Population structure of indigenous inhabitants of Arabia

English version

Autoři: Katsuhiko Mineta ^aff001; Kosuke Goto ^aff001; Takashi Gojobori ^aff001; Fowzan S. Alkuraya ^aff002
Působiště autorů: Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia ^aff001; Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia ^aff002; Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia ^aff003; Saudi Human Genome Program, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia ^aff004
Vyšlo v časopise: Population structure of indigenous inhabitants of Arabia. PLoS Genet 17(1): e1009210. doi:10.1371/journal.pgen.1009210
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pgen.1009210

Souhrn

Modern day Saudi Arabia occupies the majority of historical Arabia, which may have contributed to ancient waves of migration out of Africa. This ancient history has left a lasting imprint in the genetics of the region, including the diverse set of tribes that call Saudi Arabia their home. How these tribes relate to each other and to the world’s major populations remains an unanswered question. In an attempt to improve our understanding of the population structure of Saudi Arabia, we conducted genomic profiling of 957 unrelated individuals who self-identify with 28 large tribes in Saudi Arabia. Consistent with the tradition of intra-tribal unions, the subjects showed strong clustering along tribal lines with the distance between clusters correlating with their geographical proximities in Arabia. However, these individuals form a unique cluster when compared to the world’s major populations. The ancient origin of these tribal affiliations is supported by analyses that revealed little evidence of ancestral origin from within the 28 tribes. Our results disclose a granular map of population structure and have important implications for future genetic studies into Mendelian and common diseases in the region.

Klíčová slova:

Asia – Europe – Haplogroups – Human genomics – Inbreeding – Population genetics – Saudi Arabia – principal component analysis

Zdroje

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