Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling
Autoři:
Mengqing Wang aff001; Daniel Witvliet aff002; Mengting Wu aff001; Lijun Kang aff004; Zhiyong Shao aff001
Působiště autorů:
Department of Neurosurgery, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, China
aff001; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
aff002; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
aff003; Department of Neurobiology and Department of Neurosurgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
aff004
Vyšlo v časopise:
Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling. PLoS Genet 17(1): e1009295. doi:10.1371/journal.pgen.1009295
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pgen.1009295
Souhrn
Environmental factors such as temperature affect neuronal activity and development. However, it remains unknown whether and how they affect synaptic subcellular specificity. Here, using the nematode Caenorhabditis elegans AIY interneurons as a model, we found that high cultivation temperature robustly induces defects in synaptic subcellular specificity through glutamatergic neurotransmission. Furthermore, we determined that the functional glutamate is mainly released by the ASH sensory neurons and sensed by two conserved inhibitory glutamate-gated chloride channels GLC-3 and GLC-4 in AIY. Our work not only presents a novel neurotransmission-dependent mechanism underlying the synaptic subcellular specificity, but also provides a potential mechanistic insight into high-temperature-induced neurological defects.
Klíčová slova:
Neurotransmission – Genetically modified animals – Glutamate – Chlorides – Interneurons – Neurons – Synapses – Test statistics
Zdroje
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