological judgments in the Trapdoor dilemma are perceived to be more prosocial in economic games than they actually are
- LFRET, a novel rapid assay for anti-tissue transglutaminase antibody detection
- Effects of isotemporal substitution of sedentary behavior with light-intensity or moderate-to-vigorous physical activity on cardiometabolic markers in male adolescents
- Topical estrogen application to wounds promotes delayed cutaneous wound healing in 80-week-old female mice
- Correction: An international randomised placebo-controlled trial of a four-component combination pill (“polypill”) in people with raised cardiovascular risk
- Correction: Evaluation of lung toxicity risk with computed tomography ventilation image for thoracic cancer patients
- Retraction: Pathological Roles of Interleukin-22 in the Development of Recurrent Hepatitis C after Liver Transplantation
- Correction: Elevational Distribution and Ecology of Small Mammals on Tanzania's Second Highest Mountain
- Correction: Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer
- Correction: Fecal microbiota dysbiosis in macaques and humans within a shared environment
- Correction: The center of pressure and ankle muscle co-contraction in response to anterior-posterior perturbations
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