Reciprocal regulation between nicotinamide adenine dinucleotide metabolism and abscisic acid and stress response pathways in Arabidopsis
Autoři:
Yechun Hong aff001; Zhen Wang aff001; Huazhong Shi aff003; Juanjuan Yao aff001; Xue Liu aff001; Fuxing Wang aff001; Liang Zeng aff001; Zhi Xie aff001; Jian-Kang Zhu aff001
Působiště autorů:
Shanghai Center for Plant Stress Biology and Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China
aff001; University of Chinese Academy of Sciences, Shanghai, P.R. China
aff002; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, United States of America
aff003; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana, United States of America
aff004
Vyšlo v časopise:
Reciprocal regulation between nicotinamide adenine dinucleotide metabolism and abscisic acid and stress response pathways in Arabidopsis. PLoS Genet 16(6): e32767. doi:10.1371/journal.pgen.1008892
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pgen.1008892
Souhrn
Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme that has emerged as a central hub linking redox equilibrium and signal transduction in living organisms. The homeostasis of NAD is required for plant growth, development, and adaption to environmental cues. In this study, we isolated a chilling hypersensitive Arabidopsis thaliana mutant named qs-2 and identified the causal mutation in the gene encoding quinolinate synthase (QS) critical for NAD biosynthesis. The qs-2 mutant is also hypersensitive to salt stress and abscisic acid (ABA) but resistant to drought stress. The qs-2 mutant accumulates a reduced level of NAD and over-accumulates reactive oxygen species (ROS). The ABA-hypersensitivity of qs-2 can be rescued by supplementation of NAD precursors and by mutations in the ABA signaling components SnRK2s or RBOHF. Furthermore, ABA-induced over-accumulation of ROS in the qs-2 mutant is dependent on the SnRK2s and RBOHF. The expression of QS gene is repressed directly by ABI4, a transcription factor in the ABA response pathway. Together, our findings reveal an unexpected interplay between NAD biosynthesis and ABA and stress signaling, which is critical for our understanding of the regulation of plant growth and stress responses.
Klíčová slova:
Arabidopsis thaliana – Biosynthesis – Leaves – Phenotypes – Plant growth and development – Plant resistance to abiotic stress – Redox signaling – Seedlings
Zdroje
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