Placental imprinting: Emerging mechanisms and functions
Autoři:
Courtney W. Hanna aff001
Působiště autorů:
Centre for Trophoblast Research, Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom
aff001; Epigenetics Programme, Babraham Institute, Cambridge, United Kingdom
aff002
Vyšlo v časopise:
Placental imprinting: Emerging mechanisms and functions. PLoS Genet 16(4): e32767. doi:10.1371/journal.pgen.1008709
Kategorie:
Review
doi:
https://doi.org/10.1371/journal.pgen.1008709
Souhrn
As the maternal–foetal interface, the placenta is essential for the establishment and progression of healthy pregnancy, regulating both foetal growth and maternal adaptation to pregnancy. The evolution and functional importance of genomic imprinting are inextricably linked to mammalian placentation. Recent technological advances in mapping and manipulating the epigenome in embryogenesis in mouse models have revealed novel mechanisms regulating genomic imprinting in placental trophoblast, the physiological implications of which are only just beginning to be explored. This review will highlight important recent discoveries and exciting new directions in the study of placental imprinting.
Klíčová slova:
DNA methylation – Epigenetics – Gene expression – Gene regulation – Genetic loci – Genomic imprinting – Mouse models – Trophoblasts
Zdroje
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