Independent validation of experimental results requires timely and unrestricted access to animal models and reagents
Autoři:
Cassandra R. Diegel aff001; Steven Hann aff002; Ugur M. Ayturk aff002; Jennifer C. W. Hu aff002; Kyung-eun Lim aff004; Casey J. Droscha aff001; Zachary B. Madaj aff005; Gabrielle E. Foxa aff001; Isaac Izaguirre aff001; aff006; Alexander G. Robling aff004; Matthew L. Warman aff002; Bart O. Williams aff001
Působiště autorů:
Program in Skeletal Disease and Tumor Microenvironment and Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, Michigan, United States of America
aff001; Orthopedic Research Labs, Boston Children’s Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
aff002; Musculoskeletal Integrity Program, Hospital for Special Surgery Research Institute, New York, New York, United States of America
aff003; Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
aff004; Bioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, Michigan, United States of America
aff005; Vivarium and Transgenics Core, Van Andel Institute, Grand Rapids, Michigan, United States of America
aff006
Vyšlo v časopise:
Independent validation of experimental results requires timely and unrestricted access to animal models and reagents. PLoS Genet 16(6): e32767. doi:10.1371/journal.pgen.1008940
Kategorie:
Formal Comment
doi:
https://doi.org/10.1371/journal.pgen.1008940
Zdroje
1. Diegel CR, Hann S, Ayturk UM, Hu JCW, Lim KE, et al. (2020) An osteocalcin-deficient mouse strain without endocrine abnormalities. PLoS Genet 16: e1008361. doi: 10.1371/journal.pgen.1008361 32463812
2. Ducy P, Desbois C, Boyce B, Pinero G, Story B, et al. (1996) Increased bone formation in osteocalcin-deficient mice. Nature 382: 448–452. doi: 10.1038/382448a0 8684484
3. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456–469. doi: 10.1016/j.cell.2007.05.047 17693256
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5. Moriishi T, Ozasa R, Ishimoto T, Nakano T, Hasegawa T, et al. (2020) Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass. PLoS Genet 16: e1008586. doi: 10.1371/journal.pgen.1008586 32463816
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8. von Herrath M, Pagni PP, Grove K, Christoffersson G, Tang-Christensen M, et al. (2019) Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes. Cell Metab 29: 795–802. doi: 10.1016/j.cmet.2019.02.004 30879984
9. Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, et al. (2008) Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135: 825–837. doi: 10.1016/j.cell.2008.09.059 19041748
10. Kode A, Obri A, Paone R, Kousteni S, Ducy P, et al. (2014) Lrp5 regulation of bone mass and serotonin synthesis in the gut. Nat Med 20: 1228–1229. doi: 10.1038/nm.3698 25375916
11. Cui Y, Niziolek PJ, MacDonald BT, Zylstra CR, Alenina N, et al. (2011) Lrp5 functions in bone to regulate bone mass. Nat Med 17: 684–691. doi: 10.1038/nm.2388 21602802
12. Cui Y, Niziolek PJ, MacDonald BT, Alenina N, Matthes S, et al. (2014) Reply to Lrp5 regulation of bone mass and gut serotonin synthesis. Nat Med 20: 1229–1230. doi: 10.1038/nm.3697 25375917
13. Lee GS, Simpson C, Sun BH, Yao C, Foer D, et al. (2014) Measurement of plasma, serum, and platelet serotonin in individuals with high bone mass and mutations in LRP5. J Bone Miner Res 29: 976–981. doi: 10.1002/jbmr.2086 24038240
14. National Academies of Sciences Engineering and Medicine (U.S.). Committee on Responsible Science, Committee on Science Engineering Medicine and Public Policy (U.S.) (2017) Fostering integrity in research. 1 online resource (1 PDF file (xv, 307 pages)) p.
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