Demographic history shaped geographical patterns of deleterious mutation load in a broadly distributed Pacific Salmon

English version

Autoři: Quentin Rougemont ^aff001; Jean-Sébastien Moore ^aff001; Thibault Leroy ^aff002; Eric Normandeau ^aff001; Eric B. Rondeau ^aff004; Ruth E. Withler ^aff006; Donald M. Van Doornik ^aff007; Penelope A. Crane ^aff008; Kerry A. Naish ^aff009; John Carlos Garza ^aff010; Terry D. Beacham ^aff006; Ben F. Koop ^aff004; Louis Bernatchez ^aff001
Působiště autorů: Département de Biologie, Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec, Québec, Canada ^aff001; ISEM, Univ. Montpellier, CNRS, EPHE, IRD, Montpellier, France ^aff002; Department of Botany & Biodiversity Research, University of Vienna, Vienna, Austria ^aff003; Centre for Biomedical Research, University of Victoria, Victoria, BC, Canada ^aff004; Department of Biology, University of Victoria, Victoria, BC, Canada ^aff005; Department of Fisheries and Ocean, Pacific Biological Station, Nanaimo, British Columbia, Canada ^aff006; National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Northwest Fisheries Science Center, Manchester Research Station, Port Orchard, Washington, United States of America ^aff007; Conservation Genetics Laboratory, U.S. Fish and Wildlife Service, Anchorage, Alaska, United States of America ^aff008; School of Aquatic and Fishery Sciences, University of Washington, Seattle, WA, United States of America ^aff009; Fisheries Ecology Division, Southwest Fisheries Science Center, National Marine Fisheries Service and Institute of Marine Sciences, University of California–Santa Cruz, Santa Cruz, California, United States of America ^aff010
Vyšlo v časopise: Demographic history shaped geographical patterns of deleterious mutation load in a broadly distributed Pacific Salmon. PLoS Genet 16(8): e32767. doi:10.1371/journal.pgen.1008348
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pgen.1008348

Souhrn

A thorough reconstruction of historical processes is essential for a comprehensive understanding of the mechanisms shaping patterns of genetic diversity. Indeed, past and current conditions influencing effective population size have important evolutionary implications for the efficacy of selection, increased accumulation of deleterious mutations, and loss of adaptive potential. Here, we gather extensive genome-wide data that represent the extant diversity of the Coho salmon (Oncorhynchus kisutch) to address two objectives. We demonstrate that a single glacial refugium is the source of most of the present-day genetic diversity, with detectable inputs from a putative secondary micro-refugium. We found statistical support for a scenario whereby ancestral populations located south of the ice sheets expanded recently, swamping out most of the diversity from other putative micro-refugia. Demographic inferences revealed that genetic diversity was also affected by linked selection in large parts of the genome. Moreover, we demonstrate that the recent demographic history of this species generated regional differences in the load of deleterious mutations among populations, a finding that mirrors recent results from human populations and provides increased support for models of expansion load. We propose that insights from these historical inferences should be better integrated in conservation planning of wild organisms, which currently focuses largely on neutral genetic diversity and local adaptation, with the role of potentially maladaptive variation being generally ignored.

Klíčová slova:

California – Deletion mutation – Effective population size – Gene flow – Genomics – Phylogeography – Population genetics – Species diversity

Zdroje

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